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Volumn 48, Issue 1, 2015, Pages 17-28

Plant lectins, from ancient sugar-binding proteins to emerging anti-cancer drugs in apoptosis and autophagy

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CARBOHYDRATE BINDING PROTEIN; CASPASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PLANT LECTIN; PROTEIN ATG; PROTEIN BCL 2; PROTEIN BNIP3; PROTEIN KINASE B; PROTEIN P53; RAF PROTEIN; RAS PROTEIN; UNCLASSIFIED DRUG;

EID: 84920941027     PISSN: 09607722     EISSN: 13652184     Source Type: Journal    
DOI: 10.1111/cpr.12155     Document Type: Article
Times cited : (107)

References (74)
  • 1
    • 84884703479 scopus 로고    scopus 로고
    • Could plant lectins become promising anti-tumour drugs for causing autophagic cell death?
    • Liu Z, Luo Y, Zhou TT, Zhang WZ (2013) Could plant lectins become promising anti-tumour drugs for causing autophagic cell death? Cell Prolif. 46, 509-515.
    • (2013) Cell Prolif. , vol.46 , pp. 509-515
    • Liu, Z.1    Luo, Y.2    Zhou, T.T.3    Zhang, W.Z.4
  • 2
    • 16644383558 scopus 로고    scopus 로고
    • The identification of inducible cytoplasmic/nuclear carbohydrate-binding proteins urges to develop novel concepts about the role of plant lectins
    • Van Damme EJ, Lannoo N, Fouquaert E, Peumans WJ (2004) The identification of inducible cytoplasmic/nuclear carbohydrate-binding proteins urges to develop novel concepts about the role of plant lectins. Glycoconj. J. 20, 449-460.
    • (2004) Glycoconj. J. , vol.20 , pp. 449-460
    • Van Damme, E.J.1    Lannoo, N.2    Fouquaert, E.3    Peumans, W.J.4
  • 3
    • 72049120117 scopus 로고    scopus 로고
    • Plant lectins: potential antineoplastic drugs from bench to clinic
    • Liu B, Bian HJ, Bao JK (2010) Plant lectins: potential antineoplastic drugs from bench to clinic. Cancer Lett. 287, 1-12.
    • (2010) Cancer Lett. , vol.287 , pp. 1-12
    • Liu, B.1    Bian, H.J.2    Bao, J.K.3
  • 4
    • 0028872958 scopus 로고
    • Use of lectins as diagnostic and therapeutic tools for cancer
    • Mody R, Joshi S, Chaney W (1995) Use of lectins as diagnostic and therapeutic tools for cancer. J. Pharmacol. Toxicol. Methods 33, 1-10.
    • (1995) J. Pharmacol. Toxicol. Methods , vol.33 , pp. 1-10
    • Mody, R.1    Joshi, S.2    Chaney, W.3
  • 5
    • 84865574556 scopus 로고    scopus 로고
    • Plant natural compounds: targeting pathways of autophagy as anti-cancer therapeutic agents
    • Zhang X, Chen LX, Ouyang L, Cheng Y, Liu B (2012) Plant natural compounds: targeting pathways of autophagy as anti-cancer therapeutic agents. Cell Prolif. 454, 466-476.
    • (2012) Cell Prolif. , vol.454 , pp. 466-476
    • Zhang, X.1    Chen, L.X.2    Ouyang, L.3    Cheng, Y.4    Liu, B.5
  • 6
    • 79960925702 scopus 로고    scopus 로고
    • Core signaling pathways of survival/death in autophagy-related cancer networks
    • Wang SY, Yu QJ, Zhang RD, Liu B (2011) Core signaling pathways of survival/death in autophagy-related cancer networks. Int. J. Biochem. Cell Biol. 43, 1263-1266.
    • (2011) Int. J. Biochem. Cell Biol. , vol.43 , pp. 1263-1266
    • Wang, S.Y.1    Yu, Q.J.2    Zhang, R.D.3    Liu, B.4
  • 7
    • 77956363593 scopus 로고    scopus 로고
    • Autophagic pathways as new targets for cancer drug development
    • Liu B, Cheng Y, Liu Q, Bao JK, Yang JM (2010) Autophagic pathways as new targets for cancer drug development. Acta Pharmacol. Sin. 31, 1154-1164.
    • (2010) Acta Pharmacol. Sin. , vol.31 , pp. 1154-1164
    • Liu, B.1    Cheng, Y.2    Liu, Q.3    Bao, J.K.4    Yang, J.M.5
  • 10
    • 80054843050 scopus 로고    scopus 로고
    • Concanavalin A: a potential anti-neoplastic agent targeting apoptosis, autophagy and anti-angiogenesis for cancer therapeutics
    • Li WW, Yu JY, Xu HL, Bao JK (2011) Concanavalin A: a potential anti-neoplastic agent targeting apoptosis, autophagy and anti-angiogenesis for cancer therapeutics. Biochem. Biophys. Res. Commun. 414, 282-286.
    • (2011) Biochem. Biophys. Res. Commun. , vol.414 , pp. 282-286
    • Li, W.W.1    Yu, J.Y.2    Xu, H.L.3    Bao, J.K.4
  • 11
    • 61649114199 scopus 로고    scopus 로고
    • Molecular mechanisms of Polygonatum cyrtonema lectin-induced apoptosis and autophagy in cancer cells
    • Liu B, Cheng Y, Bian HJ, Bao JK (2009) Molecular mechanisms of Polygonatum cyrtonema lectin-induced apoptosis and autophagy in cancer cells. Autophagy 5, 253-255.
    • (2009) Autophagy , vol.5 , pp. 253-255
    • Liu, B.1    Cheng, Y.2    Bian, H.J.3    Bao, J.K.4
  • 12
    • 67349118806 scopus 로고    scopus 로고
    • Bioinformatics analyses of the mannose-binding lectins from Polygonatum cyrtonema, Ophiopogon japonicus and Liparis noversa with anti-proliferative and apoptosis-inducing activities
    • Liu B, Peng H, Yao Q, Li J, Van Damme E, Balzarini J et al. (2009) Bioinformatics analyses of the mannose-binding lectins from Polygonatum cyrtonema, Ophiopogon japonicus and Liparis noversa with anti-proliferative and apoptosis-inducing activities. Phytomedicine 6, 601-608.
    • (2009) Phytomedicine , vol.6 , pp. 601-608
    • Liu, B.1    Peng, H.2    Yao, Q.3    Li, J.4    Van Damme, E.5    Balzarini, J.6
  • 13
    • 38449085362 scopus 로고    scopus 로고
    • Uses of plant lectins in bioscience and biomedicine
    • Pusztai A, Bardocz S, Ewen SW (2008) Uses of plant lectins in bioscience and biomedicine. Front. Biosci. 13, 1130-1140.
    • (2008) Front. Biosci. , vol.13 , pp. 1130-1140
    • Pusztai, A.1    Bardocz, S.2    Ewen, S.W.3
  • 14
    • 79959464070 scopus 로고    scopus 로고
    • Glycan microarrays for decoding the glycome
    • Rillahan CD, Paulson JC (2013) Glycan microarrays for decoding the glycome. Annu. Rev. Biochem. 80, 797-823.
    • (2013) Annu. Rev. Biochem. , vol.80 , pp. 797-823
    • Rillahan, C.D.1    Paulson, J.C.2
  • 15
    • 84888272143 scopus 로고    scopus 로고
    • Lectins in human cancer: both a devil and an angel?
    • Dan XL, Ng TB (2013) Lectins in human cancer: both a devil and an angel? Curr. Protein Pept. Sci. 14, 481-491.
    • (2013) Curr. Protein Pept. Sci. , vol.14 , pp. 481-491
    • Dan, X.L.1    Ng, T.B.2
  • 16
    • 78649634631 scopus 로고    scopus 로고
    • Targeting apoptotic and autophagic pathways for cancer therapeutics
    • Liu JJ, Lin M, Yu JY, Liu B, Bao JK (2011) Targeting apoptotic and autophagic pathways for cancer therapeutics. Cancer Lett. 300, 105-114.
    • (2011) Cancer Lett. , vol.300 , pp. 105-114
    • Liu, J.J.1    Lin, M.2    Yu, J.Y.3    Liu, B.4    Bao, J.K.5
  • 17
    • 0036480161 scopus 로고    scopus 로고
    • Korean mistletoe lectin-induced apoptosis in hepatocarcinoma cells is associated with inhibition of telomerase via mitochondrial controlled pathway independent of p53
    • Lyu SY, Choi SH, Park WB (2002) Korean mistletoe lectin-induced apoptosis in hepatocarcinoma cells is associated with inhibition of telomerase via mitochondrial controlled pathway independent of p53. Arch. Pharm. Res. 25, 93-101.
    • (2002) Arch. Pharm. Res. , vol.25 , pp. 93-101
    • Lyu, S.Y.1    Choi, S.H.2    Park, W.B.3
  • 18
    • 34250890733 scopus 로고    scopus 로고
    • Induction of autophagy by concanavalin A and its application in anti-tumour therapy
    • Lei HY, Chang CP (2007) Induction of autophagy by concanavalin A and its application in anti-tumour therapy. Autophagy 3, 402-404.
    • (2007) Autophagy , vol.3 , pp. 402-404
    • Lei, H.Y.1    Chang, C.P.2
  • 19
    • 58749105634 scopus 로고    scopus 로고
    • Polygonatum cyrtonema lectin induces apoptosis and autophagy in human melanoma A375 cells through a mitochondria -mediated ROS-p38-p53 pathway
    • Liu B, Cheng Y, Zhang B, Bian HJ, Bao JK (2009) Polygonatum cyrtonema lectin induces apoptosis and autophagy in human melanoma A375 cells through a mitochondria -mediated ROS-p38-p53 pathway. Cancer Lett. 275, 54-60.
    • (2009) Cancer Lett. , vol.275 , pp. 54-60
    • Liu, B.1    Cheng, Y.2    Zhang, B.3    Bian, H.J.4    Bao, J.K.5
  • 20
    • 84861212393 scopus 로고    scopus 로고
    • Mitochondria and cell signalling
    • Tait SW, Green DR (2012) Mitochondria and cell signalling. J. Cell Sci. 125, 807-815.
    • (2012) J. Cell Sci. , vol.125 , pp. 807-815
    • Tait, S.W.1    Green, D.R.2
  • 22
    • 84919341324 scopus 로고    scopus 로고
    • Molecular mechanisms of liver injury: apoptosis or necrosis
    • Wang K (2014) Molecular mechanisms of liver injury: apoptosis or necrosis. Exp. Toxicol. Pathol. 66, 351-356. S0940-2993(14)00052-9
    • (2014) Exp. Toxicol. Pathol. , vol.66 , pp. 351-356
    • Wang, K.1
  • 23
    • 84902466692 scopus 로고    scopus 로고
    • Functions of the C-terminal domains of apoptosis-related proteins of the Bcl-2 family
    • Gómez-Fernández JC (2014) Functions of the C-terminal domains of apoptosis-related proteins of the Bcl-2 family. Chem. Phys. Lipids 183, 77-90. S0009-3084(14)00065-6
    • (2014) Chem. Phys. Lipids , vol.183 , pp. 77-90
    • Gómez-Fernández, J.C.1
  • 25
    • 58849153349 scopus 로고    scopus 로고
    • Antiproliferative activity and apoptosis-inducing mechanism of Concanavalin A on human melanoma A375 cells
    • Liu B, Li CY, Bian HJ, Min MW, Chen LF, Bao JK (2009) Antiproliferative activity and apoptosis-inducing mechanism of Concanavalin A on human melanoma A375 cells. Arch. Biochem. Biophys. 482, 1-6.
    • (2009) Arch. Biochem. Biophys. , vol.482 , pp. 1-6
    • Liu, B.1    Li, C.Y.2    Bian, H.J.3    Min, M.W.4    Chen, L.F.5    Bao, J.K.6
  • 26
    • 77952890932 scopus 로고    scopus 로고
    • In silico and experimental studies of Concanavalin A: insights into its antiproliferative activity and apoptotic mechanism
    • Liu ZY, Li XF, Ding XP, Yang Y (2010) In silico and experimental studies of Concanavalin A: insights into its antiproliferative activity and apoptotic mechanism. Appl. Biochem. Biotechnol. 162, 134-145.
    • (2010) Appl. Biochem. Biotechnol. , vol.162 , pp. 134-145
    • Liu, Z.Y.1    Li, X.F.2    Ding, X.P.3    Yang, Y.4
  • 28
    • 84864436118 scopus 로고    scopus 로고
    • Concanavalin-A-induced autophagy biomarkers requires membrane type-1 matrix metalloproteinase intracellular signaling in glioblastoma cells
    • Pratt J, Roy R, Annabi B (2012) Concanavalin-A-induced autophagy biomarkers requires membrane type-1 matrix metalloproteinase intracellular signaling in glioblastoma cells. Glycobiology 22, 1245-1255.
    • (2012) Glycobiology , vol.22 , pp. 1245-1255
    • Pratt, J.1    Roy, R.2    Annabi, B.3
  • 29
    • 34250826027 scopus 로고    scopus 로고
    • A novel role for p73 in the regulation of Akt-Foxo1a-Bim signaling and apoptosis induced by the plant lectin, Concanavalin A
    • Ruhul Amin AR, Paul RK, Thakur VS, Agarwal ML (2007) A novel role for p73 in the regulation of Akt-Foxo1a-Bim signaling and apoptosis induced by the plant lectin, Concanavalin A. Cancer Res. 67, 5617-5621.
    • (2007) Cancer Res. , vol.67 , pp. 5617-5621
    • Ruhul Amin, A.R.1    Paul, R.K.2    Thakur, V.S.3    Agarwal, M.L.4
  • 30
    • 29844438773 scopus 로고    scopus 로고
    • Suppression of growth of tumor cell lines in vitro and tumors in vivo by mistletoe lectins
    • Pryme IF, Bardocz S, Pusztai A, Ewen SWB (2006) Suppression of growth of tumor cell lines in vitro and tumors in vivo by mistletoe lectins. Histol. Histopathol. 21, 285-299.
    • (2006) Histol. Histopathol. , vol.21 , pp. 285-299
    • Pryme, I.F.1    Bardocz, S.2    Pusztai, A.3    Ewen, S.W.B.4
  • 31
    • 0037928493 scopus 로고    scopus 로고
    • Recombinant mistletoe lectin induces p53-independent apoptosis in tumor cells and cooperates with ionizing radiation
    • Hostanska K, Vuong V, Rocha S, Soengas MS, Glanzmann C, Saller R et al. (2003) Recombinant mistletoe lectin induces p53-independent apoptosis in tumor cells and cooperates with ionizing radiation. Br. J. Cancer 88, 1785-1792.
    • (2003) Br. J. Cancer , vol.88 , pp. 1785-1792
    • Hostanska, K.1    Vuong, V.2    Rocha, S.3    Soengas, M.S.4    Glanzmann, C.5    Saller, R.6
  • 32
    • 0034833942 scopus 로고    scopus 로고
    • Roles of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase in apoptosis of human monoblastic leukemia U937 cells by lectin-II isolated from Korean mistletoe
    • Pae HO, Oh GS, Kim NY, Shin MK, Lee HS, Yun YG et al. (2001) Roles of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase in apoptosis of human monoblastic leukemia U937 cells by lectin-II isolated from Korean mistletoe. In Vitr. Mol. Toxicol. 14, 99-106.
    • (2001) In Vitr. Mol. Toxicol. , vol.14 , pp. 99-106
    • Pae, H.O.1    Oh, G.S.2    Kim, N.Y.3    Shin, M.K.4    Lee, H.S.5    Yun, Y.G.6
  • 33
    • 78650726497 scopus 로고    scopus 로고
    • Recombinant expression of Polygonatum cyrtonema lectin with anti-viral; apoptosis-inducing activities and preliminary crystallization
    • Li CY, Luo P, Liu JJ, Wang EQ, Li WW, Ding ZH et al. (2011) Recombinant expression of Polygonatum cyrtonema lectin with anti-viral; apoptosis-inducing activities and preliminary crystallization. Process Biochem. 46, 533-542.
    • (2011) Process Biochem. , vol.46 , pp. 533-542
    • Li, C.Y.1    Luo, P.2    Liu, J.J.3    Wang, E.Q.4    Li, W.W.5    Ding, Z.H.6
  • 34
    • 44849096361 scopus 로고    scopus 로고
    • Apoptosis-inducing effect and structural basis of Polygonatum cyrtonema lectin and chemical modification properties on its mannose-binding sites
    • Liu B, Xu XC, Cheng Y, Huang J, Liu YH, Liu Z et al. (2008) Apoptosis-inducing effect and structural basis of Polygonatum cyrtonema lectin and chemical modification properties on its mannose-binding sites. BMB Rep. 41, 369-375.
    • (2008) BMB Rep. , vol.41 , pp. 369-375
    • Liu, B.1    Xu, X.C.2    Cheng, Y.3    Huang, J.4    Liu, Y.H.5    Liu, Z.6
  • 35
    • 67349118806 scopus 로고    scopus 로고
    • Bioinformatics analyses of the mannose-binding lectins from Ophiopogon japonicus and Liparis noversa with antiproliferative and apoptosis-inducing activities
    • Liu B, Peng H, Yao Q, Li J, Van Damme EJ, Balzarini J et al. (2009) Bioinformatics analyses of the mannose-binding lectins from Ophiopogon japonicus and Liparis noversa with antiproliferative and apoptosis-inducing activities. Phytomedicine 16, 601-608.
    • (2009) Phytomedicine , vol.16 , pp. 601-608
    • Liu, B.1    Peng, H.2    Yao, Q.3    Li, J.4    Van Damme, E.J.5    Balzarini, J.6
  • 36
    • 78649797432 scopus 로고    scopus 로고
    • Polygonatum cyrtonema lectin induces murine fibrosarcoma L929 cell apoptosis via a caspasedependent pathway as compared to Ophiopogon japonicus lectin
    • Zhang ZT, Peng H, Li CY, Liu JJ, Zhou TT, Yan YF et al. (2010) Polygonatum cyrtonema lectin induces murine fibrosarcoma L929 cell apoptosis via a caspasedependent pathway as compared to Ophiopogon japonicus lectin. Phytomedicine 18, 25-31.
    • (2010) Phytomedicine , vol.18 , pp. 25-31
    • Zhang, Z.T.1    Peng, H.2    Li, C.Y.3    Liu, J.J.4    Zhou, T.T.5    Yan, Y.F.6
  • 37
    • 51549084813 scopus 로고    scopus 로고
    • A mannose-binding lectin from Sophora flavescens induces apoptosis in HeLa cells
    • Liu Z, Liu B, Zhang ZT, Zhou TT, Bian HJ, Min MW et al. (2008) A mannose-binding lectin from Sophora flavescens induces apoptosis in HeLa cells. Phytomedicine 15, 867-875.
    • (2008) Phytomedicine , vol.15 , pp. 867-875
    • Liu, Z.1    Liu, B.2    Zhang, Z.T.3    Zhou, T.T.4    Bian, H.J.5    Min, M.W.6
  • 38
    • 62549131255 scopus 로고    scopus 로고
    • A novel sialic acid-specific lectin from Phaseolus coccineus seeds with potent antineoplastic and antifungal activities
    • Chen J, Liu B, Ji N, Zhou J, Bian JH, Li CY et al. (2009) A novel sialic acid-specific lectin from Phaseolus coccineus seeds with potent antineoplastic and antifungal activities. Phytomedicine 16, 352-360.
    • (2009) Phytomedicine , vol.16 , pp. 352-360
    • Chen, J.1    Liu, B.2    Ji, N.3    Zhou, J.4    Bian, J.H.5    Li, C.Y.6
  • 39
    • 84887845281 scopus 로고    scopus 로고
    • Purification of a mannose-binding lectin Pinellia ternata agglutinin and its induction of apoptosis in Bel-7404 cells
    • Zhou W, Gao Y, Xu S, Yang Z, Xu T (2014) Purification of a mannose-binding lectin Pinellia ternata agglutinin and its induction of apoptosis in Bel-7404 cells. Protein Expr. Purif. 93, 11-17.
    • (2014) Protein Expr. Purif. , vol.93 , pp. 11-17
    • Zhou, W.1    Gao, Y.2    Xu, S.3    Yang, Z.4    Xu, T.5
  • 40
    • 84886087904 scopus 로고    scopus 로고
    • Pea lectin inhibits growth of Ehrlich ascites carcinoma cells by inducing apoptosis and G2/M cell cycle arrest in vivo in mice
    • Kabir SR, Nabi MM, Haque A, Zaman Rokon Uz, Mahmud ZH, Reza MA (2013) Pea lectin inhibits growth of Ehrlich ascites carcinoma cells by inducing apoptosis and G2/M cell cycle arrest in vivo in mice. Phytomedicine 20, 1288-1296.
    • (2013) Phytomedicine , vol.20 , pp. 1288-1296
    • Kabir, S.R.1    Nabi, M.M.2    Haque, A.3    Zaman, R.U.4    Mahmud, Z.H.5    Reza, M.A.6
  • 41
    • 84867237348 scopus 로고    scopus 로고
    • Purified mulberry leaf lectin (MLL) induces apoptosis and cell cycle arrest in human breast cancer and colon cancer cells
    • Deepa M, Sureshkumar T, Satheeshkumar PK, Priya S (2012) Purified mulberry leaf lectin (MLL) induces apoptosis and cell cycle arrest in human breast cancer and colon cancer cells. Chem. Biol. Interact. 200, 38-44.
    • (2012) Chem. Biol. Interact. , vol.200 , pp. 38-44
    • Deepa, M.1    Sureshkumar, T.2    Satheeshkumar, P.K.3    Priya, S.4
  • 42
    • 84868159209 scopus 로고    scopus 로고
    • Recombinant VAA-I from viscum album induces apoptotic cell death of hepatocellular carcinoma SMMC7721 cells
    • Yang X, Jiang S, Liu Y, Zhang P, Xie S, Wang G (2012) Recombinant VAA-I from viscum album induces apoptotic cell death of hepatocellular carcinoma SMMC7721 cells. Molecules 17, 11435-11446.
    • (2012) Molecules , vol.17 , pp. 11435-11446
    • Yang, X.1    Jiang, S.2    Liu, Y.3    Zhang, P.4    Xie, S.5    Wang, G.6
  • 43
    • 84866045135 scopus 로고    scopus 로고
    • Antiproliferative effects of lectins from Canavalia ensiformis and Canavalia brasiliensis in human leukemia cell lines
    • Faheina-Martins GV, da Silveira AL, Cavalcanti BC, Ramos MV, Moraes MO, Pessoa C et al. (2012) Antiproliferative effects of lectins from Canavalia ensiformis and Canavalia brasiliensis in human leukemia cell lines. Toxicol. In Vitro 26, 1161-1169.
    • (2012) Toxicol. In Vitro , vol.26 , pp. 1161-1169
    • Faheina-Martins, G.V.1    da Silveira, A.L.2    Cavalcanti, B.C.3    Ramos, M.V.4    Moraes, M.O.5    Pessoa, C.6
  • 44
    • 84864036834 scopus 로고    scopus 로고
    • The MAP30 protein from bitter gourd (Momordica charantia) seeds promotes apoptosis in liver cancer cells in vitro and in vivo
    • Fang EF, Zhang CZ, Wong JH, Shen JY, Li CH, Ng TB (2012) The MAP30 protein from bitter gourd (Momordica charantia) seeds promotes apoptosis in liver cancer cells in vitro and in vivo. Cancer Lett. 324, 66-74.
    • (2012) Cancer Lett. , vol.324 , pp. 66-74
    • Fang, E.F.1    Zhang, C.Z.2    Wong, J.H.3    Shen, J.Y.4    Li, C.H.5    Ng, T.B.6
  • 45
    • 84862907973 scopus 로고    scopus 로고
    • Momordica charantia lectin, a type II ribosome inactivating protein, exhibits antitumor activity toward human nasopharyngeal carcinoma cells in vitro and in vivo
    • Fang EF, Zhang CZ, Ng TB, Wong JH, Pan WL, Ye XJ et al. (2012) Momordica charantia lectin, a type II ribosome inactivating protein, exhibits antitumor activity toward human nasopharyngeal carcinoma cells in vitro and in vivo. Cancer Prev. Res. (Phila.) 5, 9-21.
    • (2012) Cancer Prev. Res. (Phila.) , vol.5 , pp. 9-21
    • Fang, E.F.1    Zhang, C.Z.2    Ng, T.B.3    Wong, J.H.4    Pan, W.L.5    Ye, X.J.6
  • 46
    • 59649088766 scopus 로고    scopus 로고
    • Saporin induces multiple death pathways in lymphoma cells with different intensity and timing as compared to ricin
    • Polito L, Bortolotti M, Farini V, Battelli MG, Barbieri L, Bolognesi A (2009) Saporin induces multiple death pathways in lymphoma cells with different intensity and timing as compared to ricin. Int. J. Biochem. Cell Biol. 41, 1055-1061.
    • (2009) Int. J. Biochem. Cell Biol. , vol.41 , pp. 1055-1061
    • Polito, L.1    Bortolotti, M.2    Farini, V.3    Battelli, M.G.4    Barbieri, L.5    Bolognesi, A.6
  • 47
    • 0035666770 scopus 로고    scopus 로고
    • Apoptosis induction associated with cell cycle dysregulation by rice bran agglutinin
    • Miyoshi N, Koyama Y, Katsuno Y, Hayakawa S, Mita T, Ohta T et al. (2001) Apoptosis induction associated with cell cycle dysregulation by rice bran agglutinin. J. Biochem. 130, 799-805.
    • (2001) J. Biochem. , vol.130 , pp. 799-805
    • Miyoshi, N.1    Koyama, Y.2    Katsuno, Y.3    Hayakawa, S.4    Mita, T.5    Ohta, T.6
  • 48
    • 70349515561 scopus 로고    scopus 로고
    • Regulation of caspase-3 and Bcl-2 expression in Dalton's lymphoma ascites cells by abrin
    • Ramnath V, Rekha P, Kuttan G, Kuttan R (2009) Regulation of caspase-3 and Bcl-2 expression in Dalton's lymphoma ascites cells by abrin. Evid. Based Complement. Alternat. Med. 6, 233-238.
    • (2009) Evid. Based Complement. Alternat. Med. , vol.6 , pp. 233-238
    • Ramnath, V.1    Rekha, P.2    Kuttan, G.3    Kuttan, R.4
  • 49
    • 67349227379 scopus 로고    scopus 로고
    • Antiproliferation and apoptosis of human tumor cell lines by a lectin (AMML) of Astragalus mongholicus
    • Yan Q, Li Y, Jiang Z, Sun Y, Zhu L, Ding Z (2009) Antiproliferation and apoptosis of human tumor cell lines by a lectin (AMML) of Astragalus mongholicus. Phytomedicine 16, 586-593.
    • (2009) Phytomedicine , vol.16 , pp. 586-593
    • Yan, Q.1    Li, Y.2    Jiang, Z.3    Sun, Y.4    Zhu, L.5    Ding, Z.6
  • 51
    • 84887486465 scopus 로고    scopus 로고
    • Survival or death: disequilibrating the oncogenic and tumor suppressive autophagy in cancer
    • Liu B, Wen X, Cheng Y (2013) Survival or death: disequilibrating the oncogenic and tumor suppressive autophagy in cancer. Cell Death Dis. 4, e892.
    • (2013) Cell Death Dis. , vol.4 , pp. e892
    • Liu, B.1    Wen, X.2    Cheng, Y.3
  • 52
    • 84881140001 scopus 로고    scopus 로고
    • Deconvoluting the role of reactive oxygen species and autophagy in human diseases
    • Wen X, Wu J, Wang F, Liu B, Huang C, Wei Y (2013) Deconvoluting the role of reactive oxygen species and autophagy in human diseases. Free Radic. Biol. Med. 65, 402-410.
    • (2013) Free Radic. Biol. Med. , vol.65 , pp. 402-410
    • Wen, X.1    Wu, J.2    Wang, F.3    Liu, B.4    Huang, C.5    Wei, Y.6
  • 53
    • 84888161072 scopus 로고    scopus 로고
    • Therapeutic targeting of autophagy in disease: biology and pharmacology
    • Cheng Y, Ren X, Hait WN, Yang JM (2013) Therapeutic targeting of autophagy in disease: biology and pharmacology. Pharmacol. Rev. 65, 1162-1197.
    • (2013) Pharmacol. Rev. , vol.65 , pp. 1162-1197
    • Cheng, Y.1    Ren, X.2    Hait, W.N.3    Yang, J.M.4
  • 54
    • 84874598403 scopus 로고    scopus 로고
    • Beclin-1: autophagic regulator and therapeutic target in cancer
    • Fu LL, Cheng Y, Liu B (2013) Beclin-1: autophagic regulator and therapeutic target in cancer. Int. J. Biochem. Cell Biol. 45, 921-924.
    • (2013) Int. J. Biochem. Cell Biol. , vol.45 , pp. 921-924
    • Fu, L.L.1    Cheng, Y.2    Liu, B.3
  • 56
    • 84923259951 scopus 로고    scopus 로고
    • Therapeutic targeting of autophagy in cancer. Part I: molecular pathways controlling autophagy
    • Nagelkerke A, Sweep FC, Geurts-Moespot A, Bussink J, Span PN (2014) Therapeutic targeting of autophagy in cancer. Part I: molecular pathways controlling autophagy. Semin. Cancer Biol. pii: S1044-579X(14)00073-X. doi: 10.1016/j.semcancer.2014.05.004.
    • (2014) Semin. Cancer Biol.
    • Nagelkerke, A.1    Sweep, F.C.2    Geurts-Moespot, A.3    Bussink, J.4    Span, P.N.5
  • 57
    • 63449123137 scopus 로고    scopus 로고
    • Lectin of Concanavalin A as an anti-hepatoma therapeutic agent
    • Lei HY, Chang CP (2009) Lectin of Concanavalin A as an anti-hepatoma therapeutic agent. J. Biomed. Sci. 16, 10.
    • (2009) J. Biomed. Sci. , vol.16 , pp. 10
    • Lei, H.Y.1    Chang, C.P.2
  • 58
    • 33847754341 scopus 로고    scopus 로고
    • Concanavalin A induces autophagy in hepatoma cells and has a therapeutic effect in a murine in situ hepatoma mode
    • Chang CP, Yang MC, Liu HS, Lin YS, Lei HY (2007) Concanavalin A induces autophagy in hepatoma cells and has a therapeutic effect in a murine in situ hepatoma mode. Hepatology 45, 286-296.
    • (2007) Hepatology , vol.45 , pp. 286-296
    • Chang, C.P.1    Yang, M.C.2    Liu, H.S.3    Lin, Y.S.4    Lei, H.Y.5
  • 59
    • 84893578869 scopus 로고    scopus 로고
    • Induction of autophagy biomarker BNIP3 requires a JAK2/STAT3 and MT1-MMP signaling interplay in Concanavalin-A-activated U87 glioblastoma cells
    • Pratt J, Annabi B (2014) Induction of autophagy biomarker BNIP3 requires a JAK2/STAT3 and MT1-MMP signaling interplay in Concanavalin-A-activated U87 glioblastoma cells. Cell. Signal. 5, 917-924.
    • (2014) Cell. Signal. , vol.5 , pp. 917-924
    • Pratt, J.1    Annabi, B.2
  • 60
    • 84893369762 scopus 로고    scopus 로고
    • Role of PI3K/Akt/mTOR and MEK/ERK pathway in Concanavalin A induced autophagy in HeLa cells
    • Roy B, Pattanaik AK, Das J, Bhutia SK, Behera B, Singh P et al. (2014) Role of PI3K/Akt/mTOR and MEK/ERK pathway in Concanavalin A induced autophagy in HeLa cells. Chem. Biol. Interact. 210, 96-102.
    • (2014) Chem. Biol. Interact. , vol.210 , pp. 96-102
    • Roy, B.1    Pattanaik, A.K.2    Das, J.3    Bhutia, S.K.4    Behera, B.5    Singh, P.6
  • 62
    • 78650250800 scopus 로고    scopus 로고
    • Polygonatum cyrtonema lectin induces murine fibrosarcoma L929 cell apoptosis and autophagy via blocking Ras-Raf and PI3K-Akt signaling pathways
    • Liu B, Wu JM, Li J, Liu JJ, Li WW, Li CY et al. (2010) Polygonatum cyrtonema lectin induces murine fibrosarcoma L929 cell apoptosis and autophagy via blocking Ras-Raf and PI3K-Akt signaling pathways. Biochimie 92, 1934-1938.
    • (2010) Biochimie , vol.92 , pp. 1934-1938
    • Liu, B.1    Wu, J.M.2    Li, J.3    Liu, J.J.4    Li, W.W.5    Li, C.Y.6
  • 63
    • 84865565698 scopus 로고    scopus 로고
    • Korean mistletoe lectin regulates self-renewal of placenta-derived mesenchymal stem cells via autophagic mechanisms
    • Choi JH, Lyu SY, Lee HJ, Jung J, Park WB, Kim GJ (2012) Korean mistletoe lectin regulates self-renewal of placenta-derived mesenchymal stem cells via autophagic mechanisms. Cell Prolif. 45, 420-429.
    • (2012) Cell Prolif. , vol.45 , pp. 420-429
    • Choi, J.H.1    Lyu, S.Y.2    Lee, H.J.3    Jung, J.4    Park, W.B.5    Kim, G.J.6
  • 64
    • 84865547975 scopus 로고    scopus 로고
    • Identification of microRNA-regulated autophagic pathways in plant lectin-induced cancer cell death
    • Fu LL, Zhao X, Xu HL, Wen X, Wang SY, Liu B et al. (2012) Identification of microRNA-regulated autophagic pathways in plant lectin-induced cancer cell death. Cell Prolif. 45, 477-485.
    • (2012) Cell Prolif. , vol.45 , pp. 477-485
    • Fu, L.L.1    Zhao, X.2    Xu, H.L.3    Wen, X.4    Wang, S.Y.5    Liu, B.6
  • 65
    • 59849118717 scopus 로고    scopus 로고
    • Autophagy induction in T cell-independent acute hepatitis induced by concanavalinA in SCID/NOD mice
    • Chang CP, Lei HY (2008) Autophagy induction in T cell-independent acute hepatitis induced by concanavalinA in SCID/NOD mice. Int. J. Immunopathol. Pharmacol. 21, 817-826.
    • (2008) Int. J. Immunopathol. Pharmacol. , vol.21 , pp. 817-826
    • Chang, C.P.1    Lei, H.Y.2
  • 66
    • 0034066496 scopus 로고    scopus 로고
    • Polyethylene glycol-modified Concanavalin A as an effective agent to stimulate anti-tumour cytotoxicity
    • Ueno T, Ohtawa K, Kimoto Y, Sakurai Y, Kodera Y, Hiroto M et al. (2000) Polyethylene glycol-modified Concanavalin A as an effective agent to stimulate anti-tumour cytotoxicity. Cancer Detect. Prev. 24, 100-106.
    • (2000) Cancer Detect. Prev. , vol.24 , pp. 100-106
    • Ueno, T.1    Ohtawa, K.2    Kimoto, Y.3    Sakurai, Y.4    Kodera, Y.5    Hiroto, M.6
  • 68
    • 0034004550 scopus 로고    scopus 로고
    • First clinical data of a natural immunomodulator in colorectal cancer
    • Mayer AF, Hoffmann A, Hidvegi M (2000) First clinical data of a natural immunomodulator in colorectal cancer. Hepatogastroenterology 47, 393-395.
    • (2000) Hepatogastroenterology , vol.47 , pp. 393-395
    • Mayer, A.F.1    Hoffmann, A.2    Hidvegi, M.3
  • 69
    • 80054853917 scopus 로고    scopus 로고
    • Case reports of sarcoma patients with optimized lectin-oriented mistletoe extract therapy
    • Kirsch A, Hajto T (2011) Case reports of sarcoma patients with optimized lectin-oriented mistletoe extract therapy. J. Altern. Complement. Med. 10, 973-979.
    • (2011) J. Altern. Complement. Med. , vol.10 , pp. 973-979
    • Kirsch, A.1    Hajto, T.2
  • 70
    • 80052753545 scopus 로고    scopus 로고
    • Quality of life and related dimensions in cancer patients treated with mistletoe extract (iscador): a meta-analysis
    • Büssing A, Raak C, Ostermann T (2012). Quality of life and related dimensions in cancer patients treated with mistletoe extract (iscador): a meta-analysis. Evid. Based Complement. Alternat. Med. 2012, 219402.
    • (2012) Evid. Based Complement. Alternat. Med. , vol.2012 , pp. 219402
    • Büssing, A.1    Raak, C.2    Ostermann, T.3
  • 72
    • 7244258916 scopus 로고    scopus 로고
    • History of lectins: from hemagglutinins to biological recognition molecules
    • Sharon N, Lis H. (2004) History of lectins: from hemagglutinins to biological recognition molecules. Glycobiology 14, 53R-62R.
    • (2004) Glycobiology , vol.14 , pp. 53R-62R
    • Sharon, N.1    Lis, H.2
  • 73
    • 0023194663 scopus 로고
    • The toxic plant proteins ricin and abrin induce apoptotic changes in mammalian lymphoid tissues and intestine
    • Griffiths GD, Leek MD, Gee DJ (1987) The toxic plant proteins ricin and abrin induce apoptotic changes in mammalian lymphoid tissues and intestine. J. Pathol. 151, 221-229.
    • (1987) J. Pathol. , vol.151 , pp. 221-229
    • Griffiths, G.D.1    Leek, M.D.2    Gee, D.J.3
  • 74
    • 0021926813 scopus 로고
    • Macrophage recognition of cells undergoing programmed cell death (apoptosis)
    • Duvall E, Wyllie AH, Morris RG. (1985) Macrophage recognition of cells undergoing programmed cell death (apoptosis). Immunology 56, 351-358.
    • (1985) Immunology , vol.56 , pp. 351-358
    • Duvall, E.1    Wyllie, A.H.2    Morris, R.G.3


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