Design, synthesis, and evaluation of 2-aryl-3-heteroaryl-1,3-thiazolidin-4-ones as anti-HIV agents

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 4, 2007, Pages 1725-1731

  Rawal, Ravindra K ^a   Tripathi, Rajkamal ^a   Katti, S B ^a   Pannecouque, Christophe ^b   De Clercq, Erik ^b  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

4 Thiazolidinones; Anti HIV activity; HIV 1RT; NNRTIs

Indexed keywords

2 (2 CHLORO 6 FLUOROPHENYL) 3 (5 ETHYL[1,3,4]THIADIAZOL 2 YL)THIAZOLIDIN 4 ONE; 2 (2,6 DICHLOROPHENYL) 3 (5 ETHYL[1,3,4]THIADIAZOL 2 YL)THIAZOLIDIN 4 ONE; 2 (2,6 DIFLUOROPHENYL) 3 (5 ETHYL[1,3,4]THIADIAZOL 2 YL)THIAZOLIDIN 4 ONE; 2' (2 CHLORO 6 FLUOROPHENYL) 4 METHYL[2,3']BITHIAZOLYL 4' ONE; 2' (2 CHLORO 6 FLUOROPHENYL) 4,5 DIMETHYL[2,3']BITHIAZOLYL 4' ONE; 2' (2 CHLORO 6 FLUOROPHENYL)[2,3']BITHIAZOLYL 4' ONE; 2' (2,6 DICHLOROPHENYL) 4 METHYL[2,3']BITHIAZOLYL 4' ONE; 2' (2,6 DICHLOROPHENYL) 4 PHENYL[2,3']BITHIAZOLYL 4' ONE; 2' (2,6 DICHLOROPHENYL) 4,5 DIMETHYL[2,3']BITHIAZOLYL 4' ONE; 2' (2,6 DICHLOROPHENYL)[2,3']BITHIAZOLYL 4' ONE; 2' (2,6 DIFLUOROPHENYL) 4 METHYL[2,3']BITHIAZOLYL 4' ONE; 2' (2,6 DIFLUOROPHENYL) 4,5 DIMETHYL[2,3']BITHIAZOLYL 4' ONE; 2' (2,6 DIFLUOROPHENYL)[2,3']BITHIAZOLYL 4' ONE; 3 BEZOTHIAZOL 2 YL 2 (2 CHLORO 6 FLUOROPHENYL)THIAZOLIDIN 4 ONE; 3 BEZOTHIAZOL 2 YL 2 (2,6 DICHLOROPHENYL)THIAZOLIDIN 4 ONE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; BENZIMIDAZOLE DERIVATIVE; RNA DIRECTED DNA POLYMERASE; THIAZOBENZIMIDAZOLE; THIAZOLIDINE DERIVATIVE; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; NONHUMAN; VIRUS STRAIN;

ANTI-HIV AGENTS; CELL LINE; CELL SURVIVAL; DRUG DESIGN; HIV INFECTIONS; HIV-1; HUMANS; THIAZOLIDINES;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 33847781693     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.12.003     Document Type: Article

References (15)

1. Turner B.G., and Summers M.F. J. Mol. Biol. 285 (1999) 1
2. Arnold E., Das K., Ding J., Yadav P.N.S., et al. Drug Des. Discov. 13 (1996) 29
3. Gazzard B., and Moyle M. Lancet 352 (1998) 314
4. De Clercq E. Trends Pharmacol. Sci. 11 (1990) 198
5. Ren J., Esnouf R., Garman E., Somers D., Ross C., Kirby I., Keeling J., Darby G., Jones Y., Stuart D., and Stammers D. Nat. Struct. Biol. 2 (1995) 293
6. Barreca M.L., Balzarini J., Chimirri A., De Clercq E., Luca L.D., Holtje M.H., Holtje M., Monforte A.M., Monforte P., Pannecouque C., Rao A., and Zappala M. J. Med. Chem. 45 (2002) 5410
7. Prabhakar Y.S., Solomon V.R., Rawal R.K., Gupta M.K., and Katti S.B. QSAR Comb. Sci. 23 (2004) 234
8. Rawal R.K., Solomon V.R., Prabhakar Y.S., Katti S.B., and De Clercq E. Comb. Chem. High Throughput Screening 8 (2005) 439
9. Prabhakar Y.S., Rawal R.K., Gupta M.K., Solomon V.R., and Katti S.B. Comb. Chem. High Throughput Screening 8 (2005) 431
10. Rawal R.K., Prabhakar Y.S., Katti S.B., and De Clercq E. Bioorg. Med. Chem. 13 (2005) 6771
11. Barreca M.L., Chimirri A., Luca L.D., Monforte A.M., Monforte P., Rao A., Zappala M., Balzarini J., De Clercq E., Pannecouque C., and Witvrouw M. Bioorg. Med. Chem. Lett. 11 (2001) 1793
12. Reverse Transcriptase Assay, Colorimetric kit, Roche Diagnostics GmbH, Roche Applied Science, Sandhofer Strasses 116, D-68305 Mannheim, Germany.
13. Pauwels R., Balzarini J., Baba M., Snoeck R., Schols D., Herdewijin P., Desmyter J., and De Clercq E. J. Virol. Meth. 20 (1988) 309
14. Balzarini J., Karlsson A., Pérez-Pérez M.-J., Vrang L., Walbers J., Zhang H., Öberg B., Vandamme A.-M., Camarasa M.-J., and De Clercq E. Virology 192 (1993) 246
15. Holmes C.P., Chinn J.P., Look C.G., Gordon E.M., and Gallop M.A. J. Org. Chem. 60 (1995) 7328