Age-related modifications of the human αβ T cell repertoire due to different clonal expansions in the CD4+ and CD8+ subsets

International Immunology

Volumn 10, Issue 9, 1998, Pages 1281-1288

  Wack, Andreas ^a,d   Cossarizza, Andrea ^b   Heltai, Silvia ^a   Barbieri, Daniela ^b   D'Addato, Sergio ^c   Fransceschi, Claudio ^b   Dellabona, Paolo ^a   Casorati, Giulia ^a  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c UNIVERSITY OF BOLOGNA   (Italy)

^d NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

Ageing; Clonal expansion; Immune system; T cell repertoire

Indexed keywords

CD4 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN; T LYMPHOCYTE RECEPTOR;

ADULT; AGED; AGING; ARTICLE; FEMALE; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; MALE; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION;

ADULT; AGED; AGED, 80 AND OVER; AGING; ANTIGENS, CD45; CD4-CD8 RATIO; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CLONE CELLS; FEMALE; HUMANS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTE SUBSETS;

EID: 0031715650     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/10.9.1281     Document Type: Article

References (32)

1. Miller, R. A. 1996. The aging immune system: primer and prospectus. Science 273:70.
2. Davis, M. M. and Bjorkman, P. J. 1988. T-cell antigen receptor genes and T-cell recognition. Nature 334:395.
3. Zinkernagel, R. M., Bachmann, M. F., Kundig, T. M., Oehen, S., Pircher, H. and Hengartner, H. 1996. On immunological memory. Annu. Rev. Immunol. 14:333.
4. Akbar, A. N., Terry, L., Timms, A., Beverley, P. C. L. and Janossy, G. 1988. Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells. J. Immunol. 140:2171.
5. Merkenschlager, M., Terry. L., Edwards. R. and Beverley, P. C. L. 1988. Limiting dilution analysis of proliferative responses in human lymphocyte population defined by the monoclonal antibody UCHL1: implications for differential CD45 expression in T cell memory formation. Eur J. Immunol. 18:1653.
6. Moss, P. A. H., Moots, R. J., Rosenberg, W. M., Rowland-Jones, S. J., Bodmer, H. C., McMichael, A. J. and Bell, J. I. 1991. Extensive conservation of α and β chains of the human T-cell receptor recognizing HLA-A2 and influenza A matrix peptide. Proc. Natl Acad. Sci. USA 88:887.
7. Casanova, J.-L., Cerottini, J.-C., Matthes, M., Necker, A., Cournier, H., Barra, C., Widmann, C., MacDonald, H. R., Lemonnier, F., Malissen, B. and Maryanski, J. L. 1992. H-2 restricted cytolytic T lymphocytes specific for HLA display T cell receptors of limited diversity. J. Exp. Med. 176:439.
8. Henwood, J., Loveridge, J., Bell, J. I. and Hill Gaston, J. S. 1993. Restricted T cell receptor expression by human T cell clones specific for mycobacterial 65-kDa heat-shock protein: selective in vivo expansion of T cells bearing defined receptors. Eur. J Immunol. 23:1256.
9. + T cells throughout life, from newborns to centenarians: implications for T cell memory. Mech. Ageing. Dev. 86:173.
10. Bell, E. B. and Sparshott, S. M. 1990. Interconversion of CD45R subsets of CD4 T cells in vivo. Nature. 348:163.
11. Michie, C. A.,McLean, A., Alcock, C. and Beverley, P. C. L. 1992. Lifespan of human lymphocyte subsets defined by CD45 isoforms. Nature. 360:264.
12. Bunce, C. and Bell, E. B. 1997. CD45RC isoforms define two types of CD4 memory T cells, one of which depends on persisting antigen. J. Exp. Med. 185:767.
13. Wack, A., Montagna, D., Dellabona, P. and Casorati, G. 1996. An improved PCR-heteroduplex method permits high-sensitivity detection of clonal expansion in complex T cell populations. J. Immunol. Methods 196:181.
14. Ligthart, G. J., Corberand, J. X., Fournier, C., Galanaud, P., Hijmans, W., Kennes, B., Muller-Hermelink, H. K. and Steinmann, G. G. 1984. Admission criteria for immunogerontological studies in man: the SENIEUR protocol. Mech. Ageing Dev. 28:47.
15. Smith, S. H., Brown, M. H., Rowe, D., Callard, R. E. and Beverley, P. C. L. 1986. Functional subsets of human helper-inducer cells defined by a new monoclonal antibody, UCHL1. Immunology 58:63.
16. Chomczynski, P. and Sacchi N. 1987. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 126:156.
17. + subset in normal human subjects. J. Immunol. 151:5762.
18. Posnett, D., Sinha. R., Kabak, S. and Russo, C. 1994. Clonal populations of T cells in normal elderly humans: the T cell equivalent to Benign Monoclonal Gammapathy'. J. Exp. Med. 179:609.
19. + T cell clone in elderly humans. J. Immunol. 158:4493.
20. + T cells in health and disease: aging, infection, or immune regulation. Human Immunol. 48:68.
21. + cells increase with age and limit the reoertoire of human γδ T cells. Eur J. Immunol. 24:1914.
22. Merkenschlager, M. and Beverley, P. C. L. 1989. Evidence for differential expression of CD45 isoforms by precursors for memory-dependent and independent cytotoxic responses: human CD8 memory CTLp selectively express CD45RO (UCHL1). Int. Immunol. 1:450
23. + T cells with predominant V beta usage during the primary immune response to HIV. Nature 370:463.
24. Akbar, A. N., Borthwick, N., Salmon, M., Gombert. W., Bofill, M., Shamsadeen, N., Pilling, D., Pett, S., Grundy, J. E. and Janossy, G. 1993. The significance of low bcl-2 expression by CD45RO T cells in normal individuals and patients with acute viral infections The role of apoptosis in T cell memory. J. Exp. Med. 178:427.
25. + T cells specific for the protein NS4 of Hepatitis C virus in patient with chronic hepatitis C. J. Exp. Med. 178:17.
26. Unutmatz, D., Pileri, P. and Abrignani, S. 1994. Antigen-independent activation of naive and memory resting T cells by a cytokine combination. J. Exp. Med. 180: 1159.
27. McLMean, A. R. and Michie, C. A. 1995. In vivo estimates of division and death rates of human T lymphocytes. Proc. Natl Acad. Sci. USA 92:3707.
28. Selin, L. K., Nahill, S. R. and Welsh, R. M. 1994. Cross-reactivities in memory cytotoxic T lymphocyte recognition of heterologous viruses. J. Exp. Med. 179:1933.
29. + cells in human longevity: studies on two healthy centenarians. Eur. J. Immunol 26: 2030.
30. - T cells in healthy ageing people, including centenarians. Immunology. 88:501.
31. + natural killer cells. Eur. J. Immunol. 18:1827.
32. Sansoni, P., Cossarizza, A., Brianti, V., Fagnoni, F., Snelli, G., Monti, D., Marcato. A., Passeri, G., Ortolani, C., Forti, E., et al. 1993. Lymphocytes subsets and natural killer cell activity in healthy old people and centenarians. Blood 82:2767.