Genetic deletion of Rnd3 results in aqueductal stenosis leading to hydrocephalus through up-regulation of Notch signaling

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 20, 2013, Pages 8236-8241

  Lin, Xi ^a   Liu, Baohui ^b   Yang, Xiangsheng ^a   Yue, Xiaojing ^a   Diao, Lixia ^c   Wang, Jing ^c   Chang, Jiang ^a  

^a TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

^b RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^c UNIVERSITY OF TEXAS   (United States)

Author keywords

Developmental brain defect; Genetic mouse model; Post translational modification

Indexed keywords

NOTCH RECEPTOR; RHO FAMILY GUANOSINE TRIPHOSPHATASE 3; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN AQUEDUCT STENOSIS; CELL GROWTH; CONTROLLED STUDY; DOWN REGULATION; EPENDYMA CELL; GENE DELETION; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; OBSTRUCTIVE HYDROCEPHALUS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION;

DEVELOPMENTAL BRAIN DEFECT; GENETIC MOUSE MODEL; POST-TRANSLATIONAL MODIFICATION;

ANIMALS; BRAIN; EPENDYMA; GENE DELETION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEK293 CELLS; HUMANS; HYDROCEPHALUS; MICE; MICE, KNOCKOUT; MUTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, NOTCH; RHO GTP-BINDING PROTEINS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84877842070     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1219995110     Document Type: Article

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