Age, T-cell homeostasis, and T-cell diversity in humans

Handbook on Immunosenescence: Basic Understanding and Clinical Applications

Volumn 9781402090639, Issue , 2009, Pages 167-192

  Lamar, David L ^a   Weyand, Cornelia M ^a   Goronzy, Jörg J ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84919770194     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4020-9063-9_9     Document Type: Chapter

References (85)

1. Bhandoola A, H von Boehmer, HT Petrie, JC Zuniga-Pflucker (2007) Commitment and developmental potential of extrathymic and intrathymic T-cell precursors: plenty to choose from. Immunity 26:678-689
2. Blom B, P. Res, E. Noteboom, K. Weijer, H. Spits (1997) Prethymic CD34+ progenitors capable of developing into T cells are not committed to the T-cell lineage. J Immunol 158:3571-3577
3. Galy A, S Verma, A Barcena, H Spits (1993) Precursors of CD3+CD4+CD8+ cells in the human thymus are defined by expression of CD34. Delineation of early events in human thymic development. J Exp Med 178:391-401
4. Blom B, MC Verschuren, MH Heemskerk, AQ Bakker, EJ van Gastel-Mol, IL Wolvers-Tettero, JJ van Dongen, H Spits (1999) TCR gene rearrangements and expression of the pre-T-cell receptor complex during human T-cell differentiation. Blood 93:3033-3043
5. Pui JC, D Allman, L Xu, S DeRocco, FG Karnell, S Bakkour, JY Lee, T Kadesch, RR Hardy, JC Aster, WS Pear (1999) Notch1 expression in early lymphopoiesis influences B versus T lineage determination. Immunity 11:299-308
6. van Dongen JJ, WM Comans-Bitter, L Wolvers-Tettero, J Borst (1990) Development of human T-lymphocytes and their thymus-dependency. Thymus 16:207-234
7. Davis MM, PJ Bjorkman (1988) T-cell antigen receptor genes and T-cell recognition. Nature 334:395-402
8. Spits H (2002) Development of alphabeta T cells in the human thymus. Nat Rev 2:760-772
9. Wilson A, W Held, HR MacDonald (1994) Two waves of recombinase gene expression in developing thymocytes. J Exp Med 179:1355-1360
10. Krangel MS (2003) Gene segment selection inV (D) J recombination: accessibility and beyond. Nat Immunol 4:624-630
11. Benedict CL, S Gilfillan, TH Thai, JF Kearney (2000) Terminal deoxynucleotidyl transferase and repertoire development. Immunol Rev 175:150-157
12. von Boehmer H (2005) Unique features of the pre-T-cell receptor alpha-chain: not just a surrogate. Nat Rev 5:571-577
13. Trigueros C, AR Ramiro, YR Carrasco, VG de Yebenes, JP Albar, ML Toribio (1998) Identification of a late stage of small noncycling pTalpha-pre-T cells as immediate precursors of T-cell receptor alpha/beta+ thymocytes. J Exp Med 188:1401-1412
14. Petrie HT, F Livak, DG Schatz, A Strasser, IN Crispe, K Shortman (1993) Multiple rearrangements in T-cell receptor alpha chain genes maximize the production of useful thymocytes. J Exp Med 178:615-622
15. Brandle D, C Muller, T Rulicke, H Hengartner, H Pircher (1992) Engagement of the T-cell receptor during positive selection in the thymus down-regulates RAG-1 expression. Proc Natl Acad Sci U S A 89:9529-9533
16. Palmer E 2003 Negative selection-clearing out the bad apples from the T-cell repertoire. Nat Rev 3:383-391
17. Fagnoni FF, R Vescovini, G Passeri, G Bologna, M Pedrazzoni, G Lavagetto, A Casti, C Franceschi, M Passeri, P Sansoni (2000) Shortage of circulating naive CD8 (+) T cells provides new insights on immunodeficiency in aging. Blood 95:2860-2868
18. Hong MS, JM Dan, JY Choi, I Kang (2004) Age-associated changes in the frequency of naive, memory and effector CD8+ T cells. Mech Ageing Dev 125:615-618
19. Naylor K, G Li, AN Vallejo, WW Lee, K Koetz, E Bryl, J Witkowski, J Fulbright, CM Weyand, JJ Goronzy (2005) The influence of age on T-cell generation and TCR diversity. J Immunol 174:7446-7452
20. Sallusto F, D Lenig, R Forster, M Lipp, A Lanzavecchia (1999) Two subsets of memory T-lymphocytes with distinct homing potentials and effector functions. Nature 401:708-712
21. Lanzavecchia A, F Sallusto (2000) Dynamics of T-lymphocyte responses: intermediates, effectors, and memory cells. Science (New York, N. Y) 290:92-97
22. Jacob J, D Baltimore (1999) Modelling T-cell memory by genetic marking of memory T cells in vivo. Nature 399:593-597
23. Opferman JT, BT Ober, PG Ashton-Rickardt (1999) Linear differentiation of cytotoxic effectors into memory T-lymphocytes. Science (New York, N. Y) 283:1745-1748
24. Faint JM, NE Annels, SJ Curnow, P Shields, D Pilling, A D Hislop, L Wu, AN Akbar, CD Buckley, PA Moss, DH Adams, A B Rickinson, M Salmon (2001) Memory T cells constitute a subset of the human CD8+CD45RA+ pool with distinct phenotypic and migratory characteristics. J Immunol 167:212-220
25. Van Den Beemd R, PP Boor, EG van Lochem, WC Hop, AW Langerak, IL Wolvers-Tettero, H Hooijkaas, JJ van Dongen (2000) Flow cytometric analysis of the Vbeta repertoire in healthy controls. Cytometry 40:336-345
26. Hadrup SR, J Strindhall, T Kollgaard, T Seremet, B Johansson, G Pawelec, P thor Straten, A Wikby (2006) Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirusspecific T cells in the very elderly. J Immunol 176:2645-2653
27. Even J, A Lim, I Puisieux, L Ferradini, PY Dietrich, A Toubert, T Hercend, F Triebel, C Pannetier, P Kourilsky (1995) T-cell repertoires in healthy and diseased human tissues analysed by T-cell receptor beta-chain CDR3 size determination: evidence for oligoclonal expansions in tumours and inflammatory diseases. Res Immunol 146:65-80
28. Arstila T P, A Casrouge, V Baron, J Even, J Kanellopoulos, P Kourilsky (1999) A direct estimate of the human alphabeta T-cell receptor diversity. Science New York, N. Y 286:958-961
29. Wagner UG, K Koetz, CM Weyand, JJ Goronzy (1998) Perturbation of the T-cell repertoire in rheumatoid arthritis. Proc Natl Acad Sci U S A 95:14447-14452
30. Taub DD, DL Longo (2005) Insights into thymic aging and regeneration. Immunol Rev 205:72-93
31. Livak F, DG Schatz (1996) T-cell receptor alpha locus V (D) J recombination by-products are abundant in thymocytes and mature T cells. Mol Cell Biol 16:609-618
32. de Villartay JP, RD Hockett, D Coran, SJ Korsmeyer, DI Cohen (1988) Deletion of the human T-cell receptor delta-gene by a site-specific recombination. Nature 335:170-174
33. Hazenberg MD, MC Verschuren, D Hamann, F Miedema, JJ van Dongen (2001) T-cell receptor excision circles as markers for recent thymic emigrants: basic aspects, technical approach, and guidelines for interpretation. J Mol Med (Berlin, Germany) 79:631-640
34. Douek DC, RD McFarland, PH Keiser, EA Gage, JM Massey, BF Haynes, MA Polis, AT Haase, MB Feinberg, JL Sullivan, BD Jamieson, JA Zack, LJ Picker, R A Koup (1998) Changes in thymic function with age and during the treatment of HIV infection. Nature 396:690-695
35. Koetz K, E Bryl, K Spickschen, WM O'Fallon, JJ Goronzy, CM Weyand (2000) T-cell homeostasis in patients with rheumatoid arthritis. Proc Natl Acad Sci U S A 97:9203-9208
36. Poulin JF, MN Viswanathan, JM Harris, KV Komanduri, E Wieder, N Ringuette, M Jenkins, J M McCune, R P Sekaly (1999) Direct evidence for thymic function in adult humans. J Exp Med 190:479-486
37. Flores KG, J Li, GD Sempowski, BF Haynes, L P Hale (1999) Analysis of the human thymic perivascular space during aging. J Clin Invest 104:1031-1039
38. Steinmann GG, B Klaus, HK Muller-Hermelink (1985) The involution of the ageing human thymic epithelium is independent of puberty. A morphometric study. Scand J Immunol 22:563-575
39. Jamieson BD, DC Douek, S Killian, LE Hultin, DD Scripture-Adams, JV Giorgi, D Marelli, R A Koup, J A Zack (1999) Generation of functional thymocytes in the human adult. Immunity 10:569-575
40. Hakim FT, SA Memon, R Cepeda, EC Jones, CK Chow, C Kasten-Sportes, J Odom, BA Vance, BL Christensen, CL Mackall, RE Gress (2005) Age-dependent incidence, time course, and consequences of thymic renewal in adults. J Clin Invest 115:930-939
41. Kimmig S, G K Przybylski, CA Schmidt, K Laurisch, B Mowes, A Radbruch, A Thiel (2002) Two subsets of naive T-helper cells with distinct T-cell receptor excision circle content in human adult peripheral blood. J Exp Med 195:789-794
42. Gerdes J, H Lemke, H Baisch, HH Wacker, U Schwab, H Stein (1984) Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol 133:1710-1715
43. Betts MR, JM Brenchley, DA Price, SC De Rosa, DC Douek, M Roederer, RA Koup (2003) Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation. J Immunol Methods 281:65-78
44. Hazenberg MD, JW Stuart, SA Otto, JC Borleffs, CA Boucher, RJ de Boer, F Miedema, D Hamann (2000) T-cell division in human immunodeficiency virus (HIV)-1 infection is mainly due to immune activation: a longitudinal analysis in patients before and during highly active antiretroviral therapy (HAART). Blood 95:249-255
45. Schonland SO, JK Zimmer, CM Lopez-Benitez, T Widmann, KD Ramin, JJ Goronzy, CM Weyand (2003) Homeostatic control of T-cell generation in neonates. Blood 102:1428-1434
46. Macallan DC, B Asquith, AJ Irvine, DL Wallace, A Worth, H Ghattas, Y Zhang, GE Griffin, DF Tough, P C Beverley (2003) Measurement and modeling of human T-cell kinetics. Eur J Immunol 33:2316-2326
47. Macallan DC, CA Fullerton, RA Neese, K Haddock, SS Park, MK Hellerstein (1998) Measurement of cell proliferation by labeling of DNA with stable isotope-labeled glucose: studies in vitro, in animals, and in humans. Proc Natl Acad Sci U S A 95:708-713
48. Neese RA, LM Misell, S Turner, A Chu, J Kim, D Cesar, R Hoh, F Antelo, A Strawford, JM McCune, M Christiansen, MK Hellerstein (2002) Measurement in vivo of proliferation rates of slow turnover cells by 2H2O labeling of the deoxyribose moiety of DNA. Proc Natl Acad Sci U S A 99:15345-15350
49. Wallace DL, Y Zhang, H Ghattas, A Worth, A Irvine, AR Bennett, GE Griffin, PC Beverley, DF Tough, DC Macallan. (2004) Direct measurement of T-cell subset kinetics in vivo in elderly men and women. J Immunol 173:1787-1794
50. Hellerstein M, MB Hanley, D Cesar, S Siler, C Papageorgopoulos, E Wieder, D Schmidt, R Hoh, R Neese, D Macallan, S Deeks, JM McCune (1999) Directly measured kinetics of circulating T-lymphocytes in normal and HIV-1-infected humans. Nat Med 5:83-89
51. Murray JM, GR Kaufmann, PD Hodgkin, SR Lewin, AD Kelleher, MP Davenport, JJ Zaunders (2003) Naive T cells are maintained by thymic output in early ages but by proliferation without phenotypic change after age twenty. Immunol Cell Biol 81:487-495
52. Brocker T (1997) Survival of mature CD4 T-lymphocytes is dependent on major histocompatibility complex class II-expressing dendritic cells. J Exp Med 186:1223-1232
53. Kirberg J, A Berns, H von Boehmer (1997) Peripheral T-cell survival requires continual ligation of the T-cell receptor to major histocompatibility complex-encoded molecules. J Exp Med 186:1269-1275
54. Tanchot C, FA Lemonnier, B Perarnau, AA Freitas, B Rocha (1997) Differential requirements for survival and proliferation of CD8 naive or memory T cells. Science (New York, N. Y) 276:2057-2062
55. Murali-Krishna K, LL Lau, S Sambhara, F Lemonnier, J Altman, R Ahmed (1999) Persistence of memory CD8 T cells in MHC class I-deficient mice. Science (New York, N. Y) 286:1377-1381
56. Ge Q, VP Rao, BK Cho, HN Eisen, J Chen (2001) Dependence of lymphopenia-induced T-cell proliferation on the abundance of peptide/MHC epitopes and strength of their interaction with T-cell receptors. Proc Natl Acad Sci U S A 98:1728-1733
57. Wang Q, J Strong, N Killeen (2001) Homeostatic competition among T cells revealed by conditional inactivation of the mouse Cd4 gene. J Exp Med 194:1721-1730
58. Jameson SC (2002) Maintaining the norm: T-cell homeostasis. Nat Rev 2:547-556
59. Tan JT, E Dudl, E LeRoy, R Murray, J Sprent, KI Weinberg, C D Surh (2001) IL-7 is critical for homeostatic proliferation and survival of naive T cells. Proc Natl Acad Sci U S A 98:8732-8737
60. Geginat J, A Lanzavecchia, F Sallusto (2003) Proliferation and differentiation potential of human CD8+ memory T-cell subsets in response to antigen or homeostatic cytokines. Blood 101:4260-4266
61. Hazenberg MD, SA Otto, JW Cohen Stuart, MC Verschuren, JC Borleffs, CA Boucher, RA Coutinho, JM Lange, TF Rinke deWit, A Tsegaye, JJ van Dongen, D Hamann, RJ de Boer, F Miedema (2000) Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T-cell population in HIV-1 infection. Nat Med 6:1036-1042
62. Goronzy JJ, WW Lee, CM Weyand (2007) Aging and T-cell diversity. Exp Gerontol 42:400-406
63. Czesnikiewicz-Guzik M, WW Lee, D Cui, Y Hiruma, DL Lamar, ZZ Yang, JG Ouslander, C M Weyand, JJ Goronzy (2008) T-cell subset-specific susceptibility to aging. Clin Immunol 127:107-118
64. Effros RB, N Boucher, V Porter, X Zhu, C Spaulding, RL Walford, M Kronenberg, D Cohen, F Schachter (1994) Decline in CD28+ T cells in centenarians and in long-term T-cell cultures: a possible cause for both in vivo and in vitro immunosenescence. Exp Gerontol 29:601-609
65. Colonna M, F Navarro, T Bellon, M Llano, P Garcia, J Samaridis, L Angman, M Cella, M Lopez-Botet (1997) A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells. J Exp Med 186:1809-1818
66. Jankovic V, I Messaoudi, J Nikolich-Zugich (2003) Phenotypic and functional T-cell aging in rhesus macaques (Macaca mulatta): differential behavior of CD4 and CD8 subsets. Blood 102:3244-3251
67. Ricalton NS, C Roberton, JM Norris, M Rewers, RF Hamman, BL Kotzin (1998) Prevalence of CD8+ T-cell expansions in relation to age in healthy individuals. J Gerontol 53:B196-B203
68. Wack A, A Cossarizza, S Heltai, D Barbieri, S D'Addato, C Fransceschi, P Dellabona, G Casorati (1998) Age-related modifications of the human alphabeta T-cell repertoire due to different clonal expansions in the CD4+ and CD8+ subsets. Int Immunol 10:1281-1288
69. Goronzy JJ, CM Weyand (2005) T-cell development and receptor diversity during aging. Curr Opin Immunol 17:468-475
70. Cicin-Sain L, I Messaoudi, B Park, N Currier, S Planer, M Fischer, S Tackitt, D Nikolich-Zugich, A Legasse, MK Axthelm, LJ Picker, M Mori, J Nikolich-Zugich (2007) Dramatic increase in naive T-cell turnover is linked to loss of naive T cells from old primates. Proc Natl Acad Sci U S A 104:19960-19965
71. Kotzin BL, VL Barr, E. Palmer (1985) A large deletion within the T-cell receptor beta-chain gene complex in New Zealand white mice. Science (New York, N. Y) 229:167-171
72. Nanda NK, R Apple, E Sercarz (1991) Limitations in plasticity of the T-cell receptor repertoire. Proc Natl Acad Sci U S A 88:9503-9507
73. Gilfillan S, A Dierich, M Lemeur, C Benoist, D Mathis (1993) Mice lacking TdT: mature animals with an immature lymphocyte repertoire. Science (New York, N. Y) 261:1175-1178
74. Kikly K, G Dennert (1992) Evidence for a role for T-cell receptors (TCR) in the effector phase of acute bone marrow graft rejection. TCR V beta 5 transgenic mice lack effector cells able to cause graft rejection. J Immunol 149:3489-3494
75. Perkins DL, YS Wang, D Fruman, JG Seidman, IJ Rimm (1991) Immunodominance is altered in T-cell receptor (beta-chain) transgenic mice without the generation of a hole in the repertoire. J Immunol 146:2960-2964
76. Noguchi M, H Yi, HM Rosenblatt, AH Filipovich, S Adelstein, WS Modi, OW McBride, W J Leonard (1993) Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans. Cell 73:147-157
77. Stephan V, V Wahn, F Le Deist, U Dirksen, B Broker, I Muller-Fleckenstein, G Horneff, H Schroten, A Fischer, G de Saint Basile (1996) Atypical X-linked severe combined immunodeficiency due to possible spontaneous reversion of the genetic defect in T cells. N Engl J Med 335:1563-1567
78. Bousso P, V Wahn, I Douagi, G Horneff, C Pannetier, F Le Deist, F Zepp, T Niehues, P Kourilsky, A Fischer, G de Saint Basile (2000) Diversity, functionality, and stability of the T-cell repertoire derived in vivo from a single human T-cell precursor. Proc Natl Acad Sci U S A 97:274-278
79. Meyer-Olson D, NH Shoukry, KW Brady, H Kim, DP Olson, K Hartman, AK Shintani, CM Walker, SA Kalams (2004) Limited T-cell receptor diversity of HCV-specific T-cell responses is associated with CTL escape. J Exp Med 200:307-319
80. Ferguson FG, A Wikby, P Maxson, J Olsson, B Johansson (1995) Immune parameters in a longitudinal study of a very old population of Swedish people: a comparison between survivors and nonsurvivors. J Gerontol 50:B378-B382
81. Wikby A, P Maxson, J Olsson, B Johansson, FG Ferguson (1998) Changes in CD8 and CD4 lymphocyte subsets, T-cell proliferation responses and non-survival in the very old: the Swedish longitudinal OCTO-immune study. Mech Ageing Dev 102:187-198
82. Khan N, A Hislop, N Gudgeon, M Cobbold, R Khanna, L Nayak, A B Rickinson, PA Moss (2004) Herpesvirus-specific CD8 T-cell immunity in old age: cytomegalovirus impairs the response to a coresident EBV infection. J Immunol 173:7481-7489
83. Goronzy JJ, JW Fulbright, CS Crowson, GA Poland, W. M. O'Fallon, and CM Weyand. (2001) Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals. J Virol 75:12182-12187
84. Trzonkowski P, J Mysliwska, E Szmit, J Wieckiewicz, K Lukaszuk, LB Brydak, M Machala, A Mysliwski (2003) Association between cytomegalovirus infection, enhanced proinflammatory response and low level of anti-hemagglutinins during the anti-influenza vaccination-an impact of immunosenescence. Vaccine 21:3826-3836
85. Strindhall J, BO Nilsson, S Lofgren, J Ernerudh, G Pawelec, B Johansson, A Wikby (2007) No immune risk profile among individuals who reach 100 years of age: findings from the Swedish NONA immune longitudinal study. Exp Gerontol 42:753-761