Gi-biased β2AR signaling links GRK2 upregulation to heart failure

Circulation Research

Volumn 110, Issue 2, 2012, Pages 265-274

  Zhu, Weizhong ^a,b,e   Petrashevskaya, Natalia ^a   Ren, Shuxun ^c   Zhao, Aizhi ^a   Chakir, Khalid ^a   Gao, Erhe ^b   Chuprun, J Kurt ^b   Wang, Yibin ^c   Talan, Mark ^a   Dorn, Gerald W ^d   Lakatta, Edward G ^a   Koch, Walter J ^b   Feldman, Arthur M ^e   Xiao, Rui Ping ^a,f  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f PEKING UNIVERSITY   (China)

Author keywords

2 adrenergic receptor; G protein coupled receptor kinase; heart failure; hypertrophy

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; G PROTEIN COUPLED RECEPTOR KINASE 2; PERTUSSIS TOXIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE EXACERBATION; GENE OVEREXPRESSION; HEART FAILURE; HEART FUNCTION; HEART LEFT VENTRICLE OVERLOAD; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE REMODELING; MALE; MORTALITY; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; UPREGULATION;

ADRENERGIC BETA-AGONISTS; ANIMALS; CARDIOMEGALY; CELLS, CULTURED; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; G-PROTEIN-COUPLED RECEPTOR KINASE 2; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; HEART FAILURE; HUMANS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; PERTUSSIS TOXIN; PHOSPHORYLATION; RECEPTORS, ADRENERGIC, BETA-2; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION; UP-REGULATION; VENTRICULAR FUNCTION, LEFT; VENTRICULAR PRESSURE; VENTRICULAR REMODELING;

EID: 84856052610     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.111.253260     Document Type: Article

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