Eltrombopag before procedures in patients with cirrhosis and thrombocytopenia

New England Journal of Medicine

Volumn 367, Issue 8, 2012, Pages 716-724

  Afdhal, Nezam H ^a   Giannini, Edoardo G ^b   Tayyab, Ghias ^d   Mohsin, Aftab ^e   Lee, Jin Woo ^f   Andriulli, Angelo ^c   Jeffers, Lennox ^h   McHutchison, John ⁱ   Chen, Pei Jer ^j   Han, Kwang Hyub ^g   Campbell, Fiona ^k   Hyde, Denise ^k   Brainsky, Andres ^l   Theodore, Dickens ^l  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b UNIVERSITY OF GENOA   (Italy)

^c CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^d Ameeruddin Medical College PGMI Lahore General Hospital M Phil Stud   (Pakistan)

^e SERVICES HOSPITAL   (Pakistan)

^f Inha University School of Medicine   (South Korea)

^g Yonsei University College of Medicine   (South Korea)

^h UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

ⁱ DUKE UNIVERSITY MEDICAL CENTER   (United States)

^j NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^k Oncology Clinical Development   (United Kingdom)

^l GLAXOSMITHKLINE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ELTROMBOPAG; PLACEBO;

ABDOMINAL PAIN; ADULT; AGED; ANEMIA; ARTICLE; ASCITES; BLEEDING; CATARACT; CHRONIC LIVER DISEASE; CONTROLLED STUDY; DIARRHEA; DISEASE SEVERITY; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG INDUCED HEADACHE; DRUG SAFETY; ELECTIVE SURGERY; EPISTAXIS; FEMALE; FEVER; GASTROENTERITIS; HEMATURIA; HEPATIC ENCEPHALOPATHY; HUMAN; HUMAN CELL; INCIDENCE; INVASIVE PROCEDURE; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; MESENTERIC VEIN THROMBOSIS; MULTICENTER STUDY; NAUSEA; PATIENT CARE; PERIPHERAL EDEMA; PORTAL VEIN THROMBOSIS; PREOPERATIVE TREATMENT; PRIORITY JOURNAL; PYURIA; RANDOMIZED CONTROLLED TRIAL; RECTUM HEMORRHAGE; SEPSIS; SIDE EFFECT; SPLANCHNIC VEIN THROMBOSIS; SPLENOPORTAL VEIN THROMBOSIS; SUPERIOR MESENTERIC VEIN THROMBOSIS; THROMBOCYTE COUNT; THROMBOCYTE TRANSFUSION; THROMBOCYTOPENIA; TREATMENT OUTCOME; TREATMENT PLANNING; UPPER ABDOMINAL PAIN; URINARY TRACT INFECTION; VEIN THROMBOSIS; VOMITING;

EID: 84984567262     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa1110709     Document Type: Article

References (19)

1. Qamar AA, Grace ND, Groszmann RJ, et al. Incidence, prevalence, and clinical significance of abnormal hematologic indices in compensated cirrhosis. Clin Gastroenterol Hepatol 2009;7:689-95.
2. Bashour FN, Teran JC, Mullen KD. Prevalence of peripheral blood cytopenias (hypersplenism) in patients with nonalcoholic chronic liver disease. Am J Gastroenterol 2000;95:2936-9.
3. Giannini EG. Thrombocytopenia in chronic liver disease and pharmacologic treatment options. Aliment Pharmacol Ther 2006;23:1055-65.
4. Peck-Radosavljevic M. Thrombocytopenia in liver disease. Can J Gastroenterol 2000;14:Suppl D:60D-66D.
5. Sallah S, Bobzien W. Bleeding problems in patients with liver disease: ways to manage the many hepatic effects on coagulation. Postgrad Med 1999;106:187-90, 193-5.
6. Afdhal N, McHutchison J, Brown R, et al. Thrombocytopenia associated with chronic liver disease. J Hepatol 2008;48: 1000-7.
7. Trotter JF. Coagulation abnormalities in patients who have liver disease. Clin Liver Dis 2006;10:665-78.
8. Poordad F. Thrombocytopenia in chronic liver disease. Aliment Pharmacol Ther 2007;26:Suppl 1:5-11.
9. Slichter SJ. Evidence-based platelet transfusion guidelines. Hematology Am Soc Hematol Educ Program 2007:172-8.
10. McHutchison JG, Dusheiko G, Shiffman ML, et al. Eltrombopag for thrombocytopenia in patients with cirrhosis associated with hepatitis C. N Engl J Med 2007;357:2227-36.
11. Pugh RN, Murray-Lyon IM, Dawson JL, Pietroni MC, Williams R. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 1973;60:646-9.
12. Kamath PS, Wiesner RH, Malinchoc M, et al. A model to predict survival in patients with end-stage liver disease. Hepatology 2001;33:464-70.
13. Heddle NM, Cook RJ, Webert KE, Sigouin C, Rebulla P. Methodologic issues in the use of bleeding as an outcome in transfusion medicine studies. Transfusion 2003;43:742-52.
14. Giannini EG, Greco A, Marenco S, Andorno E, Valente U, Savarino V. Incidence of bleeding following invasive procedures in patients with thrombocytopenia and advanced liver disease. Clin Gastroenterol Hepatol 2010;8:899-902.
15. Lisman T, Caldwell SH, Burroughs AK, et al. Hemostasis and thrombosis in patients with liver disease: the ups and downs. J Hepatol 2010;53:362-71.
16. Tripodi A, Primignani M, Mannucci PM. Abnormalities of hemostasis and bleeding in chronic liver disease: the paradigm is challenged. Intern Emerg Med 2010;5:7-12.
17. Amitrano L, Guardascione MA, Ames PR. Coagulation abnormalities in cirrhotic patients with portal vein thrombosis. Clin Lab 2007;53:583-9.
18. De Stefano V, Martinelli I. Splanchnic vein thrombosis: clinical presentation, risk factors and treatment. Intern Emerg Med 2010;5:487-94.
19. Kulik LM, Carr BI, Mulcahy MF, et al. Safety and efficacy of 90Y radiotherapy for hepatocellular carcinoma with and without portal vein thrombosis. Hepatology 2008;47:71-81.