Inhibition of leptin regulation of parasympathetic signaling as a cause of extreme body weight-associated asthma

Cell Metabolism

Volumn 17, Issue 1, 2013, Pages 35-48

  Arteaga Solis, Emilio ^a   Zee, Tiffany ^a   Emala, Charles W ^a   Vinson, Charles ^b   Wess, Jürgen ^c   Karsenty, Gerard ^a  

^a Columbia University ^*  (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; MELANOCORTIN; MUSCARINIC M3 RECEPTOR;

ADIPOCYTE; AIRWAY DYNAMICS; AIRWAY RESISTANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; BODY WEIGHT; BRONCHOSPASM; CONTROLLED STUDY; DISEASE ASSOCIATION; FOOD INTAKE; LUNG FUNCTION; MALE; MOUSE; NONHUMAN; OBESITY; PARASYMPATHETIC FUNCTION; PARASYMPATHETIC TONE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; SYMPATHETIC TONE;

ANIMALS; ASTHMA; BODY WEIGHT; BRONCHI; BRONCHOCONSTRICTION; CHOLINERGIC ANTAGONISTS; CHOLINERGIC NEURONS; DIET, HIGH-FAT; INFLAMMATION; LEPTIN; MICE; MICE, INBRED C57BL; MICE, OBESE; MYOCYTES, SMOOTH MUSCLE; OBESITY; PARASYMPATHETIC NERVOUS SYSTEM; RECEPTOR, MUSCARINIC M3; SIGNAL TRANSDUCTION;

MUS;

EID: 84872124577     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2012.12.004     Document Type: Article

References (41)

1. P.J. Barnes The pharmacological properties of tiotropium Chest 117 2, Suppl 2000 63S 66S (Pubitemid 30111568)
2. M. Björnholm, H. Münzberg, R.L. Leshan, E.C. Villanueva, S.H. Bates, G.W. Louis, J.C. Jones, R. Ishida-Takahashi, C. Bjørbaek, and M.G. Myers Jr. Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function J. Clin. Invest. 117 2007 1354 1360 (Pubitemid 46718423)
3. A.A. Butler, R.A. Kesterson, K. Khong, M.J. Cullen, M.A. Pelleymounter, J. Dekoning, M. Baetscher, and R.D. Cone A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse Endocrinology 141 2000 3518 3521 (Pubitemid 32269044)
4. Z. Callaerts-Vegh, K.L. Evans, N. Dudekula, D. Cuba, B.J. Knoll, P.F. Callaerts, H. Giles, F.R. Shardonofsky, and R.A. Bond Effects of acute and chronic administration of beta-adrenoceptor ligands on airway function in a murine model of asthma Proc. Natl. Acad. Sci. USA 101 2004 4948 4953 (Pubitemid 38469183)
5. B.J. Canning Reflex regulation of airway smooth muscle tone J. Appl. Physiol. 101 2006 971 985 (Pubitemid 44352315)
6. B.J. Canning, and D. Spina Sensory nerves and airway irritability Handb. Exp. Pharmacol. 194 2009 139 183
7. J.C. Celedón, L.J. Palmer, A.A. Litonjua, S.T. Weiss, B. Wang, Z. Fang, and X. Xu Body mass index and asthma in adults in families of subjects with asthma in Anqing, China Am. J. Respir. Crit. Care Med. 164 2001 1835 1840 (Pubitemid 33152316)
8. A.J. Chruscinski, D.K. Rohrer, E. Schauble, K.H. Desai, D. Bernstein, and B.K. Kobilka Targeted disruption of the beta2 adrenergic receptor gene J. Biol. Chem. 274 1999 16694 16700
9. F.R. Coulson, and A.D. Fryer Muscarinic acetylcholine receptors and airway diseases Pharmacol. Ther. 98 2003 59 69 (Pubitemid 36349761)
10. A.E. Dixon, F. Holguin, A. Sood, C.M. Salome, R.E. Pratley, D.A. Beuther, J.C. Celedón, S.A. Shore American Thoracic Society Ad Hoc Subcommittee on Obesity and Lung Disease An official American Thoracic Society Workshop report: obesity and asthma Proc. Am. Thorac. Soc. 7 2010 325 335
11. A.E. Dixon, R.E. Pratley, P.M. Forgione, D.A. Kaminsky, L.A. Whittaker-Leclair, L.A. Griffes, J. Garudathri, D. Raymond, M.E. Poynter, J.Y. Bunn, and C.G. Irvin Effects of obesity and bariatric surgery on airway hyperresponsiveness, asthma control, and inflammation J. Allergy Clin. Immunol. 128 2011 508 515 e1-e2
12. C.S. Farah, J.A. Kermode, S.R. Downie, N.J. Brown, K.M. Hardaker, N. Berend, G.G. King, and C.M. Salome Obesity is a determinant of asthma control independent of inflammation and lung mechanics Chest 140 2011 659 666
13. J.T. Fisher, S.G. Vincent, J. Gomeza, M. Yamada, and J. Wess Loss of vagally mediated bradycardia and bronchoconstriction in mice lacking M2 or M3 muscarinic acetylcholine receptors FASEB J. 18 2004 711 713
14. D. Gautam, S.J. Han, F.F. Hamdan, J. Jeon, B. Li, J.H. Li, Y. Cui, D. Mears, H. Lu, and C. Deng A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo Cell Metab. 3 2006 449 461 (Pubitemid 43811775)
15. J. Gomeza, H. Shannon, E. Kostenis, C. Felder, L. Zhang, J. Brodkin, A. Grinberg, H. Sheng, and J. Wess Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice Proc. Natl. Acad. Sci. USA 96 1999 1692 1697 (Pubitemid 29098513)
16. K. Huang, R. Rabold, E. Abston, B. Schofield, V. Misra, E. Galdzicka, H. Lee, S. Biswal, W. Mitzner, and C.G. Tankersley Effects of leptin deficiency on postnatal lung development in mice J. Appl. Physiol. 105 2008 249 259
17. D. Huszar, C.A. Lynch, V. Fairchild-Huntress, J.H. Dunmore, Q. Fang, L.R. Berkemeier, W. Gu, R.A. Kesterson, B.A. Boston, and R.D. Cone Targeted disruption of the melanocortin-4 receptor results in obesity in mice Cell 88 1997 131 141 (Pubitemid 27180337)
18. R.A. Johnston, T.A. Theman, F.L. Lu, R.D. Terry, E.S. Williams, and S.A. Shore Diet-induced obesity causes innate airway hyperresponsiveness to methacholine and enhances ozone-induced pulmonary inflammation J. Appl. Physiol. 104 2008 1727 1735
19. M. Kattan, R. Kumar, G.R. Bloomberg, H.E. Mitchell, A. Calatroni, P.J. Gergen, C.M. Kercsmar, C.M. Visness, E.C. Matsui, and S.F. Steinbach Asthma control, adiposity, and adipokines among inner-city adolescents J. Allergy Clin. Immunol. 125 2010 584 592
20. G.G. King, N.J. Brown, C. Diba, C.W. Thorpe, P. Muñoz, G.B. Marks, B. Toelle, K. Ng, N. Berend, and C.M. Salome The effects of body weight on airway calibre Eur. Respir. J. 25 2005 896 901 (Pubitemid 40667690)
21. A.D. Loewy, and K.M. Spyer Central Regulation of Autonomic Functions 1990 Oxford University Press New York
22. F.L. Lu, R.A. Johnston, L. Flynt, T.A. Theman, R.D. Terry, I.N. Schwartzman, A. Lee, and S.A. Shore Increased pulmonary responses to acute ozone exposure in obese db/db mice Am. J. Physiol. Lung Cell. Mol. Physiol. 290 2006 L856 L865
23. A.B. Lumb Nunn's Applied Respiratory Physiology Seventh Edition 2010 Churchill Livingstone/Elsevier Edinburgh
24. L. Madisen, T.A. Zwingman, S.M. Sunkin, S.W. Oh, H.A. Zariwala, H. Gu, L.L. Ng, R.D. Palmiter, M.J. Hawrylycz, and A.R. Jones A robust and high-throughput Cre reporting and characterization system for the whole mouse brain Nat. Neurosci. 13 2010 133 140
25. C. Mantzoros, J.S. Flier, M.D. Lesem, T.D. Brewerton, and D.C. Jimerson Cerebrospinal fluid leptin in anorexia nervosa: correlation with nutritional status and potential role in resistance to weight gain J. Clin. Endocrinol. Metab. 82 1997 1845 1851 (Pubitemid 127495198)
26. J.E. McMinn, S.M. Liu, I. Dragatsis, P. Dietrich, T. Ludwig, S. Eiden, and S.C. Chua Jr. An allelic series for the leptin receptor gene generated by CRE and FLP recombinase Mamm. Genome 15 2004 677 685 (Pubitemid 39159192)
27. J. Moitra, M.M. Mason, M. Olive, D. Krylov, O. Gavrilova, B. Marcus-Samuels, L. Feigenbaum, E. Lee, T. Aoyama, and M. Eckhaus Life without white fat: a transgenic mouse Genes Dev. 12 1998 3168 3181 (Pubitemid 28496262)
28. M.G. Myers Jr., H. Münzberg, G.M. Leinninger, and R.L. Leshan The geometry of leptin action in the brain: more complicated than a simple ARC Cell Metab. 9 2009 117 123
29. P. Nair, K. Radford, A. Fanat, L.J. Janssen, M. Peters-Golden, and P.G. Cox The effects of leptin on airway smooth muscle responses Am. J. Respir. Cell Mol. Biol. 39 2008 475 481
30. L.P. Nguyen, R. Lin, S. Parra, O. Omoluabi, N.A. Hanania, M.J. Tuvim, B.J. Knoll, B.F. Dickey, and R.A. Bond Beta2-adrenoceptor signaling is required for the development of an asthma phenotype in a murine model Proc. Natl. Acad. Sci. USA 106 2009 2435 2440
31. M. Peters-Golden, A. Swern, S.S. Bird, C.M. Hustad, E. Grant, and J.M. Edelman Influence of body mass index on the response to asthma controller agents Eur. Respir. J. 27 2006 495 503 (Pubitemid 43372522)
32. Y.M. Rivera-Sanchez, R.A. Johnston, I.N. Schwartzman, J. Valone, E.S. Silverman, J.J. Fredberg, and S.A. Shore Differential effects of ozone on airway and tissue mechanics in obese mice J. Appl. Physiol. 96 2004 2200 2206 (Pubitemid 38661502)
33. S.A. Shore, Y.M. Rivera-Sanchez, I.N. Schwartzman, and R.A. Johnston Responses to ozone are increased in obese mice J. Appl. Physiol. 95 2003 938 945 (Pubitemid 37033985)
34. B. Stenius-Aarniala, T. Poussa, J. Kvarnström, E.L. Grönlund, M. Ylikahri, and P. Mustajoki Immediate and long term effects of weight reduction in obese people with asthma: randomised controlled study BMJ 320 2000 827 832 (Pubitemid 30175861)
35. M. Van Heek, D.S. Compton, C.F. France, R.P. Tedesco, A.B. Fawzi, M.P. Graziano, E.J. Sybertz, C.D. Strader, and H.R. Davis Jr. Diet-induced obese mice develop peripheral, but not central, resistance to leptin J. Clin. Invest. 99 1997 385 390 (Pubitemid 27414794)
36. J.A. Vanoirbeek, M. Rinaldi, V. De Vooght, S. Haenen, S. Bobic, G. Gayan-Ramirez, P.H. Hoet, E. Verbeken, M. Decramer, B. Nemery, and W. Janssens Noninvasive and invasive pulmonary function in mouse models of obstructive and restrictive respiratory diseases Am. J. Respir. Cell Mol. Biol. 42 2010 96 104
37. S.E. Wenzel Asthma phenotypes: the evolution from clinical to molecular approaches Nat. Med. 18 2012 716 725
38. A. Wirth, Z. Benyó, M. Lukasova, B. Leutgeb, N. Wettschureck, S. Gorbey, P. Orsy, B. Horváth, C. Maser-Gluth, and E. Greiner G12-G13-LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension Nat. Med. 14 2008 64 68
39. V.K. Yadav, F. Oury, N. Suda, Z.W. Liu, X.B. Gao, C. Confavreux, K.C. Klemenhagen, K.F. Tanaka, J.A. Gingrich, and X.E. Guo A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure Cell 138 2009 976 989
40. M. Yamada, T. Miyakawa, A. Duttaroy, A. Yamanaka, T. Moriguchi, R. Makita, M. Ogawa, C.J. Chou, B. Xia, and J.N. Crawley Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean Nature 410 2001 207 212 (Pubitemid 32216592)
41. T. Yamanishi, C.R. Chapple, K. Yasuda, and R. Chess-Williams The role of M(2)-muscarinic receptors in mediating contraction of the pig urinary bladder in vitro Br. J. Pharmacol. 131 2000 1482 1488