2-Heteroarylimino-5-arylidene-4-thiazolidinones as a new class of non-nucleoside inhibitors of HCV NS5B polymerase

European Journal of Medicinal Chemistry

Volumn 69, Issue , 2013, Pages 931-941

  Küçükgüzel, Ilkay ^a   Satilmiş, Gökhan ^a   Gurukumar, K R ^b   Basu, Amartya ^b   Tatar, Esra ^a   Nichols, Daniel B ^b   Talele, Tanaji T ^c   Kaushik Basu, Neerja ^b  

^a MARMARA UNIVERSITY   (Turkey)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^c ST JOHN'S UNIVERSITY   (United States)

Author keywords

Antiviral agents; HCV NS5B polymerase; Hepatitis C; Thiazolidinones

Indexed keywords

2 [(5 (4 CHLOROPHENYL) 1,3,4 THIADIAZOL 2 YL)IMINO] 1,3 THIAZOLIDINE 4 ONE; 2 [(5 (4 CHLOROPHENYL) 1,3,4 THIADIAZOL 2 YL)IMINO] 5 (2 CHLORO 6 FLUORO BENZYLIDENE) 1,3 THIAZOLIDIN 4 ONE; 2 [(5 (4 CHLOROPHENYL) 1,3,4 THIADIAZOL 2 YL)IMINO] 5 (2 CHLOROBENZYLIDENE) 1,3 THIAZOLIDIN 4 ONE; 2 [(5 (4 CHLOROPHENYL) 1,3,4 THIADIAZOL 2 YL)IMINO] 5 (2 FLUOROBENZYLIDENE) 1,3 THIAZOLIDIN 4 ONE; 2 [(5 (4 CHLOROPHENYL) 1,3,4 THIADIAZOL 2 YL)IMINO] 5 (2,4 DICHLOROBENZYLIDENE) 1,3 THIAZOLIDIN 4 ONE; 2 [(5 (4 CHLOROPHENYL) 1,3,4 THIADIAZOL 2 YL)IMINO] 5 (2,6 DIMETHOXY BENZYLIDENE) 1,3 THIAZOLIDIN 4 ONE; 2 [(5 (4 CHLOROPHENYL) 1,3,4 THIADIAZOL 2 YL)IMINO] 5 (3 FLUOROBENZYLIDENE) 1,3 THIAZOLIDIN 4 ONE; 2 [(5 (4 CHLOROPHENYL) 1,3,4 THIADIAZOL 2 YL)IMINO] 5 (4 FLUOROBENZYLIDENE) 1,3 THIAZOLIDIN 4 ONE; 2 [(5 (4 CHLOROPHENYL) 1,3,4 THIADIAZOL 2 YL)IMINO] 5 (4 NITROBENZYLIDENE) 1,3 THIAZOLIDIN 4 ONE; 2 [(5 (4 FLUOROPHENYL) 1,3,4 THIADIAZOL 2 YL)IMINO] 1,3 THIAZOLIDINE 4 ONE; 2 [(5 (4 FLUOROPHENYL) 1,3,4 THIADIAZOL 2 YL)IMINO] 5 (2 CHLORO 6 FLUORO BENZYLIDENE) 1,3 THIAZOLIDIN 4 ONE; 2 [(5 (4 FLUOROPHENYL) 1,3,4 THIADIAZOL 2 YL)IMINO] 5 (2 CHLOROBENZYLIDENE) 1,3 THIAZOLIDIN 4 ONE; 2 [(5 (4 FLUOROPHENYL) 1,3,4 THIADIAZOL 2 YL)IMINO] 5 (2 FLUOROBENZYLIDENE) 1,3 THIAZOLIDIN 4 ONE; 2 [(5 (4 FLUOROPHENYL) 1,3,4 THIADIAZOL 2 YL)IMINO] 5 (2,4 DICHLOROBENZYLIDENE) 1,3 THIAZOLIDIN 4 ONE; 2 [(5 (4 FLUOROPHENYL) 1,3,4 THIADIAZOL 2 YL)IMINO] 5 (2,6 DICHLOROBENZYLIDENE) 1,3 THIAZOLIDIN 4 ONE; 2 [(5 (4 FLUOROPHENYL) 1,3,4 THIADIAZOL 2 YL)IMINO] 5 (2,6 DIMETHOXYBENZYLIDENE) 1,3 THIAZOLIDIN 4 ONE; 2 [(5 (4 FLUOROPHENYL) 1,3,4 THIADIAZOL 2 YL)IMINO] 5 (3 FLUOROBENZYLIDENE) 1,3 THIAZOLIDIN 4 ONE; 2 [(5 (4 FLUOROPHENYL) 1,3,4 THIADIAZOL 2 YL)IMINO] 5 (4 FLUOROBENZYLIDENE) 1,3 THIAZOLIDIN 4 ONE; 2 [(5 (4 FLUOROPHENYL) 1,3,4 THIADIAZOL 2 YL)IMINO] 5 (4 NITROBENZYLIDENE) 1,3 THIAZOLIDIN 4 ONE; 2 AMINO 5 (4 CHLOROPHENYL) 1,3,4 THIADIAZOLE; 2 AMINO 5 (4 FLUOROPHENYL) 1,3,4 THIADIAZOLE; 2 CHLORO N [5 (4 CHLOROPHENYL) 1,3,4 THIADIAZOL 2 YL]ACETAMIDE; 2 CHLORO N [5 (4 FLUOROPHENYL) 1,3,4 THIADIAZOL 2 YL]ACETAMIDE; 2 HETEROARYLIMINO 5 ARYLIDENE 4 THIAZOLIDINONE; 4 CHLOROBENZOYLTHIOSEMICARBAZIDE; 4 FLUOROBENZOYLTHIOSEMICARBAZIDE; 4 THIAZOLIDINONE DERIVATIVE; ANTIVIRUS AGENT; UNCLASSIFIED DRUG;

ALLOSTERISM; ANTIVIRAL ACTIVITY; ARTICLE; CELL ACTIVITY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVITY; GENOTYPE; HEPATITIS C; HEPATITIS C VIRUS; IC 50; MOLECULAR DOCKING;

ALLOSTERIC POCKET; ANTIVIRAL AGENTS; AP; HCV; HCV NS5B POLYMERASE; HEPATITIS C; HEPATITIS C VIRUS; NI; NNI; NON-NUCLEOSIDE INHIBITOR; NUCLEOSIDE INHIBITOR; PALM POCKET-I; PP-I; RDRP; RNA-DEPENDENT RNA POLYMERASE; SP; SUBPOCKET; THIAZOLIDINONES; THUMB POCKET; TP;

ANTIVIRAL AGENTS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; GENOTYPE; HEPACIVIRUS; HUMANS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLIDINES; VIRAL NONSTRUCTURAL PROTEINS;

EID: 84886146926     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.08.043     Document Type: Article

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