Discovery of flavonoid derivatives as anti-HCV agents via pharmacophore search combining molecular docking strategy

European Journal of Medicinal Chemistry

Volumn 52, Issue , 2012, Pages 33-43

  Liu, Ming Ming ^a   Zhou, Lu ^a   He, Pei Lan ^b   Zhang, Yi Nan ^a   Zhou, Jia Yi ^a   Shen, Qing ^a   Chen, Xin Wen ^c   Zuo, Jian Ping ^b   Li, Wei ^a   Ye, De Yong ^a  

^a FUDAN UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^c WUHAN INSTITUTE OF VIROLOGY   (China)

Author keywords

Anti HCV agents; Flavonoids; Ligand based pharmacophore; NS5B polymerase; Virtual screening

Indexed keywords

ANTIVIRUS AGENT; APIGENIN; FLAVONOID; LUTEOLIN;

ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR DOCKING; MOLECULAR INTERACTION; MOLECULAR MODEL; NONHUMAN; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION;

ANTIVIRAL AGENTS; CELL LINE, TUMOR; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; FLAVONOIDS; HEPACIVIRUS; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; REPRODUCIBILITY OF RESULTS; STRUCTURE-ACTIVITY RELATIONSHIP; USER-COMPUTER INTERFACE; VIRUS REPLICATION;

EID: 84862814306     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.03.002     Document Type: Article

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