Conformation determines the seeding potencies of native and recombinant Tau aggregates

Journal of Biological Chemistry

Volumn 290, Issue 2, 2015, Pages 1049-1065

  Falcon, Benjamin ^a   Cavallini, Annalisa ^b   Angers, Rachel ^a,b,d   Glover, Sarah ^b   Murray, Tracey K ^b   Barnham, Luanda ^b,e   Jackson, Samuel ^b,f   O'Neill, Michael J ^b   Isaacs, Adrian M ^c   Hutton, Michael L ^b   Szekeres, Philip G ^b   Goedert, Michel ^a   Bose, Suchira ^b  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b ELI LILLY AND COMPANY   (United States)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d N30 Pharmaceuticals Inc   (United States)

^e JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^f National Centre for the Replacement   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AGGREGATES; MAMMALS;

ALZHEIMER DISEASE; ANIMAL MODEL; CONFORMATIONAL DIFFERENCES; INTER-CELLULAR PROPAGATION; MOLECULAR CHARACTERISTICS; MOLECULAR PROPERTIES; TAU PATHOLOGY; TRANSGENIC MICE;

NEURODEGENERATIVE DISEASES;

GUANIDINE; TAU PROTEIN; MAPT PROTEIN, HUMAN; PROTEIN AGGREGATE;

ACTIN FILAMENT; AMINO ACID SEQUENCE; ARTICLE; CELL CULTURE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ELECTRON MICROSCOPY; FLOW CYTOMETRY; FLUORESCENCE IMAGING; GENE DELETION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; NONHUMAN; PINOCYTOSIS; PROTEIN AGGREGATION; PROTEIN ASSEMBLY; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; BRAIN; CHEMISTRY; CYTOSKELETON; DISEASE MODEL; HEK293 CELL LINE; METABOLISM; MOUSE; PATHOLOGY; PHOSPHORYLATION; PROTEINOSIS; TAUOPATHY; TRANSGENIC MOUSE;

ANIMALIA; MUS; MUS MUSCULUS;

ANIMALS; BRAIN; CYTOSKELETON; DISEASE MODELS, ANIMAL; HEK293 CELLS; HUMANS; MICE; MICE, TRANSGENIC; PHOSPHORYLATION; PROTEIN AGGREGATES; PROTEIN AGGREGATION, PATHOLOGICAL; PROTEIN CONFORMATION; TAU PROTEINS; TAUOPATHIES;

EID: 84920901644     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.589309     Document Type: Article

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