Insulin relaxes bladder via PI3K/AKT/eNOS pathway activation in mucosa: Unfolded protein response-dependent insulin resistance as a cause of obesity-associated overactive bladder

Journal of Physiology

Volumn 591, Issue 9, 2013, Pages 2259-2273

  Leiria, Luiz O ^a   Sollon, Carolina ^a   Báu, Fernando R ^a   Mónica, Fabíola Z ^a   D'Ancona, Carlos L ^a   De Nucci, Gilberto ^a   Grant, Andrew D ^b   Anhê, Gabriel F ^a   Antunes, Edson ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 PHENYLBUTYRIC ACID; ACTIVATING TRANSCRIPTION FACTOR 4; CYCLIC GMP; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE; PROTEIN KINASE B; TRIBBLE 3 PROTEIN; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER CONTRACTION; BLADDER MUCOSA; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; INSULIN RESISTANCE; LIPID DIET; MALE; MOUSE; NONHUMAN; OBESITY; OVERACTIVE BLADDER; PRIORITY JOURNAL; SMOOTH MUSCLE RELAXATION; UNFOLDED PROTEIN RESPONSE; URINARY FREQUENCY;

ADOLESCENT; ADULT; ANIMALS; DIET, HIGH-FAT; HUMANS; INSULIN; INSULIN RESISTANCE; MALE; MICE; MICE, INBRED C57BL; MIDDLE AGED; MUCOUS MEMBRANE; MUSCLE RELAXATION; NITRIC OXIDE SYNTHASE TYPE III; OBESITY; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; UNFOLDED PROTEIN RESPONSE; URINARY BLADDER; URINARY BLADDER, OVERACTIVE; YOUNG ADULT;

EID: 84877005644     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2013.251843     Document Type: Article

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