Darwinian evolution of prions in cell culture

Science

Volumn 327, Issue 5967, 2010, Pages 869-872

  Li, Jiali ^a   Browning, Shawn ^a   Mahal, Sukhvir P ^a   Oelschlegel, Anja M ^a   Weissmann, Charles ^a  

^a Scripps Florida ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEIC ACID; SWAINSONINE;

BRAIN; CLONE; GENOME; MUTATION; NUCLEIC ACID; PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BETA SHEET; BRAIN CELL; CELL CULTURE; CELL TRANSPORT; CLONE; CONFORMATION; CONTROLLED STUDY; EVOLUTION; GENE AMPLIFICATION; GENE MUTATION; GENOME; MOUSE; MUTANT; NONHUMAN; PRION; PRIORITY JOURNAL;

ANIMALS; BRAIN CHEMISTRY; CELL LINE; CELL LINE, TUMOR; CULTURE MEDIA; CULTURE MEDIA, CONDITIONED; EVOLUTION, MOLECULAR; MICE; MICE, INBRED C57BL; MUTATION; PRION DISEASES; PRIONS; PROTEIN CONFORMATION; PRPSC PROTEINS; SWAINSONINE;

EID: 76749109480     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1183218     Document Type: Article

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33. We thank C. A. Demczyk for assistance with cell culture, E. Smith for assistance with the SSCA I. Suponitsky-Kroyter for the proteolytic digestion analyses, and A. Sherman for histochemistry and animal work. We thank T. Bartfai, G. Joyce, and C. Lasmezas for critical reading of the manuscript and valuable suggestions. The project was supported by an R01 grant (#NSO59543) from the NIH and by a generous donation from the Alafi Family Foundation to C.W.