Genetic deletion of Rnd3/RhoE results in mouse heart calcium leakage through upregulation of protein kinase a signaling

Circulation Research

Volumn 116, Issue 1, 2015, Pages e1-e10

  Yang, Xiangsheng ^a   Wang, Tiannan ^b   Lin, Xi ^a   Yue, Xiaojing ^a   Wang, Qiongling ^b   Wang, Guoliang ^b   Fu, Qin ^c   Ai, Xun ^d   Chiang, David Y ^b   Miyake, Christina Y ^b   Wehrens, Xander H T ^b   Chang, Jiang ^a  

^a TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

adrenergic receptor, beta 2; arrhythmias, cardiac; calcium; rho GTP binding proteins; ubiquitination

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; NCX1 PROTEIN; PHOSPHOLAMBAN; PROTEIN; RND3 PROTEIN; RYANODINE RECEPTOR 2; SERCA2ALPHA PROTEIN; UNCLASSIFIED DRUG; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RND3 PROTEIN, MOUSE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; ENZYME ACTIVATION; ENZYME MECHANISM; FEMALE; FETAL HEART ARRHYTHMIA; FETUS DISEASE; FETUS HEART; GENE CONTROL; GENE DELETION; GENE TARGETING; HAPLOINSUFFICIENCY; HEART; HEART ARRHYTHMIA; HEART FUNCTION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART VENTRICLE ARRHYTHMIA; INTRACELLULAR SIGNALING; KNOCKOUT MOUSE; LETHALITY; LOSS OF FUNCTION MUTATION; LYSOSOME; MOUSE; MOUSE EMBRYO; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; UBIQUITINATION; UPREGULATION; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CARDIAC MUSCLE CELL; CELL CULTURE; DEFICIENCY; GENETICS; MALE; METABOLISM; NEWBORN; PHYSIOLOGY; RAT;

ANIMALS; ANIMALS, NEWBORN; CALCIUM; CELLS, CULTURED; CYCLIC AMP-DEPENDENT PROTEIN KINASES; FEMALE; GENE DELETION; HEART; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOCYTES, CARDIAC; RATS; RHO GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84920888549     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.116.304940     Document Type: Article

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