Structure-based design of a novel thiazolone scaffold as HCV NS5B polymerase allosteric inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 22, 2006, Pages 5888-5891

  Yan, Shunqi ^a   Appleby, Todd ^a   Larson, Gary ^a   Wu, Jim Z ^a   Hamatake, Robert ^a   Hong, Zhi ^a   Yao, Nanhua ^a  

^a Valeant Research and Development   (United States)

Author keywords

HCV; HCV NS5B allosteric inhibitors; HCV NS5B inhibitors; HCV NS5B polymerase; Thiazolone

Indexed keywords

ENZYME INHIBITOR; THIAZOLE DERIVATIVE; VIRUS ENZYME;

ALLOSTERISM; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HEPATITIS C VIRUS; NONHUMAN; STRUCTURE ANALYSIS; X RAY ANALYSIS;

ALLOSTERIC REGULATION; ANTIVIRAL AGENTS; COMPUTATIONAL BIOLOGY; CRYSTALLOGRAPHY, X-RAY; DNA-DIRECTED RNA POLYMERASES; ENZYME INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS;

EID: 33749249403     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.08.056     Document Type: Article

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