Lyn tyrosine kinase regulates thrombopoietin-induced proliferation of hematopoietic cell lines and primary megakaryocytic progenitors

Blood

Volumn 103, Issue 10, 2004, Pages 3736-3743

  Lannutti, Brian J ^a   Drachman, Jonathan G ^b  

^a PUGET SOUND BLOOD CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

JANUS KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN KINASE LYN; PROTEIN SHC; PROTEIN TYROSINE KINASE; PYRROLOPYRIMIDINE 1; PYRROLOPYRIMIDINE 2; PYRROLOPYRIMIDINE DERIVATIVE; STAT3 PROTEIN; STAT5 PROTEIN; THROMBOPOIETIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STIMULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE MUTATION; HEMATOPOIETIC CELL; MEGAKARYOCYTE; MEGAKARYOPOIESIS; MOUSE; NONHUMAN; PLOIDY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION;

EID: 2342571558     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2003-10-3566     Document Type: Article

References (47)

1. Drachman JG. Role of thrombopoietin in hematopoietic stem cell and progenitor regulation. Curr Opin Hematol. 2000;7:183-190.
2. Geddls A, Linden HM, Kaushansky K. Thrombopoietin: a pan-hematopoietic cytokine. Cytokine Growth Factor Rev. 2002;13:81-73.
3. Kaushansky K. Thrombopoietin: the primary regulator of platelet production. Blood. 1995;88: 419-431.
4. Drachman JG, Millett KM, Kaushansky K. Thrombopoietin signal transduction requires functional JAK2, not TYK2. J Biol Chem. 1999;274:13480-13484.
5. Filippi MD, Porteu F, Le Pesteur F, et al. Requirement for mitogen-activated protein kinase activation in the response of embryonic stem cell-derived hematopoietic cells to thrombopoietin in vitro. Blood. 2002;99:1174-1182.
6. Parganas E, Wang D, Stravopodis D, et al. JAK2 is essential for signaling through a variety of cytokine receptors. Cell. 1998;93:385-395.
7. Ihle JN. The Janus protein tyrosine kinases in hematopoietic cytokine signaling. Semin Immunol. 1995;7:247-254.
8. Rojnuckarin P, Drachman JG, Kaushansky K. Thrombopoietin-induced activation of the mitogen-activated protein kinase (MAPK) pathway in normal megakaryocytes: role in endomitosis. Blood. 1999;94:1273-1282.
9. Gumey AL, Wong SC, Henzel WJ, de Sauvage FJ. Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and Shc phosphorylation. Proc Natl Acad Sci U S A. 1995;92:5292-5298.
10. Rouyez MC, Boucheron C, Gisselbrecht S, Dusanter-Fourt I, Porteu F. Control of thrombopoietin-induced megakaryocytic differentiation by the mitogen-activated protein kinase pathway. Mol Cell Biol. 1997;17:4991-5000.
11. Drachman JG, Rojnuckarin, Kaushansky K. Thrombopoietin signal transduction: studies from cell lines and primary cells. Methods. 1999:238-249.
12. Miyakawa Y, Oda A, Druker BJ, et al. Recombinant thrombopoietin induces rapid protein tyrosine phosphorylation of Janus kinase 2 and Shc in human blood platelets. Blood. 1995;86:23-27.
13. Drachman JG, Sabath DF, Fox NE, Kaushansky K. Thrombopoietin signal transduction in purified murine megakaryocytes. Blood. 1997;89:483-492.
14. Brown MT, Cooper JD. Regulation, substrates and functions of Src. Biochim Biophys Acta. 1996;1287:121-149.
15. Thomas SM, Brugge JS. Cellular functions regulated by Src family kinases. Annu Rev Cell Dev Biol. 1997:513-609.
16. Schwartzberg PL. The many faces of Src: multiple functions of a prototypical tyrosine kinase. Oncogene. 1998;17:1463-1468.
17. Corey SJ, Anderson SM. Src-related protein tyrosine kinases in hematopoiesis. Blood. 1999;93: 1-14.
18. Kassenbrock CK, Hunter S, Garl P, Johnson GL, Anderson SM. Inhibition of Src family kinases blocks epidermal growth factor (EGF)-induced activation of Akt, phosphorylation of c-Cbl, and ubiquitination of the EGF receptor. J Biol Chem. 2002;277:24967-24975.
19. Tilbrook PA, Ingley E, Williams JH, Hibbs ML, Klinken SP. Lyn tyrosine kinase is essential for erythropoietin-induced differentiation of J2E erythroid cells. EMBO J. 1997;16:1610-1619.
20. Linnekin D, DeBerry CS, Mou S. Lyn associates with the juxtamembrane region of c-Kit and is activated by stem cell factor in hematopoietic cell lines and normal progenitor cells. J Biol Chem. 1997;272:27450-27455.
21. Reddy EP, Korapati A, Chaturvedi P, Rane S. IL-3 signaling and the role of Src kinases, JAKs and STATs: a covert liaison unveiled. Oncogene. 2000:2532-2547.
22. Stafford S, Lowell C, Sur S, Alam R. Lyn tyrosine kinase is important for IL-5 stimulated eosinophil differentiation. J Immunol. 2002;168:1978-1983.
23. Anderson SM, Jorgensen B. Activation of src-related tyrosine kinases by IL-3. J Immunol. 1995;155:1660-1670.
24. Ernst M, Gearing DP, Dunn AR. Functional and biochemical association of hck with the LIF/IL-6 receptor signaling transduction subunit gp130 in embryonic stem cells. EMBO J. 1994;13:1574-1584.
25. Hatakeyama M, Kono T, Kobayashi N, et al. Interaction of the IL-2 receptor with the src-family kinase p58lk: identification of novel intermolecular association. Science. 1991;252:1523-1528.
26. Tilbrook P, Palmer G, Bittorf T, et al. Maturation of erythroid cells and erythreleukemia development are affected by kinase activity of Lyn. Cancer Res. 2001;81:2453-2458.
27. Rane SG, Reddy EP. JAKs, STATs and Src kinases in hematopoiesis. Oncogene. 2002;21: 3334-3358.
28. Chaturvedi P, Reddy MV, Reddy EP. Src kinases and not JAKs activate STATs during IL-3 induced myeloid cell proliferation. Oncogene. 1998;16: 1749-1758.
29. Chin H, Arai A, Wakao H, Kamiyama R, Miyasaka N, Miura O. Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway. Blood. 1998;91: 3734-3745.
30. Corey SJ, Dombrosky-Ferlan PM, Zuo S, et al. Requirement of Src kinase Lyn for induction of DNA synthesis by granulocyte colony-stimulating factor. J Biol Chem. 1998;273:3230-3235.
31. Roginskaya V, Zuo S, Caudell E, Nambudiri G, Kraker AJ, Corey SJ. Therapeutic targeting of Src-kinase Lyn in myeloid leukemic cell growth. Leukemia. 1999;13:855-861.
32. Pestina TI, Stenberg PE, Druker BJ, et al. Identification of the Src family kinases, Lck and Fgr in platelets. Their tyrosine phosphorylation status and subcellular distribution compared with other Src family members. Arterioscler Thromb Vasc Biol. 1997;17:3278-3285.
33. Lannutti BJ., Shim M-H, Blake N, Reems J, Drachman JG. Identification and activation of Src family kinases in primary megakaryocytes. Exp Hematol. 2003;12:1268-1274.
34. Drachman JG, Kaushansky K. Dissecting the thrombopoietin receptor: functional elements of the Mpl cytoplasmic domain. Proc Natl Acad Sci U S A. 1997;94:2350-2355.
35. O'Laughlin-Bunner B, Radosevic N, Taylor ML, et al. Lyn is required for normal stem factor-induced preliferation and chemotaxis of primary hematopoietic cells. Blood. 2001;98:343-350.
36. Drachman JG, Griffin JD, Kaushansky K. The c-Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of JAK2, Shc, and c-Mpl. J Biol Chem. 1995;270:4979-4982.
37. Alexander WS, Maurer AB, Novak U, Harrison Smith M. Tyrosine-599 of the c-Mpl receptor is required for Shc phosphorylation and the induction of cellular differentiation. EMBO J. 1998;15: 6531-6540.
38. Sasaki K, Odai H, Hanazono Y, et al. TPO/c-mpl ligand induces tyrosine phosphorylation of multiple cellular proteins including proto-oncogene products, Vav and c-Cbl, and Ras signaling molecules. Biochem Biophys Res Commun. 1995; 218:338-347.
39. Baran CP, Tridandapani S, Helgason CD, Humphries RK, Krystal G, Marsh CB. The inositol 5′-phosphatase SHIP-1 and the Src kinase Lyn negatively regulate macrophage colony-stimulating factor-induced Akt activity. J Biol Chem. 2003; 278:38628-38636.
40. Porteu F, Rouyez MC, Cocault L, et al. Functional regions of the mouse thrombopoietin receptor cytoplasmic domain: evidence for a critical region which is involved in differentiation and can be complemented by erythropoietin. Mol Cell Biol. 1996;16:2473-2482.
41. Cobb MH. MAP kinase pathways. Prog Biophys Mol Biol. 1999;71:479-500.
42. Melemed AS, Ryder JW, Vik TA. Activation of the mitogen-activated protein kinase pathway is involved in and sufficient for megakaryocytic differentiation of CMK cells. Blood. 1997;90:3462-3470.
43. DeFranco AL, Chan VWF, Lowell CA. Positive and negative roles of the tyrosine kinase Lyn in B cell function. Semin Immunol. 1998;10:299-307.
44. Clevenger CV, Medaglia MV. The protein tyrosine kinase P59fyn is associated with prolactin (PRL) receptor and is activated by PRL stimulation of T-lymphocytes. Mol Endocrinol. 1994;6:674-681.
45. 1 phase cell cycle machinery. Bioessays. 2000;22:818-826.
46. Lavoie JN, L'Allemain G, Brunet A, Muller R, Pouyssegur J. Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway. J Biol Chem. 1996; 271:20608-20616.
47. 2-M progression. Requirement for phosphorylation at the activation lip and signaling downstream of MKK. J Biol Chem. 1999; 274:6168-6174.