Overexpression of Transforming Growth Factor (TGF) β1 Type II Receptor Restores TGF-β1 Sensitivity and Signaling in Human Prostate Cancer Cells

Cell Growth and Differentiation

Volumn 9, Issue 2, 1998, Pages 185-193

  Guo, Yanping ^a   Kyprianou, Natasha ^a,b  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b Department of Surgery   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; CDKN1A PROTEIN, HUMAN; CDKN2B PROTEIN, HUMAN; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN DEPENDENT KINASE INHIBITOR 2B; CYCLINE; MICROTUBULE ASSOCIATED PROTEIN; PROSTATE SPECIFIC ANTIGEN; PROTEIN P16INK4A; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA TYPE II RECEPTOR; TRANSFORMING GROWTH FACTOR-BETA TYPE II RECEPTOR; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; BIOSYNTHESIS; CELL CULTURE; CELL DIVISION; CLONOGENIC ASSAY; DRUG ANTAGONISM; GENE EXPRESSION; GENETIC TRANSFECTION; GENETICS; HUMAN; MALE; METABOLISM; PATHOLOGY; PROSTATE TUMOR; SIGNAL TRANSDUCTION;

CARRIER PROTEINS; CELL CYCLE PROTEINS; CELL DIVISION; COLONY-FORMING UNITS ASSAY; CYCLIN-DEPENDENT KINASE INHIBITOR P15; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; CYCLINS; GENE EXPRESSION; HUMANS; MALE; MICROTUBULE-ASSOCIATED PROTEINS; PROSTATE-SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

EID: 0031990782     PISSN: 10449523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Wingo, P. A., Tong, T. N., and Bolden, S. Cancer statistics. CA Cancer J. Clin., 45: 8-30, 1995.
2. Carter, B. S., Carter, H. B., and Isaacs, J. T. Epidemiologic evidence regarding predisposing factors to prostate cancer. Prostate, 16: 39-48, 1990.
3. Thompson, T. C. A review: growth factors and oncogenes in prostate cancer. Cancer Cells, 2: 345-354, 1990.
4. Martikainen, P., Kyprianou, N., and Isaacs, J. T. Effect of transforming growth factor-β1 on proliferation and death of rat prostatic cells. Endocrinology, 127: 2936-2968, 1990.
5. Kyprianou, N., and Isaacs, J. T. Expression of transforming growth factor-β in the rat ventral prostate during castration-induced programmed cell death. Mol. Endocrinol., 3: 1515-1522, 1989.
6. Massagué, J., Attisano, L., and Wrana, J. L. The TGF-β family and its composite receptors. Trends Cell Biol., 4: 172-178, 1994.
7. Lin, H. Y., Wang, X., Ng-Eaton, E., Weinberg, R. A., and Lodish, H. F. Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase. Cell, 68: 775-785, 1992.
8. Wrana, J. Attisano, L., Wiesert, R. Ventura, F., and Massagué, J. Mechanism of activation of the TGF-β receptor. Nature (Lond.), 370: 341-347, 1994.
9. Franzen, P., Ten Djike, P., Ichjio, H., Yamashita, H., Schulz, P., Heldin, C., and Miyazomo, K. Cloning of a TGF-β type I receptor that forms a heteroduplex with the TGF-β type II receptor. Cell, 67: 785-795, 1994.
10. Sun, L., Wu, G., Wilson, J. K., Zborowska, E., Yang, J., Rajkarunanyake, J., Wang, J., Gentry, L. E., Wang, X-F., and Brattain, M. G. Expression of transforming growth factor-β type II receptor leads to reduced malignancy in human breast cancer MCF-7 cells. J. Biol. Chem., 269: 26449-26455, 1994.
11. Kadin, M. E., Cavill-col, M. N., Gertz, R., Massagué, J., Cheifez, S., and George, D. Loss of receptors for transforming growth factor-β in human T-cell malignancies. Proc. Natl. Acad. Sci. USA, 97: 6002-6006, 1994.
12. Markowitz, S., Wang, J., Myeroff, L., Parsons, R., Sun, L-Z., Lutterbaugh, J., Zborowska, E., Kinzler, K. W., Vogelstein, B., Brattain, M., and Willson, J. K. V. Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability. Science (Washington DC), 68: 1336-1338, 1995.
13. Garrigue-Antar, L., Munoz-Antonia, T., Antonia, S. J., Gesmonde, J., Vellucci, V. F., and Reiss, M. Missense mutations of the transforming growth factor-β type II receptor in human head and neck squamous carcinoma cells. Cancer Res., 55: 1515-1522, 1995.
14. Guo, Y., Jacobs, S. C., and Kyprianou, N. Down-regulation of mRNA and protein expression for TGF-β type I and type II receptors in human prostate cancer. Int. J. Cancer, 71: 573-579, 1997.
15. Williams, R. H., Stapleton, A. M. F., Yang, G., Truong, L. D., Rogers, E., Timme, T. L., Wheeler, T. M., Scardino, P. T., and Thompson, T. C. Reduced levels of transforming growth factor β receptor type II in human prostate cancer: an immunohistochemical study. Clin. Cancer Res., 2: 635-640, 1996.
16. Kim, I. Y., Ahn, H-A., Zelner, D. J., Shaw, J. W., Lang, S., Kato, M., Oefelein, M. G., Miyazono, K., Nemeth, J. A., Kozlowski, J. M., and Lee, C. Loss of expression of transforming growth factor-β type I and type II receptors correlates with tumor grade in human prostate cancer tissues. Clin. Cancer Res., 2: 1255-1261, 1996.
17. Schuurmans, M., Bolt, J., and Mulder, E. Androgens and transforming growth factor β modulate the growth response to epidermal growth factor in human prostatic tumor cells (LNCaP). Mol. Cell. Endocrinol., 60: 101-104, 1988.
18. Wilding, G., Zugmeir, G., Knabbe, C., Flanders, K., and Gelman, E. Differential effects of transforming growth factor-β on human prostate cancer cells in vitro. Mol. Cell. Endocrinol., 62: 79-87, 1989.
19. Gleave, M. E., Hsieh, J-T., Wu, H-C., von Eschenbach, A. C., and Chung, L. W. K. Serum prostate specific antigen levels in mice bearing human prostate LNCaP tumors as determined by tumor volume and endocrine and growth factors. Cancer Res., 52: 1598-1605, 1992.
20. Datto, M. B., Li, Y., Panus, J. F., Howe, D. J., Xiong, Y., and Wang, X-F. Transforming growth factor-β induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. Proc. Natl. Acad. Sci., USA, 92: 5545-5549, 1994.
21. INK4B is a potential effector of TGF-β induced cell cycle arrest. Nature (Lond.), 371: 257-259, 1994.
22. Polyak, K., Lee, M-H., Erjument-Bromage, H., Koff, A., Roberts, J. M., Tempst, P., and Massagué, J. Cloning of p27, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell, 78: 59-66, 1994.
23. Inagaki, M., Moustakas, A., Lin, H. Y., Lodish, H. F., and Carr, B. I. Growth inhibition by transforming growth factor-β (TGF-β) type II is restored in TGF-β resistant hepatoma cell lines after expression of TGF-β receptor type II cDNA. Proc. Natl. Acad. Sci. USA, 90: 5359-5363, 1993.
24. Peter, M., and Herskowitz, I. Joining the complex: cyclin-dependent kinase inhibitory proteins and the cell cycle. Cell, 79: 181-184, 1994.
25. Kim, I. Y., Ahn, H-J., Zelner, D. J., Shaw, J. W., Sensibar, J. A., Kim, J-H., Kato, M., and Lee, C. Genetic change in transforming growth factor-β receptor type I gene correlates with insensitivity to TGF-β1 in human prostate cancer cells. Cancer Res., 56: 44-48, 1996.
26. Carcamo, J., Zentella, A., and Massagué, J. Disruption of transforming growth factor-β signaling by a mutation that prevents transphospho-rylation within the receptor complex. Mol. Cell Biol., 15: 1573-1582, 1995.
27. Wiesert, R., Attisano, L., Wrana, J. F., and Massagué, J. Signaling activity of transforming growth factor type II receptors lacking specific domains in the cytoplasmic region. Mol. Cell. Biol., 13: 7239-7247, 1993.
28. Jackson, R. J. Cytoplasmic regulation of mRNA function: the importance of the 3′ untranslated region. Cell, 74: 9-14, 1993.
29. Ross, J. mRNA stability in mammalian cells. Microbiol. Rev., 59: 423-450, 1995.
30. Bae, H. W., Geiser, A. G., Kim, D. H., Chung, M. T., Burmester, J. K., Sporn, M. B., Roberts, A. B., and Kim, S-J. Characterization of the promoter region of the human transforming growth factor-β type II receptor gene. J. Biol. Chem., 270: 29460-29468, 1995.
31. Munoz-Antonia, T., Li, X., Reiss, M., Jackson, R., and Antonia, S. A mutation in the transforming growth factor type II receptor gene promoter associated with loss of gene expression. Cancer Res., 56: 4831-4835, 1996.
32. Burney, T. L., Rockove, S., Eiseman, J., Jacobs, S. C., and Kyprianou, N. Partial growth suppression of human prostate cancer cells by the K-rev-1 suppressor gene. Prostate, 25: 176-188, 1994.