Suppression of growth of tumour cell lines in vitro and tumours in vivo by mistletoe lectins

Histology and Histopathology

Volumn 21, Issue 1-3, 2006, Pages 285-299

  Pryme, Ian F ^a   Bardocz, S ^b   Pusztai, A ^b   Ewen, S W B ^c  

^a UNIVERSITY OF BERGEN   (Norway)

^b ROWETT RESEARCH INSTITUTE   (United Kingdom)

^c UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Anti angiogenesis; Apoptosis; Mistletoe lectin; Peyer's patch; Tumour growth

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ANTINEOPLASTIC AGENT; ASPARTATE AMINOTRANSFERASE; AVISCUMINE; GAMMA GLUTAMYLTRANSFERASE; GAMMA INTERFERON; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; LECTIN; LIPOCORTIN 5; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; MULTIDRUG RESISTANCE PROTEIN 1; PACLITAXEL; POLYADENYLIC ACID; RECOMBINANT MISTLETOE LECTIN; RIBOSOME INACTIVATING PROTEIN; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE 1; TELOMERASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UNINDEXED DRUG; VISCUM ALBUM LECTIN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANGIOGENESIS; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLADDER CANCER; CANCER CELL; CANCER GROWTH; CANCER IMMUNOTHERAPY; CANCER INHIBITION; CANCER SURVIVAL; CELL GROWTH; CLINICAL TRIAL; CYTOKINE RELEASE; CYTOTOXICITY; DOSE RESPONSE; DRUG HALF LIFE; DRUG HYPERSENSITIVITY; DRUG INFUSION; DRUG POTENTIATION; DRUG PURIFICATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FATIGUE; FEVER; FOLLOW UP; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; GLIOBLASTOMA; HISTOPATHOLOGY; HUMAN; HUMAN CELL CULTURE; IMMUNOMODULATION; IMMUNOPOTENTIATION; IN VITRO STUDY; IN VIVO STUDY; LIVER TOXICITY; MAXIMUM PERMISSIBLE DOSE; NAUSEA; NONHODGKIN LYMPHOMA; NONHUMAN; PEYER PATCH; PROTEIN FUNCTION; PROTEIN ISOLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; SENSITIVITY ANALYSIS; SURVIVAL RATE; SURVIVAL TIME; VOMITING;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CLINICAL TRIALS; CYTOKINES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASM METASTASIS; NEOPLASMS; NEOVASCULARIZATION, PHYSIOLOGIC; PLANT PREPARATIONS; PLANT PROTEINS; TOXINS, BIOLOGICAL; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; VISCUM ALBUM;

EID: 29844438773     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (76)

1. Bantel H., Engels I.H., Voelter W., Schulze-Osthoff K. and Wesselborg S. (1999). Mistletoe lectin activates caspase-8/FGLICE independently of death receptor signaling and enhances anticancer drug-induced apoptosis. Cancer Res. 59, 2083-2090.
2. Bardocz S., Grant G., Duguid T.J., Brown D.S., Pusztai A. and Pryme I.F. (1994a). Effect of phytohaemagglutinin on the growth of Krebs II tumour cells, body metabolism and internal organs of mice. Int. J. Oncol. 5, 1369-1374.
3. Bardocz S., Grant G., Duguid T.J., Brown D.S., Sakhri M., Pusztai A., Pryme I.F., Mayer D. and Wayb K. (1994b). Phytohaemagglutinin in the diet induces growth of the gut and modifies some organ weights in mice. Med. Sci. Res. 22, 101-103.
4. Bardocz S., Grant G., Duguid T.J., Brown D.S., Pusztai A. and Pryme I.F. (1997). Intracellular levels of polyamines in Krebs II lymphosarcoma cells in mice fed phytohaemagglutinin-containing diets are coupled with altered tumour growth. Cancer Lett. 121, 25-29.
5. Bardocz S., Grant G., Hughes E.L., Brown D.S. and Pusztai A. (1999). Uptake, inter-organ distribution and metabolism of dietary polyamines in the rat. In: Polyamines in health and nutrition. Bardocz S. and White A. (eds). Kluwer Academic Publishers Boston/Dordrecht/London. pp 241-258.
6. Baxevanis C.N., Voutsas I.F., Soler M.H.J., Gritzapis A.D., Tsitsilonis O.E., Stoeva S., Voelter W., Arsenis P. and Papamichail M. (1998). Mistletoe lectin I-incluced effects on human cytotoxic lymphocytes. I. Synergism with IL-2 in the induction of enhanced LAK cytotoxicity. Immunopharmacol. Immunotoxicol. 20, 355-372.
7. Büssing A., Wagner M., Wagner B., Stein G.M., Schietzel M., Schaller G. and Pfüller U. (1999). Induction of mitochondrial Apo2.7 molecules and generation of reactive oxygen-intermediates in cultured lymphocytes by the toxic proteins from Viscum album L. Cancer Lett. 139, 79-88.
8. Choi S.H., Lyu S.Y. and Park W.B. (2004). Mistletoe lectin induces apoptosis and telomerase inhibition in human A253 cancer cells through dephosphorylation of Akt. Arch. Pharm. Res. 27, 68-76.
9. Eifler R., Pfüller K., Göckeritz W. and Pfüller U. (1993). Improved procedures for isolation of mistletoe lectins and their subunits: lectin pattern of the European mistletoe. In: Lectins: Biology, biochemistry, clinical biochemistry. Vol. 9. Basu J. Kundu M. and Chakrabarty P. (eds). Wiley Eastern Limited New Delhi. pp 144-151.
10. Elsasser-Beile U., Ruhnau T., Freudenberg N., Wetterauer U. and Mengs U. (2001). Antitumoural effect of recombinant mistletoe lectin on chemically induced urinary bladder carcinogenesis in a rat model. Cancer 91, 998-1004.
11. Elsasser-Beile U., Leiber C., Wolf P., Lucht M., Mengs U. and Wetterauer U. (2005). Adjuvant intravesical treatment of superficial bladder cancer with a standardized mistletoe extract. J. Urol. 174, 76-79.
12. Ewen S.W.B., Bardocz S., Grant G., Pryme I.F. and Pusztai A. (1998). The effects of PHA and mistletoe lectin binding to epithelium of rat and mouse gut. In: Effects of antinutrients on the nutritional value of legume diets. Vol. 5. Bardocz S., Pfüller U. and Pusztai A. (eds). COST 98. EC Publication. Luxembourg. pp 221-225.
13. Ewen S.W.B., Pryme I.F., Bardocz S. and Pusztai A. (1999). Does oral ingestion of ML-I lectin ablate murine transplanted non-Hodgkin lymphoma by apoptosis or necrosis? In: Effects of antinutrients on the nutritional value of legume diets. Vol. 6. Bardocz S., Hajos G. and Pusztai A. (eds). COST 98. EC Publication. Luxembourg. pp 126-133.
14. Frantz M., Jung M.L., Ribereau-Gayon G. and Anton R. (2000). Modulation of mistletoe (Viscum album L.) lectins cytotoxicity by carbohydrates and serum glycoproteins. Drug Res. 50, 471-478.
15. Hall A.H., Spoerke D.G. and Rumack B.H. (1986). Assessing mistletoe toxicity. Ann. Emerg. Med. 15, 1320-1323.
16. Halto T., Hostanska K. and Gabius H.J. (1989). Modulatory potency of the beta-galactoside-specific lectin from mistletoe extract (Iscador) on the host defense system in vivo in rabbits and patients. Cancer Res. 49, 4803-4908.
17. Heiny B.M., Albrecht V. and Beuth J. (1998). Correlation of immune cell activities and beta-endorphin release in breast carcinoma patients treated with galactose-specific lectin standardized mistletoe extract. Anticancer Res. 18, 583-586.
18. Kim M.S., So H.S., Lee K.M., Park J.S., Lee J.H., Moon S.K., Ryu D.G., Chung S.Y., Jung B.H., Kim Y.K., Moon G. and Park R. (2000). Activation of caspase cascades in Korean mistletoe (Viscum album var. coloratum) lectin-II-induced apoptosis of human myeloleukemic U937 cells. Gen. Pharmacol. 34, 349-355.
19. Kopp J., Körner I.-J., Pfüller U., Göckeritz W., Eiffler R., Pfüller K. and Franz H. (1993). Toxicity of mistletoe lectins I, II and III on normal and malignant cells. In: Lectins: Biology, biochemistry, clinical biochemistry. Vol. 8. Van Driessche E., Franz H., Beekmans S., Pfüller U., Kallikorm A. and Bøg-Hansen T.C. (eds). Textop, Hellerup, Denmark. pp 41-47.
20. Köteles G.J., Kubasova T., Hurná E., Horváth Gy. and Pfüller U. (1998). Cellular and cytogenetic approaches in testing toxic and safe concentrations of mistletoe lectins. In: Effects of antinutrients on the nutritional value of legume diets. Vol. 5. Bardocz S., Pfüller U. and Pusztai A, (eds). COST 98. EC Publication. Luxembourg. pp 202-207.
21. Krenzelok T.D., Jacobsen E.P. and Aronis J. (1997). American mistletoe exposures. Am. J. Emerg. Med. 15, 516-520.
22. Kubasova T., Pfüller U., Bojtor I. and Köteles G.J. (1998). Modulation of immune response by mistletoe lectin 1 as detected on tumour model in vivo. In: Effects of antinutrients on the nutritional value of legume diets. Vol. 5. Bardocz S., Pfüller U. and Pusztai A. (eds). COST 98 EC Publication. Luxembourg. pp 81-86.
23. Kubasova T., Petcu I., Pfüller U. and Köteles G.J. (1999). Effects of mistletoe lectin I and ionizing radiation on the glucose and thymidine uptake in tumour cells in vitro. Phytother Res. 13, 655-659.
24. Lavelle E.C., Grant G., Pusztai A., Pfüller U. and O'Hagan D.T. (2000). Mucosal immunogenicity of plant lectins in mice. Immunology 99, 30-37.
25. Lavelle E.C., Grant G., Pusztai A., Pfüller U. and O'Hagan D.T. (2001).The identification of plant lectins with mucosal adjuvant activity. Immunology 102, 77-86.
26. Lavelle E.C., Grant G., Pusztai A., Pfüller U., Leavy O., McNeela E., Mills K.H. and O'Hagan D.T. (2002). Mistletoe lectins enhance immune responses to intranasally co-administered herpes simplex virus glycoprotein D2. Immunology 107, 268-274.
27. Lenartz D., Andermahr J., Plum G., Menzel J. and Beuth J. (1998). Efficiency of treatment with galactoside-specific lectin from mistletoe against rat glioma. Anticancer Res. 18, 1011-1014.
28. Lenartz D., Dott U., Menzel J., Schierholz J.M. and Beuth J. (2000). Survival of glioma patients after complementary treatment with galactoside-specific lectin from mistletoe. Anticancer Res. 20, 2073-2076.
29. Lyu S.Y., Park W.B., Choi K.H. and Kim W.H. (2001). Involvement of caspase-3 in apoptosis induced by Viscum album var. coloratum agglutinin in HL-60 cells. Biosci. Biotechnol. Biochem. 65, 534-541.
30. Lyu S.Y., Choi S.H. and Park W.B. (2002). Korean mistletoe lectin-induced apoptosis in hepatocarcinoma cells is associated with inhibition of telomerase via mitochondrial controlled pathway independent of p53. Arch. Pharm. Res. 25, 93-101.
31. Mannel D.N., Becker H., Gundt A., Kist A. and Franz H. (1991). Induction of tumour necrosis factor expression by a lectin from Viscum album. Cancer Immunol. Immunother. 33, 177-182.
32. Mengs U., Schwarz T., Bulitta M. and Weber K. (2000). Antitumoural effects of an intravesically applied aqueous mistletoe extract on urinary bladder carcinoma MB49 in mice. Anticancer Res. 20, 3565-3568.
33. Mockel B., Schwarz T., Zinke H., Eck J., Langer M. and Lentzen H. (1997). Effects of mistletoe lectin I on human blood cell lines and peripheral blood cells. Cytotoxicity, apoptosis and induction of cytokines. Drug Research. 47, 1145-1151.
34. Pas H.O., Seo W.G., Shin M.K., Lee H.S., Kim S.B., and Chung H.T. (2000a). Protein kinase A or C modulates the apoptosis induced by lectin II isolated from Korean mistletoe, Viscum album var. Coloratum, in the human leukemic HL-60 cells. Immunopharmacol. Immunotoxicol. 22, 279-295.
35. Pae H.O., Seo W.G., Oh G.S., Shin M.K., Lee H.S., Lee H.S., Kim S.B. and Chung H.T. (2000b). Potentiation of tumour necrosis factor-alpha-induced apoptosis by mistletoe lectin. Immunopharmacol. Immunotoxicol. 22, 697-709.
36. Pae H.O., Oh G.S., Seo W.G., Shin M.K., Hong S.G., Lee H.S. and Chung H.T. (2001a). Mistletoe lectin synergizes with paclitaxel in human SK-hep1 hepatocarcinoma cells. Immunopharmacol. Immunotoxicol. 23, 531-540.
37. Pae H.O., Oh G.S., Kim N.Y., Shin M.K., Lee H.S., Yun Y.G., Oh H., Kim Y.M. and Chung H.T. (2001b). Roles of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase in apoptosis of human monoblastic leukemia U937 cells by lectin-II isolated from Korean mistletoe. In vitro Mol. Toxicol. 14, 99-106.
38. Park R., Kim M.S., So H.S., Jung B.H., Moon S.R., Chung S.Y., Ko C.B., Kim B.R. and Chung H.T. (2000). Activation of c-Jun N-terminal kinase 1 (JNK1) in mistletoe lectin III-induced apoptosis of human myeloleukemic U937 cells. Biochem. Pharmacol. 60, 1685-1691.
39. Park W.B., Lyu S.Y., Kim J.H., Choi S.H., Chung H.K., Ahn S.H., Hong S.Y., Yoon T.J. and Choi M.J. (2001). Inhibition of tumour growth and metastasis by Korean mistletoe lectin is associated with apoptosis and antiangiogenesis. Cancer Biother. Radiopharm. 16, 439-447.
40. Pfüller U. (2000). Chemical constituents of European mistletoe (Viscum album L.). Isolation and characterization of the main relevant ingredients: lectins, viscotoxins, oligo-/polysaccharides, flavonoids. In: Mistletoe. The genus viscum. Büssing A. (ed). Harwood Academic Publishers, Amsterdam, pp 101-122.
41. Pryme I.F., Bardocz S. and Pusztai A. (1994a). A diet containing the lectin phytohaemagglutinin (PHA) slows down the proliferation of Krebs II cell tumours in mice. Cancer Lett. 76, 133-137.
42. Pryme I.F., Pusztai A. and Bardocz S. (1994b). The initial growth rate of Krebs II ascites cell tumours in mice is slowed down by the inclusion of phytohaemagglutinin in the diet. Int. J. Oncol. 5, 1105-1107.
43. Pryme I.F., Bardocz S., Grant G., Duguid T.J., Brown D.S. and Pusztai A. (1995). Switching between control and phytohaemagglutinin-containing diets affects growth of Krebs II ascites cells and produces differences in the levels of putrescine, spermidine and spermine. Cancer Lett. 93, 233-237.
44. Pryme I.F., Bardocz S., Grant G., Duguid T.J., Brown D.S. and Pusztai A. (1996a). Inclusion of the plant lectin phytohaemagglutinin in the diet and its effects on development of murine tumours. In: Effects of antinutrients on the nutritional value of legume diets. Vol. 1. Bardocz S., Gelencser E. and Pusztai A. (eds). COST 98. EC Publication. Luxembourg. pp. 34-40.
45. Pryme I.F., Bardocz S., Grant G., Duguid T.J., Brown D.S. and Pusztai A. (1996b). The plant lectin PHA as a tool for reducing the progression of tumour growth. In: Effects of antinutrients on the nutritional value of legume diets. Vol. 2. Bardocz S. and Pusztai A. (eds). COST 98. EC Publication, Luxembourg. pp. 24-29.
46. Pryme I.F., Pusztai A., Grant G. and Bardocz S. (1996c). Phytohaemagglutinin induced gut hyperplasia and the growth of a mouse lymphosarcoma tumour. J. Exp. Therap. Oncol. 1, 171-176.
47. Pryme I.F., Pusztai A., Grant G. and Bardocz S. (1996d). Dietary phytohaemagglutinin slows down the proliferation of a mouse plasmacytoma (MPC-11) tumour in Balb/c mice. Cancer Lett. 103, 151-155.
48. Pryme I.F., Bardocz S., Grant G., Ewen S.W.B., Pusztai A. and Pfüller U. (1998a). The plant lectins PHA and ML-I suppress the growth of a lymphosarcoma tumour in mice. In: Effects of antinutrients on the nutritional value of legume diets. Vol. 5. Bardocz S., Pfüller U. and Pusztai A. (eds). COST 98. EC Publication. Luxembourg. pp 215-220.
49. Pryme I.F., Pusztai A., Grant G. and Bardocz S. (1998b). The induction of gut hyperplasia by phytohaemagglutinin in the diet and limitation of tumour growth. Histol. Histopathol. 13, 575-583.
50. Pryme I.F., Pusztai A., Bardocz S. and Ewen S.W.B. (1999a). A combination of dietary protein depletion and PHA-induced gut growth reduce the mass of a murine non-Hodgkin lymphoma. Cancer Lett. 139, 145-152.
51. Pryme I.F., Bardocz S., Pusztai A. and Ewen S.W.B. (1999b). The growth of an established murine non-Hodgkin lymphoma tumour is limited by switching to a phytohaemagglutinin-containing diet. Cancer Lett. 146, 87-91.
52. Pryme I.F., Bardocz S., Pusztai A. and Ewen S.W.B. (2000a). The extent of PHA-induced gut hyperplasia is reduced by a developing murine non-Hodgkin lymphoma tumour. In: Effects of antinutrients on the nutritional value of legume diets. Vol. 8. Krogdahl A., Mathiesen S.D. and Pryme I.F. (eds). COST 98. EC Publication. Luxembourg. pp 65-69.
53. Pryme I.F., Pusztai A., Bardocz S. and Ewen S.W.B. (2000b). Dietary phytohaemagglutinin reduces growth of a murine non-Hodgkin lymphoma. In: Dietary anticarcinogens and antimutagens: Chemical and biological aspects. Johnson, I.T. and Fenwick G.R. (eds). Athenaeum Press Ltd. UK. pp 350-354.
54. Pryme I.F., Bardocz S., Pusztai A. and Ewen S.W.B. (2002). Dietary mistletoe lectin supplementation and reduced growth of a murine non-Hodgkin lymphoma. Histol Histopathol. 17, 261-271.
55. Pryme I.F., Bardocz S., Pusztai A., Ewen S.W.B. and Pfuller U. (2004). A mistletoe lectin (ML-1)-containing diet reduces the viability of a murine non-Hodgkin lymphoma tumour. Cancer Detect. Prev. 28, 52-56.
56. Pusztai A. (1991) Plant lectins. Cambridge University Press. Cambridge, UK. pp 1-251.
57. Pusztai A., Ewen S.W.B., Grant G., Peumanns, W.J., van Damme E.J.M., Rubio L.A. and Bardocz S. (1990). Relationship between survival and binding of plant lectins during small intestinal passage and their effectiveness as growth factors. Digestion. 46, Suppl. 2, 308-316.
58. Pusztai A., Grant G., Gelencser E., Ewen S.W.B, Pfüller U., Eifler R. and Bardocz S. (1998). Effects of an orally administered mistletoe (type-2 RIP) lectin on growth, body composition, small intestinal structure, and insulin levels in young rats. Nutr. Biochem. 9, 31-36.
59. Ribereau Gayon G., Jung M.L., Frantz M. and Anton R. (1997). Modulation of cytotoxicity and enhancement of cytokine release induced by Viscum album L. extracts or mistletoe lectins. Anticancer Drugs 8 (Suppl 1), S3-8.
60. Schaffrath B., Mengs U., Schwarz T., Hilgers R.D., Beuth J., Mockel B., Lentzen H. and Gerstmayer B. (2001). Anticancer activity of rViscumin (recombinant mistletoe lectin) in tumour colonization models with immunocompetent mice. Anticancer Res. 21, 3981-3987.
61. Schoffski P., Riggert S., Fumoleau P., Campone M., Bolte Q, Marreaud S., Lacombe D., Baron B., Herold M., Zwierzina H., Wilhelm-Ogunbiyi K., Lentzen H. and Twelves C. (2004). Phase I trial of intravenous aviscumine (rViscumin) in patients with solid tumours: a study of the European Organization for Research and Treatment of Cancer New Drug Development Group. Ann. Oncol. 15, 1816-1824.
62. Schumacher U. Feldhaus S and Mengs U. (2000). Recombinant mistletoe lectin (rML) is successful in treating human ovarian cancer cells transplanted into severe combined immunodeficient (SCID) mice. Cancer Lett. 150, 171-175.
63. Sharma R., van Damme E.J.M., Peumans W.J., Sarsfield P. and Schumacher U. (1996). Lectin binding reveals divergent carbohydrate expression in human and mouse Peyer's patches. Histochem Cell Biol. 195, 459-465.
64. Siegle I., Fritz P., McClellan M., Gutzeit S. and Murdter T.E. (2001). Combined cytotoxic action of Viscum album agglutinin-1 and anticancer agents against human A549 lung cancer cells. Anticancer Res. 21, 2687-2691.
65. Stein G.M., Stettin A., Schultze J. and Berg P.A. (1997). Induction of anti-mistletoe lectin antibodies in relation to different mistletoe-extracts. Anticancer Drugs 8 (Suppl 1), S57-89.
66. Stein G.M., Henn W., von Laue H. and Berg P. (1998). Modulation of the cellular and humoral immune responses of tumour patients by mistletoe therapy. Eur. J. Med. Res. 3, 194-202.
67. Stein G.M., Pfüller U., Schietzel M. and Büssing A. (2000). Expression of interleukin-4 in apoptotic cells: stimulation of the type-2 cytokine by different toxins in human peripheral blood mononuclear and tumour cells. Cytometry 41, 261-270.
68. Stettin A., Schultze J.L., Stechemesser E. and Berg P.A. (1990). Anti-mistletoe lectin antibodies are produced in patients during therapy with an aqueous mistletoe extract derived from Viscum album L. and neutralize lectin-induced cytotoxicity in vitro. Klin Wochenschr. 68, 896-900.
69. Thies A., Nugel D., Pfüller U., Moll I. and Schumacher U. (2005). Influence of mistletoe lectins and cytokines induced by them on cell proliferation of human melanoma cells in vitro. Toxicology 207, 105-116.
70. Valentiner U., Pfuller U., Baum C. and Schumacher U. (2002). The cytotoxic effect of mistletoe lectins I, II and III on sensitive and multidrug resistant human colon cancer cell lines in vitro. Toxicology 171, 187-199.
71. Van Huyen J.P., Bayry J., Delignat S., Gaston A.T., Michel O., Bruneval P., Kazatchkine M.D., Nicoletti A. and Kaveri S.V. (2002). Induction of apoptosis of endothelial cells by Viscum album: a role for anti-tumoural properties of mistletoe lectins. Mol. Med. 8, 600-606.
72. Vervecken W., Kleff S., Pfüller U. and Büssing A. (2000). Induction of apoptosis by mistletoe lectin 1 and its subunits. No evidence for cytotoxic effects caused by isolated A- and B-chains. Int. J. Biochem. Cell Biol. 32, 317-326.
73. i, and induces cell death. Naunyn Schmiedebergs Arch Pharmacol. 355, 190-197.
74. Yoon T.J., Yoo Y.C., Choi O.B., Do M.S., Kang T.B., Lee K.H., Azuma I. and Kim J.B. (1995). Inhibitory effect of Korean mistletoe (Viscum album coloratum) extract on tumour angiogenesis and of hematogenous and non-hematogenous tumour cells in mice. Cancer Lett. 97, 83-91.
75. Yoon T.J., Yoo Y.C., Kang T.B., Baek Y.J., Huh C.S., Song S.K., Lee K.H., Azuma I. and Kim J.B. (1998). Prophylactic effect of Korean mistletoe (Viscum album coloratum) extract on tumour metastasis is mediated by enhancement of NK cell activity. Int. J. Immunopharmacol. 20, 163-172.
76. Yoon T.J., Yoo Y.C., Kang T.B., Shimazaki K., Song S.K., Lee K.H., Kim S.H., Park C.H., Azuma I. and Kim J.B. (1999). Lectins isolated from Korean mistletoe (Viscum album coloratum) induce apoptosis in tumour cells. Cancer Lett. 136, 33-40.