Akt phosphorylates HK-II at Thr-473 and increases mitochondrial HK-II association to protect cardiomyocytes

Journal of Biological Chemistry

Volumn 288, Issue 33, 2013, Pages 23798-23806

  Roberts, David J ^a   Tan Sah, Valerie P ^a   Smith, Jeffery M ^a   Miyamoto, Shigeki ^a  

^a San Diego   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; MITOCHONDRIA;

CARDIOMYOCYTES; CELL PROTECTION; CELL SURVIVAL; CELL VIABILITY; HEXOKINASE II;

CELL SIGNALING;

GLUCOSE 6 PHOSPHATE; HEXOKINASE; HEXOKINASE ISOENZYME; HYDROGEN PEROXIDE; PROTEIN KINASE B; THREONINE; UNCLASSIFIED DRUG; MUTANT PROTEIN; PHOSPHOTHREONINE; PROTEIN BINDING; SOMATOMEDIN C;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL PROTECTION; CELL SURVIVAL; CELL VIABILITY; CELLULAR DISTRIBUTION; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; HEART MUSCLE CELL; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RAT; ANIMAL; BIOLOGICAL MODEL; CYTOLOGY; DRUG EFFECTS; ENZYME ACTIVATION; ENZYMOLOGY; HEART MITOCHONDRION; METABOLISM; MOUSE; PHOSPHORYLATION; SPRAGUE DAWLEY RAT;

ANIMALS; ANIMALS, NEWBORN; CYTOPROTECTION; ENZYME ACTIVATION; GLUCOSE-6-PHOSPHATE; HEXOKINASE; HYDROGEN PEROXIDE; INSULIN-LIKE GROWTH FACTOR I; MICE; MITOCHONDRIA, HEART; MODELS, BIOLOGICAL; MUTANT PROTEINS; MYOCYTES, CARDIAC; PHOSPHORYLATION; PHOSPHOTHREONINE; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84882321254     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.482026     Document Type: Article

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