Induction of autophagy by concanavalin A and its application in anti-tumor therapy

Autophagy

Volumn 3, Issue 4, 2007, Pages 402-404

  Lei, Huan Yao ^a   Chang, Chih Peng ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

Autophagy; Con A; Hepatitis; Hepatoma; Lectin; Therapy

Indexed keywords

ANTINEOPLASTIC AGENT; CA 15-3 ANTIGEN; CANAVALIA ENSIFORMIS EXTRACT; CELL MEMBRANE PROTEIN; CONCANAVALIN A; MANNOSE; MANNOSE BINDING LECTIN; MITOGENIC AGENT; PLANT EXTRACT; PROTEIN BNIP3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE HEPATITIS; AUTOPHAGY; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG TARGETING; HEPATITIS; IMMUNOLOGICAL MEMORY; IMMUNOMODULATION; LIVER; LIVER NODULE; MITOCHONDRION; MOUSE; NONHUMAN; PROTEIN BINDING; SURVIVAL TIME; T LYMPHOCYTE; TUMOR CELL; TUMOR CELL DESTRUCTION;

CANAVALIA ENSIFORMIS; MUS;

EID: 34250890733     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.4280     Document Type: Article

References (25)

1. Tiegs G, Hentschel J, Wendel A. AT cell-dependent experimental liver injury in mice inducible by concanavalin A. J Clin Invest 1992; 90:196-203.
2. Kaneko Y, Harada M, Kawano T, Yamashita M, Shibata Y, Gejyo F, Nakayama T, Taniguchi M. Augmentation of Valpha 14 NKT cell-mediated cytotoxicity by interleukin 4 in an autocrine mechanism resulting in the development of concanavalin A-induced hepatitis. J Exp Med 2000; 191:105-14.
3. Chang CP, Yang MC, Liu HS, Lin YS, Lei HY. Concanavalin A induces autophagy in hepatoma cells and has a therapeutic effect in a murine in situ hepatoma model. Hepatology 2007; 45:286-96.
4. Kanzawa T, Zhang L, Xiao L, Germano IM, Kondo Y, Kondo S. Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP3. Oncogene 2005; 24:980-91.
5. ARF induces autophagy and caspase-independent cell death. Mol Cell 2006; 22:463-75.
6. Miyagi T, Takehara T, Tatsumi T, Suzuki T, Suzuki T, Jinushi M, Kanazawa Y, Hiramatsu N, Kanto T, Tsuji S, Hori M, Hayashi N. Concanavalin A injection acrivates intrahepatic innate immune cells to provoke an antitumor effect in murine liver. Hepatology 2004; 40:1190-6.
7. Petrovski G, Zahuczky G, Katona K, Vereb G, Martiner W, Nemes Z, Bursch W, Fesus L. Clearance of dying autophagic cells of different origin by professional and non-professional phagocytes. Cell Death Differ 2007, (doi:10.1038/sj.cdd.4402112).
8. Sodhi A, Tarang S, Kesherwani V. Concanavalin A induced expression of Toll-like receptors in murine peritoneal macrophages in vitro. Int Immunopharmco 2007; 7:454-63.
9. Pua HH, Dzhagalov I, Chuck M, Mizushima N, He YW. A critical role for the autophagy gene Atg5 in T cell survival and proliferation. J Exp Med 2007; 204:25-31.
10. Li C, Capan E, Zhao Y, Zhao J, Stolz D, Watkins SC, Lin S, Lu B. Autophagy is induced in CD4 T cells and important for the growth factor-withdrawal cell death. J Immunol 2006; 177:5163-8.
11. Munz C. Autophagy and antigen presentation. Cell Micro 2006; 8:891-8.
12. Schmid D, Pypaert M, Munz C. Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes. Immunity 2007; 26:79-92.
13. Kondo Y, Kanzawa T, Sawaya R, Kondo S. The role of autophagy in cancer development and response to therapy. Nat Rev Cancer 2005; 5:726-34.
14. Degenhardt K, Mathew R, Beaudoin B, Bray K, Anderson D, Chen G, Mukherjee C, Shi Y, Gelinas C, Fan Y, Nelson DA, Jin S, White E. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell 2006; 10:51-46.
15. Paglin S, Yahalom J. Pathways that regulate autophagy and their role in mediating tumor response to treatment. Autophagy 2006; 2:291-3.
16. Kanzawa T, Kondo Y, Ito H, Kondo S, Germano I. Induction of autophagic cell death in malignant glioma cells by arsenic trioxide. Cancer Res 2003; 63:2103-8.
17. Opipari AW, Tan L, Boitano AE, Sorenson DR, Aurora A, Liu JR. Resveratrol-induced autophagocytosis in ovarian cancer cells. Cancer Res 2004; 64:696-703.
18. Ellington AA, Berhow M, Singlerary KW. Induction of macroautophagy in human colon cancer cells by soybean B-group triterpenoid saponins. Carcinogenesis 2005; 26:159-67.
19. Aoki H, Takada Y, Kondo S, Sawaya R, Aggarwal B, Kondo Y. Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: Role of Akt and ERK signaling pathways. Mol Pharmacol 2007, (doi: 10.1124/ mol.106.033167).
20. Rubinsztein D, Gestwicki JE, Murphy LO, Klionsky DJ. Potential therapeutic applications of autophagy. Nat Rev Drug Discov 2007; 6:304-12.
21. Rosenberg SA, Yang YC, Restifo NP. Cancer immunotherapy: Moving beyond current vaccines. Nat Med 2004; 10:909-15.
22. Mocellin S, Mandruzzato S, Bronte V, Marincola FM. Cancer vaccines: Pessimism in check. Nat Med 2004; 10:1278-9.
23. Schumacher K, Schneider B, Reich G, Stiefel T, Stoll G, Bock PR, Hanisch J, Beuth J. Influence of postoperative complementary treatment with lectin-srandardized mistletoe extract on breast cancer patients: A controlled epidemiological multicentric retrolective cohort study. Anticancer Res 2003; 23:5081-7.
24. de Mejia EG, Bradford T, Hasler C. The anticarcinogenic potential of soybean lectin and lunasin. Nutr Rev 2003; 61:239-46.
25. Pryme IF, Bardocz S, Puszrai A, Ewen SW. The growth of an established murine non-Hodgkin lymphoma tumour is limited by switching to a phytohaemagglutinin-containing diet. Cancer Lett 1999; 146:87-91.