Type 2 diabetes risk alleles demonstrate extreme directional differentiation among human populations, compared to other diseases

PLoS Genetics

Volumn 8, Issue 4, 2012, Pages

  Chen, Rong ^a,b,d   Corona, Erik ^a,b   Sikora, Martin ^a   Dudley, Joel T ^a,b   Morgan, Alex A ^a,b   Moreno Estrada, Andres ^a   Nilsen, Geoffrey B ^c   Ruau, David ^a,b   Lincoln, Stephen E ^c   Bustamante, Carlos D ^a   Butte, Atul J ^a,b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LUCILE PACKARD CHILDREN S HOSPITAL   (United States)

^c Complete Genomics ^*  (United States)

^d Personalis   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BACKGROUND SELECTION; BIODIVERSITY; CALORIC INTAKE; CONTROLLED STUDY; ETHNIC DIFFERENCE; ETHNICITY; FREQUENCY ANALYSIS; GENE FREQUENCY; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC CROSS; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HEALTH DISPARITY; HUMAN; NON INSULIN DEPENDENT DIABETES MELLITUS; NULL ALLELE; POPULATION DIFFERENTIATION; POPULATION DISTRIBUTION; RISK ASSESSMENT; RISK FACTOR; SEQUENCE ANALYSIS; ASIAN; CAUCASIAN; GENE LINKAGE DISEQUILIBRIUM; GENETIC PREDISPOSITION; GENETICS; HAPLOTYPE; HAPLOTYPE MAP; HUMAN GENOME; NEGRO; POPULATION GENETICS; SINGLE NUCLEOTIDE POLYMORPHISM;

BLOOD GLUCOSE; BLOOD PRESSURE; BRADYKININ; CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 2; EXERCISE; FEMALE; HUMANS; MALE; NITRIC OXIDE; PLASMA KALLIKREIN; POST-EXERCISE HYPOTENSION; RISK FACTORS; AFRICAN CONTINENTAL ANCESTRY GROUP; ASIAN CONTINENTAL ANCESTRY GROUP; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENETICS, POPULATION; GENOME, HUMAN; GENOME-WIDE ASSOCIATION STUDY; HAPLOTYPES; HAPMAP PROJECT; LINKAGE DISEQUILIBRIUM; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84860547622     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002621     Document Type: Article

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