Novel 4-thiazolidinones as non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA polymerase

Archiv der Pharmazie

Volumn 348, Issue 1, 2015, Pages 10-22

  Çakir, Gizem ^a   Küҫükgüzel, Ilkay ^a   Guhamazumder, Rupa ^b   Tatar, Esra ^a   Manvar, Dinesh ^b   Basu, Amartya ^b   Patel, Bhargav A ^c   Zia, Javairia ^b   Talele, Tanaji T ^c   Kaushik Basu, Neerja ^b  

^a MARMARA UNIVERSITY   (Turkey)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^c ST JOHN'S UNIVERSITY   (United States)

Author keywords

4 thiazolidinones; Antiviral agents; HCV NS5B polymerase; Hepatitis C; Molecular modeling

Indexed keywords

2 (2 CHLORO 6 FLUOROBENZYLIDENE)HYDRAZINECARBOTHIOAMIDE; 2 (2 CHLOROBENZYLIDENE)HYDRAZINECARBOTHIOAMIDE; 2 (2 FLUOROBENZYLIDENE)HYDRAZINECARBOTHIOAMIDE; 2 (2,4 DICHLOROBENZYLIDENE)HYDRAZINECARBOTHIOAMIDE; 2 (2,6 DICHLOROBENZYLIDENE)HYDRAZINECARBOTHIOAMIDE; 2 (3 FLUOROBENZYLIDENE)HYDRAZINECARBOTHIOAMIDE; 2 (PYRIDIN 3 YLMETHYLIDENE)HYDRAZINECARBOTHIOAMIDE; 2 CHLORO N [5 (2 CHLORO 6 FLUOROPHENYL) 1,3,4 THIADIAZOL 2 YL]ACETAMIDE; 2 CHLORO N [5 (2 CHLOROPHENYL) 1,3,4 THIADIAZOL 2 YL]ACETAMIDE; 2 CHLORO N [5 (2 FLUOROPHENYL) 1,3,4 THIADIAZOL 2 YL]ACETAMIDE; 2 CHLORO N [5 (2,4 DICHLOROPHENYL) 1,3,4 THIADIAZOL 2 YL]ACETAMIDE; 2 CHLORO N [5 (2,6 DICHLOROPHENYL) 1,3,4 THIADIAZOL 2 YL]ACETAMIDE; 2 CHLORO N [5 (3 FLUOROPHENYL) 1,3,4 THIADIAZOL 2 YL]ACETAMIDE; 2 CHLORO N [5 (PYRIDIN 3 YL) 1,3,4 THIADIAZOL 2 YL]ACETAMIDE; 2 [[5 (2 CHLOROPHENYL) 1,3,4 THIADIAZOL 2 YL]IMINO] 1,3 THIAZOLIDIN 4 ONE; 2 [[5 (2 FLUOROPHENYL) 1,3,4 THIADIAZOL 2 YL]IMINO] 1,3 THIAZOLIDIN 4 ONE; 2 [[5 (3 FLUOROPHENYL) 1,3,4 THIADIAZOL 2 YL]IMINO] 1,3 THIAZOLIDIN 4 ONE; 2 [[5 (PYRIDIN 3 YL) 1,3,4 THIADIAZOL 2 YL]IMINO] 1,3 THIAZOLIDIN 4 ONE; 4 THIAZOLIDINONE DERIVATIVE; 5 (2 CHLORO 6 FLUOROPHENYL) 1,3,4 THIADIAZOL 2 AMINE; 5 (2 CHLOROPHENYL) 1,3,4 THIADIAZOL 2 AMINE; 5 (2 FLUOROPHENYL) 1,3,4 THIADIAZOL 2 AMINE; 5 (2,4 DICHLOROPHENYL) 1,3,4 THIADIAZOL 2 AMINE; 5 (2,6 DICHLOROPHENYL) 1,3,4 THIADIAZOL 2 AMINE; 5 (3 FLUOROPHENYL) 1,3,4 THIADIAZOL 2 AMINE; 5 (PYRIDIN 3 YL) 1,3,4 THIADIAZOL 2 AMINE; ANTIVIRUS AGENT; NONSTRUCTURAL PROTEIN 5B; RNA DIRECTED RNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; ENZYME INHIBITOR; NS-5 PROTEIN, HEPATITIS C VIRUS; THIAZOLIDINE DERIVATIVE; VIRUS PROTEIN;

ABSORPTION; ARTICLE; BIOLOGICAL ACTIVITY; CARBON NUCLEAR MAGNETIC RESONANCE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYCLIZATION; DRUG BINDING SITE; ELECTROSPRAY MASS SPECTROMETRY; HEPATITIS C; HEPATITIS C VIRUS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHOBICITY; IC50; IN VITRO STUDY; MELTING POINT; MOLECULAR DOCKING; MOLECULAR MODEL; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION TIME; REPLICON CELL; RNA REPLICATION; STATIC ELECTRICITY; THIN LAYER CHROMATOGRAPHY; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMICAL STRUCTURE; COMPARATIVE STUDY; COMPUTER AIDED DESIGN; DOSE RESPONSE; DRUG DESIGN; DRUG EFFECTS; ENZYMOLOGY; HEPACIVIRUS; HIGH THROUGHPUT SCREENING; HUMAN; METABOLISM; MICROBIAL SENSITIVITY TEST; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANTIVIRAL AGENTS; BINDING SITES; CELL LINE, TUMOR; COMPUTER-AIDED DESIGN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ENZYME INHIBITORS; HEPACIVIRUS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLIDINES; VIRAL NONSTRUCTURAL PROTEINS;

EID: 84920732166     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.201400247     Document Type: Article

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