The fuzzy coat of pathological human Tau fibrils is a two-layered polyelectrolyte brush

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 4, 2012, Pages E313-E321

  Wegmann, Susanne ^a,b   Medalsy, Izhar D ^a   Mandelkow, Eckhard ^c,d,e   Müller, Daniel J ^a  

^a ETH ZURICH   (Switzerland)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^d CENTER OF ADVANCED EUROPEAN STUDIES AND RESEARCH CAESAR   (Germany)

^e MAX PLANCK INSTITUTE FOR NEUROLOGICAL RESEARCH   (Germany)

Author keywords

Alzheimer's disease; Paired helical filaments; Protein aggregation

Indexed keywords

POLYELECTROLYTE; TAU PROTEIN; TRYPSIN; ELECTROLYTE; MAPT PROTEIN, HUMAN; RECOMBINANT PROTEIN;

ADHESION; ARTICLE; ATOMIC FORCE MICROSCOPY; CARBOXY TERMINAL SEQUENCE; CELL INTERACTION; CELL PH; FORCE; HUMAN; LIPID MEMBRANE; MECHANICS; PRIORITY JOURNAL; PROTEIN DEGRADATION; RIGIDITY; STATIC ELECTRICITY; SURFACE CHARGE; SURFACE PROPERTY; THICKNESS; TRANSMISSION ELECTRON MICROSCOPY; BIOMECHANICS; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; IMMUNOELECTRON MICROSCOPY; PH; PHYSIOLOGY; PROTEIN DOMAIN; PROTEIN MULTIMERIZATION; ULTRASTRUCTURE;

ADHESIVENESS; BIOMECHANICS; ELECTROLYTES; HUMANS; HYDROGEN-ION CONCENTRATION; MICROSCOPY, ATOMIC FORCE; MICROSCOPY, IMMUNOELECTRON; MODELS, MOLECULAR; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN MULTIMERIZATION; RECOMBINANT PROTEINS; TAU PROTEINS;

MLCS; MLOWN;

EID: 84875279731     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1212100110     Document Type: Article

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