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Volumn 14, Issue 11, 2014, Pages 1-17

Insights into the Genetic Susceptibility to Type 2 Diabetes from Genome-Wide Association Studies of Glycaemic Traits

Author keywords

2 h post prandial glucose; Association; Birth weight; Body mass index; Candidate gene study; Cardiometabolic traits; Effect size; Fasting glucose; Fasting insulin; Genome wide association study; Glycated haemoglobin (HbA1c); Homeostasis model assessment of insulin resistance (HOMA IR); Homeostasis model assessment of cell function (HOMA B); Insulin resistance; Insulin secretion; Maturity onset diabetes of the young (MODY); Meta analysis; Oral glucose tolerance test (OGTT); Proinsulin; Risk prediction; Single nucleotide polymorphism (SNP); Thrifty gene hypothesis; Type 2 diabetes; cell function

Indexed keywords

GLYCOSYLATED HEMOGLOBIN; INSULIN; GLUCOSE BLOOD LEVEL; HEMOGLOBIN A1C PROTEIN, HUMAN; PROINSULIN;

EID: 84920927246     PISSN: 15344827     EISSN: 15390829     Source Type: Journal    
DOI: 10.1007/s11892-014-0551-8     Document Type: Review
Times cited : (35)

References (98)
  • 1
    • 84920893884 scopus 로고    scopus 로고
    • IDF diabetes atlas
    • International Diabetes Federation. IDF diabetes atlas, 6th edn. 2013.
    • (2013) 6th edn
  • 2
    • 56349158387 scopus 로고    scopus 로고
    • Type 2 diabetes: new genes, new understanding
    • COI: 1:CAS:528:DC%2BD1cXhsVWrt7nN, PID: 18952314
    • Prokopenko I, McCarthy MI, Lindgren CM. Type 2 diabetes: new genes, new understanding. Trends Genet. 2008;24:613–21.
    • (2008) Trends Genet , vol.24 , pp. 613-621
    • Prokopenko, I.1    McCarthy, M.I.2    Lindgren, C.M.3
  • 4
    • 17044386953 scopus 로고    scopus 로고
    • Type 2 diabetes: principles of pathogenesis and therapy
    • COI: 1:CAS:528:DC%2BD2MXjtF2iu7g%3D, PID: 15823385
    • Stumvoll M, Goldstein BJ, van Haeften TW. Type 2 diabetes: principles of pathogenesis and therapy. Lancet. 2005;365:1333–46.
    • (2005) Lancet , vol.365 , pp. 1333-1346
    • Stumvoll, M.1    Goldstein, B.J.2    van Haeften, T.W.3
  • 5
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group
    • Group UPDSU. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet. 1998;352:837–53.
    • (1998) Lancet , vol.352 , pp. 837-853
    • Group, U.P.D.S.U.1
  • 6
    • 45149133036 scopus 로고    scopus 로고
    • Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes
    • Group AC, Patel A, MacMahon S, Chalmers J, Neal B, Billot L, et al. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med. 2008;358:2560–72.
    • (2008) N Engl J Med , vol.358 , pp. 2560-2572
    • Group, A.C.1    Patel, A.2    MacMahon, S.3    Chalmers, J.4    Neal, B.5    Billot, L.6
  • 7
    • 53749096863 scopus 로고    scopus 로고
    • 10-year follow-up of intensive glucose control in type 2 diabetes
    • COI: 1:CAS:528:DC%2BD1cXht1Wgt7nK, PID: 18784090
    • Holman RR, Paul SK, Bethel MA, Matthews DR, Neil HA. 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med. 2008;359:1577–89.
    • (2008) N Engl J Med , vol.359 , pp. 1577-1589
    • Holman, R.R.1    Paul, S.K.2    Bethel, M.A.3    Matthews, D.R.4    Neil, H.A.5
  • 8
    • 65649106228 scopus 로고    scopus 로고
    • Effect of intensive control of glucose on cardiovascular outcomes and death in patients with diabetes mellitus: a meta-analysis of randomised controlled trials
    • COI: 1:CAS:528:DC%2BD1MXmtleksbc%3D, PID: 19465231
    • Ray KK, Seshasai SR, Wijesuriya S, Sivakumaran R, Nethercott S, Preiss D, et al. Effect of intensive control of glucose on cardiovascular outcomes and death in patients with diabetes mellitus: a meta-analysis of randomised controlled trials. Lancet. 2009;373:1765–72.
    • (2009) Lancet , vol.373 , pp. 1765-1772
    • Ray, K.K.1    Seshasai, S.R.2    Wijesuriya, S.3    Sivakumaran, R.4    Nethercott, S.5    Preiss, D.6
  • 9
    • 84920893883 scopus 로고    scopus 로고
    • Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia: report of a WHO/IDF consultation
    • World Health Organization 2006. Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia: report of a WHO/IDF consultation. 2006.
    • (2006) 2006
  • 10
    • 79960016921 scopus 로고    scopus 로고
    • Type 2 diabetes and obesity: genomics and the clinic
    • COI: 1:CAS:528:DC%2BC3MXotlyrtbk%3D, PID: 21647602
    • Travers ME, McCarthy MI. Type 2 diabetes and obesity: genomics and the clinic. Hum Genet. 2011;130:41–58.
    • (2011) Hum Genet , vol.130 , pp. 41-58
    • Travers, M.E.1    McCarthy, M.I.2
  • 11
    • 84876276050 scopus 로고    scopus 로고
    • Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes
    • COI: 1:CAS:528:DC%2BC3sXlt1GksQ%3D%3D, PID: 23160641, One of the first large exome sequencing studies for metabolic phenotypes with large-scale genotyping follow-up
    • Albrechtsen A, Grarup N, Li Y, Sparso T, Tian G, Cao H, et al. Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes. Diabetologia. 2013;56:298–310. One of the first large exome sequencing studies for metabolic phenotypes with large-scale genotyping follow-up.
    • (2013) Diabetologia , vol.56 , pp. 298-310
    • Albrechtsen, A.1    Grarup, N.2    Li, Y.3    Sparso, T.4    Tian, G.5    Cao, H.6
  • 12
    • 84655162045 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians
    • COI: 1:CAS:528:DC%2BC3MXhs1eitr7P, Large meta-analysis of GWA studies in East Asians
    • Cho YS, Chen CH, Hu C, Long J, Ong RT, Sim X, et al. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nat Genet. 2012;44:67–72. Large meta-analysis of GWA studies in East Asians.
    • (2012) Nat Genet , vol.44 , pp. 67-72
    • Cho, Y.S.1    Chen, C.H.2    Hu, C.3    Long, J.4    Ong, R.T.5    Sim, X.6
  • 13
    • 75749086085 scopus 로고    scopus 로고
    • New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
    • COI: 1:CAS:528:DC%2BC3cXntVCqsw%3D%3D, PID: 20081858, The first large scale meta-analysis of GWA studies for fasting glycaemic traits that identified 5 novel T2D loci
    • Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet. 2010;42:105–16. The first large scale meta-analysis of GWA studies for fasting glycaemic traits that identified 5 novel T2D loci.
    • (2010) Nat Genet , vol.42 , pp. 105-116
    • Dupuis, J.1    Langenberg, C.2    Prokopenko, I.3    Saxena, R.4    Soranzo, N.5    Jackson, A.U.6
  • 14
    • 84891821161 scopus 로고    scopus 로고
    • A genome-wide association study in American Indians implicates DNER as a susceptibility locus for type 2 diabetes
    • COI: 1:CAS:528:DC%2BC2cXhsFOjsg%3D%3D, PID: 24101674
    • Hanson RL, Muller YL, Kobes S, Guo T, Bian L, Ossowski V, et al. A genome-wide association study in American Indians implicates DNER as a susceptibility locus for type 2 diabetes. Diabetes. 2014;63:369–76.
    • (2014) Diabetes , vol.63 , pp. 369-376
    • Hanson, R.L.1    Muller, Y.L.2    Kobes, S.3    Guo, T.4    Bian, L.5    Ossowski, V.6
  • 15
    • 84890397941 scopus 로고    scopus 로고
    • Genome-wide association study identifies three novel loci for type 2 diabetes
    • COI: 1:CAS:528:DC%2BC3sXhvFegsLrF, PID: 23945395
    • Hara K, Fujita H, Johnson TA, Yamauchi T, Yasuda K, Horikoshi M, et al. Genome-wide association study identifies three novel loci for type 2 diabetes. Hum Mol Genet. 2014;23:239–46.
    • (2014) Hum Mol Genet , vol.23 , pp. 239-246
    • Hara, K.1    Fujita, H.2    Johnson, T.A.3    Yamauchi, T.4    Yasuda, K.5    Horikoshi, M.6
  • 16
    • 80053385333 scopus 로고    scopus 로고
    • Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci
    • COI: 1:CAS:528:DC%2BC3MXhtV2gtrfK, PID: 21874001, Large GWA study for T2D in South Asians
    • Kooner JS, Saleheen D, Sim X, Sehmi J, Zhang W, Frossard P, et al. Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. Nat Genet. 2011;43:984–9. Large GWA study for T2D in South Asians.
    • (2011) Nat Genet , vol.43 , pp. 984-989
    • Kooner, J.S.1    Saleheen, D.2    Sim, X.3    Sehmi, J.4    Zhang, W.5    Frossard, P.6
  • 17
    • 84872033833 scopus 로고    scopus 로고
    • A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans
    • COI: 1:CAS:528:DC%2BC3sXlt1KjsQ%3D%3D, PID: 22961080
    • Li H, Gan W, Lu L, Dong X, Han X, Hu C, et al. A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans. Diabetes. 2013;62:291–8.
    • (2013) Diabetes , vol.62 , pp. 291-298
    • Li, H.1    Gan, W.2    Lu, L.3    Dong, X.4    Han, X.5    Hu, C.6
  • 18
    • 84895868553 scopus 로고    scopus 로고
    • DIAbetes Genetics Replication Meta-analysis Consortium, Asian Genetic Epidemiology Network, Type 2 Diabetes Consortium, South Asian Type 2 Diabetes Consortium, Mexican American Type 2 Diabetes Consortium, Type 2 Diabetes Genetic Exploration by Next-generation sequencing in multi-Ethnic Samples Consortium. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. 2014;46:234–244. Large-scale meta-analysis of GWA studies from multiple ethnic groups for T2D
    • DIAbetes Genetics Replication Meta-analysis Consortium, Asian Genetic Epidemiology Network, Type 2 Diabetes Consortium, South Asian Type 2 Diabetes Consortium, Mexican American Type 2 Diabetes Consortium, Type 2 Diabetes Genetic Exploration by Next-generation sequencing in multi-Ethnic Samples Consortium. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet. 2014;46:234–244. Large-scale meta-analysis of GWA studies from multiple ethnic groups for T2D.
    • Nat Genet.
  • 19
    • 84868337361 scopus 로고    scopus 로고
    • Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
    • COI: 1:CAS:528:DC%2BC38XhtFOgsLfP, PID: 22885922, Large-scale follow-up with the Metabochip array and combined meta-analysis of the discovery GWA studies by the DIAGRAM consortium for T2D
    • Morris AP, Voight BF, Teslovich TM, Ferreira T, Segre AV, Steinthorsdottir V, et al. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet. 2012;44:981–90. Large-scale follow-up with the Metabochip array and combined meta-analysis of the discovery GWA studies by the DIAGRAM consortium for T2D.
    • (2012) Nat Genet , vol.44 , pp. 981-990
    • Morris, A.P.1    Voight, B.F.2    Teslovich, T.M.3    Ferreira, T.4    Segre, A.V.5    Steinthorsdottir, V.6
  • 20
    • 84855405312 scopus 로고    scopus 로고
    • A genome-wide association search for type 2 diabetes genes in African Americans
    • COI: 1:CAS:528:DC%2BC38XptF2muw%3D%3D, PID: 22238593
    • Palmer ND, McDonough CW, Hicks PJ, Roh BH, Wing MR, An SS, et al. A genome-wide association search for type 2 diabetes genes in African Americans. PLoS ONE. 2012;7:e29202.
    • (2012) PLoS ONE , vol.7 , pp. e29202
    • Palmer, N.D.1    McDonough, C.W.2    Hicks, P.J.3    Roh, B.H.4    Wing, M.R.5    An, S.S.6
  • 21
    • 84863670156 scopus 로고    scopus 로고
    • Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases
    • COI: 1:CAS:528:DC%2BC38XosVeksLk%3D, PID: 22693455
    • Perry JR, Voight BF, Yengo L, Amin N, Dupuis J, Ganser M, et al. Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. PLoS Genet. 2012;8:e1002741.
    • (2012) PLoS Genet , vol.8 , pp. e1002741
    • Perry, J.R.1    Voight, B.F.2    Yengo, L.3    Amin, N.4    Dupuis, J.5    Ganser, M.6
  • 22
    • 84862785585 scopus 로고    scopus 로고
    • Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci
    • COI: 1:CAS:528:DC%2BC38XitFKgtbo%3D, PID: 22325160
    • Saxena R, Elbers CC, Guo Y, Peter I, Gaunt TR, Mega JL, et al. Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. Am J Hum Genet. 2012;90:410–25.
    • (2012) Am J Hum Genet , vol.90 , pp. 410-425
    • Saxena, R.1    Elbers, C.C.2    Guo, Y.3    Peter, I.4    Gaunt, T.R.5    Mega, J.L.6
  • 23
    • 84876536835 scopus 로고    scopus 로고
    • Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India
    • COI: 1:CAS:528:DC%2BC3sXhtVSnurfF, PID: 23300278
    • Saxena R, Saleheen D, Been LF, Garavito ML, Braun T, Bjonnes A, et al. Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India. Diabetes. 2013;62:1746–55.
    • (2013) Diabetes , vol.62 , pp. 1746-1755
    • Saxena, R.1    Saleheen, D.2    Been, L.F.3    Garavito, M.L.4    Braun, T.5    Bjonnes, A.6
  • 24
    • 78049438674 scopus 로고    scopus 로고
    • Identification of new genetic risk variants for type 2 diabetes
    • PID: 20862305
    • Shu XO, Long J, Cai Q, Qi L, Xiang YB, Cho YS, et al. Identification of new genetic risk variants for type 2 diabetes. PLoS Genet. 2010;6:e1001127.
    • (2010) PLoS Genet , vol.6 , pp. e1001127
    • Shu, X.O.1    Long, J.2    Cai, Q.3    Qi, L.4    Xiang, Y.B.5    Cho, Y.S.6
  • 25
    • 84895858002 scopus 로고    scopus 로고
    • Identification of low-frequency and rare sequence variants associated with elevated or reduced risk of type 2 diabetes
    • COI: 1:CAS:528:DC%2BC2cXht12ju7g%3D, PID: 24464100, A study in Icelandic subjects employing next-generation sequencing followed by imputation identifying rare variants within CCND2, PAM and PDX1 associated with T2D
    • Steinthorsdottir V, Thorleifsson G, Sulem P, Helgason H, Grarup N, Sigurdsson A, et al. Identification of low-frequency and rare sequence variants associated with elevated or reduced risk of type 2 diabetes. Nat Genet. 2014;46:294–8. A study in Icelandic subjects employing next-generation sequencing followed by imputation identifying rare variants within CCND2, PAM and PDX1 associated with T2D.
    • (2014) Nat Genet , vol.46 , pp. 294-298
    • Steinthorsdottir, V.1    Thorleifsson, G.2    Sulem, P.3    Helgason, H.4    Grarup, N.5    Sigurdsson, A.6
  • 26
    • 84874418247 scopus 로고    scopus 로고
    • Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21
    • COI: 1:CAS:528:DC%2BC3sXjsFGqsL0%3D, PID: 23209189
    • Tabassum R, Chauhan G, Dwivedi OP, Mahajan A, Jaiswal A, Kaur I, et al. Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21. Diabetes. 2013;62:977–86.
    • (2013) Diabetes , vol.62 , pp. 977-986
    • Tabassum, R.1    Chauhan, G.2    Dwivedi, O.P.3    Mahajan, A.4    Jaiswal, A.5    Kaur, I.6
  • 27
    • 84865693681 scopus 로고    scopus 로고
    • The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits
    • COI: 1:CAS:528:DC%2BC38XhtFKlurjE, PID: 22876189, Large-scale meta-analysis of GWA studies by the DIAGRAM consortium for T2D
    • Voight BF, Kang HM, Ding J, Palmer CD, Sidore C, Chines PS, et al. The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits. PLoS Genet. 2012;8:e1002793. Large-scale meta-analysis of GWA studies by the DIAGRAM consortium for T2D.
    • (2012) PLoS Genet , vol.8 , pp. e1002793
    • Voight, B.F.1    Kang, H.M.2    Ding, J.3    Palmer, C.D.4    Sidore, C.5    Chines, P.S.6
  • 29
    • 42349106044 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
    • COI: 1:CAS:528:DC%2BD1cXltFylurY%3D, PID: 18372903, The first meta-analysis of three GWA studies with large-scale replication by the DIAGRAM consortium for T2D
    • Zeggini E, Scott LJ, Saxena R, Voight BF, Marchini JL, Hu T, et al. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet. 2008;40:638–45. The first meta-analysis of three GWA studies with large-scale replication by the DIAGRAM consortium for T2D.
    • (2008) Nat Genet , vol.40 , pp. 638-645
    • Zeggini, E.1    Scott, L.J.2    Saxena, R.3    Voight, B.F.4    Marchini, J.L.5    Hu, T.6
  • 30
    • 55649105963 scopus 로고    scopus 로고
    • Clinical risk factors, DNA variants, and the development of type 2 diabetes
    • COI: 1:CAS:528:DC%2BD1cXhtl2gurnF, PID: 19020324
    • Lyssenko V, Jonsson A, Almgren P, Pulizzi N, Isomaa B, Tuomi T, et al. Clinical risk factors, DNA variants, and the development of type 2 diabetes. N Engl J Med. 2008;359:2220–32.
    • (2008) N Engl J Med , vol.359 , pp. 2220-2232
    • Lyssenko, V.1    Jonsson, A.2    Almgren, P.3    Pulizzi, N.4    Isomaa, B.5    Tuomi, T.6
  • 31
    • 56749101779 scopus 로고    scopus 로고
    • Genotype score in addition to common risk factors for prediction of type 2 diabetes
    • COI: 1:CAS:528:DC%2BD1cXhtl2gurnE, PID: 19020323
    • Meigs JB, Shrader P, Sullivan LM, McAteer JB, Fox CS, Dupuis J, et al. Genotype score in addition to common risk factors for prediction of type 2 diabetes. N Engl J Med. 2008;359:2208–19.
    • (2008) N Engl J Med , vol.359 , pp. 2208-2219
    • Meigs, J.B.1    Shrader, P.2    Sullivan, L.M.3    McAteer, J.B.4    Fox, C.S.5    Dupuis, J.6
  • 32
    • 56149124681 scopus 로고    scopus 로고
    • Predicting diabetes: clinical, biological, and genetic approaches: data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR)
    • COI: 1:CAS:528:DC%2BD1cXht1Kksb7I, PID: 18689695
    • Balkau B, Lange C, Fezeu L, Tichet J, de Lauzon-Guillain B, Czernichow S, et al. Predicting diabetes: clinical, biological, and genetic approaches: data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR). Diabetes Care. 2008;31:2056–61.
    • (2008) Diabetes Care , vol.31 , pp. 2056-2061
    • Balkau, B.1    Lange, C.2    Fezeu, L.3    Tichet, J.4    de Lauzon-Guillain, B.5    Czernichow, S.6
  • 33
    • 76249109928 scopus 로고    scopus 로고
    • Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study
    • PID: 20075150
    • Talmud PJ, Hingorani AD, Cooper JA, Marmot MG, Brunner EJ, Kumari M, et al. Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study. BMJ. 2010;340:b4838.
    • (2010) BMJ , vol.340 , pp. b4838
    • Talmud, P.J.1    Hingorani, A.D.2    Cooper, J.A.3    Marmot, M.G.4    Brunner, E.J.5    Kumari, M.6
  • 34
    • 79951715822 scopus 로고    scopus 로고
    • Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms
    • PID: 20889853
    • de Miguel-Yanes JM, Shrader P, Pencina MJ, Fox CS, Manning AK, Grant RW, et al. Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms. Diabetes Care. 2011;34:121–5.
    • (2011) Diabetes Care , vol.34 , pp. 121-125
    • de Miguel-Yanes, J.M.1    Shrader, P.2    Pencina, M.J.3    Fox, C.S.4    Manning, A.K.5    Grant, R.W.6
  • 35
    • 78649842241 scopus 로고    scopus 로고
    • Genomics, type 2 diabetes, and obesity
    • COI: 1:CAS:528:DC%2BC3cXhsFGkt7zO, PID: 21142536
    • McCarthy MI. Genomics, type 2 diabetes, and obesity. N Engl J Med. 2010;363:2339–50.
    • (2010) N Engl J Med , vol.363 , pp. 2339-2350
    • McCarthy, M.I.1
  • 36
    • 2342627300 scopus 로고    scopus 로고
    • Genome-wide scans reveal quantitative trait Loci on 8p and 13q related to insulin action and glucose metabolism: the San Antonio Family Heart Study
    • COI: 1:CAS:528:DC%2BD2cXjslKhs7w%3D, PID: 15111508
    • Cai G, Cole SA, Freeland-Graves JH, MacCluer JW, Blangero J, Comuzzie AG. Genome-wide scans reveal quantitative trait Loci on 8p and 13q related to insulin action and glucose metabolism: the San Antonio Family Heart Study. Diabetes. 2004;53:1369–74.
    • (2004) Diabetes , vol.53 , pp. 1369-1374
    • Cai, G.1    Cole, S.A.2    Freeland-Graves, J.H.3    MacCluer, J.W.4    Blangero, J.5    Comuzzie, A.G.6
  • 37
    • 20044368001 scopus 로고    scopus 로고
    • Genome-wide linkage scans for fasting glucose, insulin, and insulin resistance in the National Heart, Lung, and Blood Institute Family Blood Pressure Program: evidence of linkages to chromosome 7q36 and 19q13 from meta-analysis
    • COI: 1:CAS:528:DC%2BD2MXitlegsbs%3D, PID: 15734873
    • An P, Freedman BI, Hanis CL, Chen YD, Weder AB, Schork NJ, et al. Genome-wide linkage scans for fasting glucose, insulin, and insulin resistance in the National Heart, Lung, and Blood Institute Family Blood Pressure Program: evidence of linkages to chromosome 7q36 and 19q13 from meta-analysis. Diabetes. 2005;54:909–14.
    • (2005) Diabetes , vol.54 , pp. 909-914
    • An, P.1    Freedman, B.I.2    Hanis, C.L.3    Chen, Y.D.4    Weder, A.B.5    Schork, N.J.6
  • 38
    • 19944430035 scopus 로고    scopus 로고
    • A genome scan for fasting insulin and fasting glucose identifies a quantitative trait locus on chromosome 17p: the insulin resistance atherosclerosis study (IRAS) family study
    • COI: 1:CAS:528:DC%2BD2MXhtVWis7g%3D, PID: 15616041
    • Rich SS, Bowden DW, Haffner SM, Norris JM, Saad MF, Mitchell BD, et al. A genome scan for fasting insulin and fasting glucose identifies a quantitative trait locus on chromosome 17p: the insulin resistance atherosclerosis study (IRAS) family study. Diabetes. 2005;54:290–5.
    • (2005) Diabetes , vol.54 , pp. 290-295
    • Rich, S.S.1    Bowden, D.W.2    Haffner, S.M.3    Norris, J.M.4    Saad, M.F.5    Mitchell, B.D.6
  • 39
    • 19944432769 scopus 로고    scopus 로고
    • Genetic regulation of birth weight and fasting glucose by a common polymorphism in the islet cell promoter of the glucokinase gene
    • COI: 1:CAS:528:DC%2BD2MXhsVCrtrY%3D, PID: 15677518
    • Weedon MN, Frayling TM, Shields B, Knight B, Turner T, Metcalf BS, et al. Genetic regulation of birth weight and fasting glucose by a common polymorphism in the islet cell promoter of the glucokinase gene. Diabetes. 2005;54:576–81.
    • (2005) Diabetes , vol.54 , pp. 576-581
    • Weedon, M.N.1    Frayling, T.M.2    Shields, B.3    Knight, B.4    Turner, T.5    Metcalf, B.S.6
  • 40
    • 33845220776 scopus 로고    scopus 로고
    • A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses
    • COI: 1:CAS:528:DC%2BD28Xht1yksr7I, PID: 17186458, Candidate gene study that identified association between GCK locus variant and fasting glucose
    • Weedon MN, Clark VJ, Qian Y, Ben-Shlomo Y, Timpson N, Ebrahim S, et al. A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses. Am J Hum Genet. 2006;79:991–1001. Candidate gene study that identified association between GCK locus variant and fasting glucose.
    • (2006) Am J Hum Genet , vol.79 , pp. 991-1001
    • Weedon, M.N.1    Clark, V.J.2    Qian, Y.3    Ben-Shlomo, Y.4    Timpson, N.5    Ebrahim, S.6
  • 41
    • 0026608764 scopus 로고
    • Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus
    • COI: 1:STN:280:DyaK387os12ltw%3D%3D, PID: 1545870
    • Froguel P, Vaxillaire M, Sun F, Velho G, Zouali H, Butel MO, et al. Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus. Nature. 1992;356:162–4.
    • (1992) Nature , vol.356 , pp. 162-164
    • Froguel, P.1    Vaxillaire, M.2    Sun, F.3    Velho, G.4    Zouali, H.5    Butel, M.O.6
  • 42
    • 0027472126 scopus 로고
    • Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus
    • COI: 1:STN:280:DyaK3s7msFSqsA%3D%3D, PID: 8433729
    • Froguel P, Zouali H, Vionnet N, Velho G, Vaxillaire M, Sun F, et al. Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus. N Engl J Med. 1993;328:697–702.
    • (1993) N Engl J Med , vol.328 , pp. 697-702
    • Froguel, P.1    Zouali, H.2    Vionnet, N.3    Velho, G.4    Vaxillaire, M.5    Sun, F.6
  • 43
    • 0027358380 scopus 로고
    • Glucokinase as pancreatic beta cell glucose sensor and diabetes gene
    • COI: 1:CAS:528:DyaK2cXivVemsA%3D%3D, PID: 8227324
    • Matschinsky F, Liang Y, Kesavan P, Wang L, Froguel P, Velho G, et al. Glucokinase as pancreatic beta cell glucose sensor and diabetes gene. J Clin Invest. 1993;92:2092–8.
    • (1993) J Clin Invest , vol.92 , pp. 2092-2098
    • Matschinsky, F.1    Liang, Y.2    Kesavan, P.3    Wang, L.4    Froguel, P.5    Velho, G.6
  • 44
    • 79953749884 scopus 로고    scopus 로고
    • Insight into the biochemical characteristics of a novel glucokinase gene mutation
    • COI: 1:CAS:528:DC%2BC3MXhvV2qsrg%3D, PID: 21104275
    • Shen Y, Cai M, Liang H, Wang H, Weng J. Insight into the biochemical characteristics of a novel glucokinase gene mutation. Hum Genet. 2011;129:231–8.
    • (2011) Hum Genet , vol.129 , pp. 231-238
    • Shen, Y.1    Cai, M.2    Liang, H.3    Wang, H.4    Weng, J.5
  • 45
    • 79959524146 scopus 로고    scopus 로고
    • A haplotype map of the human genome
    • Consortium IH. A haplotype map of the human genome. Nature. 2005;437:1299–320.
    • (2005) Nature , vol.437 , pp. 1299-1320
    • Consortium, I.H.1
  • 46
    • 34249888775 scopus 로고    scopus 로고
    • Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
    • Diabetes Genetics Initiative of Broad Institute of Harvard, Mit Lund University, Novartis Institutes of BioMedical ResearchCOI: 1:CAS:528:DC%2BD2sXmtVyitrk%3D, PID: 17463246, One of the first round GWA studies for T2D published in 2007
    • Diabetes Genetics Initiative of Broad Institute of Harvard, Mit Lund University, Novartis Institutes of BioMedical Research, Saxena R, Voight BF, Lyssenko V, Burtt NP, de Bakker PI, et al. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science. 2007;316:1331–6. One of the first round GWA studies for T2D published in 2007.
    • (2007) Science , vol.316 , pp. 1331-1336
    • Saxena, R.1    Voight, B.F.2    Lyssenko, V.3    Burtt, N.P.4    de Bakker, P.I.5
  • 47
    • 34249885875 scopus 로고    scopus 로고
    • A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
    • COI: 1:CAS:528:DC%2BD2sXmtVyitrY%3D, PID: 17463248, One of the first round of GWA studies for T2D published in 2007
    • Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, Duren WL, et al. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science. 2007;316:1341–5. One of the first round of GWA studies for T2D published in 2007.
    • (2007) Science , vol.316 , pp. 1341-1345
    • Scott, L.J.1    Mohlke, K.L.2    Bonnycastle, L.L.3    Willer, C.J.4    Li, Y.5    Duren, W.L.6
  • 48
    • 34249895023 scopus 로고    scopus 로고
    • Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
    • COI: 1:CAS:528:DC%2BD2sXmtVymtb0%3D, PID: 17463249, One of the first round GWA studies for T2D published in 2007
    • Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, et al. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science. 2007;316:1336–41. One of the first round GWA studies for T2D published in 2007.
    • (2007) Science , vol.316 , pp. 1336-1341
    • Zeggini, E.1    Weedon, M.N.2    Lindgren, C.M.3    Frayling, T.M.4    Elliott, K.S.5    Lango, H.6
  • 49
    • 33847176604 scopus 로고    scopus 로고
    • A genome-wide association study identifies novel risk loci for type 2 diabetes
    • COI: 1:CAS:528:DC%2BD2sXhvFGiurw%3D, PID: 17293876, The first GWA study for T2D
    • Sladek R, Rocheleau G, Rung J, Dina C, Shen L, Serre D, et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature. 2007;445:881–5. The first GWA study for T2D.
    • (2007) Nature , vol.445 , pp. 881-885
    • Sladek, R.1    Rocheleau, G.2    Rung, J.3    Dina, C.4    Shen, L.5    Serre, D.6
  • 50
    • 44449091627 scopus 로고    scopus 로고
    • A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels
    • COI: 1:CAS:528:DC%2BD1cXmtVKnsLc%3D, PID: 18451265, GWA study describing association at G6PC2 with fasting glucose
    • Bouatia-Naji N, Rocheleau G, Van Lommel L, Lemaire K, Schuit F, Cavalcanti-Proenca C, et al. A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels. Science. 2008;320:1085–8. GWA study describing association at G6PC2 with fasting glucose.
    • (2008) Science , vol.320 , pp. 1085-1088
    • Bouatia-Naji, N.1    Rocheleau, G.2    Van Lommel, L.3    Lemaire, K.4    Schuit, F.5    Cavalcanti-Proenca, C.6
  • 51
    • 46749100599 scopus 로고    scopus 로고
    • Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels
    • COI: 1:CAS:528:DC%2BD1cXot1Onu74%3D, PID: 18521185, GWA study describing association at G6PC2 with fasting glucose
    • Chen WM, Erdos MR, Jackson AU, Saxena R, Sanna S, Silver KD, et al. Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels. J Clin Invest. 2008;118:2620–8. GWA study describing association at G6PC2 with fasting glucose.
    • (2008) J Clin Invest , vol.118 , pp. 2620-2628
    • Chen, W.M.1    Erdos, M.R.2    Jackson, A.U.3    Saxena, R.4    Sanna, S.5    Silver, K.D.6
  • 52
    • 84861614905 scopus 로고    scopus 로고
    • A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
    • COI: 1:CAS:528:DC%2BC38XmvFCjtbw%3D, PID: 22581228, Large-scale joint meta-analysis of GWA studies by the MAGIC investigators for fasting insulin and glucose levels accounting for the effects of BMI on their variability
    • Manning AK, Hivert MF, Scott RA, Grimsby JL, Bouatia-Naji N, Chen H, et al. A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet. 2012;44:659–69. Large-scale joint meta-analysis of GWA studies by the MAGIC investigators for fasting insulin and glucose levels accounting for the effects of BMI on their variability.
    • (2012) Nat Genet , vol.44 , pp. 659-669
    • Manning, A.K.1    Hivert, M.F.2    Scott, R.A.3    Grimsby, J.L.4    Bouatia-Naji, N.5    Chen, H.6
  • 53
    • 35748976848 scopus 로고    scopus 로고
    • Genome-wide association with diabetes-related traits in the Framingham Heart Study
    • PID: 17903298
    • Meigs JB, Manning AK, Fox CS, Florez JC, Liu C, Cupples LA, et al. Genome-wide association with diabetes-related traits in the Framingham Heart Study. BMC Med Genet. 2007;8(1):S16.
    • (2007) BMC Med Genet , vol.8 , Issue.1 , pp. S16
    • Meigs, J.B.1    Manning, A.K.2    Fox, C.S.3    Florez, J.C.4    Liu, C.5    Cupples, L.A.6
  • 54
    • 58149156287 scopus 로고    scopus 로고
    • Variants in MTNR1B influence fasting glucose levels
    • COI: 1:CAS:528:DC%2BD1cXhsVKlt7vM, PID: 19060907, The first large-scale meta-analysis effort of the MAGIC investigators for fasting glucose, which identified a genetic link between circadian rhythms and T2D
    • Prokopenko I, Langenberg C, Florez JC, Saxena R, Soranzo N, Thorleifsson G, et al. Variants in MTNR1B influence fasting glucose levels. Nat Genet. 2009;41:77–81. The first large-scale meta-analysis effort of the MAGIC investigators for fasting glucose, which identified a genetic link between circadian rhythms and T2D.
    • (2009) Nat Genet , vol.41 , pp. 77-81
    • Prokopenko, I.1    Langenberg, C.2    Florez, J.C.3    Saxena, R.4    Soranzo, N.5    Thorleifsson, G.6
  • 55
    • 77954143522 scopus 로고    scopus 로고
    • Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
    • COI: 1:CAS:528:DC%2BC3cXnvFykt70%3D, PID: 20581827, The second large-scale meta-analysis of GWA studies for T2D by the DIAGRAM consortium
    • Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, Welch RP, et al. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet. 2010;42:579–89. The second large-scale meta-analysis of GWA studies for T2D by the DIAGRAM consortium.
    • (2010) Nat Genet , vol.42 , pp. 579-589
    • Voight, B.F.1    Scott, L.J.2    Steinthorsdottir, V.3    Morris, A.P.4    Dina, C.5    Welch, R.P.6
  • 56
    • 58149175669 scopus 로고    scopus 로고
    • Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion
    • COI: 1:CAS:528:DC%2BD1cXhsVKlt77J, PID: 19060908, The report providing a comprehensive description of in vitro and in vivo effects of the common variant rs10830963 in the MTNR1B gene on islet function and risk of T2D
    • Lyssenko V, Nagorny CL, Erdos MR, Wierup N, Jonsson A, Spegel P, et al. Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nat Genet. 2009;41:82–8. The report providing a comprehensive description of in vitro and in vivo effects of the common variant rs10830963 in the MTNR1B gene on islet function and risk of T2D.
    • (2009) Nat Genet , vol.41 , pp. 82-88
    • Lyssenko, V.1    Nagorny, C.L.2    Erdos, M.R.3    Wierup, N.4    Jonsson, A.5    Spegel, P.6
  • 57
    • 58149175143 scopus 로고    scopus 로고
    • A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk
    • COI: 1:CAS:528:DC%2BD1cXhsVKlt7zP, PID: 19060909, The GWA study describing association between a variant in MTNR1B gene and fasting glucose
    • Bouatia-Naji N, Bonnefond A, Cavalcanti-Proenca C, Sparso T, Holmkvist J, Marchand M, et al. A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk. Nat Genet. 2009;41:89–94. The GWA study describing association between a variant in MTNR1B gene and fasting glucose.
    • (2009) Nat Genet , vol.41 , pp. 89-94
    • Bouatia-Naji, N.1    Bonnefond, A.2    Cavalcanti-Proenca, C.3    Sparso, T.4    Holmkvist, J.5    Marchand, M.6
  • 58
    • 75749091912 scopus 로고    scopus 로고
    • Saxena R, Hivert MF, Langenberg C, Tanaka T, Pankow JS, Vollenweider P, et al. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.2010;42:142–8. Large-scale meta-analysis of GWA studies by the MAGIC investigators for 2-hour post-prandial glucose levels
    • Saxena R, Hivert MF, Langenberg C, Tanaka T, Pankow JS, Vollenweider P, et al. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet. 2010;42:142–8. Large-scale meta-analysis of GWA studies by the MAGIC investigators for 2-hour post-prandial glucose levels.
    • Nat Genet.
  • 59
    • 58149151217 scopus 로고    scopus 로고
    • Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women’s Genome Health Study
    • PID: 19096518
    • Pare G, Chasman DI, Parker AN, Nathan DM, Miletich JP, Zee RY, et al. Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women’s Genome Health Study. PLoS Genet. 2008;4:e1000312.
    • (2008) PLoS Genet , vol.4 , pp. e1000312
    • Pare, G.1    Chasman, D.I.2    Parker, A.N.3    Nathan, D.M.4    Miletich, J.P.5    Zee, R.Y.6
  • 61
    • 80053405321 scopus 로고    scopus 로고
    • Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes
    • COI: 1:CAS:528:DC%2BC3MXhtl2is73K, PID: 21873549, Large-scale meta-analysis of GWA studies by the MAGIC investigators for fasting proinsulin levels
    • Strawbridge RJ, Dupuis J, Prokopenko I, Barker A, Ahlqvist E, Rybin D, et al. Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. Diabetes. 2011;60:2624–34. Large-scale meta-analysis of GWA studies by the MAGIC investigators for fasting proinsulin levels.
    • (2011) Diabetes , vol.60 , pp. 2624-2634
    • Strawbridge, R.J.1    Dupuis, J.2    Prokopenko, I.3    Barker, A.4    Ahlqvist, E.5    Rybin, D.6
  • 62
    • 58149161560 scopus 로고    scopus 로고
    • Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
    • COI: 1:CAS:528:DC%2BD1cXhsVKlt7rF, PID: 19060911
    • Aulchenko YS, Ripatti S, Lindqvist I, Boomsma D, Heid IM, Pramstaller PP, et al. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet. 2009;41:47–55.
    • (2009) Nat Genet , vol.41 , pp. 47-55
    • Aulchenko, Y.S.1    Ripatti, S.2    Lindqvist, I.3    Boomsma, D.4    Heid, I.M.5    Pramstaller, P.P.6
  • 63
    • 84865693929 scopus 로고    scopus 로고
    • Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
    • COI: 1:CAS:528:DC%2BC38XhtFOgsbzJ, PID: 22885924, Large-scale follow-up with the Metabochip array and combined meta-analysis of the discovery GWA studies by the MAGIC investigators for fasting glucose and insulin and 2-hour post-prandial glucose
    • Scott RA, Lagou V, Welch RP, Wheeler E, Montasser ME, Luan J, et al. Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet. 2012;44:991–1005. Large-scale follow-up with the Metabochip array and combined meta-analysis of the discovery GWA studies by the MAGIC investigators for fasting glucose and insulin and 2-hour post-prandial glucose.
    • (2012) Nat Genet , vol.44 , pp. 991-1005
    • Scott, R.A.1    Lagou, V.2    Welch, R.P.3    Wheeler, E.4    Montasser, M.E.5    Luan, J.6
  • 64
    • 84901378366 scopus 로고    scopus 로고
    • A central role for GRB10 in regulation of islet function in man
    • PID: 24699409, Large-scale meta-analysis of GWA studies by the MAGIC investigators for insulin secretion traits with deep characterisation of the role of the GRB10 gene, novel association at which was detected in this study
    • Prokopenko I, Poon W, Magi R, Prasad BR, Salehi SA, Almgren P, et al. A central role for GRB10 in regulation of islet function in man. PLoS Genet. 2014;10:e1004235. Large-scale meta-analysis of GWA studies by the MAGIC investigators for insulin secretion traits with deep characterisation of the role of the GRB10 gene, novel association at which was detected in this study.
    • (2014) PLoS Genet , vol.10 , pp. e1004235
    • Prokopenko, I.1    Poon, W.2    Magi, R.3    Prasad, B.R.4    Salehi, S.A.5    Almgren, P.6
  • 65
    • 84901298851 scopus 로고    scopus 로고
    • Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity
    • COI: 1:CAS:528:DC%2BC2cXhsV2ls7rM, PID: 24296717, The study investigated the relationships between 37 T2D susceptibility loci and indices of proinsulin processing, insulin secretion and insulin sensitivity and provided important mechanistic insights into T2D variants impact in disease predisposition
    • Dimas AS, Lagou V, Barker A, Knowles JW, Magi R, Hivert MF, et al. Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity. Diabetes. 2014;63:2158–71. The study investigated the relationships between 37 T2D susceptibility loci and indices of proinsulin processing, insulin secretion and insulin sensitivity and provided important mechanistic insights into T2D variants impact in disease predisposition.
    • (2014) Diabetes , vol.63 , pp. 2158-2171
    • Dimas, A.S.1    Lagou, V.2    Barker, A.3    Knowles, J.W.4    Magi, R.5    Hivert, M.F.6
  • 66
    • 2342466734 scopus 로고    scopus 로고
    • Global prevalence of diabetes: estimates for the year 2000 and projections for 2030
    • PID: 15111519
    • Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27:1047–53.
    • (2004) Diabetes Care , vol.27 , pp. 1047-1053
    • Wild, S.1    Roglic, G.2    Green, A.3    Sicree, R.4    King, H.5
  • 67
    • 84856253386 scopus 로고    scopus 로고
    • The importance of global studies of the genetics of type 2 diabetes
    • PID: 21738890
    • McCarthy MI. The importance of global studies of the genetics of type 2 diabetes. Diabetes Metab J. 2011;35:91–100.
    • (2011) Diabetes Metab J , vol.35 , pp. 91-100
    • McCarthy, M.I.1
  • 68
    • 77957370404 scopus 로고    scopus 로고
    • Consistent association of type 2 diabetes risk variants found in Europeans in diverse racial and ethnic groups
    • Waters KM, Stram DO, Hassanein MT, Le Marchand L, Wilkens LR, Maskarinec G, et al. Consistent association of type 2 diabetes risk variants found in Europeans in diverse racial and ethnic groups. PLoS Genet. 2010;6:e1001078.
    • (2010) PLoS Genet , vol.e1001078 , pp. 6
    • Waters, K.M.1    Stram, D.O.2    Hassanein, M.T.3    Le Marchand, L.4    Wilkens, L.R.5    Maskarinec, G.6
  • 69
    • 70350542772 scopus 로고    scopus 로고
    • Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type 2 diabetes among Indian Asians and European Caucasians
    • COI: 1:CAS:528:DC%2BD1MXhsVCht7zM, PID: 19651812
    • Chambers JC, Zhang W, Zabaneh D, Sehmi J, Jain P, McCarthy MI, et al. Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type 2 diabetes among Indian Asians and European Caucasians. Diabetes. 2009;58:2703–8.
    • (2009) Diabetes , vol.58 , pp. 2703-2708
    • Chambers, J.C.1    Zhang, W.2    Zabaneh, D.3    Sehmi, J.4    Jain, P.5    McCarthy, M.I.6
  • 70
    • 84862796277 scopus 로고    scopus 로고
    • Association of glycosylated hemoglobin with the gene encoding CDKAL1 in the Korean Association Resource (KARE) study
    • COI: 1:CAS:528:DC%2BC38Xjs1Wqur8%3D, PID: 22290723
    • Ryu J, Lee C. Association of glycosylated hemoglobin with the gene encoding CDKAL1 in the Korean Association Resource (KARE) study. Hum Mutat. 2012;33:655–9.
    • (2012) Hum Mutat , vol.33 , pp. 655-659
    • Ryu, J.1    Lee, C.2
  • 71
    • 84867135782 scopus 로고    scopus 로고
    • Genome-wide association study identifies novel loci association with fasting insulin and insulin resistance in African Americans
    • COI: 1:CAS:528:DC%2BC38XhsVartrbN, PID: 22791750
    • Chen G, Bentley A, Adeyemo A, Shriner D, Zhou J, Doumatey A, et al. Genome-wide association study identifies novel loci association with fasting insulin and insulin resistance in African Americans. Hum Mol Genet. 2012;21:4530–6.
    • (2012) Hum Mol Genet , vol.21 , pp. 4530-4536
    • Chen, G.1    Bentley, A.2    Adeyemo, A.3    Shriner, D.4    Zhou, J.5    Doumatey, A.6
  • 72
    • 84880891741 scopus 로고    scopus 로고
    • New susceptibility loci in MYL2, C12orf51 and OAS1 associated with 1-h plasma glucose as predisposing risk factors for type 2 diabetes in the Korean population
    • COI: 1:CAS:528:DC%2BC3sXhtValtbvM, PID: 23575436
    • Go MJ, Hwang JY, Kim YJ, Hee Oh J, Kim YJ, Heon Kwak S, et al. New susceptibility loci in MYL2, C12orf51 and OAS1 associated with 1-h plasma glucose as predisposing risk factors for type 2 diabetes in the Korean population. J Hum Genet. 2013;58:362–5.
    • (2013) J Hum Genet , vol.58 , pp. 362-365
    • Go, M.J.1    Hwang, J.Y.2    Kim, Y.J.3    Hee Oh, J.4    Kim, Y.J.5    Heon Kwak, S.6
  • 73
    • 77951858557 scopus 로고    scopus 로고
    • Detailed physiologic characterization reveals diverse mechanisms for novel genetic loci regulating glucose and insulin metabolism in humans
    • COI: 1:CAS:528:DC%2BC3cXmtFegtrk%3D, PID: 20185807, A detailed analysis of the physiological effects of glycaemia and insulin-associated variants on insulin processing, secretion, and sensitivity
    • Ingelsson E, Langenberg C, Hivert MF, Prokopenko I, Lyssenko V, Dupuis J, et al. Detailed physiologic characterization reveals diverse mechanisms for novel genetic loci regulating glucose and insulin metabolism in humans. Diabetes. 2010;59:1266–75. A detailed analysis of the physiological effects of glycaemia and insulin-associated variants on insulin processing, secretion, and sensitivity.
    • (2010) Diabetes , vol.59 , pp. 1266-1275
    • Ingelsson, E.1    Langenberg, C.2    Hivert, M.F.3    Prokopenko, I.4    Lyssenko, V.5    Dupuis, J.6
  • 74
    • 84862899735 scopus 로고    scopus 로고
    • Insights into the pathogenicity of rare missense GCK variants from the identification and functional characterization of compound heterozygous and double mutations inherited in cis
    • COI: 1:CAS:528:DC%2BC38Xht1Sht7vN, PID: 22611063
    • Beer NL, Osbak KK, van de Bunt M, Tribble ND, Steele AM, Wensley KJ, et al. Insights into the pathogenicity of rare missense GCK variants from the identification and functional characterization of compound heterozygous and double mutations inherited in cis. Diabetes Care. 2012;35:1482–4.
    • (2012) Diabetes Care , vol.35 , pp. 1482-1484
    • Beer, N.L.1    Osbak, K.K.2    van de Bunt, M.3    Tribble, N.D.4    Steele, A.M.5    Wensley, K.J.6
  • 75
    • 77951766379 scopus 로고    scopus 로고
    • Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight
    • COI: 1:CAS:528:DC%2BC3cXktlSgu7k%3D, PID: 20372150, The first large-scale meta-analysis of GWA studies by the EGG consortium for birth weight that highlighted the link of early growth-associated variants to adult T2D
    • Freathy RM, Mook-Kanamori DO, Sovio U, Prokopenko I, Timpson NJ, Berry DJ, et al. Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nat Genet. 2010;42:430–5. The first large-scale meta-analysis of GWA studies by the EGG consortium for birth weight that highlighted the link of early growth-associated variants to adult T2D.
    • (2010) Nat Genet , vol.42 , pp. 430-435
    • Freathy, R.M.1    Mook-Kanamori, D.O.2    Sovio, U.3    Prokopenko, I.4    Timpson, N.J.5    Berry, D.J.6
  • 76
    • 84871987100 scopus 로고    scopus 로고
    • New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism
    • COI: 1:CAS:528:DC%2BC38XhslGktb7K, PID: 23202124, The second large-scale meta-analysis of GWA studies by the EGG consortium for birth weight that highlighted links between early growth loci and adult phenotypes
    • Horikoshi M, Yaghootkar H, Mook-Kanamori DO, Sovio U, Taal HR, Hennig BJ, et al. New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. Nat Genet. 2013;45:76–82. The second large-scale meta-analysis of GWA studies by the EGG consortium for birth weight that highlighted links between early growth loci and adult phenotypes.
    • (2013) Nat Genet , vol.45 , pp. 76-82
    • Horikoshi, M.1    Yaghootkar, H.2    Mook-Kanamori, D.O.3    Sovio, U.4    Taal, H.R.5    Hennig, B.J.6
  • 77
    • 0033594787 scopus 로고    scopus 로고
    • The fetal insulin hypothesis: an alternative explanation of the association of low birthweight with diabetes and vascular disease
    • COI: 1:STN:280:DyaK1M3nsFOltg%3D%3D, PID: 10348008
    • Hattersley AT, Tooke JE. The fetal insulin hypothesis: an alternative explanation of the association of low birthweight with diabetes and vascular disease. Lancet. 1999;353:1789–92.
    • (1999) Lancet , vol.353 , pp. 1789-1792
    • Hattersley, A.T.1    Tooke, J.E.2
  • 78
    • 34250827858 scopus 로고    scopus 로고
    • Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals
    • COI: 1:CAS:528:DC%2BD2sXmtFGmsbc%3D, PID: 17503332
    • Freathy RM, Weedon MN, Bennett A, Hypponen E, Relton CL, Knight B, et al. Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals. Am J Hum Genet. 2007;80:1150–61.
    • (2007) Am J Hum Genet , vol.80 , pp. 1150-1161
    • Freathy, R.M.1    Weedon, M.N.2    Bennett, A.3    Hypponen, E.4    Relton, C.L.5    Knight, B.6
  • 80
    • 84856757156 scopus 로고    scopus 로고
    • Common genetic variants differentially influence the transition from clinically defined states of fasting glucose metabolism
    • COI: 1:CAS:528:DC%2BC3MXhs1ynur7O, PID: 22038522
    • Walford GA, Green T, Neale B, Isakova T, Rotter JI, Grant SF, et al. Common genetic variants differentially influence the transition from clinically defined states of fasting glucose metabolism. Diabetologia. 2012;55:331–9.
    • (2012) Diabetologia , vol.55 , pp. 331-339
    • Walford, G.A.1    Green, T.2    Neale, B.3    Isakova, T.4    Rotter, J.I.5    Grant, S.F.6
  • 81
    • 84857654651 scopus 로고    scopus 로고
    • Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes
    • COI: 1:CAS:528:DC%2BC38XhtlOktbk%3D, PID: 22286214, A first large scale exon re-sequencing study of the MTNR1B gene. It provided the first evidence of a number of rare variants in the MTNR1B gene with partial or total loss-of-function properties
    • Bonnefond A, Clement N, Fawcett K, Yengo L, Vaillant E, Guillaume JL, et al. Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes. Nat Genet. 2012;44:297–301. A first large scale exon re-sequencing study of the MTNR1B gene. It provided the first evidence of a number of rare variants in the MTNR1B gene with partial or total loss-of-function properties.
    • (2012) Nat Genet , vol.44 , pp. 297-301
    • Bonnefond, A.1    Clement, N.2    Fawcett, K.3    Yengo, L.4    Vaillant, E.5    Guillaume, J.L.6
  • 82
    • 33645098511 scopus 로고    scopus 로고
    • Parallel signaling pathways of melatonin in the pancreatic beta-cell
    • COI: 1:CAS:528:DC%2BD28XisFKjtLc%3D, PID: 16441556
    • Peschke E, Bach AG, Muhlbauer E. Parallel signaling pathways of melatonin in the pancreatic beta-cell. J Pineal Res. 2006;40:184–91.
    • (2006) J Pineal Res , vol.40 , pp. 184-191
    • Peschke, E.1    Bach, A.G.2    Muhlbauer, E.3
  • 83
    • 84859228435 scopus 로고    scopus 로고
    • Circadian gene variants and susceptibility to type 2 diabetes: a pilot study
    • PID: 22485135
    • Kelly MA, Rees SD, Hydrie MZ, Shera AS, Bellary S, O'Hare JP, et al. Circadian gene variants and susceptibility to type 2 diabetes: a pilot study. PLoS ONE. 2012;7:e32670.
    • (2012) PLoS ONE , vol.7 , pp. e32670
    • Kelly, M.A.1    Rees, S.D.2    Hydrie, M.Z.3    Shera, A.S.4    Bellary, S.5    O'Hare, J.P.6
  • 84
    • 70349566593 scopus 로고
    • Diabetes mellitus: a “thrifty” genotype rendered detrimental by “progress”?
    • COI: 1:STN:280:DyaF387ivFGmtw%3D%3D, PID: 13937884
    • Neel JV. Diabetes mellitus: a “thrifty” genotype rendered detrimental by “progress”? Am J Hum Genet. 1962;14:353–62.
    • (1962) Am J Hum Genet , vol.14 , pp. 353-362
    • Neel, J.V.1
  • 85
    • 0033000423 scopus 로고    scopus 로고
    • The “thrifty genotype” in 1998
    • COI: 1:STN:280:DyaK1MzhvFCqsQ%3D%3D, PID: 10391020
    • Neel JV. The “thrifty genotype” in 1998. Nutr Rev. 1999;57:S2–9.
    • (1999) Nutr Rev , vol.57 , pp. S2-S9
    • Neel, J.V.1
  • 86
    • 84893730773 scopus 로고    scopus 로고
    • Revisiting the thrifty gene hypothesis via 65 loci associated with susceptibility to type 2 diabetes
    • COI: 1:CAS:528:DC%2BC2cXns1Cgtg%3D%3D, PID: 24412096, Recent study investigating the thrifty gene hypothesis using a large number of T2D risk loci with additional stratification by their impact on β-cell function or insulin resistance
    • Ayub Q, Moutsianas L, Chen Y, Panoutsopoulou K, Colonna V, Pagani L, et al. Revisiting the thrifty gene hypothesis via 65 loci associated with susceptibility to type 2 diabetes. Am J Hum Genet. 2014;94:176–85. Recent study investigating the thrifty gene hypothesis using a large number of T2D risk loci with additional stratification by their impact on β-cell function or insulin resistance.
    • (2014) Am J Hum Genet , vol.94 , pp. 176-185
    • Ayub, Q.1    Moutsianas, L.2    Chen, Y.3    Panoutsopoulou, K.4    Colonna, V.5    Pagani, L.6
  • 87
    • 68449102930 scopus 로고    scopus 로고
    • Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?
    • COI: 1:CAS:528:DC%2BD1MXpsFyrs78%3D, PID: 19526209
    • Southam L, Soranzo N, Montgomery SB, Frayling TM, McCarthy MI, Barroso I, et al. Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants? Diabetologia. 2009;52:1846–51.
    • (2009) Diabetologia , vol.52 , pp. 1846-1851
    • Southam, L.1    Soranzo, N.2    Montgomery, S.B.3    Frayling, T.M.4    McCarthy, M.I.5    Barroso, I.6
  • 88
    • 79953831476 scopus 로고    scopus 로고
    • Natural selection at genomic regions associated with obesity and type-2 diabetes: East Asians and sub-Saharan Africans exhibit high levels of differentiation at type-2 diabetes regions
    • PID: 21188420
    • Klimentidis YC, Abrams M, Wang J, Fernandez JR, Allison DB. Natural selection at genomic regions associated with obesity and type-2 diabetes: East Asians and sub-Saharan Africans exhibit high levels of differentiation at type-2 diabetes regions. Hum Genet. 2011;129:407–18.
    • (2011) Hum Genet , vol.129 , pp. 407-418
    • Klimentidis, Y.C.1    Abrams, M.2    Wang, J.3    Fernandez, J.R.4    Allison, D.B.5
  • 89
    • 84860547622 scopus 로고    scopus 로고
    • Type 2 diabetes risk alleles demonstrate extreme directional differentiation among human populations, compared to other diseases
    • COI: 1:CAS:528:DC%2BC38XmtFGiuro%3D, PID: 22511877
    • Chen R, Corona E, Sikora M, Dudley JT, Morgan AA, Moreno-Estrada A, et al. Type 2 diabetes risk alleles demonstrate extreme directional differentiation among human populations, compared to other diseases. PLoS Genet. 2012;8:e1002621.
    • (2012) PLoS Genet , vol.8 , pp. e1002621
    • Chen, R.1    Corona, E.2    Sikora, M.3    Dudley, J.T.4    Morgan, A.A.5    Moreno-Estrada, A.6
  • 90
    • 84878484584 scopus 로고    scopus 로고
    • Analysis of the genetic basis of disease in the context of worldwide human relationships and migration
    • COI: 1:CAS:528:DC%2BC3sXpsFelu7c%3D, PID: 23717210
    • Corona E, Chen R, Sikora M, Morgan AA, Patel CJ, Ramesh A, et al. Analysis of the genetic basis of disease in the context of worldwide human relationships and migration. PLoS Genet. 2013;9:e1003447.
    • (2013) PLoS Genet , vol.9 , pp. e1003447
    • Corona, E.1    Chen, R.2    Sikora, M.3    Morgan, A.A.4    Patel, C.J.5    Ramesh, A.6
  • 91
    • 84884587371 scopus 로고    scopus 로고
    • Positive selection of protective variants for type 2 diabetes from the Neolithic onward: a case study in Central Asia
    • COI: 1:CAS:528:DC%2BC3sXhsV2jtr3N, PID: 23340510
    • Segurel L, Austerlitz F, Toupance B, Gautier M, Kelley JL, Pasquet P, et al. Positive selection of protective variants for type 2 diabetes from the Neolithic onward: a case study in Central Asia. Eur J Hum Genet. 2013;21:1146–51.
    • (2013) Eur J Hum Genet , vol.21 , pp. 1146-1151
    • Segurel, L.1    Austerlitz, F.2    Toupance, B.3    Gautier, M.4    Kelley, J.L.5    Pasquet, P.6
  • 92
    • 79953216697 scopus 로고    scopus 로고
    • Updated genetic score based on 34 confirmed type 2 diabetes loci is associated with diabetes incidence and regression to normoglycemia in the diabetes prevention program
    • COI: 1:CAS:528:DC%2BC3MXms1Wkt7o%3D, PID: 21378175
    • Hivert MF, Jablonski KA, Perreault L, Saxena R, McAteer JB, Franks PW, et al. Updated genetic score based on 34 confirmed type 2 diabetes loci is associated with diabetes incidence and regression to normoglycemia in the diabetes prevention program. Diabetes. 2011;60:1340–8.
    • (2011) Diabetes , vol.60 , pp. 1340-1348
    • Hivert, M.F.1    Jablonski, K.A.2    Perreault, L.3    Saxena, R.4    McAteer, J.B.5    Franks, P.W.6
  • 93
    • 84877907738 scopus 로고    scopus 로고
    • The value of genetic information for diabetes risk prediction—differences according to sex, age, family history and obesity
    • PID: 23700469
    • Muhlenbruch K, Jeppesen C, Joost HG, Boeing H, Schulze MB. The value of genetic information for diabetes risk prediction—differences according to sex, age, family history and obesity. PLoS ONE. 2013;8:e64307.
    • (2013) PLoS ONE , vol.8 , pp. e64307
    • Muhlenbruch, K.1    Jeppesen, C.2    Joost, H.G.3    Boeing, H.4    Schulze, M.B.5
  • 94
    • 84904746615 scopus 로고    scopus 로고
    • Type 2 diabetes-related genetic risk scores associated with variations in fasting plasma glucose and development of impaired glucose homeostasis in the prospective DESIR study
    • Vaxillaire M, Yengo L, Lobbens S, Rocheleau G, Eury E, et al. Type 2 diabetes-related genetic risk scores associated with variations in fasting plasma glucose and development of impaired glucose homeostasis in the prospective DESIR study. Diabetologia. 2014;57(8):1601−10.
    • (2014) Diabetologia , vol.57 , Issue.8 , pp. 1600-1601
    • Vaxillaire, M.1    Yengo, L.2    Lobbens, S.3    Rocheleau, G.4    Eury, E.5
  • 95
    • 84871941957 scopus 로고    scopus 로고
    • Diagnosis and classification of diabetes mellitus
    • American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2013;36(1):S67–74.
    • (2013) Diabetes Care , vol.36 , Issue.1 , pp. S67-S74
    • American Diabetes Association1
  • 96
    • 0021813187 scopus 로고
    • Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    • COI: 1:CAS:528:DyaL2MXlslKnu7k%3D, PID: 3899825
    • Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–9.
    • (1985) Diabetologia , vol.28 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3    Naylor, B.A.4    Treacher, D.F.5    Turner, R.C.6
  • 97
    • 0031737373 scopus 로고    scopus 로고
    • Correct homeostasis model assessment (HOMA) evaluation uses the computer program
    • COI: 1:STN:280:DyaK1M%2Fls1CqtA%3D%3D, PID: 9839117
    • Levy JC, Matthews DR, Hermans MP. Correct homeostasis model assessment (HOMA) evaluation uses the computer program. Diabetes Care. 1998;21:2191–2.
    • (1998) Diabetes Care , vol.21 , pp. 2191-2192
    • Levy, J.C.1    Matthews, D.R.2    Hermans, M.P.3


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