Purified mulberry leaf lectin (MLL) induces apoptosis and cell cycle arrest in human breast cancer and colon cancer cells

Chemico-Biological Interactions

Volumn 200, Issue 1, 2012, Pages 38-44

  Deepa, Mundekkad ^a   Sureshkumar, Thavamani ^a   Satheeshkumar, Padikara Kutty ^a   Priya, Sulochana ^a  

^a VIT UNIVERSITY   (India)

Author keywords

Anticancer; Caspase 3; Morus alba

Indexed keywords

CASPASE 3; CISPLATIN; LECTIN;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER CELL DESTRUCTION; CANCER INHIBITION; CANCER MORPHOLOGY; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL VIABILITY; COLON CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INDUCTION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; MULBERRY; PLANT LEAF; STRUCTURE ANALYSIS;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CASPASE 3; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; COLONIC NEOPLASMS; HUMANS; MCF-7 CELLS; MORUS; PLANT LEAVES; PLANT LECTINS;

MORUS (ANGIOSPERM); MORUS ALBA;

EID: 84867237348     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2012.08.025     Document Type: Article

References (40)

1. V.R. Kumar, and S. Chauhan Mulberry: life enhancer J. Med. Plant Res. 2 2008 271 278
2. T. Kikuchi, M. Nihei, H. Nagai, H. Fukushi, K. Tabata, T. Suzuki, and T. Akihisa Albanol A from the root bark of Morus alba L. induces apoptotic cell death in HL60 human leukemia cell line Chem. Pharm. Bull. 58 2010 568 571
3. N.T. Dat, P.T. Binh, T.P. le Quynh, C. Van Minh, H.T. Huong, and J.J. Lee Cytotoxic prenylated flavonoids from Morus alba Fitoterapia 81 2010 1224 1227
4. Y.S. Chi, H.G. Jong, K.H. Son, H.W. Chang, S.S. Kang, and H.P. Kim Effects of naturally occurring prenylated flavonoids on enzymes metabolizing arachidonic acid: cyclooxygenases and lipoxygenases Biochem. Pharmacol. 62 2001 1185 1191 (Pubitemid 33055622)
5. W. Naowaratwattana, W. De-Eknamkul, and E.G. De Mejia Phenolic-containing organic extracts of mulberry (Morus alba L.) leaves inhibit HepG2 hepatoma cells through G2/M phase arrest, induction of apoptosis and inhibition of topoisomerase IIα activity J. Med. Food 13 2010 1045 1056
6. Y. Kimura, H. Okuda, T. Nomura, T. Fukai, and S. Arichi Effects of phenolic constituents from the mulberry tree on arachidonate metabolism in rat platelets J. Nat. Prod. 49 1986 639 644 (Pubitemid 16001138)
7. I.J. Goldstein, and R.D. Poretz Isolation, physicochemical characterization and carbohydrate-binding specificity of lectins F.E. Liemer, N. Sharon, I.J. Goldstein, The Lectins: Properties Functions and Applications in Biology and Medicine 1986 Academic Press Orlando, Florida 33 247
8. B. Liu, H. Bian, and J. Bao Plant lectins: potential antineoplastic drugs from bench to clinic Cancer Lett. 287 2010 1 12
9. Z. Liu, B. Liu, Z.T. Zhang, T.T. Zhou, H.J. Bian, M.W. Min, Y.H. Liu, J. Chen, and J.K. Bao A mannose- binding lectin from Sophora flavescens induces apoptosis in HeLa cells Phytomedicine 15 2008 867 875
10. S.Y. Lyu, S.H. Choi, and W.B. Park Korean mistletoe lectin-induced apoptosis in hepatocarcinoma cells is associated with inhibition of telomerase via mitochondrial controlled pathway independent of p53 Arch. Pharmacal Res. 25 2002 93 101
11. K. Hostanska, V. Vuong, S. Rocha, M.S. Soengas, C. Glanzmann, R. Saller, S. Bodis, and M. Pruschy Recombinant mistletoe lectin induces p53-independent apoptosis in tumour cells and cooperates with ionising radiation Br. J. Cancer 88 2003 1785 1792 (Pubitemid 36760425)
12. E. Gorelik, U. Galili, and A. Raz On the role of cell surface carbohydrates and their binding proteins (lectins) in tumor metastasis Cancer Metastasis Rev. 20 2001 245 277 (Pubitemid 34595270)
13. C.P. Chang, M.C. Yang, H.S. Liu, Y.S. Lin, and H.Y. Lei Concanavalin A induces autophagy in hepatoma cells and has a therapeutic effect in a murine in situ hepatoma model Hepatology 45 2007 286 296
14. A. Thies, P. Dautel, A. Meyer, U. Pfüller, and U. Schumacher Low-dose mistletoe lectin-I reduces melanoma growth and spread in a scid mouse xenograft model Br. J. Cancer 98 2007 106 112
15. C.E. Hong, and S.Y. Lyu The antimutagenic effect of Mistletoe lectin (Viscum album L. var. coloratum agglutinin) Phytother. Res. 26 2012 787 790
16. M. Deepa, and S. Priya Purification and characterization of a novel anti-proliferative lectin from Morus alba L. leaves Protein Pept. Lett. 19 2012 839 845
17. M. Kaur, J. Singh, S.S. Kamboj, and A.K. Saxena A lectin with anti-proliferative, mitogenic and anti-insect potential from the tubers of Caladium bicolor Vent, Asian & Australian J. Plant Sci. Biotechnol. 5 2011 1 9
18. G.Q. Zhang, J. Sun, H.X. Wang, and T.B. Ng A novel lectin with antiproliferative activity from the medicinal mushroom Pholiota adipose Acta Biochim. Pol. 56 2009 415 421
19. D.A. Scudiero, R.H. Shoemaker, K.D. Paull, A. Monks, S. Tierney, T.H. Nofziger, M.J. Currens, D. Seniff, and M.R. Boyd Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines Cancer Res. 48 1988 4827 4833
20. F.A. Tanious, J.M. Veal, H. Buczak, L.S. Ratmeyer, and W.D. Wilson DAPI (4′,6-diamidino-2- phenylindole) binds differently to DNA and RNA: minor-groove binding at AT sites and intercalation at AU sites Biochemistry 31 1992 3103 3112
21. J.J. Cohen Apoptosis Immunol. Today 14 1993 126 130 (Pubitemid 23068297)
22. L.H. Huang, Q.J. Yan, N.K. Kopparapu, Z.Q. Jiang, and Y. Sun Astragalus membranaceus lectin (AML) induces caspase-dependent apoptosis in human leukemia cells Cell Prolif. 45 2012 15 21
23. N.D. Rambaruth, P. Greenwell, and M.V. Dwek The lectin Helix pomatia agglutinin recognizes O-GlcNAc containing glycoproteins in human breast cancer Glycobiology 22 2012 839 848
24. V.E. Plattner, M. Wagner, G. Ratzinger, F. Gabor, and M. Wirth Targeted drug delivery: binding and uptake of plant lectins using human 5637 bladder cancer cells Eur. J. Pharm. Biopharm. 70 2008 572 576
25. G.D. Kapche, D. Amadou, P. Waffo-Teguo, J.H. Donfack, C.D. Fozing, D. Harakat, A.N. Tchana, J.M. Mérillon, P.F. Moundipa, B.T. Ngadjui, and B.M. Abegaz Hepatoprotective and antioxidant arylbenzofurans and flavonoids from the twigs of Morus mesozygia Planta Med. 77 2011 1044 1047
26. Y. X. Tan, H. Q. Wang, R. Y. Chen, Anti-inflammatory and cytotoxic 2-arylbenzofurans from Morus wittiorum, Fitotherapia 2012 [Epub ahead of print].
27. J.C. Jeong, S.W. Jang, T.H. Kim, C.H. Kwon, and Y.K. Kim Mulberry fruit (Moris fructus) extracts induce human glioma cell death in vitro through ROS-dependent mitochondrial pathway and inhibits glioma tumor growth in vivo Nutr. Cancer 62 2010 402 412
28. S. Chon, Y. Kim, Y. Park, B. Heo, Y. Park, and S. Gorinstein Antioxidant and antiproliferative effects of methanol extracts from raw and fermented parts of mulberry plant (Morus alba L.) Eur. Food Res. Technol. 230 2009 231 237
29. A.P. Boleti, C.A. Ventura, G.Z. Justo, R.A. Silva, A.C. de Sousa, C.V. Ferreira, T. Yano, and M.L. Macedo Pouterin, a novel potential cytotoxic lectin-like protein with apoptosis-inducing activity in tumorigenic mammalian cells Toxicon 51 2008 1321 1330 (Pubitemid 351787342)
30. G. Zhang, V. Gurtu, S.R. Kain, and G. Yan Early detection of apoptosis using a fluorescent conjugate of annexin V Biotechniques 23 1997 525 531 (Pubitemid 27398205)
31. Y.S. Chan, J.H. Wong, E.F. Fang, W. Pan, and T.B. Ng Isolation of a glucosamine binding leguminous lectin with mitogenic activity towards splenocytes and anti-proliferative activity towards tumor cells PLoS ONE 7 2012 e38961
32. T.T. Hajtó, T.T. Berki, F.F. Boldizsár, and P.P. Németh Galactoside-specific plant lectin, Viscum album agglutinin-I induces enhanced proliferation and apoptosis of murine thymocytes in vivo Immunol. Lett. 86 2003 23 27
33. G.S. Salvesan, and V.M. Dixit Caspase activation: The induced-proximity model Proc. Natl. Acad. Sci. USA 96 1999 10964 10967 (Pubitemid 29487313)
34. S.K. Lam, and T.B. Ng First report of a haemagglutinin-induced apoptotic pathway in breast cancer cells Biosci. Rep. 30 2010 307 317
35. F.Q.B. Alenzi Links between apoptosis, proliferation and the cell cycle Br. J. Biomed. Sci. 61 2004 1 4
36. Q. Yan, Y. Li, Z. Jiang, Y. Sun, L. Zhu, and Z. Ding Antiproliferation and apoptosis of human tumor cell lines by a lectin (AMML) of Astragalus mongholicus Phytomedicine 16 2009 586 593
37. H. Lin, B. Moon, F. Yu, and H.C. Kim Galectin-3 mediates genistein induced G2/M arrest and inhibits apoptosis Carcinogenesis 21 2000 1941 1945
38. B. Liu, J. Wu, J. Li, J. Liu, W. Li, C. Li, H. Xu, and J. Bao Polygonatum cyrtonema lectin induces murine fibrosarcoma L929 cell apoptosis via blocking Ras-Raf and PI3K-Akt signaling pathways Biochimie 92 2010 1934 1938
39. B. Liu, B. Zhang, M. Min, H. Bian, L. Chen, Q. Liu, and J. Bao Induction of apoptosis by Polygonatum odoratum lectin and its molecular mechanisms in murine fibrosarcoma L929 cells Biochim. Biophys. Acta 1790 2009 840 844
40. A.R.M.R. Amin, R.K. Paul, V.S. Thakur, and M.L. Agarwal A novel role for p73 in the regulation of Akt-Foxo1a-Bim signaling and apoptosis induced by the plant lectin Concanavalin A, Cancer Res. 67 2007 5617 5621 (Pubitemid 46984991)