-
1
-
-
0024509701
-
Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome
-
Choo Q.L., Kuo G., Weiner A.J., Overby L.R., Bradley D.W., Houghton M. (1989) Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science;244:359-362.
-
(1989)
Science
, vol.244
, pp. 359-362
-
-
Choo, Q.L.1
Kuo, G.2
Weiner, A.J.3
Overby, L.R.4
Bradley, D.W.5
Houghton, M.6
-
2
-
-
0025862146
-
Molecular biology of the hepatitis C viruses: implications for diagnosis, development and control of viral disease
-
Houghton M., Weiner A., Han J., Kuo G., Choo Q.L. (1991) Molecular biology of the hepatitis C viruses: implications for diagnosis, development and control of viral disease. Hepatology;14:381-388.
-
(1991)
Hepatology
, vol.14
, pp. 381-388
-
-
Houghton, M.1
Weiner, A.2
Han, J.3
Kuo, G.4
Choo, Q.L.5
-
3
-
-
0027068086
-
The natural history of community-acquired hepatitis C in the United States. The Sentinel Counties Chronic non-A, non-B Hepatitis Study Team
-
Alter M.J., Margolis H.S., Krawczynski K., Judson F.N., Mares A., Alexander W.J., Hu P.Y., Miller J.K., Gerber M.A., Sampliner R.E., Meeks E.L., Beach M.J. (1992) The natural history of community-acquired hepatitis C in the United States. The Sentinel Counties Chronic non-A, non-B Hepatitis Study Team. N Engl J Med;327:1899-1905.
-
(1992)
N Engl J Med
, vol.327
, pp. 1899-1905
-
-
Alter, M.J.1
Margolis, H.S.2
Krawczynski, K.3
Judson, F.N.4
Mares, A.5
Alexander, W.J.6
Hu, P.Y.7
Miller, J.K.8
Gerber, M.A.9
Sampliner, R.E.10
Meeks, E.L.11
Beach, M.J.12
-
4
-
-
33748301260
-
Global challenges in liver disease
-
Williams R. (2006) Global challenges in liver disease. Hepatology;44:521-526.
-
(2006)
Hepatology
, vol.44
, pp. 521-526
-
-
Williams, R.1
-
5
-
-
33646834272
-
Pegylated interferon plus ribavirin for chronic hepatitis C: the role of combination therapy today, tomorrow and in the future
-
Ferenci P. (2006) Pegylated interferon plus ribavirin for chronic hepatitis C: the role of combination therapy today, tomorrow and in the future. Minerva Gastroenterol Dietol;52:157-174.
-
(2006)
Minerva Gastroenterol Dietol
, vol.52
, pp. 157-174
-
-
Ferenci, P.1
-
6
-
-
30644457351
-
Hepatitis C virus population dynamics during infection
-
Pawlotsky J.M. (2006) Hepatitis C virus population dynamics during infection. Curr Top Microbiol Immunol;299:261-284.
-
(2006)
Curr Top Microbiol Immunol
, vol.299
, pp. 261-284
-
-
Pawlotsky, J.M.1
-
7
-
-
11244340636
-
HCV persistence: cure is still a four letter word
-
Feld J.J., Liang T.J. (2005) HCV persistence: cure is still a four letter word. Hepatology;41:23-25.
-
(2005)
Hepatology
, vol.41
, pp. 23-25
-
-
Feld, J.J.1
Liang, T.J.2
-
8
-
-
84856371566
-
New Merck and Vertex drugs raise standard of care in hepatitis C
-
Sheridan C. (2011) New Merck and Vertex drugs raise standard of care in hepatitis C. Nat Biotechnol;29:553-554.
-
(2011)
Nat Biotechnol
, vol.29
, pp. 553-554
-
-
Sheridan, C.1
-
9
-
-
79958851236
-
Perspective: miles to go before we sleep
-
Rice C. (2011) Perspective: miles to go before we sleep. Nature;474:S8.
-
(2011)
Nature
, vol.474
-
-
Rice, C.1
-
10
-
-
80755159044
-
Hepatitis C: move over interferon
-
Garber K. (2011) Hepatitis C: move over interferon. Nat Biotechnol;29:963-966.
-
(2011)
Nat Biotechnol
, vol.29
, pp. 963-966
-
-
Garber, K.1
-
11
-
-
0030051777
-
Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus
-
Behrens S.E., Tomei L., De Francesco R. (1996) Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus. EMBO J;15:12-22.
-
(1996)
EMBO J
, vol.15
, pp. 12-22
-
-
Behrens, S.E.1
Tomei, L.2
De Francesco, R.3
-
12
-
-
8644265138
-
Membrane association of the RNA-dependent RNA polymerase is essential for hepatitis C virus RNA replication
-
Moradpour D., Brass V., Bieck E., Friebe P., Gosert R., Blum H.E., Bartenschlager R., Penin F., Lohmann V. (2004) Membrane association of the RNA-dependent RNA polymerase is essential for hepatitis C virus RNA replication. J Virol;78:13278-13284.
-
(2004)
J Virol
, vol.78
, pp. 13278-13284
-
-
Moradpour, D.1
Brass, V.2
Bieck, E.3
Friebe, P.4
Gosert, R.5
Blum, H.E.6
Bartenschlager, R.7
Penin, F.8
Lohmann, V.9
-
13
-
-
0033920304
-
Hepatitis C virus-encoded enzymatic activities and conserved RNA elements in the 3′ nontranslated region are essential for virus replication in vivo
-
Kolykhalov A.A., Mihalik K., Feinstone S.M., Rice C.M. (2000) Hepatitis C virus-encoded enzymatic activities and conserved RNA elements in the 3′ nontranslated region are essential for virus replication in vivo. J Virol;74:2046-2051.
-
(2000)
J Virol
, vol.74
, pp. 2046-2051
-
-
Kolykhalov, A.A.1
Mihalik, K.2
Feinstone, S.M.3
Rice, C.M.4
-
14
-
-
84862816908
-
Recent progress in the development of selected hepatitis C virus NS3.4A protease and NS5B polymerase inhibitors
-
Kwong A.D., McNair L., Jacobson I., George S. (2008) Recent progress in the development of selected hepatitis C virus NS3.4A protease and NS5B polymerase inhibitors. Curr Opin Pharmacol;8:522-531.
-
(2008)
Curr Opin Pharmacol
, vol.8
, pp. 522-531
-
-
Kwong, A.D.1
McNair, L.2
Jacobson, I.3
George, S.4
-
15
-
-
0037300878
-
New therapies on the horizon for hepatitis C: are we close?
-
xi.
-
De Francesco R., Rice C.M. (2003) New therapies on the horizon for hepatitis C: are we close? Clin Liver Dis;7:211-242, xi.
-
(2003)
Clin Liver Dis
, vol.7
, pp. 211-242
-
-
De Francesco, R.1
Rice, C.M.2
-
16
-
-
79959802300
-
Allosteric inhibition of the hepatitis C virus NS5B polymerase: in silico strategies for drug discovery and development
-
Barreca M.L., Iraci N., Manfroni G., Cecchetti V. (2011) Allosteric inhibition of the hepatitis C virus NS5B polymerase: in silico strategies for drug discovery and development. Future Med Chem;3:1027-1055.
-
(2011)
Future Med Chem
, vol.3
, pp. 1027-1055
-
-
Barreca, M.L.1
Iraci, N.2
Manfroni, G.3
Cecchetti, V.4
-
17
-
-
0036120573
-
Structural analysis of the hepatitis C virus RNA polymerase in complex with ribonucleotides
-
Bressanelli S., Tomei L., Rey F.A., De Francesco R. (2002) Structural analysis of the hepatitis C virus RNA polymerase in complex with ribonucleotides. J Virol;76:3482-3492.
-
(2002)
J Virol
, vol.76
, pp. 3482-3492
-
-
Bressanelli, S.1
Tomei, L.2
Rey, F.A.3
De Francesco, R.4
-
18
-
-
0033539482
-
Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus
-
Bressanelli S., Tomei L., Roussel A., Incitti I., Vitale R.L., Mathieu M., De Francesco R., Rey F.A. (1999) Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus. Proc Natl Acad Sci USA;96:13034-13039.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 13034-13039
-
-
Bressanelli, S.1
Tomei, L.2
Roussel, A.3
Incitti, I.4
Vitale, R.L.5
Mathieu, M.6
De Francesco, R.7
Rey, F.A.8
-
19
-
-
0032876683
-
Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site
-
Lesburg C.A., Cable M.B., Ferrari E., Hong Z., Mannarino A.F., Weber P.C. (1999) Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site. Nat Struct Biol;6:937-943.
-
(1999)
Nat Struct Biol
, vol.6
, pp. 937-943
-
-
Lesburg, C.A.1
Cable, M.B.2
Ferrari, E.3
Hong, Z.4
Mannarino, A.F.5
Weber, P.C.6
-
20
-
-
0033571463
-
Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus
-
Ago H., Adachi T., Yoshida A., Yamamoto M., Habuka N., Yatsunami K., Miyano M. (1999) Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus. Structure;7:1417-1426.
-
(1999)
Structure
, vol.7
, pp. 1417-1426
-
-
Ago, H.1
Adachi, T.2
Yoshida, A.3
Yamamoto, M.4
Habuka, N.5
Yatsunami, K.6
Miyano, M.7
-
21
-
-
77953463393
-
Nucleoside analog inhibitors of hepatitis C viral replication: recent advances, challenges and trends
-
Furman P.A., Lam A.M., Murakami E. (2009) Nucleoside analog inhibitors of hepatitis C viral replication: recent advances, challenges and trends. Future Med Chem;1:1429-1452.
-
(2009)
Future Med Chem
, vol.1
, pp. 1429-1452
-
-
Furman, P.A.1
Lam, A.M.2
Murakami, E.3
-
22
-
-
67650156483
-
Slow binding inhibition and mechanism of resistance of non-nucleoside polymerase inhibitors of hepatitis C virus
-
Hang J.Q., Yang Y., Harris S.F., Leveque V., Whittington H.J., Rajyaguru S., Ao-Ieong G., McCown M.F., Wong A., Giannetti A.M., Le Pogam S., Talamás F., Cammack N., Nájera I., Klumpp K. (2009) Slow binding inhibition and mechanism of resistance of non-nucleoside polymerase inhibitors of hepatitis C virus. J Biol Chem;284:15517-15529.
-
(2009)
J Biol Chem
, vol.284
, pp. 15517-15529
-
-
Hang, J.Q.1
Yang, Y.2
Harris, S.F.3
Leveque, V.4
Whittington, H.J.5
Rajyaguru, S.6
Ao-Ieong, G.7
McCown, M.F.8
Wong, A.9
Giannetti, A.M.10
Le Pogam, S.11
Talamás, F.12
Cammack, N.13
Nájera, I.14
Klumpp, K.15
-
23
-
-
0038322074
-
Non-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase. Crystal structures and mechanism of inhibition
-
Wang M., Ng K.K., Cherney M.M., Chan L., Yannopoulos C.G., Bedard J., Morin N., Nguyen-Ba N., Alaoui-Ismaili M.H., Bethell R.C., James M.N. (2003) Non-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase. Crystal structures and mechanism of inhibition. J Biol Chem;278:9489-9495.
-
(2003)
J Biol Chem
, vol.278
, pp. 9489-9495
-
-
Wang, M.1
Ng, K.K.2
Cherney, M.M.3
Chan, L.4
Yannopoulos, C.G.5
Bedard, J.6
Morin, N.7
Nguyen-Ba, N.8
Alaoui-Ismaili, M.H.9
Bethell, R.C.10
James, M.N.11
-
25
-
-
41149136756
-
Identification and characterization of coumestans as novel HCV NS5B polymerase inhibitors
-
Kaushik-Basu N., Bopda-Waffo A., Talele T.T., Basu A., Costa P.R., da Silva A.J., Sarafianos S.G., Noël F. (2008) Identification and characterization of coumestans as novel HCV NS5B polymerase inhibitors. Nucleic Acids Res;36:1482-1496.
-
(2008)
Nucleic Acids Res
, vol.36
, pp. 1482-1496
-
-
Kaushik-Basu, N.1
Bopda-Waffo, A.2
Talele, T.T.3
Basu, A.4
Costa, P.R.5
da Silva, A.J.6
Sarafianos, S.G.7
Noël, F.8
-
26
-
-
33750065138
-
Structure-activity relationship of wedelolactone analogues: structural requirements for inhibition of Na+, K+ -ATPase and binding to the central benzodiazepine receptor
-
Pocas E.S., Lopes D.V., da Silva A.J., Pimenta P.H., Leitao F.B., Netto C.D., Buarque C.D., Brito F.V., Costa P.R., Noël F. (2006) Structure-activity relationship of wedelolactone analogues: structural requirements for inhibition of Na+, K+ -ATPase and binding to the central benzodiazepine receptor. Bioorg Med Chem;14:7962-7966.
-
(2006)
Bioorg Med Chem
, vol.14
, pp. 7962-7966
-
-
Pocas, E.S.1
Lopes, D.V.2
da Silva, A.J.3
Pimenta, P.H.4
Leitao, F.B.5
Netto, C.D.6
Buarque, C.D.7
Brito, F.V.8
Costa, P.R.9
Noël, F.10
-
27
-
-
77950643074
-
Coumarins: old compounds with novel promising therapeutic perspectives
-
Riveiro M.E., De Kimpe N., Moglioni A., Vazquez R., Monczor F., Shayo C., Davio C. (2010) Coumarins: old compounds with novel promising therapeutic perspectives. Curr Med Chem;17:1325-1338.
-
(2010)
Curr Med Chem
, vol.17
, pp. 1325-1338
-
-
Riveiro, M.E.1
De Kimpe, N.2
Moglioni, A.3
Vazquez, R.4
Monczor, F.5
Shayo, C.6
Davio, C.7
-
28
-
-
70450162772
-
The structure and pharmacological functions of coumarins and their derivatives
-
Wu L., Wang X., Xu W., Farzaneh F., Xu R. (2009) The structure and pharmacological functions of coumarins and their derivatives. Curr Med Chem;16:4236-4260.
-
(2009)
Curr Med Chem
, vol.16
, pp. 4236-4260
-
-
Wu, L.1
Wang, X.2
Xu, W.3
Farzaneh, F.4
Xu, R.5
-
29
-
-
15944389028
-
Simple coumarins and analogues in medicinal chemistry: occurrence, synthesis and biological activity
-
Borges F., Roleira F., Milhazes N., Santana L., Uriarte E. (2005) Simple coumarins and analogues in medicinal chemistry: occurrence, synthesis and biological activity. Curr Med Chem;12:887-916.
-
(2005)
Curr Med Chem
, vol.12
, pp. 887-916
-
-
Borges, F.1
Roleira, F.2
Milhazes, N.3
Santana, L.4
Uriarte, E.5
-
30
-
-
79959304675
-
A review of plants of genus Leucas
-
Chouhan H.S., Singh S.K. (2011) A review of plants of genus Leucas. Pharmacogn Rev;3:13-26.
-
(2011)
Pharmacogn Rev
, vol.3
, pp. 13-26
-
-
Chouhan, H.S.1
Singh, S.K.2
-
31
-
-
80755188989
-
Synthesis of coumarins and neoflavones through zinc chloride-catalyzed hydroarylation of acetylenic esters with phenols
-
Leao R.A.C., de Moraes P.D.F., Pedro M.C.B.C., Costa P.R.R. (2011) Synthesis of coumarins and neoflavones through zinc chloride-catalyzed hydroarylation of acetylenic esters with phenols. Synthesis;22:3692-3696.
-
(2011)
Synthesis
, vol.22
, pp. 3692-3696
-
-
Leao, R.A.C.1
de Moraes, P.D.F.2
Pedro, M.C.B.C.3
Costa, P.R.R.4
-
32
-
-
84887616647
-
Nuclear allylation of hydroxycoumarins. II. Allylation of 5,7-dihydroxy-4-phenylcoumarin and 5,7-dihydroxycoumarin
-
Ahluwalia V.K., Seshadri T.R., Venkateswarlu P. (1972) Nuclear allylation of hydroxycoumarins. II. Allylation of 5, 7-dihydroxy-4-phenylcoumarin and 5, 7-dihydroxycoumarin. Indian J Chem;10:260-262.
-
(1972)
Indian J Chem
, vol.10
, pp. 260-262
-
-
Ahluwalia, V.K.1
Seshadri, T.R.2
Venkateswarlu, P.3
-
33
-
-
33745677020
-
Synthesis and crystal structure of synthesis and crystal structure of 5,7-diallyloxy-4-methylcoumarin
-
Goswami S., Gupta V.K., Gupta B.D., Sivakumar K. (2006) Synthesis and crystal structure of synthesis and crystal structure of 5, 7-diallyloxy-4-methylcoumarin. J Chem Crystallogr;36:77-82.
-
(2006)
J Chem Crystallogr
, vol.36
, pp. 77-82
-
-
Goswami, S.1
Gupta, V.K.2
Gupta, B.D.3
Sivakumar, K.4
-
34
-
-
0001646601
-
Silylated coumarin dyes in sol-gel hosts. 1. Structure and environmental factors on fluorescent properties
-
Suratwala T., Gardlund Z., Davidson K., Uhlmann D.R. (1998) Silylated coumarin dyes in sol-gel hosts. 1. Structure and environmental factors on fluorescent properties. Chem Mater;10:190-198.
-
(1998)
Chem Mater
, vol.10
, pp. 190-198
-
-
Suratwala, T.1
Gardlund, Z.2
Davidson, K.3
Uhlmann, D.R.4
-
35
-
-
84945046820
-
Difurocoumarins, psoralen analogs: synthesis and DNA photobinding
-
Caffieri S., Moor A.C.E., Beijersbergen van Henegouwen G.M.J., Dall'Acqua F., Guiotto A., Chilin A., Rodighiero P. (1995) Difurocoumarins, psoralen analogs: synthesis and DNA photobinding. Z Naturforsch;50:1257-1264.
-
(1995)
Z Naturforsch
, vol.50
, pp. 1257-1264
-
-
Caffieri, S.1
Moor, A.C.E.2
Beijersbergen van Henegouwen, G.M.J.3
Dall'Acqua, F.4
Guiotto, A.5
Chilin, A.6
Rodighiero, P.7
-
36
-
-
0344323946
-
Claisen migration in substituted 4-phenylcoumarins
-
Ahuja M., Seshadri T.R. (1974) Claisen migration in substituted 4-phenylcoumarins. Indian J Chem;12:292-294.
-
(1974)
Indian J Chem
, vol.12
, pp. 292-294
-
-
Ahuja, M.1
Seshadri, T.R.2
-
37
-
-
0035801767
-
A novel class of inhibitors for steroid 5alpha-reductase: synthesis and evaluation of umbelliferone derivatives
-
Fan G., Mar W., Park M.K., Choi E.W., Kim K., Kim S. (2001) A novel class of inhibitors for steroid 5alpha-reductase: synthesis and evaluation of umbelliferone derivatives. Bioorg Med Chem Lett;11:2361-2363.
-
(2001)
Bioorg Med Chem Lett
, vol.11
, pp. 2361-2363
-
-
Fan, G.1
Mar, W.2
Park, M.K.3
Choi, E.W.4
Kim, K.5
Kim, S.6
-
38
-
-
84857860783
-
Dioxane dibromide mediated bromination of substituted coumarins under solvent-free conditions
-
Chaudhuri S.K., Roy S., Bhar S. (2012) Dioxane dibromide mediated bromination of substituted coumarins under solvent-free conditions. Beilstein J Org Chem;8:323-329.
-
(2012)
Beilstein J Org Chem
, vol.8
, pp. 323-329
-
-
Chaudhuri, S.K.1
Roy, S.2
Bhar, S.3
-
39
-
-
0035021270
-
Difurocoumarins: psoralen analogs as photochemotherapeutic agents
-
Chilin A., Manzini P., Caffieri S., Rodighiero P., Guiotto A. (2001) Difurocoumarins: psoralen analogs as photochemotherapeutic agents. J Heterocycl Chem;38:431-434.
-
(2001)
J Heterocycl Chem
, vol.38
, pp. 431-434
-
-
Chilin, A.1
Manzini, P.2
Caffieri, S.3
Rodighiero, P.4
Guiotto, A.5
-
40
-
-
44349106966
-
Sequential Claisen rearrangement and intramolecular Heck reaction as a route to medium-ring oxacycle-fused heterocycles
-
Chattopadhyay S.K., Neogi K., Singha S.K., Dey R. (2008) Sequential Claisen rearrangement and intramolecular Heck reaction as a route to medium-ring oxacycle-fused heterocycles. Synlett;8:1137-1140.
-
(2008)
Synlett
, vol.8
, pp. 1137-1140
-
-
Chattopadhyay, S.K.1
Neogi, K.2
Singha, S.K.3
Dey, R.4
-
41
-
-
0036532321
-
Synthesis of thio- and oxo-analogues of isopsoralen
-
Clarke D.J., Robinson R.S. (2002) Synthesis of thio- and oxo-analogues of isopsoralen. Tetrahedron;58:2831-2837.
-
(2002)
Tetrahedron
, vol.58
, pp. 2831-2837
-
-
Clarke, D.J.1
Robinson, R.S.2
-
42
-
-
0037152303
-
Combined Claisen rearrangement and ring-closing metathesis as a route to oxepin- and oxocin-annulated coumarins
-
Chattopadhyay S.K., Maity S., Panja S. (2002) Combined Claisen rearrangement and ring-closing metathesis as a route to oxepin- and oxocin-annulated coumarins. Tetrahedron Lett;43:7781-7783.
-
(2002)
Tetrahedron Lett
, vol.43
, pp. 7781-7783
-
-
Chattopadhyay, S.K.1
Maity, S.2
Panja, S.3
-
43
-
-
42649110011
-
4-Thiazolidinones: a novel class of hepatitis C virus NS5B polymerase inhibitors
-
Kaushik-Basu N., Bopda-Waffo A., Talele T.T., Basu A., Chen Y., Kucukguzel S.G. (2008) 4-Thiazolidinones: a novel class of hepatitis C virus NS5B polymerase inhibitors. Front Biosci;13:3857-3868.
-
(2008)
Front Biosci
, vol.13
, pp. 3857-3868
-
-
Kaushik-Basu, N.1
Bopda-Waffo, A.2
Talele, T.T.3
Basu, A.4
Chen, Y.5
Kucukguzel, S.G.6
-
44
-
-
70350347384
-
Characterization of aurintricarboxylic acid as a potent hepatitis C virus replicase inhibitor
-
Chen Y., Bopda-Waffo A., Basu A., Krishnan R., Silberstein E., Taylor D.R., Talele T.T., Arora P., Kaushik-Basu N. (2009) Characterization of aurintricarboxylic acid as a potent hepatitis C virus replicase inhibitor. Antivir Chem Chemother;20:19-36.
-
(2009)
Antivir Chem Chemother
, vol.20
, pp. 19-36
-
-
Chen, Y.1
Bopda-Waffo, A.2
Basu, A.3
Krishnan, R.4
Silberstein, E.5
Taylor, D.R.6
Talele, T.T.7
Arora, P.8
Kaushik-Basu, N.9
-
45
-
-
84862811181
-
Inhibition of hepatitis C virus NS5B polymerase by S-trityl-l-cysteine derivatives
-
Nichols D.B., Fournet G., Gurukumar K.R., Basu A., Lee J.C., Sakamoto N., Kozielski F., Musmuca I., Joseph B., Ragno R., Kaushik-Basu N. (2012) Inhibition of hepatitis C virus NS5B polymerase by S-trityl-l-cysteine derivatives. Eur J Med Chem;49C:191-199.
-
(2012)
Eur J Med Chem
, vol.49 C
, pp. 191-199
-
-
Nichols, D.B.1
Fournet, G.2
Gurukumar, K.R.3
Basu, A.4
Lee, J.C.5
Sakamoto, N.6
Kozielski, F.7
Musmuca, I.8
Joseph, B.9
Ragno, R.10
Kaushik-Basu, N.11
-
46
-
-
77949487755
-
Inhibitors of hepatitis C virus polymerase: synthesis and characterization of novel 2-oxy-6-fluoro-N-((S)-1-hydroxy-3-phenylpropan-2-yl)-benzamides
-
Cheng C.C., Shipps G.W. Jr, Yang Z., Kawahata N., Lesburg C.A., Duca J.S., Bandouveres J., Bracken J.D., Jiang C.K., Agrawal S., Ferrari E., Huang H.C. (2010) Inhibitors of hepatitis C virus polymerase: synthesis and characterization of novel 2-oxy-6-fluoro-N-((S)-1-hydroxy-3-phenylpropan-2-yl)-benzamides. Bioorg Med Chem Lett;20:2119-2124.
-
(2010)
Bioorg Med Chem Lett
, vol.20
, pp. 2119-2124
-
-
Cheng, C.C.1
Shipps Jr, G.W.2
Yang, Z.3
Kawahata, N.4
Lesburg, C.A.5
Duca, J.S.6
Bandouveres, J.7
Bracken, J.D.8
Jiang, C.K.9
Agrawal, S.10
Ferrari, E.11
Huang, H.C.12
-
47
-
-
69249205467
-
Identification of allosteric inhibitors blocking the hepatitis C virus polymerase NS5B in the RNA synthesis initiation step
-
Betzi S., Eydoux C., Bussetta C., Blemont M., Leyssen P., Debarnot C., Ben-Rahou M. et al. (2009) Identification of allosteric inhibitors blocking the hepatitis C virus polymerase NS5B in the RNA synthesis initiation step. Antiviral Res;84:48-59.
-
(2009)
Antiviral Res
, vol.84
, pp. 48-59
-
-
Betzi, S.1
Eydoux, C.2
Bussetta, C.3
Blemont, M.4
Leyssen, P.5
Debarnot, C.6
Ben-Rahou, M.7
-
48
-
-
78651071881
-
Discovery of (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase
-
Narjes F., Crescenzi B., Ferrara M., Habermann J., Colarusso S., Ferreira Mdel R., Stansfield I. et al. (2011) Discovery of (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7, 8-dihydro-6H-indolo[1, 2-e][1, 5]benzoxazocine-11-carboxylic acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase. J Med Chem;54:289-301.
-
(2011)
J Med Chem
, vol.54
, pp. 289-301
-
-
Narjes, F.1
Crescenzi, B.2
Ferrara, M.3
Habermann, J.4
Colarusso, S.5
Ferreira Mdel, R.6
Stansfield, I.7
-
49
-
-
64349088294
-
Discovery of (R)-6-cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-on e (PF-00868554) as a potent and orally available hepatitis C virus polymerase inhibitor
-
Li H., Tatlock J., Linton A., Gonzalez J., Jewell T., Patel L., Ludlum S. et al. (2009) Discovery of (R)-6-cyclopentyl-6-(2-(2, 6-diethylpyridin-4-yl)ethyl)-3-((5, 7-dimethyl-[1, 2, 4]triazolo[1, 5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5, 6-dihydropyran-2-on e (PF-00868554) as a potent and orally available hepatitis C virus polymerase inhibitor. J Med Chem;52:1255-1258.
-
(2009)
J Med Chem
, vol.52
, pp. 1255-1258
-
-
Li, H.1
Tatlock, J.2
Linton, A.3
Gonzalez, J.4
Jewell, T.5
Patel, L.6
Ludlum, S.7
-
50
-
-
33847771635
-
Optimization of novel acyl pyrrolidine inhibitors of hepatitis C virus RNA-dependent RNA polymerase leading to a development candidate
-
Slater M.J., Amphlett E.M., Andrews D.M., Bravi G., Burton G., Cheasty A.G., Corfield J.A. et al. (2007) Optimization of novel acyl pyrrolidine inhibitors of hepatitis C virus RNA-dependent RNA polymerase leading to a development candidate. J Med Chem;50:897-900.
-
(2007)
J Med Chem
, vol.50
, pp. 897-900
-
-
Slater, M.J.1
Amphlett, E.M.2
Andrews, D.M.3
Bravi, G.4
Burton, G.5
Cheasty, A.G.6
Corfield, J.A.7
-
51
-
-
58749089998
-
New therapies for hepatitis C virus infection
-
Soriano V., Peters M.G., Zeuzem S. (2009) New therapies for hepatitis C virus infection. Clin Infect Dis;48:313-320.
-
(2009)
Clin Infect Dis
, vol.48
, pp. 313-320
-
-
Soriano, V.1
Peters, M.G.2
Zeuzem, S.3
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