Obesity and asthma: Beyond TH2 inflammation

Metabolism: Clinical and Experimental

Volumn 64, Issue 2, 2015, Pages 172-181

  Leiria, Luiz O S ^a   Martins, Milton A ^b   Saad, Mário J A ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Adiponectin; Airway hyperreactivity; Insulin; Leptin

Indexed keywords

ADIPONECTIN; INSULIN; LEPTIN; ADIPOQ PROTEIN, HUMAN;

AIRWAY SMOOTH MUSCLE; ASTHMA; DISEASE CONTROL; DISEASE SEVERITY; HUMAN; INFLAMMATION; NONHUMAN; OBESITY; PATHOPHYSIOLOGY; PHENOTYPE; REVIEW; SMOOTH MUSCLE; TH2 CELL; ADIPOSE TISSUE; AIRWAY RESISTANCE; ANIMAL; BIOLOGICAL MODEL; BLOOD; IMMUNOLOGY; METABOLISM; SECRETION (PROCESS);

ADIPONECTIN; ADIPOSE TISSUE; ADIPOSITY; AIRWAY RESISTANCE; ANIMALS; ASTHMA; HUMANS; LEPTIN; MODELS, BIOLOGICAL; OBESITY; TH2 CELLS;

EID: 84920561939     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2014.10.002     Document Type: Review

References (98)

1. E.S. Ford The epidemiology of obesity and asthma J Allergy Clin Immunol 115 2005 897 909
2. B. Taylor, D. Mannino, C. Brown, D. Crocker, N. Twum-Baah, and F. Holguin Body mass index and asthma severity in the National Asthma Survey Thorax 63 2008 14 20
3. B.M. Popkin Global nutrition dynamics: the world is shifting rapidly toward a diet linked with noncommunicable diseases Am J Clin Nutr 84 2006 289 298
4. M.J. Akerman, C.M. Calacanis, and M.K. Madsen Relationship between asthma severity and obesity J Asthma 41 2004 521 526
5. M. Peters-Golden, A. Swern, S.S. Bird, C.M. Hustad, E. Grant, and J.M. Edelman Influence of body mass index on the response to asthma controller agents Eur Respir J 27 2006 495 503
6. E.R. Sutherland, E.B. Lehman, M. Teodorescu, and M.E. Wechsler National Heart, Lung, and Blood Institute's Asthma Clinical Research Network. Body mass index and phenotype in subjects with mild-to-moderate persistent asthma J Allergy Clin Immunol 123 2009 1328 1334
7. C.A. Camargo Jr., L.P. Boulet, E.R. Sutherland, W.W. Busse, S.W. Yancey, and A.H. Emmett Body mass index and response to asthma therapy: fluticasone propionate/salmeterol versus montelukast J Asthma 47 2010 76 82
8. E.D. Telenga, S.W. Tideman, H.A. Kerstjens, N.H. Hacken, W. Timens, and D.S. Postma Obesity in asthma: more neutrophilic inflammation as a possible explanation for a reduced treatment response Allergy 67 2012 1060 1068
9. R.M. Locksley Asthma and allergic inflammation Cell 140 2010 777 783
10. S.E. Wenzel Asthma phenotypes: the evolution from clinical to molecular approaches Nat Med 18 2012 716 725
11. G.G. King, N.J. Brown, C. Diba, C.W. Thorpe, P. Muñoz, and G.B. Marks The effects of body weight on airway calibre Eur Respir J 25 2005 896 901
12. D.G. Chapman, N. Berend, G.G. King, and C.M. Salome Increased airway closure is a determinant of airway hyperresponsiveness Eur Respir J 32 2008 1563 1569
13. C.S. Farah, J.A. Kermode, S.R. Downie, N.J. Brown, K.M. Hardaker, and N. Berend Obesity is a determinant of asthma control independent of inflammation and lung mechanics Chest 140 2011 659 666
14. A. Lessard, H. Turcotte, Y. Cormier, and L.P. Boulet Obesity and asthma: a specific phenotype? Chest 134 2008 317 323
15. D.C. Todd, S. Armstrong, L. D'Silva, C.J. Allen, F.E. Hargreave, and K. Parameswaran Effect of obesity on airway inflammation: a cross-sectional analysis of body mass index and sputum cell counts Clin Exp Allergy 37 2007 1049 1054
16. T.J. Sutherland, J.O. Cowan, S. Young, A. Goulding, A.M. Grant, and A. Williamson The association between obesity and asthma: interactions between systemic and airway inflammation Am J Respir Crit Care Med 178 2008 469 475
17. S.A. Shore Obesity and asthma: location, location, location Eur Respir J 41 2013 253 254
18. O. Sideleva, B.T. Suratt, K.E. Black, W.G. Tharp, R.E. Pratley, and P. Forgione Obesity and asthma: an inflammatory disease of adipose tissue not the airway Am J Respir Crit Care Med 186 2012 598 605
19. C.A. Camargo Jr., E.R. Sutherland, W. Bailey, M. Castro, S.W. Yancey, and A.H. Emmett Effect of increased body mass index on asthma risk, impairment and response to asthma controller therapy in African Americans Curr Med Res Opin 26 2010 1629 1635
20. E. Arteaga-Solis, T. Zee, C.W. Emala, C. Vinson, J. Wess, and G. Karsenty Inhibition of leptin regulation of parasympathetic signaling as a cause of extreme body weight-associated asthma Cell Metab 17 2013 35 48
21. H.A. Scott, P.G. Gibson, M.L. Garg, and L.G. Wood Airway inflammation is augmented by obesity and fatty acids in asthma Eur Respir J 38 2011 594 602
22. D. Desai, C. Newby, F.A. Symon, P. Haldar, S. Shah, and S. Gupta Elevated sputum interleukin-5 and submucosal eosinophilia in obese individuals with severe asthma Am J Respir Crit Care Med 188 2013 657 663
23. M.B. Grotta, D.M. Squebola-Cola, A.A. Toro, M.A. Ribeiro, S.B. Mazon, and J.D. Ribeiro Obesity increases eosinophil activity in asthmatic children and adolescents BMC Pulm Med 13 2013 39
24. M.C. Calixto, L. Lintomen, A. Schenka, M.J. Saad, A. Zanesco, and E. Antunes Obesity enhances eosinophilic inflammation in a murine model of allergic asthma Br J Pharmacol 159 2010 617 625
25. N. Mito, C. Kitada, T. Hosoda, and K. Sato Effect of diet-induced obesity on ovalbumin-specific immune response in a murine asthma model Metabolism 51 2002 1241 1246
26. L. Lintomen, M.C. Calixto, A. Schenka, and E. Antunes Allergen-induced bone marrow eosinophilopoiesis and airways eosinophilic inflammation in leptin-deficient ob/ob mice Obesity (Silver Spring) 20 2012 1959 1965
27. C.M. Lloyd, and S. Saglani Eosinophils in the Spotlight: Finding the link between obesity and asthma Nat Med 19 2013 976 977
28. L.P. Boulet Asthma and obesity Clin Exp Allergy 43 2013 8 21
29. P.J. Barnes, and I.M. Adcock Glucocorticoid resistance in inflammatory diseases Lancet 373 2009 1905 1917
30. L.P. Boulet, and E. Franssen Influence of obesity on response to fluticasone with or without salmeterol in moderate asthma Respir Med 101 2007 2240 2247
31. Z. Nie, D.B. Jacoby, and A.D. Fryer Hyperinsulinemia potentiates airway responsiveness to parasympathetic nerve stimulation in obese rats Am J Respir Cell Mol Biol 2014 10.1165/rcmb.2013-0452OC
32. A. Al-Alwan, J.H. Bates, D.G. Chapman, D.A. Kaminsky, M.J. DeSarno, and C.G. Irvin The nonallergic asthma of obesity. A matter of distal lung compliance Am J Respir Crit Care Med 189 2014 1494 1502
33. A.E. Dixon, R.E. Pratley, P.M. Forgione, D.A. Kaminsky, L.A. Whittaker-Leclair, and L.A. Griffes Effects of obesity and bariatric surgery on airway hyperresponsiveness, asthma control, and inflammation J Allergy Clin Immunol 128 2011 508 515
34. P.E. Scherer, S. Williams, M. Fogliano, G. Baldini, and H.F. Lodish A novel serum protein similar to C1q, produced exclusively in adipocytes J Biol Chem 270 1995 26746 26749
35. T. Schraw, Z.V. Wang, N. Halberg, M. Hawkins, and P.E. Scherer Plasma adiponectin complexes have distinct biochemical characteristics Endocrinology 149 5 2008 2270 2282
36. T.S. Tsao, H.E. Murrey, C. Hug, D.H. Lee, and H.F. Lodish Oligomerization state-dependent activation of NF-kappa B signaling pathway by adipocyte complement-related protein of 30 kDa (Acrp30) J Biol Chem 277 2002 29359 29362
37. T. Yamauchi, J. Kamon, Y. Ito, A. Tsuchida, T. Yokomizo, and S. Kita Cloning of adiponectin receptors that mediate antidiabetic metabolic effects Nature 423 2003 762 769
38. A.H. Berg, T.P. Combs, X. Du, M. Brownlee, and P.E. Scherer The adipocyte-secreted protein Acrp30 enhances hepatic insulin action Nat Med 7 2001 947 953
39. U.B. Pajvani, X. Du, T.P. Combs, A.H. Berg, M.W. Rajala, and T. Schulthess Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications for metabolic regulation and bioactivity J Biol Chem 278 2003 9073 9085
40. H. Waki, T. Yamauchi, J. Kamon, Y. Ito, S. Uchida, and S. Kita Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin J Biol Chem 278 2003 40352 40363
41. T. Kadowaki, T. Yamauchi, N. Kubota, K. Hara, K. Ueki, and K. Tobe Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome J Clin Invest 116 2006 1784 1792
42. S. Li, H.J. Shin, E.L. Ding, and R.M. van Dam Adiponectin levels and risk of type 2 diabetes: a systematic review and meta-analysis JAMA 302 2009 179 188
43. U.B. Pajvani, M. Hawkins, T.P. Combs, M.W. Rajala, T. Doebber, and J.P. Berger Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity J Biol Chem 279 2004 12152 12162
44. T. Yamauchi, Y. Nio, T. Maki, M. Kobayashi, T. Takazawa, and M. Iwabu Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions Nat Med 13 2007 332 339
45. A.S. Williams, D.I. Kasahara, N.G. Verbout, A.V. Fedulov, M. Zhu, and H. Si Role of the adiponectin binding protein, T-cadherin(Cdh13), in allergic airways responses in mice PLoS One 7 2012 e41088
46. B.D. Medoff, Y. Okamoto, P. Leyton, M. Weng, B.P. Sandall, and M.J. Raher Adiponectin deficiency increases allergic airway inflammation and pulmonary vascular remodeling Am J Respir Cell Mol Biol 41 2009 397 406
47. D.I. Kasahara, H.Y. Kim, A.S. Williams, N.G. Verbout, J. Tran, and H. Si Pulmonary inflammation induced by subacute ozone is augmented in adiponectin-deficient mice: role of IL-17A J Immunol 188 2012 4558 4567
48. J.V. Fahy, K.W. Kim, J. Liu, and H.A. Boushey Prominent neutrophilic inflammation in sputum from subjects with asthma exacerbation J Allergy Clin Immunol 95 1995 843 852
49. C.L. Ordonez, T.E. Shaughnessy, M.A. Matthay, and J.V. Fahy Increased neutrophil numbers and il-8 levels in airway secretions in acute severe asthma: clinical and biologic significance Am J Respir Crit Care Med 161 2000 1185 1190
50. X.L. Zhu, X.Q. Qin, Y. Xiang, Y.R. Tan, X.P. Qu, and H.J. Liu Adipokine adiponectin is a potential protector to human bronchial epithelial cell for regulating proliferation, wound repair and apoptosis: comparison with leptin and resistin Peptides 40 2013 34 41
51. T. Jartti, L. Saarikoski, L. Jartti, I. Lisinen, A. Jula, and R. Huupponen Obesity, adipokines and asthma Allergy 64 2009 770 777
52. F. Holguin, M. Rojas, L.A. Brown, and A.M. Fitzpatrick Airway and plasma leptin and adiponectin in lean and obese asthmatics and controls J Asthma 48 2011 217 223
53. M. Aydin, C. Koca, D. Ozol, S. Uysal, Z. Yildirim, and H.S. Kavakli Interaction of metabolic syndrome with asthma in postmenopausal women: role of adipokines Inflammation 36 2013 1232 1238
54. A. Sood, C. Qualls, M. Schuyler, B. Thyagarajan, M.W. Steffes, and L.J. Smith Low serum adiponectin predicts future risk for asthma in women Am J Respir Crit Care Med 186 2012 41 47
55. M.W. Schwartz, and D. Porte Jr. Diabetes, obesity, and the brain Science 307 2005 375 379
56. J.K. Elmquist, R. Coppari, N. Balthasar, M. Ichinose, and B.B. Lowell Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis J Comp Neurol 493 2005 63 71
57. L.A. Campfield, F.J. Smith, Y. Guisez, R. Devos, and P. Burn Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks Science 269 1995 546 549
58. L.A. Tartaglia, M. Dembski, X. Weng, N. Deng, J. Culpepper, and R. Devos Identification and expression cloning of a leptin receptor, OB-R Cell 83 1995 1263 1271
59. C.T. Montague, I.S. Farooqi, J.P. Whitehead, M.A. Soos, H. Rau, and N.J. Wareham Congenital leptin deficiency is associated with severe early-onset obesity in humans Nature 387 1997 903 908
60. K. Clément, C. Vaisse, N. Lahlou, S. Cabrol, V. Pelloux, and D. Cassuto A mutation in the humanleptin receptor gene causes obesity and pituitary dysfunction Nature 392 1998 398 401
61. M.G. Myers Jr., and D.P. Olson Central nervous system control of metabolism Nature 491 2012 357 363
62. P.L. Zamorano, V.B. Mahesh, L.M. De Sevilla, L.P. Chorich, G.K. Bhat, and D.W. Brann Expression and localization of the leptin receptor in endocrine and neuroendocrine tissues of the rat Neuroendocrinology 65 1997 223 228
63. H. Fei, H.J. Okano, C. Li, G.H. Lee, C. Zhao, and R. Darnell Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues Proc Natl Acad Sci U S A 94 1997 7001 7005
64. P. Cohen, C. Zhao, X. Cai, J.M. Montez, S.C. Rohani, and P. Feinstein Selective deletion of leptin receptor in neurons leads to obesity J Clin Invest 108 2001 1113 1121
65. C. de Luca, T.J. Kowalski, Y. Zhang, J.K. Elmquist, C. Lee, and M.W. Kilimann Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes J Clin Invest 115 2005 3484 3493
66. B. Li, Z. Shi, P.A. Cassaglia, and V.L. Brooks Leptin acts in the forebrain to differentially influence baroreflex control of lumbar, renal, and splanchnic sympathetic nerve activity and heart rate Hypertension 61 2013 812 819
67. J.P. Després, and I. Lemieux Abdominal obesity and metabolic syndrome Nature 444 2006 881 887
68. M.J. Saad, J.B. Carvalheira, and L.A. Velloso Birth weight and type 2 diabetes in adults JAMA 301 2009 1539
69. D.M. Tsukumo, M.A. Carvalho-Filho, J.B. Carvalheira, P.O. Prada, S.M. Hirabara, and A.A. Schenka Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance Diabetes 56 2007 1986 1998
70. M. Milanski, G. Degasperi, A. Coope, J. Morari, R. Denis, and D.E. Cintra Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity J Neurosci 29 2009 359 370
71. B.H. Thuesen, L.L. Husemoen, L.G. Hersoug, C. Pisinger, and A. Linneberg Insulin resistance as a predictor of incident asthma-like symptoms in adults Clin Exp Allergy 39 2009 700 707
72. M. Arshi, J. Cardinal, R.J. Hill, P.S. Davies, and C. Wainwright Asthma and insulin resistance in children Respirology 15 2010 779 784
73. A. Vikram, G.B. Jena, and P. Ramarao Increased cell proliferation and contractility of prostate in insulin resistant rats: linking hyperinsulinemia with benign prostate hyperplasia Prostate 70 2010 79 89
74. C.R. Carvalho, J.B. Carvalheira, M.H. Lima, S.F. Zimmerman, L.C. Caperuto, and A. Amanso Novel signal transduction pathway for luteinizing hormone and its interaction with insulin: activation of Janus kinase/signal transducer and activator of transcription and phosphoinositol 3-kinase/Akt pathways Endocrinology 144 2003 638 647
75. H.G. Zecchin, F.B. Priviero, C.T. Souza, K.G. Zecchin, P.O. Prada, and J.B. Carvalheira Defective insulin and acetylcholine induction of endothelial cell-nitric oxide synthase through insulin receptor substrate/Akt signaling pathway in aorta of obese rats Diabetes 56 2007 1014 1024
76. C. Contreras, A. Sánchez, P. Martínez, R. Raposo, B. Climent, and A. García-Sacristán Insulin resistance in penile arteries from a rat model of metabolic syndrome Br J Pharmacol 161 2010 350 364
77. L.O. Leiria, C. Sollon, F.R. Báu, F.Z. Mónica, C.L. D'Ancona, and G. De Nucci Insulin relaxes bladder via PI3K/AKT/eNOS pathway activation in mucosa: unfolded protein response-dependent insulin resistance as a cause of obesity-associated overactive bladder J Physiol 591 2013 2259 2273
78. U. Scherrer, D. Randin, P. Vollenweider, L. Vollenweider, and P. Nicod Nitric oxide release accounts for insulin's vascular effects in humans J Clin Invest 94 1994 2511 2515
79. J.H. Lee, and L. Ragolia AKT phosphorylation is essential for insulin-induced relaxation of rat vascular smooth muscle cells Am J Physiol Cell Physiol 291 2006 C1355 C1365
80. S. Dimmeler, I. Fleming, B. Fisslthaler, C. Hermann, R. Busse, and A.M. Zeiher Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation Nature 399 1999 601 605
81. K.E. Belmonte, D.B. Jacoby, and A.D. Fryer Increased function of inhibitory neuronal M2 muscarinic receptors in diabetic rat lungs Br J Pharmacol 121 1997 1287 1294
82. D. Schaafsma, R. Gosens, J.M. Ris, J. Zaagsma, H. Meurs, and S.A. Nelemans Insulin induces airway smooth muscle contraction Br J Pharmacol 150 2007 136 142
83. S.C. Cavalher-Machado, W.T. de Lima, A.S. Damazo, V. de Frias Carvalho, M.A. Martins, and P.M. e Silva Down-regulation of mast cell activation and airway reactivity in diabetic rats: role of insulin Eur Respir J 24 2004 552 558
84. K.E. Belmonte, A.D. Fryer, and R.W. Costello Role of insulin in antigen-induced airway eosinophilia and neuronal M2 muscarinic receptor dysfunction J Appl Physiol 85 1998 1708 1718
85. I.F. Douek, N.J. Leech, H.A. Gillmor, P.J. Bingley, and E.A. Gale Children with type-1 diabetes and their unaffected siblings have fewer symptoms of asthma Lancet 353 1999 1850
86. B.M. Filippi, C.S. Yang, C. Tang, and T.K. Lam Insulin activates Erk1/2 signaling in the dorsal vagal complex to inhibit glucose production Cell Metab 16 2012 500 510
87. P. Kc, and R.J. Martin Role of central neurotransmission and chemoreception on airway control Respir Physiol Neurobiol 173 2010 213 222
88. A.G. Oliveira, T.G. Araujo, B.M. Carvalho, D. Guadagnini, G.Z. Rocha, and R.A. Bagarolli Acute exercise induces a phenotypic switch in adipose tissue macrophage polarization in diet-induced obese rats Obesity (Silver Spring) 21 2013 2545 2556
89. J. Clària, A. González-Périz, C. López-Vicario, B. Rius, and E. Titos New insights into the role of macrophages in adipose tissue inflammation and fatty liver disease: modulation by endogenous omega-3 Fatty Acid-derived lipid mediators Front Immunol 2 2011 49
90. G.S. Hotamisligil, P. Peraldi, A. Budavari, R. Ellis, M.F. White, and B.M. Spiegelman IRS- 1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha-and obesity-induced insulin resistance Science 271 2006 665 668
91. G.S. Hotamisligil Inflammation and metabolic disorders Nature 444 2006 860 867
92. A.S. Williams, L. Chen, D.I. Kasahara, H. Si, A.P. Wurmbrand, and S.A. Shore Obesity and airway responsiveness: role of TNFR2 Pulm Pharmacol Ther 26 2013 444 454
93. N.L. Lugogo, J.W. Hollingsworth, D.L. Howell, L.G. Que, D. Francisco, and T.D. Church Alveolar macrophages from overweight/obese subjects with asthma demonstrate a proinflammatory phenotype Am J Respir Crit Care Med 186 2012 404 411
94. M. Coccia, O.J. Harrison, C. Schiering, M.J. Asquith, B. Becher, and F. Powrie IL-1beta mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4(1) Th17 cells J Exp Med 209 2012 1595 1609
95. M. Kudo, A.C. Melton, C. Chen, M.B. Engler, K.E. Huang, and X. Ren IL-17A produced by alphabeta T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction Nat Med 18 2012 547 554
96. H.Y. Kim, H.J. Lee, Y.J. Chang, M. Pichavant, S.A. Shore, and K.A. Fitzgerald Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity Nat Med 20 2014 54 61
97. D.I. Kasahara, H.Y. Kim, J.A. Mathews, N.G. Verbout, A.S. Williams, and A.P. Wurmbrand Pivotal role of IL-6 in the hyperinflammatory responses to subacute ozone in adiponectin deficient mice Am J Physiol Lung Cell Mol Physiol 306 2014 L508 L520
98. M.C. Calixto, L. Lintomen, and D.M. André Metformin attenuates the exacerbation of the allergic eosinophilic inflammation in high fat-diet-induced obesity in mice PLoS One 8 2013 e76786