Obesity enhances eosinophilic inflammation in a murine model of allergic asthma

British Journal of Pharmacology

Volumn 159, Issue 3, 2010, Pages 617-625

  Calixto, M C ^a   Lintomen, L ^a   Schenka, A ^a   Saad, M J ^a   Zanesco, A ^b   Antunes, E ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Asthma; Bone marrow; Eosinophil; Eotaxin; Obesity; T H2 cytokines

Indexed keywords

ADIPONECTIN; CHEMOKINE; EOTAXIN; GLUCOSE; INTERLEUKIN 10; INTERLEUKIN 5; LEPTIN; LIPID; OVALBUMIN; TUMOR NECROSIS FACTOR ALPHA;

AIRWAY; ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BONE MARROW; BRONCHUS; C57BL 6 MOUSE; CELL COUNT; CELL MIGRATION; COMPARATIVE STUDY; CONNECTIVE TISSUE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EOSINOPHIL; EPIDIDYMIS FAT; FEEDING; GLUCOSE INTOLERANCE; HORMONE BLOOD LEVEL; LIPID DIET; LUNG LAVAGE; LUNG PARENCHYMA; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM;

ANIMALS; ASTHMA; BONE MARROW; BRONCHI; BRONCHOALVEOLAR LAVAGE FLUID; CHEMOKINE CCL11; CYTOKINES; EOSINOPHILIA; EOSINOPHILS; HYPERSENSITIVITY; INFLAMMATION; INTERLEUKIN-10; INTERLEUKIN-5; LUNG; LUNG DISEASES; MALE; MICE; MICE, INBRED C57BL; OBESITY; OVALBUMIN; PNEUMONIA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 76449095106     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00560.x     Document Type: Article

References (53)

1. Akerman MJ, Calacanis CM, Madsen MK (2004). Relationship between asthma severity and obesity. J Asthma 41 : 521 526.
2. Brightling C, Berry M, Amrani Y (2008). Targeting TNF-α: a novel therapeutic approach for asthma. J Allergy Clin Immunol 121 : 5 10.
3. Chin JE, Winterrowd GE, Hatfield CA, Brashler JR, Griffin RL, Vonderfecht SL et al. (1998). Involvement of intercellular adhesion molecule-1 in the antigen-induced infiltration of eosinophils and lymphocytes into the airways in a murine model of pulmonary inflammation. Am J Respir Cell Mol Biol 18 : 158 167.
4. Doganci A, Sauer K, Karwot R, Finotto S (2005). Pathological role of IL-6 in the experimental allergic bronchial asthma in mice. Clin Rev Allergy Immunol 28 : 257 270.
5. Esposito K, Pontillo A, Giugliano F, Giugliano G, Marfella R, Nicoletti G et al. (2003). Association of low interleukin-10 levels with the metabolic syndrome in obese women. J Clin Endocrinol Metab 88 : 1055 1058.
6. Fantuzzi G (2005). Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol 115 : 911 919.
7. Galgani J, Ravussin E (2008). Energy metabolism, fuel selection and body weight regulation. Int J Obes (Lond) 32 : S109 S119.
8. Gallou-Kabani C, Vigé A, Gross MS, Rabès JP, Boileau C, Larue-Achagiotis C et al. (2007). C57BL/6J and A/J mice fed a high-fat diet delineate components of metabolic syndrome. Obesity (Silver Spring) 15 : 1996 2005.
9. Gleich GJ, Motojima S, Frigas E, Kephart GM, Fujisawa T, Kravis LP (1987). The eosinophilic leukocyte and the pathology of fatal bronchial asthma: evidence for pathologic heterogeneity. J Allergy Clin Immunol 80 : 412 415.
10. Hogan SP, Rosenberg HF, Moqbel R, Phipps S, Foster PS, Lacy P et al. (2008). Eosinophils: biological properties and role in health and disease. Clin Exp Allergy 38 : 709 750.
11. Ikemoto S, Takahashi M, Tsunoda N, Maruyama K, Itakura H, Ezaki O (1996). High-fat diet-induced hyperglycemia and obesity in mice: differential effects of dietary oils. Metabolism 45 : 1539 1546.
12. Johnston RA, Schwartzman IN, Flynt L, Shore SA (2005). Role of interleukin-6 in murine airway responses to ozone. Am J Physiol Lung Cell Mol Physiol 288 : L390 L397.
13. Johnston RA, Theman TA, Shore SA (2006). Augmented responses to ozone in obese carboxypeptidase E-deficient mice. Am J Physiol Regul Integr Comp Physiol 290 : 126 133.
14. Johnston RA, Zhu M, Rivera-Sanchez YM, Lu FL, Theman TA, Flynt L et al. (2007). Allergic airway responses in obese mice. Am J Respir Crit Care Med 176 : 650 658.
15. Kips JC, Tavernier JH, Joos GF, Peleman RA, Pauwels RA (1993). The potential role of tumour necrosis factor alpha in asthma. Clin Exp Allergy 23 : 247 250.
16. Kroegel C, Virchow JC, Walker C (1993). Asthma. N Engl J Med 328 : 1639 1640.
17. Kung TT, Stelts D, Zurcher JA, Watnick AS, Jones H, Mauser PJ et al. (1994). Mechanisms of allergic pulmonary eosinophilia in the mouse. J Allergy Clin Immunol 94 : 1217 1224.
18. Lamkhioued B, Renzi PM, Abi-Younes S, Garcia-Zepada EA, Allakhverdi Z, Ghaffar O et al. (1997). Increased expression of eotaxin in bronchoalveolar lavage and airways of asthmatics contributes to the chemotaxis of eosinophils to the site of inflammation. J Immunol 159 : 4593 4601.
19. Li J, Saito H, Crawford L, Inman MD, Cyr MM, Denburg JA (2005). Hemopoietic mechanisms in murine allergic upper and lower airways inflammation. Immunology 114 : 386 396.
20. Lilly CM, Nakamura H, Belostotsky OI, Haley KJ, Garcia-Zepeda EA, Luster AD et al. (2001). Eotaxin expression after segmental allergen challenge in subjects with atopic asthma. Am J Respir Crit Care Med 163 : 1669 1675.
21. Lintomen L, Elsas MI, Maximiano ES, de Paula Neto HA, Joseph D, Vargaftig BB et al. (2002). Allergenic sensitization prevents upregulation of haemopoiesis by cyclo-oxygenase inhibitors in mice. Br J Pharmacol 135 : 1315 1323.
22. Lu FL, Johnston RA, Flynt L, Theman TA, Terry RD, Schwartzman IN et al. (2006). Increased pulmonary responses to acute ozone exposure in obese db/db mice. Am J Physiol Lung Cell Mol Physiol 290 : L856 L865.
23. MacEwan DJ (2002). TNF ligands and receptors - a matter of life and death. Br J Pharmacol 135 : 855 875.
24. Medoff BD, Okamoto Y, Leyton P, Weng M, Sandall BP, Raher MJ et al. (2009). Adiponectin-deficiency increases allergic airway inflammation and pulmonary vascular remodeling. Am J Respir Cell Mol Biol 41 : 397 406.
25. Mohle R, Salemi P, Moore MAS, Rafii S (1997). Expression of interleukin-5 by human bone marrow microvascular endothelial cells: implications for the regulation of eosinophilopoiesis in vivo. Br J Haematol 99 : 732 738.
26. Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A (2001). Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 19 : 683 765.
27. Mould AW, Matthaei KI, Young IG, Foster PS (1997). Relationship between interleukin-5 and eotaxin in regulating blood and tissue eosinophilia in mice. J Clin Invest 99 : 1064 1071.
28. Nakae S, Ho LH, Yu M, Monteforte R, Iikura M, Suto H et al. (2007). Mast cell-derived TNF contributes to airway hyperreactivity, inflammation, and TH2 cytokine production in an asthma model in mice. J Allergy Clin Immunol 120 : 48 55.
29. Ouchi N, Kihara S, Funahashi T, Matsuzawa Y, Walsh K (2003). Obesity, adiponectin and vascular inflammatory disease. Curr Opin Lipidol 14 : 561 566.
30. Palframan RT, Collins PD, Severs NJ, Rothery S, Williams TJ, Rankin SM (1998). Mechanisms of acute eosinophil mobilization from the bone marrow stimulated by interleukin 5: the role of specific adhesion molecules and phosphatidylinositol 3-kinase. J Exp Med 188 : 1621 1632.
31. Palmqvist C, Wardlaw AJ, Bradding P (2007). Chemokines and their receptors as potential targets for the treatment of asthma. Br J Pharmacol 151 : 725 736.
32. Pease JE, Williams TJ (2006). The attraction of chemokines as a target for specific anti-inflammatory therapy. Br J Pharmacol 147 : S212 S221.
33. Peters-Golden M, Swern A, Bird SS, Hustad CM, Grant E, Edelman JM (2006). Influence of body mass index on the response to asthma controller agents. Eur Respir J 27 : 495 503.
34. Rivera-Sanchez YM, Johnston RA, Schwartzman IN, Valone J, Silverman ES, Fredberg JJ et al. (2004). Differential effects of ozone on airway and tissue mechanics in obese mice. J Appl Physiol 96 : 2200 2206.
35. Rosenberg HF, Phipps S, Foster PS (2007). Eosinophil trafficking in allergy and asthma. J Allergy Clin Immunol 119 : 1311 1312.
36. Rothenberg ME, Hogan SP (2006). The eosinophil. Annu Rev Immunol 24 : 147 174.
37. Shi H-Z, Humbles A, Gerard C, Jin Z, Weller PF (2000). Lymph node trafficking and antigen presentation by endobronchial eosinophils. J Clin Invest 105 : 945 953.
38. Shore SA (2008). Obesity and asthma: possible mechanisms. J Allergy Clin Immunol 121 : 1087 1093.
39. Shore SA, Johnston RA (2006). Obesity and asthma. Pharmacol Ther 110 : 83 102.
40. Shore SA, Rivera-Sanchez YM, Schwartzman IN, Johnston RA (2003). Responses to ozone are increased in obese mice. J Appl Physiol 95 : 938 945.
41. Shore SA, Schwartzman IN, Mellema MS, Flynt L, Imrich A, Johnston RA (2005). Effect of leptin on allergic airway responses in mice. J Allergy Clin Immunol 115 : 103 109.
42. Surwit RS, Feinglos MN, Rodin J, Sutherland A, Petro AE, Opara EC et al. (1995). Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and A/J mice. Metabolism 44 : 645 651.
43. Tateno H, Nakamura H, Minematsu N, Nakajima T, Takahashi S, Nakamura M et al. (2004). Plasma eotaxin level and severity of asthma treated with corticosteroid. Respir Med 98 : 782 790.
44. Thomson CC, Clark S, Camargo CA Jr. (2003). Body mass index and asthma severity among adults presenting to the emergency department. Chest 124 : 795 802.
45. Tilg H, Moschen AR (2006). Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 6 : 772 783.
46. Tsukumo DM, Carvalho-Filho MA, Carvalheira JB, Prada PO, Hirabara SM, Schenka AA et al. (2007). Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes 56 : 1986 1998.
47. Vasudevan AR, Wu H, Xydakis AM, Jones PH, Smith EO, Sweeney JF et al. (2006). Eotaxin and obesity. J Clin Endocrinol Metab 91 : 256 261.
48. de Vries A, Hazlewood L, Fitch PM, Seckl JR, Foster P, Howie SE (2009). High-fat feeding redirects cytokine responses and decreases allergic airway eosinophilia. Clin Exp Allergy 39 : 731 739.
49. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr. (2003). Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112 : 1796 1808.
50. Weiss ST (2005). Obesity: insight into the origins of asthma. Nat Immunol 6 : 537 539.
51. Wong CK, Zhang JP, Ip WK, Lam CW (2002). Activation of p38 mitogen-activated protein kinase and nuclear factor-kappaB in tumour necrosis factor-induced eotaxin release of human eosinophils. Clin Exp Immunol 128 : 483 489.
52. Wood LJ, Inman MD, Denburg JA, O'Byrne PM (1998). Allergen challenge increases cell traffic between bone marrow and lung. Am J Respir Cell Mol Biol 18 : 759 767.
53. Wood LJ, Sehmi R, Dorman S, Hamid Q, Tulic MK, Watson RM et al. (2002). Allergen-induced increases in bone marrow T lymphocytes and interleukin-5 expression in subjects with asthma. Am J Respir Crit Care Med 166 : 883 889.