메뉴 건너뛰기




Volumn 2, Issue OCT, 2011, Pages

New insights into the role of macrophages in adipose tissue inflammation and fatty liver disease: Modulation by endogenous omega-3 fatty acid-derived lipid mediators

Author keywords

Adipocytes; Docosahexaenoic acid; Kupffer cells; M2 macrophages; Obesity; Resolvins

Indexed keywords


EID: 84867940403     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2011.00049     Document Type: Review
Times cited : (45)

References (79)
  • 1
    • 19644369581 scopus 로고    scopus 로고
    • Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acidinduced colitis
    • Arita, M., Yoshida, M., Hong, S., Tjonahen, E., Glickman, J. N., Petasis, N. A., Blumberg, R. S., and Serhan, C. N. (2005). Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acidinduced colitis. Proc. Natl. Acad. Sci. U.S.A. 102, 7671-7676.
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 7671-7676
    • Arita, M.1    Yoshida, M.2    Hong, S.3    Tjonahen, E.4    Glickman, J.N.5    Petasis, N.A.6    Blumberg, R.S.7    Serhan, C.N.8
  • 2
    • 67349205002 scopus 로고    scopus 로고
    • Kupffer cells in non-alcoholic fatty liver disease: The emerging view
    • Baffy, G. (2009). Kupffer cells in non-alcoholic fatty liver disease: the emerging view. J. Hepatol. 51, 212-223.
    • (2009) J. Hepatol. , vol.51 , pp. 212-223
    • Baffy, G.1
  • 3
    • 77957942833 scopus 로고    scopus 로고
    • Specialized pro-resolving lipid mediators in the inflammatory response: an update
    • Bannenberg, G., and Serhan, C. N. (2010). Specialized pro-resolving lipid mediators in the inflammatory response: an update. Biochim. Biophys. Acta 1801, 1260-1273.
    • (2010) Biochim. Biophys. Acta , vol.1801 , pp. 1260-1273
    • Bannenberg, G.1    Serhan, C.N.2
  • 4
    • 67649306416 scopus 로고    scopus 로고
    • PPAR gamma is highly expressed in F4/80(hi) adipose tissue macrophages and dampens adipose-tissue inflammation
    • Bassaganya-Riera, J., Misyak, S., Guri, A. J., and Hontecillas, R. (2009). PPAR gamma is highly expressed in F4/80(hi) adipose tissue macrophages and dampens adipose-tissue inflammation. Cell. Immunol. 258, 138-146.
    • (2009) Cell. Immunol. , vol.258 , pp. 138-146
    • Bassaganya-Riera, J.1    Misyak, S.2    Guri, A.J.3    Hontecillas, R.4
  • 6
    • 33750999322 scopus 로고    scopus 로고
    • Role of Kupffer cells in host defense and liver disease
    • Bilzer, M., Roggel, F., and Gerbes, A. L. (2006). Role of Kupffer cells in host defense and liver disease. Liver Int. 26, 1175-1186.
    • (2006) Liver Int , vol.26 , pp. 1175-1186
    • Bilzer, M.1    Roggel, F.2    Gerbes, A.L.3
  • 8
    • 34147108829 scopus 로고    scopus 로고
    • N-3 fatty acids in the treatment of diabetic patients: biological rationale and clinical data
    • De Caterina, R., Madonna, R., Bertolotto, A., and Schmidt, E. B. (2007). n-3 fatty acids in the treatment of diabetic patients: biological rationale and clinical data. Diabetes Care 30, 1012-1026.
    • (2007) Diabetes Care , vol.30 , pp. 1012-1026
    • De Caterina, R.1    Madonna, R.2    Bertolotto, A.3    Schmidt, E.B.4
  • 9
    • 0025051058 scopus 로고
    • Biologically active products of stimulated liver macrophages (Kupffer cells)
    • Decker, K. (1990). Biologically active products of stimulated liver macrophages (Kupffer cells). Eur. J. Biochem. 192, 245-261.
    • (1990) Eur. J. Biochem. , vol.192 , pp. 245-261
    • Decker, K.1
  • 10
    • 0032700843 scopus 로고    scopus 로고
    • Increased monocyte MCP-1 production in acute alcoholic hepatitis
    • Devalaraja, M. N., Mcclain, C. J., Barve, S., Vaddi, K., and Hill, D. B. (1999). Increased monocyte MCP-1 production in acute alcoholic hepatitis. Cytokine 11, 875-881.
    • (1999) Cytokine , vol.11 , pp. 875-881
    • Devalaraja, M.N.1    Mcclain, C.J.2    Barve, S.3    Vaddi, K.4    Hill, D.B.5
  • 11
    • 77950355734 scopus 로고    scopus 로고
    • Antiinflammatory agents: present and future
    • Dinarello, C. A. (2010). Antiinflammatory agents: present and future. Cell 140, 935-950.
    • (2010) Cell , vol.140 , pp. 935-950
    • Dinarello, C.A.1
  • 13
    • 50949126869 scopus 로고    scopus 로고
    • Resolvin E1, an EPA-derived mediator in whole blood, selectively counterregulates leukocytes and platelets
    • Dona, M., Fredman, G., Schwab, J. M., Chiang, N., Arita, M., Goodarzi, A., Cheng, G., von Andrian, U. H., and Serhan, C. N. (2008). Resolvin E1, an EPA-derived mediator in whole blood, selectively counterregulates leukocytes and platelets. Blood 112, 848-855.
    • (2008) Blood , vol.112 , pp. 848-855
    • Dona, M.1    Fredman, G.2    Schwab, J.M.3    Chiang, N.4    Arita, M.5    Goodarzi, A.6    Cheng, G.7    von Andrian, U.H.8    Serhan, C.N.9
  • 14
    • 77954693077 scopus 로고    scopus 로고
    • Murine Kupffer cells are protective in total hepatic ischemia/reperfusion injury with bowel congestion through IL-10
    • Ellett, J. D., Atkinson, C., Evans, Z. P., Amani, Z., Balish, E., Schmidt, M. G., van, Rooijen N., Schnellmann, R. G., and Chavin, K. D. (2010). Murine Kupffer cells are protective in total hepatic ischemia/reperfusion injury with bowel congestion through IL-10. J. Immunol. 184, 5849-5858.
    • (2010) J. Immunol. , vol.184 , pp. 5849-5858
    • Ellett, J.D.1    Atkinson, C.2    Evans, Z.P.3    Amani, Z.4    Balish, E.5    Schmidt, M.G.6    van, R.N.7    Schnellmann, R.G.8    Chavin, K.D.9
  • 16
    • 34548639473 scopus 로고    scopus 로고
    • Obesityinduced inflammation: a metabolic dialogue in the language of inflammation
    • Ferrante, A. W. Jr. (2007). Obesityinduced inflammation: a metabolic dialogue in the language of inflammation. J. Intern. Med. 262, 408-414.
    • (2007) J. Intern. Med. , vol.262 , pp. 408-414
    • Ferrante Jr., A.W.1
  • 19
    • 0037265240 scopus 로고    scopus 로고
    • Alternative activation of macrophages
    • Gordon, S. (2003). Alternative activation of macrophages. Nat. Rev. Immunol. 3, 23-35.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 23-35
    • Gordon, S.1
  • 20
    • 28544446111 scopus 로고    scopus 로고
    • Monocyte and macrophage heterogeneity
    • Gordon, S., and Taylor, P. R. (2005). Monocyte and macrophage heterogeneity. Nat. Rev. Immunol. 5, 953-964.
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 953-964
    • Gordon, S.1    Taylor, P.R.2
  • 21
    • 17644394983 scopus 로고    scopus 로고
    • A role for the mouse 12/15-lipoxygenase pathway in promoting epithelial wound healing and host defense
    • Gronert, K., Maheshwari, N., Khan, N., Hassan, I. R., Dunn, M., and Laniado, S. M. (2005). A role for the mouse 12/15-lipoxygenase pathway in promoting epithelial wound healing and host defense. J. Biol. Chem. 280, 15267-15278.
    • (2005) J. Biol. Chem. , vol.280 , pp. 15267-15278
    • Gronert, K.1    Maheshwari, N.2    Khan, N.3    Hassan, I.R.4    Dunn, M.5    Laniado, S.M.6
  • 22
    • 44449173556 scopus 로고    scopus 로고
    • Candida albicans modulates host defense by biosynthesizing the pro-resolving mediator resolvin E1
    • doi:10.1371/journal.pone.0001316
    • Haas-Stapleton, E. J., Lu, Y., Hong, S., Arita, M., Favoreto, S., Nigam, S., Serhan, C. N., and Agabian, N. (2007). Candida albicans modulates host defense by biosynthesizing the pro-resolving mediator resolvin E1. PLoS ONE 2, e1316. doi:10.1371/journal.pone.0001316
    • (2007) PLoS ONE , vol.2
    • Haas-Stapleton, E.J.1    Lu, Y.2    Hong, S.3    Arita, M.4    Favoreto, S.5    Nigam, S.6    Serhan, C.N.7    Agabian, N.8
  • 23
    • 47849086917 scopus 로고    scopus 로고
    • Resolvin E1 regulates interleukin 23, interferon-gamma and lipoxin A4 to promote the resolution of allergic airway inflammation
    • Haworth, O., Cernadas, M., Yang, R., Serhan, C. N., and Levy, B. D. (2008). Resolvin E1 regulates interleukin 23, interferon-gamma and lipoxin A4 to promote the resolution of allergic airway inflammation. Nat. Immunol. 9, 873-879.
    • (2008) Nat. Immunol. , vol.9 , pp. 873-879
    • Haworth, O.1    Cernadas, M.2    Yang, R.3    Serhan, C.N.4    Levy, B.D.5
  • 24
    • 79960187627 scopus 로고    scopus 로고
    • Resolvin D1 decreases adipose tissue macrophage accumulation and improves insulin sensitivity in obese-diabetic mice
    • Hellmann, J., Tang, Y., Kosuri, M., Bhatnagar, A., and Spite, M. (2011). Resolvin D1 decreases adipose tissue macrophage accumulation and improves insulin sensitivity in obese-diabetic mice. FASEB J. 25, 2399-2407.
    • (2011) FASEB J , vol.25 , pp. 2399-2407
    • Hellmann, J.1    Tang, Y.2    Kosuri, M.3    Bhatnagar, A.4    Spite, M.5
  • 25
    • 0038013967 scopus 로고    scopus 로고
    • Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells, Autacoids in antiinflammation
    • Hong, S., Gronert, K., Devchand, P. R., Moussignac, R. L., and Serhan, C. N. (2003). Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in antiinflammation. J. Biol. Chem. 278, 14677-14687.
    • (2003) J. Biol. Chem. , vol.278 , pp. 14677-14687
    • Hong, S.1    Gronert, K.2    Devchand, P.R.3    Moussignac, R.L.4    Serhan, C.N.5
  • 27
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • Hotamisligil, G. S. (2006). Inflammation and metabolic disorders. Nature 444, 860-867.
    • (2006) Nature , vol.444 , pp. 860-867
    • Hotamisligil, G.S.1
  • 28
    • 0030061922 scopus 로고    scopus 로고
    • IRS1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alphaand obesity-induced insulin resistance
    • Hotamisligil, G. S., Peraldi, P., Budavari, A., Ellis, R., White, M. F., and Spiegelman, B. M. (1996). IRS1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alphaand obesity-induced insulin resistance. Science 271, 665-668.
    • (1996) Science , vol.271 , pp. 665-668
    • Hotamisligil, G.S.1    Peraldi, P.2    Budavari, A.3    Ellis, R.4    White, M.F.5    Spiegelman, B.M.6
  • 29
    • 33751436631 scopus 로고    scopus 로고
    • Fat uses a TOLLroad to connect inflammation and diabetes
    • Kim, J. K. (2006). Fat uses a TOLLroad to connect inflammation and diabetes. Cell Metab. 4, 417-419.
    • (2006) Cell Metab , vol.4 , pp. 417-419
    • Kim, J.K.1
  • 32
    • 0036787682 scopus 로고    scopus 로고
    • Imbalanced intrahepatic expression of interleukin 12, interferon gamma, and interleukin 10 in fulminant hepatitis B
    • Leifeld, L., Cheng, S., Ramakers, J., Dumoulin, F. L., Trautwein, C., Sauerbruch, T., and Spengler, U. (2002). Imbalanced intrahepatic expression of interleukin 12, interferon gamma, and interleukin 10 in fulminant hepatitis B. Hepatology 36, 1001-1008.
    • (2002) Hepatology , vol.36 , pp. 1001-1008
    • Leifeld, L.1    Cheng, S.2    Ramakers, J.3    Dumoulin, F.L.4    Trautwein, C.5    Sauerbruch, T.6    Spengler, U.7
  • 35
    • 1842409036 scopus 로고    scopus 로고
    • Role of oxidative stress and antioxidant therapy in alcoholic and nonalcoholic liver diseases
    • Lieber, C. S. (1997). Role of oxidative stress and antioxidant therapy in alcoholic and nonalcoholic liver diseases. Adv. Pharmacol. 38, 601-628.
    • (1997) Adv. Pharmacol. , vol.38 , pp. 601-628
    • Lieber, C.S.1
  • 36
    • 33846026712 scopus 로고    scopus 로고
    • Obesity induces a phenotypic switch in adipose tissue macrophage polarization
    • Lumeng, C. N., Bodzin, J. L., and Saltiel, A. R. (2007). Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J. Clin. Invest. 117, 175-184.
    • (2007) J. Clin. Invest. , vol.117 , pp. 175-184
    • Lumeng, C.N.1    Bodzin, J.L.2    Saltiel, A.R.3
  • 37
    • 79957920754 scopus 로고    scopus 로고
    • Inflammatory links between obesity and metabolic disease
    • Lumeng, C. N., and Saltiel, A. R. (2011). Inflammatory links between obesity and metabolic disease. J. Clin. Invest. 121, 2111-2117.
    • (2011) J. Clin. Invest. , vol.121 , pp. 2111-2117
    • Lumeng, C.N.1    Saltiel, A.R.2
  • 38
    • 33846352854 scopus 로고    scopus 로고
    • New vistas on macrophage differentiation and activation
    • Mantovani, A., Sica, A., and Locati, M. (2007). New vistas on macrophage differentiation and activation. Eur. J. Immunol. 37, 14-16.
    • (2007) Eur. J. Immunol. , vol.37 , pp. 14-16
    • Mantovani, A.1    Sica, A.2    Locati, M.3
  • 39
    • 67650485985 scopus 로고    scopus 로고
    • Alternative activation of macrophages: an immunologic functional perspective
    • Martínez, F. O., Helming, L., and Gordon, S. (2009). Alternative activation of macrophages: an immunologic functional perspective. Annu. Rev. Immunol. 27, 451-483.
    • (2009) Annu. Rev. Immunol. , vol.27 , pp. 451-483
    • Martínez, F.O.1    Helming, L.2    Gordon, S.3
  • 42
    • 56749174940 scopus 로고    scopus 로고
    • Exploring the full spectrum of macrophage activation
    • Mosser, D. M., and Edwards, J. P. (2008). Exploring the full spectrum of macrophage activation. Nat. Rev. Immunol. 8, 958-969.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 958-969
    • Mosser, D.M.1    Edwards, J.P.2
  • 43
    • 73349136974 scopus 로고    scopus 로고
    • Role of free radicals in liver diseases
    • Muriel, P. (2009). Role of free radicals in liver diseases. Hepatol. Int. 3, 526-536.
    • (2009) Hepatol. Int. , vol.3 , pp. 526-536
    • Muriel, P.1
  • 44
    • 14744280322 scopus 로고    scopus 로고
    • N3 Long-chain polyunsaturated fatty acids in type 2 diabetes: A review
    • Nettleton, J. A., and Katz, R. (2005). n3 Long-chain polyunsaturated fatty acids in type 2 diabetes: a review. J. Am. Diet. Assoc. 105, 428-440.
    • (2005) J. Am. Diet. Assoc. , vol.105 , pp. 428-440
    • Nettleton, J.A.1    Katz, R.2
  • 46
    • 36849005372 scopus 로고    scopus 로고
    • A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNKdependent pathways
    • Nguyen, M. T., Favelyukis, S., Nguyen, A. K., Reichart, D., Scott, P. A., Jenn, A., Liu-Bryan, R., Glass, C. K., Neels, J. G., and Olefsky, J. M. (2007). A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNKdependent pathways. J. Biol. Chem. 282, 35279-35292.
    • (2007) J. Biol. Chem. , vol.282 , pp. 35279-35292
    • Nguyen, M.T.1    Favelyukis, S.2    Nguyen, A.K.3    Reichart, D.4    Scott, P.A.5    Jenn, A.6    Liu-Bryan, R.7    Glass, C.K.8    Neels, J.G.9    Olefsky, J.M.10
  • 48
    • 77956165390 scopus 로고    scopus 로고
    • GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects
    • Oh, D. Y., Talukdar, S., Bae, E. J., Imamura, T., Morinaga, H., Fan, W., Li, P., Lu, W. J., Watkins, S. M., and Olefsky, J. M. (2010). GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell 142, 687-698.
    • (2010) Cell , vol.142 , pp. 687-698
    • Oh, D.Y.1    Talukdar, S.2    Bae, E.J.3    Imamura, T.4    Morinaga, H.5    Fan, W.6    Li, P.7    Lu, W.J.8    Watkins, S.M.9    Olefsky, J.M.10
  • 49
    • 77951918926 scopus 로고    scopus 로고
    • Macrophages, inflammation, and insulin resistance
    • Olefsky, J. M., and Glass, C. K. (2010). Macrophages, inflammation, and insulin resistance. Annu.Rev.Physiol. 72, 219-246.
    • (2010) Annu. Rev. Physiol. , vol.72 , pp. 219-246
    • Olefsky, J.M.1    Glass, C.K.2
  • 51
    • 52749092267 scopus 로고    scopus 로고
    • Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals
    • Patsouris, D., Li, P. P., Thapar, D., Chapman, J., Olefsky, J. M., and Neels, J. G. (2008). Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell Metab. 8, 301-309.
    • (2008) Cell Metab , vol.8 , pp. 301-309
    • Patsouris, D.1    Li, P.P.2    Thapar, D.3    Chapman, J.4    Olefsky, J.M.5    Neels, J.G.6
  • 52
    • 4243344912 scopus 로고    scopus 로고
    • PDGF and signal transduction in hepatic stellate cells
    • Pinzani, M. (2002). PDGF and signal transduction in hepatic stellate cells. Front. Biosci. 7, 1720.
    • (2002) Front. Biosci. , vol.7 , pp. 1720
    • Pinzani, M.1
  • 53
    • 21744459082 scopus 로고    scopus 로고
    • The selective cyclooxygenase-2 inhibitor SC-236 reduces liver fibrosis by mechanisms involving non-parenchymal cell apoptosis and PPARgamma activation
    • Planagumà, A., Clària, J., Miquel, R., López-Parra, M., Titos, E., Masferrer, J. L., Arroyo, V., and Rodés, J. (2005). The selective cyclooxygenase-2 inhibitor SC-236 reduces liver fibrosis by mechanisms involving non-parenchymal cell apoptosis and PPARgamma activation. FASEB J. 19, 1120-1122.
    • (2005) FASEB J , vol.19 , pp. 1120-1122
    • Planagumà, A.1    Clària, J.2    Miquel, R.3    López-Parra, M.4    Titos, E.5    Masferrer, J.L.6    Arroyo, V.7    Rodés, J.8
  • 54
    • 0027220182 scopus 로고
    • Liver cytoprotection by prostaglandins
    • Quiroga, J., and Prieto, J. (1993). Liver cytoprotection by prostaglandins. Pharmacol. Ther. 58, 67-91.
    • (1993) Pharmacol. Ther. , vol.58 , pp. 67-91
    • Quiroga, J.1    Prieto, J.2
  • 56
    • 51349126118 scopus 로고    scopus 로고
    • Physiology and pathophysiology of liver inflammation, damage and repair
    • Ramadori, G., Moriconi, F., Malik, I., and Dudas, J. (2008). Physiology and pathophysiology of liver inflammation, damage and repair. J. Physiol. Pharmacol. 59(Suppl. 1), 107-117.
    • (2008) J. Physiol. Pharmacol. , vol.59 , Issue.SUPPL. 1 , pp. 107-117
    • Ramadori, G.1    Moriconi, F.2    Malik, I.3    Dudas, J.4
  • 57
    • 20444473800 scopus 로고    scopus 로고
    • Mechanisms of disease: pathogenesis of nonalcoholic fatty liver disease
    • Sanyal, A. J. (2005). Mechanisms of disease: pathogenesis of nonalcoholic fatty liver disease. Nat. Clin. Pract. Gastroenterol. Hepatol. 2, 46-53.
    • (2005) Nat. Clin. Pract. Gastroenterol. Hepatol. , vol.2 , pp. 46-53
    • Sanyal, A.J.1
  • 58
    • 78851471818 scopus 로고    scopus 로고
    • Saturated-efferocytosis generates pro-resolving CD11b low macrophages: modulation by resolvins and glucocorticoids
    • Schif-Zuck, S., Gross, N., Assi, S., Rostoker, R., Serhan, C. N., and Ariel, A. (2011). Saturated-efferocytosis generates pro-resolving CD11b low macrophages: modulation by resolvins and glucocorticoids. Eur. J. Immunol. 41, 366-379.
    • (2011) Eur. J. Immunol. , vol.41 , pp. 366-379
    • Schif-Zuck, S.1    Gross, N.2    Assi, S.3    Rostoker, R.4    Serhan, C.N.5    Ariel, A.6
  • 59
    • 34250357688 scopus 로고    scopus 로고
    • Resolvin E1 and protectin D1 activate inflammation-resolution programmes
    • Schwab, J. M., Chiang, N., Arita, M., and Serhan, C. N. (2007). Resolvin E1 and protectin D1 activate inflammation-resolution programmes. Nature 447, 869-874.
    • (2007) Nature , vol.447 , pp. 869-874
    • Schwab, J.M.1    Chiang, N.2    Arita, M.3    Serhan, C.N.4
  • 60
    • 12144266586 scopus 로고    scopus 로고
    • Transcriptional profiling reveals complex regulation of the monocyte IL-1 beta system by IL-13
    • Scotton, C. J., Martinez, F. O., Smelt, M. J., Sironi, M., Locati, M., Mantovani, A., and Sozzani, S. (2005). Transcriptional profiling reveals complex regulation of the monocyte IL-1 beta system by IL-13. J. Immunol. 174, 834-845.
    • (2005) J. Immunol. , vol.174 , pp. 834-845
    • Scotton, C.J.1    Martinez, F.O.2    Smelt, M.J.3    Sironi, M.4    Locati, M.5    Mantovani, A.6    Sozzani, S.7
  • 61
    • 79955663260 scopus 로고    scopus 로고
    • The resolution of inflammation: the devil in the flask and in the details
    • Serhan, C. N. (2011). The resolution of inflammation: the devil in the flask and in the details. FASEB J. 25, 1441-1448.
    • (2011) FASEB J , vol.25 , pp. 1441-1448
    • Serhan, C.N.1
  • 63
    • 42649089790 scopus 로고    scopus 로고
    • Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators
    • Serhan, C. N., Chiang, N., and Van Dyke, T. E. (2008). Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators. Nat. Rev. Immunol. 8, 349-361.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 349-361
    • Serhan, C.N.1    Chiang, N.2    Van Dyke, T.E.3
  • 64
    • 0034675852 scopus 로고    scopus 로고
    • Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing
    • Serhan, C. N., Clish, C. B., Brannon, J., Colgan, S. P., Chiang, N., and Gronert, K. (2000). Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing. J. Exp. Med. 192, 1197-1204.
    • (2000) J. Exp. Med. , vol.192 , pp. 1197-1204
    • Serhan, C.N.1    Clish, C.B.2    Brannon, J.3    Colgan, S.P.4    Chiang, N.5    Gronert, K.6
  • 65
    • 0037152160 scopus 로고    scopus 로고
    • Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals
    • Serhan, C. N., Hong, S., Gronert, K., Colgan, S. P., Devchand, P. R., Mirick,G.,and Moussignac,R. L. (2002). Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals. J. Exp. Med. 196, 1025-1037.
    • (2002) J. Exp. Med. , vol.196 , pp. 1025-1037
    • Serhan, C.N.1    Hong, S.2    Gronert, K.3    Colgan, S.P.4    Devchand, P.R.5    Mirick, G.6    Moussignac, R.L.7
  • 66
    • 79451476075 scopus 로고    scopus 로고
    • The therapeutic potential of long-chain omega-3 fatty acids in nonalcoholic fatty liver disease
    • Shapiro, H., Tehilla, M., Attal-Singer, J., Bruck, R., Luzzatti, R., and Singer, P. (2011). The therapeutic potential of long-chain omega-3 fatty acids in nonalcoholic fatty liver disease. Clin. Nutr. 30, 6-19.
    • (2011) Clin. Nutr. , vol.30 , pp. 6-19
    • Shapiro, H.1    Tehilla, M.2    Attal-Singer, J.3    Bruck, R.4    Luzzatti, R.5    Singer, P.6
  • 67
    • 33745861300 scopus 로고    scopus 로고
    • Inflammation and insulin resistance
    • Shoelson, S. E., Lee, J., and Goldfine, A. B. (2006). Inflammation and insulin resistance. J. Clin. Invest. 116, 1793-1801.
    • (2006) J. Clin. Invest. , vol.116 , pp. 1793-1801
    • Shoelson, S.E.1    Lee, J.2    Goldfine, A.B.3
  • 69
    • 72949116358 scopus 로고    scopus 로고
    • Macrophage death and defective inflammation resolution in atherosclerosis
    • Tabas, I. (2010). Macrophage death and defective inflammation resolution in atherosclerosis. Nat. Rev. Immunol. 10, 36-46.
    • (2010) Nat. Rev. Immunol. , vol.10 , pp. 36-46
    • Tabas, I.1
  • 70
    • 1542410321 scopus 로고    scopus 로고
    • Interleukin 18 causes hepatic ischemia/reperfusion injury by suppressing anti-inflammatory cytokine expression in mice
    • Takeuchi, D., Yoshidome, H., Kato, A., Ito, H., Kimura, F., Shimizu, H., Ohtsuka, M., Morita, Y., and Miyazaki, M. (2004). Interleukin 18 causes hepatic ischemia/reperfusion injury by suppressing anti-inflammatory cytokine expression in mice. Hepatology 39, 699-710.
    • (2004) Hepatology , vol.39 , pp. 699-710
    • Takeuchi, D.1    Yoshidome, H.2    Kato, A.3    Ito, H.4    Kimura, F.5    Shimizu, H.6    Ohtsuka, M.7    Morita, Y.8    Miyazaki, M.9
  • 71
    • 5044232017 scopus 로고    scopus 로고
    • Liver regeneration: from myth to mechanism
    • Taub, R. (2004). Liver regeneration: from myth to mechanism. Nat. Rev. Mol. Cell Biol. 5, 836-847.
    • (2004) Nat. Rev. Mol. Cell Biol. , vol.5 , pp. 836-847
    • Taub, R.1
  • 72
    • 55649103668 scopus 로고    scopus 로고
    • Insulin resistance, inflammation, and non-alcoholic fatty liver disease
    • Tilg, H., and Moschen, A. R. (2008). Insulin resistance, inflammation, and non-alcoholic fatty liver disease. Trends Endocrinol. Metab. 19, 371-379.
    • (2008) Trends Endocrinol. Metab. , vol.19 , pp. 371-379
    • Tilg, H.1    Moschen, A.R.2
  • 76
    • 81455131791 scopus 로고    scopus 로고
    • Resolvin D1 and its precursor docosahexaenoic acid promote resolution of adipose tissue inflammation by eliciting macrophage polarization toward an M2-like phenotype
    • In press
    • Titos, E., Rius, B., González-Périz, A., López-Vicario, C., Morán-Salvador, E., Martínez-Clemente, M., Arroyo, V., and Clària, J. (2011). Resolvin D1 and its precursor docosahexaenoic acid promote resolution of adipose tissue inflammation by eliciting macrophage polarization toward an M2-like phenotype. J. Immunol. (in press).
    • (2011) J. Immunol.
    • Titos, E.1    Rius, B.2    González-Périz, A.3    López-Vicario, C.4    Morán-Salvador, E.5    Martínez-Clemente, M.6    Arroyo, V.7    Clària, J.8
  • 78
    • 0347985272 scopus 로고    scopus 로고
    • Obesity-induced inflammatory changes in adipose tissue
    • Wellen, K. E., and Hotamisligil, G. S. (2003). Obesity-induced inflammatory changes in adipose tissue. J. Clin. Invest. 112, 1785-1788.
    • (2003) J. Clin. Invest. , vol.112 , pp. 1785-1788
    • Wellen, K.E.1    Hotamisligil, G.S.2
  • 79
    • 77954961992 scopus 로고    scopus 로고
    • Macrophages: master regulators of inflammation and fibrosis
    • Wynn, T. A., and Barron, L. (2010). Macrophages: master regulators of inflammation and fibrosis. Semin. Liver Dis. 30, 245-257.
    • (2010) Semin. Liver Dis. , vol.30 , pp. 245-257
    • Wynn, T.A.1    Barron, L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.