5-Arylidene-2,4-thiazolidinediones as inhibitors of protein tyrosine phosphatases

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 15, 2007, Pages 5137-5149

  Maccari, Rosanna ^a   Paoli, Paolo ^b   Ottanà, Rosaria ^a   Jacomelli, Michela ^b   Ciurleo, Rosella ^a   Manao, Giampaolo ^b   Steindl, Theodora ^c   Langer, Thierry ^c   Vigorita, Maria Gabriella ^a   Camici, Guido ^b  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

^c UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Diabetes mellitus; Molecular modelling; Protein tyrosine phosphatases; PTP1B and LMW PTP inhibitors

Indexed keywords

4 (5 ARYLIDENE 2,4 DIOXOTHIAZOLIDIN 3 YL)METHYLBENZOIC ACID; 4 (5 NAPTHALEN 1 YLMETHYLENE 2,4 DIOXOTHIAZOLIDIN 3 YL)METHYLBENZOIC ACID; 4 (5 NAPTHALEN 2 YLMETHYLENE 2,4 DIOXOTHIAZOLIDIN 3 YL)METHYLBENZOIC ACID; 4 [2,4 DIOXO 5 (3 PHENOXYBENZYLIDENE)THIAZOLIDIN 3 YL]METHYLBENZOIC ACID; 4 [2,4 DIOXO 5 (4 PHENOXYBENZYLIDENE)THIAZOLIDIN 3 YL]METHYLBENZOIC ACID; 4 [5 (3 BENZYLOXYBENZYLIDENE) 2,4 DIOXOTHIAZOLIDIN 3 YL]METHYLBENZOIC ACID; 4 [5 (3 HYDROXYBENZYLIDENE) 2,4 DIOXOTHIAZOLIDIN 3 YL]METHYLBENZOIC ACID; 4 [5 (4 BENZYLOXYBENZYLIDENE) 2,4 DIOXOTHIAZOLIDIN 3 YL]METHYLBENZOIC ACID; 4 [5 (4 CARBOXYMETHOXYBENZYLIDENE) 2,4 DIOXOTHIAZOLIDIN 3 YL]METHYLBENZOIC ACID; 4 [5 (4 HYDROXY 3 METHOXYBENZYLIDENE) 2,4 DIOXOTHIAZOLIDIN 3 YL]METHYLBENZOIC ACID; 4 [5 (4 HYDROXYBENZYLIDENE) 2,4 DIOXOTHIAZOLIDIN 3 YL]METHYLBENZOIC ACID; 5 ARYLIDENE 2,4 THIAZOLIDINEDIONE; BENZOIC ACID DERIVATIVE; INSULIN; PHOSPHOTYROSINE; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME ASSAY; ENZYME INHIBITION; HUMAN; METABOLIC CAPACITY; MITOSIS RATE; MOLECULAR MODEL;

BINDING SITES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN-TYROSINE-PHOSPHATASE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THIAZOLIDINEDIONES;

EID: 34249940515     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.05.027     Document Type: Article

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