Thrombopoiesis

Seminars in Hematology

Volumn 52, Issue 1, 2015, Pages 4-11

  Kaushansky, Kenneth ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 11; INTERLEUKIN 3; INTERLEUKIN 6; JANUS KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; RECOMBINANT THROMBOPOIETIN; STAT PROTEIN; STEM CELL FACTOR; STROMAL CELL DERIVED FACTOR 1; THROMBOPOIETIN; THROMBOPOIETIN RECEPTOR; CYTOKINE;

BONE MARROW STROMA CELL; CELL MIGRATION; CYTOKINE PRODUCTION; HEMATOPOIETIC STEM CELL; HUMAN; INFLAMMATION; MEGAKARYOCYTE; MOLECULAR CLONING; MYELOPROLIFERATIVE NEOPLASM; NONHUMAN; REVIEW; STEM CELL EXPANSION; STEM CELL NICHE; THROMBOCYTE ADHESION; THROMBOCYTE COUNT; THROMBOCYTOPENIA; THROMBOCYTOPOIESIS; THROMBOCYTOSIS; THROMBOSIS; ANIMAL; BONE MARROW; BONE MARROW CELL; CYTOLOGY; DRUG EFFECTS; METABOLISM;

ANIMALS; BONE MARROW; BONE MARROW CELLS; CYTOKINES; HUMANS; THROMBOPOIESIS; THROMBOPOIETIN;

EID: 84920663729     PISSN: 00371963     EISSN: 15328686     Source Type: Journal    
DOI: 10.1053/j.seminhematol.2014.10.003     Document Type: Review

References (86)

1. Kelemen E., Cserhati I., Tanos B. Demonstration and some properties of human thrombopoietin in thrombocythemic sera. Acta Haematol (Basel) 1958, 20:350-355.
2. Wendling F., Varlet P., Charon M., Tambourin P. A retrovirus complex inducing an acute myeloproliferative leukemia disorder in mice. Virology 1986, 149:242-246.
3. Souyri M., Vigon I., Penciolelli J.-F., Tambourin P., Wendling F. A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors. Cell 1990, 63:1137-1147.
4. Vigon I., Mornon J.-P., Cocault L., et al. Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: Identification of a member of the hematopoietic growth factor receptor superfamily. Proc Natl Acad Sci USA 1992, 89:5640-5644.
5. Sohma Y., Akahori H., Seki N., et al. Molecular cloning and chromosomal localization of the human thrombopoietin gene. FEBS Letters 1994, 353:57-61.
6. de Sauvage F.J., Hass P.E., Spencer S.D., et al. Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature 1994, 369:533-538.
7. Lok S., Kaushansky K., Holly R.D., et al. Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature 1994, 369:565-568.
8. Kaushansky K., Lok S., Holly R.D., et al. Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin. Nature 1994, 369:568-571.
9. Feese M.D., Tamada T., Kato Y., et al. Structure of the receptor-binding domain of human thrombopoietin determined by complexation with a neutralizing antibody fragment. Proc Natl Acad Sci U S A 2004, 101:1816-1821.
10. Harker L.A., Marzec U.M., Hunt P., et al. Dose response effects of pegylated human megakaryocyte growth and development factor on platelet production and function in nonhuman primates. Blood 1996, 88:511-521.
11. Linden H.M., Kaushansky K. The glycan domain of thrombopoietin enhances its secretion. Biochemistry 2000, 39:3044-3051.
12. Broudy V.C., Lin N.L., Kaushansky K. Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and IL-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro. Blood 1995, 85:1719-1726.
13. Zeigler F.C., de Sauvage F., Widmer H.R., et al. In vitro megakaryocytopoietic and thrombopoietic activity of c-mpl ligand (TPO) on purified murine hematopoietic stem cells. Blood 1994, 84:4045-4052.
14. Zucker-Franklin D., Kaushansky K. The effect of Thrombopoietin on the development of megakaryocytes and platelets: An ultrastructural analysis. Blood 1996, 88:1632-1638.
15. Carow C.E., Fox N., Kaushansky K. The Kinetics of Endomitosis in Primary Murine Megakaryocytes. J Cell Physiol 2001, 188:291-303.
16. Choi E.S., Hokom M.M., Chen J.L., et al. The role of megakaryocyte growth and development factor in terminal stages of thrombopoiesis. Br J Haematol 1996, 95:227-233.
17. Ku H., Yonemura Y., Kaushansky K., Ogawa M. Thrombopoietin, the ligand for the Mpl receptor, synergizes with steel factor and other early-acting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice. Blood 1996, 87:4544-4551.
18. Sitnicka E., Lin N., Priestley G.V., et al. The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells. Blood 1996, 87:4998-5005.
19. Qian H., Buza-Vidas N., Hyland C.D., et al. Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells. Cell Stem Cell 2007, 1:671-684.
20. Arai F., Yoshihara H., Hosokawa K., et al. Niche regulation of hematopoietic stem cells in the endosteum. Ann N Y Acad Sci 2009, 1176:36-46.
21. Yagi M., Ritchie K.A., Sitnicka E., Storey C., Roth G.J., Bartelmez S. Sustained ex vivo expansion of hematopoietic stem cells mediated by thrombopoietin. Proc Natl Acad Sci U S A 1999, 96:8126-8131.
22. Nishino T., Miyaji K., Ishiwata N., et al. Ex vivo expansion of human hematopoietic stem cells by a small-molecule agonist of c-MPL. Exp Hematol 2009, 37:1364-1377.
23. Yoshihara H., Arai F., Hosokawa K., et al. Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche. Cell Stem Cell 2007, 1:685-697.
24. de Laval B., Pawlikowska P., Petit-Cocault L., et al. Thrombopoietin-increased DNA-PK-dependent DNA repair limits hematopoietic stem and progenitor cell mutagenesis in response to DNA damage. Cell Stem Cell 2013, 12:37-48.
25. Gurney A.L., Carver-Moore K., de Sauvage F.J., Moore M.W. Thrombocytopenia in c-mpl-deficient mice. Science 1994, 265:1445-1447.
26. de Sauvage F.J., Carver-Moore K., Luoh S.-M., et al. Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin. J Exp Med 1996, 183:651-656.
27. Solar G.P., Kerr W.G., Zeigler F.C., et al. Role of c-mpl in early hematopoiesis. Blood 1998, 92:4-10.
28. Fox N.E., Priestley G.V., Th Papayannopoulou, Kaushansky K. Thrombopoietin (TPO) expands hematopoietic stem cells (HSCs) in vivo. J Clin Invest 2002, 110:389-394.
29. Ballmaier M., Germeshausen M., Schulze H., et al. c-mpl mutations are the cause of congenital amegakaryocytic thrombocytopenia. Blood 2001, 97:139-146.
30. Avecilla S.T., Hattori K., Heissig B., et al. Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis. Nat Med 2004, 10:64-71.
31. Akkerman J.W. Thrombopoietin and platelet function. Semin Thromb Hemost 2006, 32:295-304.
32. van Willigen G., Gorter G., Akkerman J.W. Thrombopoietin increases platelet sensitivity to alpha-thrombin via activation of the ERK2-cPLA2 pathway. Thromb Haemost 2000, 83:610-616.
33. Van Os E., Wu Y.P., Pouwels J.G., et al. Thrombopoietin increases platelet adhesion under flow and decreases rolling. Br J Haematol 2003, 121:482-490.
34. Afdhal N.H., Giannini E.G., Tayyab G., et al. Eltrombopag before procedures in patients with cirrhosis and thrombocytopenia. N Engl J Med 2012, 367:716-724.
35. Calvi L.M., Adams G.B., Weibrecht K.W., et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 2003, 425:841-846.
36. Kiel M.J., Morrison S.J. Maintaining hematopoietic stem cells in the vascular niche. Immunity 2006, 25:862-864.
37. Junt T., Schulze H., Chen Z., et al. Dynamic visualization of thrombopoiesis within bone marrow. Science 2007, 317:1767-1770.
38. Malara A., Currao M., Gruppi C., et al. Megakaryocytes contribute to the bone marrow-matrix environment by expressing fibronectin, type IV collagen, and laminin. Stem Cells 2014, 32:926-937.
39. McCarty J.M., Sprugel K.H., Fox N.E., Sabath D.E., Kaushansky K. Murine thrombopoietin mRNA levels are modulated by platelet count. Blood 1995, 86:3668-3675.
40. Guerriero A., Worford L., Holland H.K., et al. Thrombopoietin is synthesized by bone marrow stromal cells. Blood 1997, 90:3444-3455.
41. Sugiyama T., Kohara H., Noda M., Nagasawa T. Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches. Immunity 2006, 25:977-988.
42. Hodohara K., Fujii N., Yamamoto N., Kaushansky K. Stromal cell derived factor 1 acts synergistically with thrombopoietin to enhance the development of megakaryocytic progenitor cells. Blood 2000, 95:769-775.
43. Miyazawa K., Williams D.A., Gotoh A., et al. Membrane-bound Steel factor induces more persistent tyrosine kinase activation and longer life span of c-kit gene-encoded protein than its soluble form. Blood 1995, 85:641-649.
44. Broudy V.C. Stem cell factor and hematopoiesis. Blood 1997, 90:1345-1364.
45. Broudy V.C., Lin N.L., Kaushansky K. Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro. Blood 1995, 85:1719-1726.
46. Avraham H., Cowley S., Chi S.Y., Jiang S., Groopman J.E. Characterization of adhesive interactions between human endothelial cells and megakaryocytes. J Clin Invest 1993, 91:2378-2384.
47. Fox N.E., Kaushansky K. Engagement of integrin α4β1 enhances thrombopoietin induced megakaryopoiesis. Exp Hematol 2005, 33:94-99.
48. Kapur R., Cooper R., Zhang L., Williams D.A. Cross-talk between alpha(4)beta(1)/alpha(5)beta(1) and c-Kit results in opposing effect on growth and survival of hematopoietic cells via the activation of focal adhesion kinase, mitogen-activated protein kinase, and Akt signaling pathways. Blood 2001, 97:1975-1981.
49. Dhanjal T.S., Pendaries C., Ross E.A., et al. A novel role for PECAM-1 in megakaryocytokinesis and recovery of platelet counts in thrombocytopenic mice. Blood 2007, 109:4237-4244.
50. Balduini A., Pallotta I., Malara A., et al. Adhesive receptors, extracellular proteins and myosin IIA orchestrate proplatelet formation by human megakaryocytes. J Thromb Haemost 2008, 6:1900-1907.
51. Nichol J., Hokom M., Hornkohl A., et al. Megakaryocyte growth and development factor: Analysis of in vitro effects on human megakaryopoiesis and endogenous serum levels during chemotherapy induced thrombocytopenia. J Clin Invest 1995, 95:2973-2978.
52. Kuter D.J., Rosenberg R.D. The reciprocal relationship of thrombopoietin (c-Mpl Ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit. Blood 1995, 85:2720-2730.
53. Sungaran R., Markovic B., Chong B.H. Localization and regulation of thrombopoietin mRNA expression in human kidney, liver, bone marrow and spleen using in situ hybridization. Blood 1997, 89:101-107.
54. Sungaran R., Chisholm O.T., Markovic B., Khachigian L.M., Tanaka Y., Chong B.H. The role of platelet alpha-granular proteins in the regulation of thrombopoietin messenger RNA expression in human bone marrow stromal cells. Blood 2000, 95:3094-3101.
55. Cerutti A., Custodi P., Duranti M., Noris P., Balduini C.L. Thrombopoietin levels in patients with primary and reactive thrombocytosis. Br J Haematol 1997, 99:281-284.
56. Wang J.C., Chen C., Novetsky A.D., Lichter S.M., Ahmed F., Friedberg N.M. Blood thrombopoietin levels in clonal thrombocytosis and reactive thrombocytosis. Am J Med 1998, 104:451-455.
57. Wolber E.M., Jelkmann W. Interleukin-6 increases thrombopoietin production in human hepatoma cells HepG2 and Hep3B. J Interferon Cytokine Res 2000, 20:499-506.
58. Burmester H., Wolber E.M., Freitag P., Fandrey J., Jelkmann W. Thrombopoietin production in wild-type and interleukin-6 knockout mice with acute inflammation. J Interferon Cytokine Res 2005, 25:407-413.
59. Taga T., Kishimoto T. Signaling mechanisms through cytokine receptors that share signal transducing receptor components. Curr Opin Immunol 1995, 7:17-23.
60. Tong W., Sulahian R., Gross A.W., Hendon N., Lodish H.F., Huang L.J. The membrane-proximal region of the thrombopoietin receptor confers its high surface expression by JAK2-dependent and -independent mechanisms. J Biol Chem 2006, 281:38930-38940.
61. Bacon C.M., Tortolani P.J., Shimosaka A., Rees R.C., Longo D.L., O'Shea J.J. Thrombopoietin (TPO) induces tyrosine phosphorylation and activation of STAT5 and STAT3. FEBS Lett 1995, 370:63-68.
62. Drachman J., Griffin J.D., Kaushansky K. Stimulation of tyrosine kinase activity by MPL-ligand (thrombopoietin). J Biol. Chem 1995, 270:4979-4982.
63. Drachman J.D., Sabath D.F., Fox N.E., Kaushansky K. Thrombopoietin signal transduction in purified murine megakaryocytes. Blood 1997, 89:483-492.
64. Hill R.J., Zozulya S., Lu Y.L., et al. Differentiation induced by the c-Mpl cytokine receptor is blocked by mutant Shc adapter protein. Cell Growth and Diff 1996, 7:1125-1134.
65. Sasaki K., Odai H., Hanazono Y., et al. TPO/c-mpl ligand induces tyrosine phosphorylation of multiple cellular proteins including proto-oncogene products, Vav and c-Cbl, and Ras signaling molecules. Biochem Biophys Res Commun 1995, 216. 338-7.
66. CBL. J Cell Physiol 1997, 171:28-33.
67. Miyakawa Y., Rojnuckarin P., Habib T., Kaushansky K. Thrombopoietin induces PI3K and SHP2 activation through Gab and IRS proteins in BaF3 cells and primary murine megakaryocytes. J Biol Chem 2001, 276:2494-2502.
68. Nagata Y., Todokoro K. Thrombopoietin induces activation of at least two distinct signaling pathways. FEBS Lett 1995, 377:497-501.
69. Sauvageau G., Thorsteinsdottir U., Eaves C.J., et al. Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo. Genes Dev 1995, 9:1753-1765.
70. Thorsteinsdottir U., Mamo A., Kroon E., et al. Overexpression of the myeloid leukemia-associated Hoxa9 gene in bone marrow cells induces stem cell expansion. Blood 2002, 99:121-129.
71. Kirito K., Fox N.E., Kaushansky K. Thrombopoietin stimulates expression of HoxB4: An explanation for the favorable effects of TPO on hematopoietic stem cells. Blood 2003, 102:3172-3178.
72. Kirito K., Fox N.E., Kaushansky K. Thrombopoietin (TPO) induces the nuclear translocation of HoxA9 in hematopoietic stem cells (HSC): A potential explanation for the favorable effects of TPO on HSCs. Mol Cell Bio 2004, 24:6751-6762.
73. Kirito K., Fox N.E., Kaushansky K. Thrombopoietin enhances expression of vascular endothelial cell growth factor (VEGF) in primitive hematopoietic cells through induction of HIF-1α. Blood 2005, 105:4258-4263.
74. Gerber H.P., Malik A.K., Solar G.P., et al. VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism. Nature 2002, 417:954-958.
75. Mukai H.Y., Motohashi H., Ohneda O., Suzuki N., Nagano M., Yamamoto M. Transgene insertion in proximity to the c-myb gene disrupts erythroid-megakaryocytic lineage bifurcation. Mol Cell Biol 2006, 26:7953-7965.
76. Barroga C., Pham H., Kaushansky K. Thrombopoietin regulates c-myb expression by modulating microRNA (miR)150 expression. Exp Hematol 2008, 36:1585-1592.
77. Geddis A.E., Kaushansky K. Endomitotic megakaryocytes form a midzone in anaphase but have a deficiency in cleavage furrow formation. Cell Cycle 2006, 5. 538-5.
78. Lordier L., Jalil A., Aurade F., et al. Megakaryocyte endomitosis is a failure of late cytokinesis related to defects in the contractile ring and Rho/Rock signaling. Blood 2008, 112:3164-3174.
79. Gao Y., Smith E., Ker E., et al. Role of RhoA-specific guanine exchange factors in regulation of endomitosis in megakaryocytes. Dev Cell 2012, 22:573-584.
80. Suzuki A., Shin J.W., Wang Y., et al. RhoA is essential for maintaining normal megakaryocyte ploidy and platelet generation. PLoS One 2013, 8:e69315.
81. Lannutti B.J., Drachman J.G. Lyn tyrosine kinase regulates thrombopoietin-induced proliferation of hematopoietic cell lines and primary megakaryocytic progenitors. Blood 2004, 103:3736-3743.
82. Lannutti B.J., Minear J., Blake N., Drachman J.G. Increased megakaryocytopoiesis in Lyn-deficient mice. Oncogene 2006, 25:3316-3324.
83. Tong W., Lodish H.F. Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis. J Exp Med 2004, 200:569-580.
84. Croker B.A., Kiu H., Nicholson S.E. SOCS regulation of the JAK/STAT signalling pathway. Semin Cell Dev Biol 2008, 19:414-422.
85. Hitchcock I., Chen M., Fox N.E., Kaushansky K. YRRL motifs in the cytoplasmic domain of the thrombopoietin receptor regulate receptor internalization and degradation. Blood 2008, 112:2222-2231.
86. Saur S.J., Geddis Sangkhae V, Kaushansky A.E., Hitchcock K. IS. Ubiquitination and degradation of the thrombopoietin receptor c-Mpl. Blood 2010, 115:1254-1263.