Obesity and asthma: A specific phenotype?

Chest

Volumn 134, Issue 2, 2008, Pages 317-323

  Lessard, Andréa ^a   Turcotte, Hélène ^a   Cormier, Yvon ^a   Boulet, Louis Philippe ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

Asthma; Asthma control; Body mass index; Inflammatory markers; Lung function; Obesity; Sputum induction; Symptom perception

Indexed keywords

BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BRONCHODILATING AGENT; C REACTIVE PROTEIN; CORTICOSTEROID; FIBRINOGEN; METHACHOLINE; SALBUTAMOL;

ADULT; ARTICLE; ASTHMA; BLOOD SAMPLING; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; EXPIRATORY RESERVE VOLUME; FEMALE; FUNCTIONAL RESIDUAL CAPACITY; HUMAN; LUNG FUNCTION; MALE; MONOTHERAPY; OBESITY; PHENOTYPE; PRIORITY JOURNAL; PROVOCATION TEST; QUESTIONNAIRE; RATING SCALE; RESIDUAL VOLUME; SPIROMETRY; SPUTUM ANALYSIS; SYMPTOM; TOTAL LUNG CAPACITY; WAIST HIP RATIO;

EID: 49449093739     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.07-2959     Document Type: Article

References (37)

1. Obesity: preventing and managing the global epidemic; report of a WHO consultation. World Health Organ Tech Rep Ser 2000; 894:i-253
2. Shore SA, Johnston RA. Obesity and asthma. Pharmacol Ther 2006; 110:83-102
3. Chen Y, Rennie D, Cormier Y, et al. Sex specificity of asthma associated with objectively measured body mass index and waist circumference: the Humboldt study. Chest 2005; 128:3048-3054
4. Hancox RJ, Milne BJ, Poulton R, et al. Sex differences in the relation between body mass index and asthma and atopy in a birth cohort. Am J Respir Crit Care Med 2005; 171:440-445
5. Boulet LP, Des CA. The link between obesity and asthma: a Canadian perspective. Can Respir J 2007; 14:217-220
6. Parameswaran K, Todd DC, Soth M. Altered respiratory physiology in obesity. Can Respir J 2006; 13:203-210
7. Boulet LP, Turcotte H, Boulet G, et al. Deep inspiration avoidance and airway response to methacholine: influence of body mass index. Can Respir J 2005; 12:371-376
8. Schachter LM, Salome CM, Peat JK, et al. Obesity is a risk for asthma and wheeze but not airway hyperresponsiveness. Thorax 2001; 56:4-8
9. Aaron SD, Fergusson D, Dent R, et al. Effect of weight reduction on respiratory function and airway reactivity in obese women. Chest 2004; 125:2046-2052
10. Bustos P, Amigo H, Oyarzun M, et al. Is there a causal relation between obesity and asthma? Evidence from Chile. Int J Obes (Lond) 2005; 29:804-809
11. Lavoie KL, Bacon SL, Labrecque M, et al. Higher BMI is associated with worse asthma control and quality of life but not asthma severity. Respir Med 2006; 100:648-657
12. Saint-Pierre P, Bourdin A, Chanez P, et al. Are overweight asthmatics more difficult to control? Allergy 2006; 61:79-84
13. Dixon AE, Shade DM, Cohen RI, et al. Effect of obesity on clinical presentation and response to treatment in asthma. J Asthma 2006; 43:553-558
14. Peters-Golden M, Swern A, Bird SS, et al. Influence of body mass index on the response to asthma controller agents. Eur Respir J 2006; 27:495-503
15. Boulet LP, Franssen E. Influence of obesity on response to fluticasone with or without salmeterol in moderate asthma. Respir Med 2007
16. Juniper EF, O'Byrne PM, Guyatt GH, et al. Development and validation of a questionnaire to measure asthma control. Eur Respir J 1999; 14:902-907
17. Miller MR, Hankinson J, Brusasco V, et al. Standardisation of spirometry. Eur Respir J 2005; 26:319-338
18. Knudson RJ, Lebowitz MD, Holberg CJ, et al. Changes in the normal maximal expiratory flow-volume curve with growth and aging. Am Rev Respir Dis 1983; 127:725-734
19. Pin I, Gibson PG, Kolendowicz R, et al. Use of induced sputum cell counts to investigate airway inflammation in asthma. Thorax 1992; 47:25-29
20. Pizzichini E, Pizzichini MM, Efthimiadis A, et al. Indices of airway inflammation in induced sputum: reproducibility and validity of cell and fluid phase measurements. Am J Respir Crit Care Med 1996; 154:308-317
21. Clausen JL. Prediction of normal values in pulmonary function testing. Clin Chest Med 1989; 10:135-143
22. Hargreave FE, Ryan G, Thomson NC, et al. Bronchial responsiveness to histamine or methacholine in asthma: measurement and clinical significance. J Allergy Clin Immunol 1981; 68:347-355
23. Borg E, Kaijser L. A comparison between three rating scales for perceived exertion and two different work tests. Scand J Med Sci Sports 2006; 16:57-69
24. Sin DD, Jones RL, Man SF. Obesity is a risk factor for dyspnea but not for airflow obstruction. Arch Intern Med 2002; 162:1477-1481
25. Cotes JE, Chinn DJ, Reed JW. Body mass, fat percentage, and fat free mass as reference variables for lung function: effects on terms for age and sex. Thorax 2001; 56:839-844
26. Biring MS, Lewis MI, Liu JT, et al. Pulmonary physiologic changes of morbid obesity. Am J Med Sci 1999; 318:293-297
27. Bedell GN, Wilson WR, Seebohm PM. Pulmonary function in obese persons. J Clin Invest 1958; 37:1049-1060
28. Ulger Z, Demir E, Tanac R, et al. The effect of childhood obesity on respiratory function tests and airway hyperresponsiveness. Turk J Pediatr 2006; 48:43-50
29. Ghabashi AE, Iqbal M. Obesity and its correlation with spirometric variables in patients with asthma. MedGenMed 2006; 8:58
30. Lin WY, Yao CA, Wang HC, et al. Impaired lung function is associated with obesity and metabolic syndrome in adults. Obesity (Silver Spring) 2006; 14:1654-1661
31. Tantisira KG, Litonjua AA, Weiss ST, et al. Association of body mass with pulmonary function in the Childhood Asthma Management Program (CAMP). Thorax 2003;58:1036-1041
32. Ding DJ, Martin JG, Macklem PT. Effects of lung volume on maximal methacholine-induced bronchoconstriction in normal humans. J Appl Physiol 1987; 62:1324-1330
33. Watt AP, Schock BC, Ennis M. Neutrophils and eosinophils: clinical implications of their appearance, presence and disappearance in asthma and COPD. Curr Drug Targets Inflamm Allergy 2005; 4:415-423
34. Todd DC, Armstrong S, D'Silva L, et al. Effect of obesity on airway inflammation: a cross-sectional analysis of body mass index and sputum cell counts. Clin Exp Allergy 2007; 37:1049-1054
35. Festa A, D'Agostino R Jr, Williams K, et al. The relation of body fat mass and distribution to markers of chronic inflammation. Int J Obes Relat Metab Disord 2001; 25:1407-1415
36. Zoico E, Di FV, Mazzali G, et al. Adipocytokines, fat distribution, and insulin resistance in elderly men and women. J Gerontol A Biol Sci Med Sci 2004; 59:M935-M939
37. Staiger H, Tschritter O, Machann J, et al. Relationship of serum adiponectin and leptin concentrations with body fat distribution in humans. Obes Res 2003; 11:368-372