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42349112088
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Genome-wide association studies for complex traits: consensus, uncertainty and challenges
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McCarthy MI, Abecasis GR, Cardon LR, Goldstein DB, Little J, Ioannidis JP, Hirschhorn JN. Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet 2008;9: 356-69.
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(2008)
Nat Rev Genet
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, pp. 356-369
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McCarthy, M.I.1
Abecasis, G.R.2
Cardon, L.R.3
Goldstein, D.B.4
Little, J.5
Ioannidis, J.P.6
Hirschhorn, J.N.7
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2
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77954143522
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MAGIC investigators; GIANT Consortium Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
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Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, Welch RP, Zeggini E, Huth C, Aulchenko YS, Thorleifsson G, McCulloch LJ, Ferreira T, Grallert H, Amin N, Wu G, Willer CJ, Raychaudhuri S, McCarroll SA, Langenberg C, Hofmann OM, Dupuis J, Qi L, Segre AV, van Hoek M, Navarro P, Ardlie K, Balkau B, Benediktsson R, Bennett AJ, Blagieva R, Boerwinkle E, Bonnycastle LL, Bengtsson Bostrom K, Bravenboer B, Bumpstead S, Burtt NP, Charpentier G, Chines PS, Cornelis M, Couper DJ, Crawford G, Doney AS, Elliott KS, Elliott AL, Erdos MR, Fox CS, Franklin CS, Ganser M, Gieger C, Grarup N, Green T, Griffin S, Groves CJ, Guiducci C, Hadjadj S, Hassanali N, Herder C, Isomaa B, Jackson AU, Johnson PR, Jorgensen T, Kao WH, Klopp N, Kong A, Kraft P, Kuusisto J, Lauritzen T, Li M, Lieverse A, Lindgren CM, Lyssenko V, Marre M, Meitinger T, Midthjell K, Morken MA, Narisu N, Nilsson P, Owen KR, Payne F, Perry JR, Petersen AK, Platou C, Proenca C, Prokopenko I, Rathmann W, Rayner NW, Robertson NR, Rocheleau G, Roden M, Sampson MJ, Saxena R, Shields BM, Shrader P, Sigurdsson G, Sparso T, Strassburger K, Stringham HM, Sun Q, Swift AJ, Thorand B, Tichet J, Tuomi T, van Dam RM, van Haeften TW, van Herpt T, van Vliet-Ostaptchouk JV, Walters GB, Weedon MN, Wijmenga C, Witteman J, Bergman RN, Cauchi S, Collins FS, Gloyn AL, Gyllensten U, Hansen T, Hide WA, Hitman GA, Hofman A, Hunter DJ, Hveem K, Laakso M, Mohlke KL, Morris AD, Palmer CN, Pramstaller PP, Rudan I, Sijbrands E, Stein LD, Tuomilehto J, Uitterlinden A, Walker M, Wareham NJ, Watanabe RM, Abecasis GR, Boehm BO, Campbell H, Daly MJ, Hattersley AT, Hu FB, Meigs JB, Pankow JS, Pedersen O, Wichmann HE, Barroso I, Florez JC, Frayling TM, Groop L, Sladek R, Thorsteinsdottir U, Wilson JF, Illig T, Froguel P, van Duijn CM, Stefansson K, Altshuler D, Boehnke M, McCarthy MI; MAGIC investigators; GIANT Consortium. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet 2010; 42: 579-89.
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(2010)
Nat Genet
, vol.42
, pp. 579-589
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Voight, B.F.1
Scott, L.J.2
Steinthorsdottir, V.3
Morris, A.P.4
Dina, C.5
Welch, R.P.6
Zeggini, E.7
Huth, C.8
Aulchenko, Y.S.9
Thorleifsson, G.10
McCulloch, L.J.11
Ferreira, T.12
Grallert, H.13
Amin, N.14
Wu, G.15
Willer, C.J.16
Raychaudhuri, S.17
McCarroll, S.A.18
Langenberg, C.19
Hofmann, O.M.20
Dupuis, J.21
Qi, L.22
Segre, A.V.23
van Hoek, M.24
Navarro, P.25
Ardlie, K.26
Balkau, B.27
Benediktsson, R.28
Bennett, A.J.29
Blagieva, R.30
Boerwinkle, E.31
Bonnycastle, L.L.32
Bengtsson Bostrom, K.33
Bravenboer, B.34
Bumpstead, S.35
Burtt, N.P.36
Charpentier, G.37
Chines, P.S.38
Cornelis, M.39
Couper, D.J.40
Crawford, G.41
Doney, A.S.42
Elliott, K.S.43
Elliott, A.L.44
Erdos, M.R.45
Fox, C.S.46
Franklin, C.S.47
Ganser, M.48
Gieger, C.49
Grarup, N.50
Green, T.51
Griffin, S.52
Groves, C.J.53
Guiducci, C.54
Hadjadj, S.55
Hassanali, N.56
Herder, C.57
Isomaa, B.58
Jackson, A.U.59
Johnson, P.R.60
Jorgensen, T.61
Kao, W.H.62
Klopp, N.63
Kong, A.64
Kraft, P.65
Kuusisto, J.66
Lauritzen, T.67
Li, M.68
Lieverse, A.69
Lindgren, C.M.70
Lyssenko, V.71
Marre, M.72
Meitinger, T.73
Midthjell, K.74
Morken, M.A.75
Narisu, N.76
Nilsson, P.77
Owen, K.R.78
Payne, F.79
Perry, J.R.80
Petersen, A.K.81
Platou, C.82
Proenca, C.83
Prokopenko, I.84
Rathmann, W.85
Rayner, N.W.86
Robertson, N.R.87
Rocheleau, G.88
Roden, M.89
Sampson, M.J.90
Saxena, R.91
Shields, B.M.92
Shrader, P.93
Sigurdsson, G.94
Sparso, T.95
Strassburger, K.96
Stringham, H.M.97
Sun, Q.98
Swift, A.J.99
Thorand, B.100
Tichet, J.101
Tuomi, T.102
van Dam, R.M.103
van Haeften, T.W.104
van Herpt, T.105
van Vliet-Ostaptchouk, J.V.106
Walters, G.B.107
Weedon, M.N.108
Wijmenga, C.109
Witteman, J.110
Bergman, R.N.111
Cauchi, S.112
Collins, F.S.113
Gloyn, A.L.114
Gyllensten, U.115
Hansen, T.116
Hide, W.A.117
Hitman, G.A.118
Hofman, A.119
Hunter, D.J.120
Hveem, K.121
Laakso, M.122
Mohlke, K.L.123
Morris, A.D.124
Palmer, C.N.125
Pramstaller, P.P.126
Rudan, I.127
Sijbrands, E.128
Stein, L.D.129
Tuomilehto, J.130
Uitterlinden, A.131
Walker, M.132
Wareham, N.J.133
Watanabe, R.M.134
Abecasis, G.R.135
Boehm, B.O.136
Campbell, H.137
Daly, M.J.138
Hattersley, A.T.139
Hu, F.B.140
Meigs, J.B.141
Pankow, J.S.142
Pedersen, O.143
Wichmann, H.E.144
Barroso, I.145
Florez, J.C.146
Frayling, T.M.147
Groop, L.148
Sladek, R.149
Thorsteinsdottir, U.150
Wilson, J.F.151
Illig, T.152
Froguel, P.153
van Duijn, C.M.154
Stefansson, K.155
Altshuler, D.156
Boehnke, M.157
McCarthy, M.I.158
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78049349396
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Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
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Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L, Steinthorsdottir V, Thorleifsson G, Zillikens MC, Speliotes EK, Magi R, Workalemahu T, White CC, Bouatia-Naji N, Harris TB, Berndt SI, Ingelsson E, Willer CJ, Weedon MN, Luan J, Vedantam S, Esko T, Kilpelainen TO, Kutalik Z, Li S, Monda KL, Dixon AL, Holmes CC, Kaplan LM, Liang L, Min JL, Moffatt MF, Molony C, Nicholson G, Schadt EE, Zondervan KT, Feitosa MF, Ferreira T, Allen HL, Weyant RJ, Wheeler E, Wood AR; MAGIC, Estrada K, Goddard ME, Lettre G, Mangino M, Nyholt DR, Purcell S, Smith AV, Visscher PM, Yang J, McCarroll SA, Nemesh J, Voight BF, Absher D, Amin N, Aspelund T, Coin L, Glazer NL, Hayward C, Heard-Costa NL, Hottenga JJ, Johansson A, Johnson T, Kaakinen M, Kapur K, Ketkar S, Knowles JW, Kraft P, Kraja AT, Lamina C, Leitzmann MF, McKnight B, Morris AP, Ong KK, Perry JR, Peters MJ, Polasek O, Prokopenko I, Rayner NW, Ripatti S, Rivadeneira F, Robertson NR, Sanna S, Sovio U, Surakka I, Teumer A, van Wingerden S, Vitart V, Zhao JH, Cavalcanti-Proenca C, Chines PS, Fisher E, Kulzer JR, Lecoeur C, Narisu N, Sandholt C, Scott LJ, Silander K, Stark K, Tammesoo ML, Teslovich TM, Timpson NJ, Watanabe RM, Welch R, Chasman DI, Cooper MN, Jansson JO, Kettunen J, Lawrence RW, Pellikka N, Perola M, Vandenput L, Alavere H, Almgren P, Atwood LD, Bennett AJ, Biffar R, Bonnycastle LL, Bornstein SR, Buchanan TA, Campbell H, Day IN, Dei M, Dorr M, Elliott P, Erdos MR, Eriksson JG, Freimer NB, Fu M, Gaget S, Geus EJ, Gjesing AP, Grallert H, Grassler J, Groves CJ, Guiducci C, Hartikainen AL, Hassanali N, Havulinna AS, Herzig KH, Hicks AA, Hui J, Igl W, Jousilahti P, Jula A, Kajantie E, Kinnunen L, Kolcic I, Koskinen S, Kovacs P, Kroemer HK, Krzelj V, Kuusisto J, Kvaloy K, Laitinen J, Lantieri O, Lathrop GM, Lokki ML, Luben RN, Ludwig B, McArdle WL, McCarthy A, Morken MA, Nelis M, Neville MJ, Pare G, Parker AN, Peden JF, Pichler I, Pietilainen KH, Platou CG, Pouta A, Ridderstrale M, Samani NJ, Saramies J, Sinisalo J, Smit JH, Strawbridge RJ, Stringham HM, Swift AJ, Teder-Laving M, Thomson B, Usala G, van Meurs JB, van Ommen GJ, Vatin V, Volpato CB, Wallaschofski H, Walters GB, Widen E, Wild SH, Willemsen G, Witte DR, Zgaga L, Zitting P, Beilby JP, James AL, Kahonen M, Lehtimaki T, Nieminen MS, Ohlsson C, Palmer LJ, Raitakari O, Ridker PM, Stumvoll M, Tonjes A, Viikari J, Balkau B, Ben-Shlomo Y, Bergman RN, Boeing H, Smith GD, Ebrahim S, Froguel P, Hansen T, Hengstenberg C, Hveem K, Isomaa B, Jorgensen T, Karpe F, Khaw KT, Laakso M, Lawlor DA, Marre M, Meitinger T, Metspalu A, Midthjell K, Pedersen O, Salomaa V, Schwarz PE, Tuomi T, Tuomilehto J, Valle TT, Wareham NJ, Arnold AM, Beckmann JS, Bergmann S, Boerwinkle E, Boomsma DI, Caulfield MJ, Collins FS, Eiriksdottir G, Gudnason V, Gyllensten U, Hamsten A, Hattersley AT, Hofman A, Hu FB, Illig T, Iribarren C, Jarvelin MR, Kao WH, Kaprio J, Launer LJ, Munroe PB, Oostra B, Penninx BW, Pramstaller PP, Psaty BM, Quertermous T, Rissanen A, Rudan I, Shuldiner AR, Soranzo N, Spector TD, Syvanen AC, Uda M, Uitterlinden A, Volzke H, Vollenweider P, Wilson JF, Witteman JC, Wright AF, Abecasis GR, Boehnke M, Borecki IB, Deloukas P, Frayling TM, Groop LC, Haritunians T, Hunter DJ, Kaplan RC, North KE, O'Connell JR, Peltonen L, Schlessinger D, Strachan DP, Hirschhorn JN, Assimes TL, Wichmann HE, Thorsteinsdottir U, van Duijn CM, Stefansson K, Cupples LA, Loos RJ, Barroso I, McCarthy MI, Fox CS, Mohlke KL, Lindgren CM. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet 2010;42: 949-60.
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(2010)
Nat Genet
, vol.42
, pp. 949-960
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Heid, I.M.1
Jackson, A.U.2
Randall, J.C.3
Winkler, T.W.4
Qi, L.5
Steinthorsdottir, V.6
Thorleifsson, G.7
Zillikens, M.C.8
Speliotes, E.K.9
Magi, R.10
Workalemahu, T.11
White, C.C.12
Bouatia-Naji, N.13
Harris, T.B.14
Berndt, S.I.15
Ingelsson, E.16
Willer, C.J.17
Weedon, M.N.18
Luan, J.19
Vedantam, S.20
Esko, T.21
Kilpelainen, T.O.22
Kutalik, Z.23
Li, S.24
Monda, K.L.25
Dixon, A.L.26
Holmes, C.C.27
Kaplan, L.M.28
Liang, L.29
Min, J.L.30
Moffatt, M.F.31
Molony, C.32
Nicholson, G.33
Schadt, E.E.34
Zondervan, K.T.35
Feitosa, M.F.36
Ferreira, T.37
Allen, H.L.38
Weyant, R.J.39
Wheeler, E.40
Wood, A.R.41
Estrada, K.42
Goddard, M.E.43
Lettre, G.44
Mangino, M.45
Nyholt, D.R.46
Purcell, S.47
Smith, A.V.48
Visscher, P.M.49
Yang, J.50
McCarroll, S.A.51
Nemesh, J.52
Voight, B.F.53
Absher, D.54
Amin, N.55
Aspelund, T.56
Coin, L.57
Glazer, N.L.58
Hayward, C.59
Heard-Costa, N.L.60
Hottenga, J.J.61
Johansson, A.62
Johnson, T.63
Kaakinen, M.64
Kapur, K.65
Ketkar, S.66
Knowles, J.W.67
Kraft, P.68
Kraja, A.T.69
Lamina, C.70
Leitzmann, M.F.71
McKnight, B.72
Morris, A.P.73
Ong, K.K.74
Perry, J.R.75
Peters, M.J.76
Polasek, O.77
Prokopenko, I.78
Rayner, N.W.79
Ripatti, S.80
Rivadeneira, F.81
Robertson, N.R.82
Sanna, S.83
Sovio, U.84
Surakka, I.85
Teumer, A.86
van Wingerden, S.87
Vitart, V.88
Zhao, J.H.89
Cavalcanti-Proenca, C.90
Chines, P.S.91
Fisher, E.92
Kulzer, J.R.93
Lecoeur, C.94
Narisu, N.95
Sandholt, C.96
Scott, L.J.97
Silander, K.98
Stark, K.99
Tammesoo, M.L.100
Teslovich, T.M.101
Timpson, N.J.102
Watanabe, R.M.103
Welch, R.104
Chasman, D.I.105
Cooper, M.N.106
Jansson, J.O.107
Kettunen, J.108
Lawrence, R.W.109
Pellikka, N.110
Perola, M.111
Vandenput, L.112
Alavere, H.113
Almgren, P.114
Atwood, L.D.115
Bennett, A.J.116
Biffar, R.117
Bonnycastle, L.L.118
Bornstein, S.R.119
Buchanan, T.A.120
Campbell, H.121
Day, I.N.122
Dei, M.123
Dorr, M.124
Elliott, P.125
Erdos, M.R.126
Eriksson, J.G.127
Freimer, N.B.128
Fu, M.129
Gaget, S.130
Geus, E.J.131
Gjesing, A.P.132
Grallert, H.133
Grassler, J.134
Groves, C.J.135
Guiducci, C.136
Hartikainen, A.L.137
Hassanali, N.138
Havulinna, A.S.139
Herzig, K.H.140
Hicks, A.A.141
Hui, J.142
Igl, W.143
Jousilahti, P.144
Jula, A.145
Kajantie, E.146
Kinnunen, L.147
Kolcic, I.148
Koskinen, S.149
Kovacs, P.150
Kroemer, H.K.151
Krzelj, V.152
Kuusisto, J.153
Kvaloy, K.154
Laitinen, J.155
Lantieri, O.156
Lathrop, G.M.157
Lokki, M.L.158
Luben, R.N.159
Ludwig, B.160
McArdle, W.L.161
McCarthy, A.162
Morken, M.A.163
Nelis, M.164
Neville, M.J.165
Pare, G.166
Parker, A.N.167
Peden, J.F.168
Pichler, I.169
Pietilainen, K.H.170
Platou, C.G.171
Pouta, A.172
Ridderstrale, M.173
Samani, N.J.174
Saramies, J.175
Sinisalo, J.176
Smit, J.H.177
Strawbridge, R.J.178
Stringham, H.M.179
Swift, A.J.180
Teder-Laving, M.181
Thomson, B.182
Usala, G.183
van Meurs, J.B.184
van Ommen, G.J.185
Vatin, V.186
Volpato, C.B.187
Wallaschofski, H.188
Walters, G.B.189
Widen, E.190
Wild, S.H.191
Willemsen, G.192
Witte, D.R.193
Zgaga, L.194
Zitting, P.195
Beilby, J.P.196
James, A.L.197
Kahonen, M.198
Lehtimaki, T.199
Nieminen, M.S.200
Ohlsson, C.201
Palmer, L.J.202
Raitakari, O.203
Ridker, P.M.204
Stumvoll, M.205
Tonjes, A.206
Viikari, J.207
Balkau, B.208
Ben-Shlomo, Y.209
Bergman, R.N.210
Boeing, H.211
Smith, G.D.212
Ebrahim, S.213
Froguel, P.214
Hansen, T.215
Hengstenberg, C.216
Hveem, K.217
Isomaa, B.218
Jorgensen, T.219
Karpe, F.220
Khaw, K.T.221
Laakso, M.222
Lawlor, D.A.223
Marre, M.224
Meitinger, T.225
Metspalu, A.226
Midthjell, K.227
Pedersen, O.228
Salomaa, V.229
Schwarz, P.E.230
Tuomi, T.231
Tuomilehto, J.232
Valle, T.T.233
Wareham, N.J.234
Arnold, A.M.235
Beckmann, J.S.236
Bergmann, S.237
Boerwinkle, E.238
Boomsma, D.I.239
Caulfield, M.J.240
Collins, F.S.241
Eiriksdottir, G.242
Gudnason, V.243
Gyllensten, U.244
Hamsten, A.245
Hattersley, A.T.246
Hofman, A.247
Hu, F.B.248
Illig, T.249
Iribarren, C.250
Jarvelin, M.R.251
Kao, W.H.252
Kaprio, J.253
Launer, L.J.254
Munroe, P.B.255
Oostra, B.256
Penninx, B.W.257
Pramstaller, P.P.258
Psaty, B.M.259
Quertermous, T.260
Rissanen, A.261
Rudan, I.262
Shuldiner, A.R.263
Soranzo, N.264
Spector, T.D.265
Syvanen, A.C.266
Uda, M.267
Uitterlinden, A.268
Volzke, H.269
Vollenweider, P.270
Wilson, J.F.271
Witteman, J.C.272
Wright, A.F.273
Abecasis, G.R.274
Boehnke, M.275
Borecki, I.B.276
Deloukas, P.277
Frayling, T.M.278
Groop, L.C.279
Haritunians, T.280
Hunter, D.J.281
Kaplan, R.C.282
North, K.E.283
O'Connell, J.R.284
Peltonen, L.285
Schlessinger, D.286
Strachan, D.P.287
Hirschhorn, J.N.288
Assimes, T.L.289
Wichmann, H.E.290
Thorsteinsdottir, U.291
van Duijn, C.M.292
Stefansson, K.293
Cupples, L.A.294
Loos, R.J.295
Barroso, I.296
McCarthy, M.I.297
Fox, C.S.298
Mohlke, K.L.299
Lindgren, C.M.300
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78049337953
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Association analyses of 249 796 individuals reveal 18 new loci associated with body mass index
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Kilpelainen, T.O.30
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Esko, T.33
Feitosa, M.F.34
Kutalik, Z.35
Mangino, M.36
Raychaudhuri, S.37
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Johansson, A.52
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Moffatt, M.F.57
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Narisu, N.59
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