메뉴 건너뛰기




Volumn 4, Issue 7, 2003, Pages 624-630

Gene segment selection in V(D)J recombination: Accessibility and beyond

Author keywords

[No Author keywords available]

Indexed keywords

LYMPHOCYTE ANTIGEN RECEPTOR; RECOMBINASE;

EID: 0037625160     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni0703-624     Document Type: Review
Times cited : (145)

References (94)
  • 2
    • 0036240127 scopus 로고    scopus 로고
    • The mechanism and regulation of chromosomal V(D)J recombination
    • Bassing, C.H., Swat, W. & Alt, F.W. The mechanism and regulation of chromosomal V(D)J recombination. Cell 109, S45-S55 (2002).
    • (2002) Cell , vol.109
    • Bassing, C.H.1    Swat, W.2    Alt, F.W.3
  • 3
    • 0034969086 scopus 로고    scopus 로고
    • Factors and forces controlling V(D)J recombination
    • Hesslein, D.G.T. & Schatz, D.G. Factors and forces controlling V(D)J recombination. Adv. Immunol. 78, 169-232 (2001).
    • (2001) Adv. Immunol. , vol.78 , pp. 169-232
    • Hesslein, D.G.T.1    Schatz, D.G.2
  • 5
    • 0029894165 scopus 로고    scopus 로고
    • Cell type-specific chromatin structure determines the targeting of V(D)J recombinase activity in vitro
    • Stanhope-Baker, P., Hudson, K.M., Shaffer, A.L., Constantinescu, A. & Schlissel, M.S. Cell type-specific chromatin structure determines the targeting of V(D)J recombinase activity in vitro. Cell 85, 887-897 (1996).
    • (1996) Cell , vol.85 , pp. 887-897
    • Stanhope-Baker, P.1    Hudson, K.M.2    Shaffer, A.L.3    Constantinescu, A.4    Schlissel, M.S.5
  • 6
    • 0032239155 scopus 로고    scopus 로고
    • Accessibility of nucleosomal DNA to V(D)J cleavage is modulated by RSS positioning and HMG1
    • Kwon, J., Imbalzano, A.N., Matthews, A. & Oettinger, M.A. Accessibility of nucleosomal DNA to V(D)J cleavage is modulated by RSS positioning and HMG1. Mol. Cell 2, 829-839 (1998).
    • (1998) Mol. Cell , vol.2 , pp. 829-839
    • Kwon, J.1    Imbalzano, A.N.2    Matthews, A.3    Oettinger, M.A.4
  • 7
    • 0033168204 scopus 로고    scopus 로고
    • Nucleosome structure completely inhibits in vitro cleavage by the V(D)J recombinase
    • Golding, A., Chandler, S., Ballestar, E., Wolffe, A.P. & Schlissel, M.S. Nucleosome structure completely inhibits in vitro cleavage by the V(D)J recombinase. EMBO J. 18, 3712-3723 (1999).
    • (1999) EMBO J. , vol.18 , pp. 3712-3723
    • Golding, A.1    Chandler, S.2    Ballestar, E.3    Wolffe, A.P.4    Schlissel, M.S.5
  • 8
    • 0029819322 scopus 로고    scopus 로고
    • Gene-targeted deletion and replacement of the T-cell receptor β-chain enhancer: The role of enhancer elements in controlling V(D)J recombination accessibility
    • Buries, J.-C., Demengeot, J., Davidson, L. & Alt, F.W. Gene-targeted deletion and replacement of the T-cell receptor β-chain enhancer: The role of enhancer elements in controlling V(D)J recombination accessibility. Proc. Natl. Acad. Sci. USA 93, 7871-7876 (1996).
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 7871-7876
    • Buries, J.-C.1    Demengeot, J.2    Davidson, L.3    Alt, F.W.4
  • 9
    • 0029842562 scopus 로고    scopus 로고
    • Deletion of the mouse T-cell receptor β gene enhancer blocks αβ T-cell development
    • Bouvier, G. et al. Deletion of the mouse T-cell receptor β gene enhancer blocks αβ T-cell development. Proc. Natl. Acad. Sci. USA 93, 7877-7881 (1996).
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 7877-7881
    • Bouvier, G.1
  • 11
    • 0036097492 scopus 로고    scopus 로고
    • Essential roles of the κ light chain intronic enhancer and 3′ enhancer in κ rearrangement and demethylation
    • Inlay, M., Alt, F.W., Baltimore, D. & Xu, Y. Essential roles of the κ light chain intronic enhancer and 3′ enhancer in κ rearrangement and demethylation. Nat. Immunol. 3, 463-468 (2002).
    • (2002) Nat. Immunol. , vol.3 , pp. 463-468
    • Inlay, M.1    Alt, F.W.2    Baltimore, D.3    Xu, Y.4
  • 12
    • 0027508340 scopus 로고
    • TCRβ and TCRα gene enhancers confer tissue- and stage-specificity on V(D)J recombination events
    • Capone, M. et al. TCRβ and TCRα gene enhancers confer tissue- and stage-specificity on V(D)J recombination events. EMBO J. 12, 4335-4346 (1993).
    • (1993) EMBO J. , vol.12 , pp. 4335-4346
    • Capone, M.1
  • 13
    • 0028276377 scopus 로고
    • Temporal and lineage-specific control of T cell receptor α/δ gene rearrangement by T cell receptor α and δ enhancers
    • Lauzurica, P. & Krangel, M.S. Temporal and lineage-specific control of T cell receptor α/δ gene rearrangement by T cell receptor α and δ enhancers. J. Exp. Med. 179, 1913-1921 (1994).
    • (1994) J. Exp. Med. , vol.179 , pp. 1913-1921
    • Lauzurica, P.1    Krangel, M.S.2
  • 14
    • 0033152430 scopus 로고    scopus 로고
    • A developmental switch from TCRδ enhancer to TCRα enhancer function during thymocyte maturation
    • Hernandez-Munain, C., Sleckman, B.P. & Krangel, M.S. A developmental switch from TCRδ enhancer to TCRα enhancer function during thymocyte maturation. Immunity 10, 723-733 (1999).
    • (1999) Immunity , vol.10 , pp. 723-733
    • Hernandez-Munain, C.1    Sleckman, B.P.2    Krangel, M.S.3
  • 16
    • 0032958101 scopus 로고    scopus 로고
    • Regulation of V(D)J recombination by transcriptional promoters
    • Sikes, M.L., Suarez, C.C. & Oltz, E.M. Regulation of V(D)J recombination by transcriptional promoters. Mol. Cell. Biol. 19, 2773-2781 (1999).
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 2773-2781
    • Sikes, M.L.1    Suarez, C.C.2    Oltz, E.M.3
  • 19
    • 0032146072 scopus 로고    scopus 로고
    • Enhancer control of V(D)J recombination at the TCRβ locus: Differential effects on DNA cleavage and joining
    • Hempel, W.M. et al. Enhancer control of V(D)J recombination at the TCRβ locus: differential effects on DNA cleavage and joining. Genes Dev. 12, 2305-2317 (1998).
    • (1998) Genes Dev. , vol.12 , pp. 2305-2317
    • Hempel, W.M.1
  • 21
    • 0029030481 scopus 로고
    • The V(D)J recombinational and transcriptional activities of the immunoglobulin heavy-chain intronic enhancer can be mediated through distinct protein-binding sites in a transgenic substrate
    • Fernex, C., Capone, M. & Ferrier, P. The V(D)J recombinational and transcriptional activities of the immunoglobulin heavy-chain intronic enhancer can be mediated through distinct protein-binding sites in a transgenic substrate. Mol. Cell. Biol. 15, 3217-3226 (1995).
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 3217-3226
    • Fernex, C.1    Capone, M.2    Ferrier, P.3
  • 22
    • 0033988495 scopus 로고    scopus 로고
    • Definition of a T-cell receptor β gene core enhancer of V(D)J recombination by transgenic mapping
    • Tripathi, R.K. et al. Definition of a T-cell receptor β gene core enhancer of V(D)J recombination by transgenic mapping. Mol. Cell. Biol. 20, 42-53 (2000).
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 42-53
    • Tripathi, R.K.1
  • 23
    • 0031595346 scopus 로고    scopus 로고
    • H-DJ recombination does not require germ line transcription of the recombining variable gene segment
    • H-DJ recombination does not require germ line transcription of the recombining variable gene segment. Mol. Cell. Biol. 18, 6253-6264 (1999).
    • (1999) Mol. Cell. Biol. , vol.18 , pp. 6253-6264
    • Angelin-Duclos, C.1    Calame, K.2
  • 24
    • 0037125979 scopus 로고    scopus 로고
    • Regulation of V(D)J recombination: A dominant role for promoter positioning in gene segment accessibility
    • Sikes, M.L., Meade, A., Tripathi, R., Krangel, M.S. & Oltz, E.M. Regulation of V(D)J recombination: A dominant role for promoter positioning in gene segment accessibility. Proc. Natl. Acad. Sci. USA 99, 12309-12314 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 12309-12314
    • Sikes, M.L.1    Meade, A.2    Tripathi, R.3    Krangel, M.S.4    Oltz, E.M.5
  • 25
    • 0034695501 scopus 로고    scopus 로고
    • A role for histone acetylation in the developmental regulation of V(D)J recombination
    • McMurry, M.T. & Krangel, M.S. A role for histone acetylation in the developmental regulation of V(D)J recombination. Science 287, 495-498 (2000).
    • (2000) Science , vol.287 , pp. 495-498
    • McMurry, M.T.1    Krangel, M.S.2
  • 26
    • 0034605064 scopus 로고    scopus 로고
    • Chromatin remodeling by the T cell receptor (TCR)-β gene enhancer during early T cell development: Implications for the control of TCR-β locus recombination
    • Mathieu, N., Hempel, W.M., Spicuglia, S., Verthuy, C. & Ferrier, P. Chromatin remodeling by the T cell receptor (TCR)-β gene enhancer during early T cell development: implications for the control of TCR-β locus recombination. J. Exp. Med. 192, 625-636 (2000).
    • (2000) J. Exp. Med. , vol.192 , pp. 625-636
    • Mathieu, N.1    Hempel, W.M.2    Spicuglia, S.3    Verthuy, C.4    Ferrier, P.5
  • 27
    • 0035794296 scopus 로고    scopus 로고
    • Histone acetylation determines the developmentally regulated accessibility for T cell receptor-γ gene recombination
    • Agata, Y. et al. Histone acetylation determines the developmentally regulated accessibility for T cell receptor-γ gene recombination. J. Exp. Med. 193, 873-879 (2001).
    • (2001) J. Exp. Med. , vol.193 , pp. 873-879
    • Agata, Y.1
  • 28
    • 0035575988 scopus 로고    scopus 로고
    • Cutting edge: Histone acetylation and recombination at the TCR γ locus follows IL-7 induction
    • Huang, J., Durum, S.K. & Muegge, K. Cutting edge: histone acetylation and recombination at the TCR γ locus follows IL-7 induction. J. Immunol. 167, 6073-6077 (2001).
    • (2001) J. Immunol. , vol.167 , pp. 6073-6077
    • Huang, J.1    Durum, S.K.2    Muegge, K.3
  • 29
    • 0034175813 scopus 로고    scopus 로고
    • Stimulation of V(D)J recombination by histone acetylation
    • McBlane, F. & Boyes, J. Stimulation of V(D)J recombination by histone acetylation. Curr. Biol. 10, 483-486 (2000).
    • (2000) Curr. Biol. , vol.10 , pp. 483-486
    • McBlane, F.1    Boyes, J.2
  • 30
    • 0032883119 scopus 로고    scopus 로고
    • Chromatin remodeling directly activates V(D)J recombination
    • Cherry, S.R. & Baltimore, D. Chromatin remodeling directly activates V(D)J recombination. Proc. Natl. Acad. Sci. USA 96, 10788-10793 (1999).
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 10788-10793
    • Cherry, S.R.1    Baltimore, D.2
  • 31
    • 0033638506 scopus 로고    scopus 로고
    • Histone acetylation and hSWI/SNF remodeling act in concert to stimulate V(D)J cleavage of nucleosomal DNA
    • Kwon, J., Morshead, K.B., Guyon, J.R., Kingston, R.E. & Oettinger, M.A. Histone acetylation and hSWI/SNF remodeling act in concert to stimulate V(D)J cleavage of nucleosomal DNA. Mol. Cell 6, 1037-1048 (2000).
    • (2000) Mol. Cell , vol.6 , pp. 1037-1048
    • Kwon, J.1    Morshead, K.B.2    Guyon, J.R.3    Kingston, R.E.4    Oettinger, M.A.5
  • 32
    • 0031876314 scopus 로고    scopus 로고
    • Disruption of higher-order folding by core histone acetylation dramatically enhances transcription of nucleosomal arrays by RNA polymerase III
    • Tse, C., Sera, T., Wolffe, A.P. & Hansen, J.C. Disruption of higher-order folding by core histone acetylation dramatically enhances transcription of nucleosomal arrays by RNA polymerase III. Mol. Cell. Biol. 18, 4629-4638 (1998).
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 4629-4638
    • Tse, C.1    Sera, T.2    Wolffe, A.P.3    Hansen, J.C.4
  • 33
    • 0037154963 scopus 로고    scopus 로고
    • Cooperation between complexes that regulate chromatin structure and transcription
    • Narlikar, G.J., Fan, H.Y. & Kingston, R.E. Cooperation between complexes that regulate chromatin structure and transcription. Cell 108, 475-487 (2002).
    • (2002) Cell , vol.108 , pp. 475-487
    • Narlikar, G.J.1    Fan, H.Y.2    Kingston, R.E.3
  • 34
    • 0034610814 scopus 로고    scopus 로고
    • The language of covalent histone modifications
    • Strahl, B.D. & Allis, D. The language of covalent histone modifications. Nature 403, 41-45 (2000).
    • (2000) Nature , vol.403 , pp. 41-45
    • Strahl, B.D.1    Allis, D.2
  • 35
    • 0035839136 scopus 로고    scopus 로고
    • Translating the histone code
    • Jenuwein, T. & Allis, C.D. Translating the histone code. Science 293, 1074-1080 (2001).
    • (2001) Science , vol.293 , pp. 1074-1080
    • Jenuwein, T.1    Allis, C.D.2
  • 36
    • 0036924095 scopus 로고    scopus 로고
    • Promoter activation by enhancer-dependent and -independent loading of activator and coactivator complexes
    • Spicuglia, S. et al. Promoter activation by enhancer-dependent and -independent loading of activator and coactivator complexes. Mol. Cell 10, 1479-1487 (2002).
    • (2002) Mol. Cell , vol.10 , pp. 1479-1487
    • Spicuglia, S.1
  • 37
    • 0037320925 scopus 로고    scopus 로고
    • Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement
    • Su, I.H. et al. Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement. Nat. Immunol. 4, 124-131 (2003).
    • (2003) Nat. Immunol. , vol.4 , pp. 124-131
    • Su, I.H.1
  • 38
    • 0037452770 scopus 로고    scopus 로고
    • Lysine-79 of histone H3 is hypomethylated at silenced loci in yeast and mammalian cells: A potential mechanism for position-effect variegation
    • Ng, H.H., Ciccone, D.N., Morshead, K.B., Oettinger, M.A. & Struhl, K. Lysine-79 of histone H3 is hypomethylated at silenced loci in yeast and mammalian cells: a potential mechanism for position-effect variegation. Proc. Natl. Acad. Sci. USA 100, 1820-1825 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 1820-1825
    • Ng, H.H.1    Ciccone, D.N.2    Morshead, K.B.3    Oettinger, M.A.4    Struhl, K.5
  • 39
    • 0026507505 scopus 로고
    • CpG methylated minichromosomes become inaccessible for V(D)J recombination after undergoing replication
    • Hsieh, C.-L. & Lieber, M.R. CpG methylated minichromosomes become inaccessible for V(D)J recombination after undergoing replication. EMBO J. 11, 315-325 (1992).
    • (1992) EMBO J. , vol.11 , pp. 315-325
    • Hsieh, C.-L.1    Lieber, M.R.2
  • 40
    • 0032526136 scopus 로고    scopus 로고
    • κ chain monoallelic demethylation and the establishment of allelic exclusion
    • Mostoslavsky, R. et al. κ chain monoallelic demethylation and the establishment of allelic exclusion. Genes Dev. 12, 1801-1811 (1998).
    • (1998) Genes Dev. , vol.12 , pp. 1801-1811
    • Mostoslavsky, R.1
  • 41
    • 0034682539 scopus 로고    scopus 로고
    • V(D)J recombination is not activated by demethylation of the κ locus
    • Cherry, S.R., Beard, C., Jaenisch, R. & Baltimore, D. V(D)J recombination is not activated by demethylation of the κ locus. Proc. Natl. Acad. Sci. USA 97, 8467-8472 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 8467-8472
    • Cherry, S.R.1    Beard, C.2    Jaenisch, R.3    Baltimore, D.4
  • 43
    • 0032060447 scopus 로고    scopus 로고
    • β transcriptional regulation in TCR β allelic exclusion
    • β transcriptional regulation in TCR β allelic exclusion. Int. Immunol. 10, 553-560 (1998).
    • (1998) Int. Immunol. , vol.10 , pp. 553-560
    • Senoo, M.1    Shinkai, Y.2
  • 44
    • 0035920573 scopus 로고    scopus 로고
    • The role of recombination activating gene (RAG) reinduction in thymocyte development in vivo
    • Yannoutsos, N. et al. The role of recombination activating gene (RAG) reinduction in thymocyte development in vivo. J. Exp. Med. 194, 471-480 (2001).
    • (2001) J. Exp. Med. , vol.194 , pp. 471-480
    • Yannoutsos, N.1
  • 45
    • 0035999828 scopus 로고    scopus 로고
    • + thymocytes
    • + thymocytes. Nat. Immunol. 3, 469-476 (2002).
    • (2002) Nat. Immunol. , vol.3 , pp. 469-476
    • Guo, J.1
  • 46
    • 0034934221 scopus 로고    scopus 로고
    • T early α (TEA) regulates initial TCRVAJA rearrangements and leads to TCRJA coincidence
    • Mauvieux, L., Villey, I. & de Villartay, J.-P. T early α (TEA) regulates initial TCRVAJA rearrangements and leads to TCRJA coincidence. Eur. J. Immunol. 31, 2080-2086 (2001).
    • (2001) Eur. J. Immunol. , vol.31 , pp. 2080-2086
    • Mauvieux, L.1    Villey, I.2    de Villartay, J.-P.3
  • 47
    • 0033681250 scopus 로고    scopus 로고
    • Ordered recruitment of chromatin modifying and general transcription factors to the IFN-β promoter
    • Agalioti, T. et al. Ordered recruitment of chromatin modifying and general transcription factors to the IFN-β promoter. Cell 103, 667-678 (2000).
    • (2000) Cell , vol.103 , pp. 667-678
    • Agalioti, T.1
  • 48
    • 0034508137 scopus 로고    scopus 로고
    • Gcn4 activator targets Gcn5 histone acetyltransferase to specific promoters independently of transcription
    • Kuo, M.-H., vom Baur, E., Struhl, K. & Allis, C.D. Gcn4 activator targets Gcn5 histone acetyltransferase to specific promoters independently of transcription. Mol. Cell 6, 1309-1320 (2000).
    • (2000) Mol. Cell , vol.6 , pp. 1309-1320
    • Kuo, M.-H.1    vom Baur, E.2    Struhl, K.3    Allis, C.D.4
  • 49
    • 0034212345 scopus 로고    scopus 로고
    • Distribution of acetylated histones resulting from Gal4-VP16 recruitment of SAGA and NuA4 complexes
    • Vignali, M., Steger, D.J., Neely, K.E. & Workman, J.L. Distribution of acetylated histones resulting from Gal4-VP16 recruitment of SAGA and NuA4 complexes. EMBO J. 19, 2629-2640 (2000).
    • (2000) EMBO J. , vol.19 , pp. 2629-2640
    • Vignali, M.1    Steger, D.J.2    Neely, K.E.3    Workman, J.L.4
  • 50
    • 0033598808 scopus 로고    scopus 로고
    • Chromatin modification by DNA tracking
    • Travers, A. Chromatin modification by DNA tracking. Proc. Natl. Acad. Sci. USA 96, 13634-13637 (1999).
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 13634-13637
    • Travers, A.1
  • 51
    • 0034727102 scopus 로고    scopus 로고
    • RNA polymerase II elongation through chromatin
    • Orphanides, G. & Reinberg, D. RNA polymerase II elongation through chromatin. Nature 407, 471-475 (2000).
    • (2000) Nature , vol.407 , pp. 471-475
    • Orphanides, G.1    Reinberg, D.2
  • 52
    • 0033918155 scopus 로고    scopus 로고
    • B-cell repertoire formation: Role of the recombination signal sequence in non-random V segment utilization
    • Feeney, A.J., Tang, A. & Ogwaro, K.M. B-cell repertoire formation: role of the recombination signal sequence in non-random V segment utilization. Immunol. Rev. 175, 59-69 (2000).
    • (2000) Immunol. Rev. , vol.175 , pp. 59-69
    • Feeney, A.J.1    Tang, A.2    Ogwaro, K.M.3
  • 53
    • 0037454957 scopus 로고    scopus 로고
    • Prospective estimation of recombination signal efficiency and identification of functional cryptic signals in the genome by statistical modeling
    • Cowell, L.G., Davila, M., Yang, K., Kepler, T.B. & Kelsoe, G. Prospective estimation of recombination signal efficiency and identification of functional cryptic signals in the genome by statistical modeling. J. Exp. Med. 197, 207-220 (2003).
    • (2003) J. Exp. Med. , vol.197 , pp. 207-220
    • Cowell, L.G.1    Davila, M.2    Yang, K.3    Kepler, T.B.4    Kelsoe, G.5
  • 54
    • 0034675843 scopus 로고    scopus 로고
    • Genetic modulation of T cell receptor gene segment usage during somatic recombination
    • Livak, F., Burtrum, D.B., Rowen, L., Schatz, D.G. & Petrie, H.T. Genetic modulation of T cell receptor gene segment usage during somatic recombination. J. Exp. Med. 192, 1191-1196 (2000).
    • (2000) J. Exp. Med. , vol.192 , pp. 1191-1196
    • Livak, F.1    Burtrum, D.B.2    Rowen, L.3    Schatz, D.G.4    Petrie, H.T.5
  • 55
    • 0037085371 scopus 로고    scopus 로고
    • H elements by the RAG complex: Implications for the immune repertoire
    • H elements by the RAG complex: implications for the immune repertoire. J. Biol. Chem. 277, 5040-5046 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 5040-5046
    • Yu, K.1    Taghva, A.2    Lieber, M.R.3
  • 56
    • 0034214049 scopus 로고    scopus 로고
    • Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule
    • Bassing, C.H. et al. Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule. Nature 405, 583-586 (2000).
    • (2000) Nature , vol.405 , pp. 583-586
    • Bassing, C.H.1
  • 57
    • 0034608888 scopus 로고    scopus 로고
    • Mechanisms that direct ordered assembly of T cell receptor β locus V, D, and J gene segments
    • Sleckman, B.P. et al. Mechanisms that direct ordered assembly of T cell receptor β locus V, D, and J gene segments. Proc. Natl. Acad. Sci. USA 97, 7975-7980 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 7975-7980
    • Sleckman, B.P.1
  • 58
    • 0037242580 scopus 로고    scopus 로고
    • Extrachromosomal recombination substrates recapitulate beyond 12/23 restricted V(D)J recombination in nonlymphoid cells
    • Jung, D., Bassing, C.H., Cheng, H.-L., Schatz, D.G. & Alt, F.W. Extrachromosomal recombination substrates recapitulate beyond 12/23 restricted V(D)J recombination in nonlymphoid cells. Immunity 18, 65-74 (2003).
    • (2003) Immunity , vol.18 , pp. 65-74
    • Jung, D.1    Bassing, C.H.2    Cheng, H.-L.3    Schatz, D.G.4    Alt, F.W.5
  • 59
    • 0037221032 scopus 로고    scopus 로고
    • β rearrangement by RSSs can be mediated by the V(D)J recombinase in the absence of additional lymphoid-specific factors
    • β rearrangement by RSSs can be mediated by the V(D)J recombinase in the absence of additional lymphoid-specific factors. J. Immunol. 170, 5-9 (2003).
    • (2003) J. Immunol. , vol.170 , pp. 5-9
    • Tillman, R.E.1
  • 60
    • 0036850786 scopus 로고    scopus 로고
    • The "dispensable" portion of RAG2 is necessary for efficient V-to-DJ rearrangement during B and T cell development
    • Liang, H.E. et al. The "dispensable" portion of RAG2 is necessary for efficient V-to-DJ rearrangement during B and T cell development. Immunity 17, 639-651 (2002).
    • (2002) Immunity , vol.17 , pp. 639-651
    • Liang, H.E.1
  • 61
    • 0037243276 scopus 로고    scopus 로고
    • β1 recombination signal sequence
    • β1 recombination signal sequence. Immunity 18, 75-85 (2003).
    • (2003) Immunity , vol.18 , pp. 75-85
    • Wu, C.1
  • 62
    • 0026687789 scopus 로고
    • The basis for the mechanistic bias for deletional over inversional V(D)J recombination
    • Gauss, G.H. & Lieber, M.R. The basis for the mechanistic bias for deletional over inversional V(D)J recombination. Genes Dev. 6, 1553-1561 (1992).
    • (1992) Genes Dev. , vol.6 , pp. 1553-1561
    • Gauss, G.H.1    Lieber, M.R.2
  • 64
    • 0030889121 scopus 로고    scopus 로고
    • H recombination and in the ordered rearrangement of the IgH locus
    • H recombination and in the ordered rearrangement of the IgH locus. Int. Immunol. 9, 515-522 (1997).
    • (1997) Int. Immunol. , vol.9 , pp. 515-522
    • Pan, P.Y.1    Lieber, M.R.2    Teale, J.M.3
  • 65
    • 0036682598 scopus 로고    scopus 로고
    • Ordered assembly of the V(D)J synaptic complex ensures accurate recombination
    • Jones, J.M. & Gellert, M. Ordered assembly of the V(D)J synaptic complex ensures accurate recombination. EMBO J. 21, 4162-4171 (2002).
    • (2002) EMBO J. , vol.21 , pp. 4162-4171
    • Jones, J.M.1    Gellert, M.2
  • 67
    • 0035890244 scopus 로고    scopus 로고
    • Stepwise activation of the immunoglobulin μ heavy chain gene locus
    • Chowdhury, D. & Sen, R. Stepwise activation of the immunoglobulin μ heavy chain gene locus. EMBO J. 20, 6394-6403 (2001).
    • (2001) EMBO J. , vol.20 , pp. 6394-6403
    • Chowdhury, D.1    Sen, R.2
  • 68
    • 0034814993 scopus 로고    scopus 로고
    • Histone acetylation beyond promoters: Long-range acetylation patterns in the chromatin world
    • Forsberg, E.C. & Bresnick, E.H. Histone acetylation beyond promoters: long-range acetylation patterns in the chromatin world. BioEssays 23, 820-830 (2001).
    • (2001) BioEssays , vol.23 , pp. 820-830
    • Forsberg, E.C.1    Bresnick, E.H.2
  • 69
    • 0036532118 scopus 로고    scopus 로고
    • ChIPs of the β-globin locus: Unraveling gene regulation within an active domain
    • Bulger, M., Sawado, T., Schubeler, D. & Groudine, M. ChIPs of the β-globin locus: unraveling gene regulation within an active domain. Curr. Opin. Genet. Dev. 12, 170-177 (2002).
    • (2002) Curr. Opin. Genet. Dev. , vol.12 , pp. 170-177
    • Bulger, M.1    Sawado, T.2    Schubeler, D.3    Groudine, M.4
  • 70
    • 0242439142 scopus 로고    scopus 로고
    • Nuclear localization and histone acetylation: A pathway for chromatin opening and transcriptional activation ofthe human β-globin locus
    • Schubeler, D. et al. Nuclear localization and histone acetylation: a pathway for chromatin opening and transcriptional activation ofthe human β-globin locus. Genes Dev. 14, 940-950 (2000 ).
    • (2000) Genes Dev. , vol.14 , pp. 940-950
    • Schubeler, D.1
  • 71
    • 0033853988 scopus 로고    scopus 로고
    • Intergenic transcription and developmental remodeling of chromatin subdomains in the human β-globin locus
    • Gribnau, J., Diderich, K., Pruzina, S., Calzolari, R. & Fraser, P. Intergenic transcription and developmental remodeling of chromatin subdomains in the human β-globin locus. Mol. Cell 5, 377-386 (2000).
    • (2000) Mol. Cell , vol.5 , pp. 377-386
    • Gribnau, J.1    Diderich, K.2    Pruzina, S.3    Calzolari, R.4    Fraser, P.5
  • 72
    • 0035477896 scopus 로고    scopus 로고
    • Core promoters: Active contributors to combinatorial gene regulation
    • Smale, S.T. Core promoters: active contributors to combinatorial gene regulation. Genes Dev. 15, 2503-2508 (2001).
    • (2001) Genes Dev. , vol.15 , pp. 2503-2508
    • Smale, S.T.1
  • 73
    • 0036467996 scopus 로고    scopus 로고
    • Insulators: Many functions, many mechanisms
    • West, A.G., Gaszner, M. & Felsenfeld, G. Insulators: many functions, many mechanisms. Genes Dev. 16, 271-288 (2002).
    • (2002) Genes Dev. , vol.16 , pp. 271-288
    • West, A.G.1    Gaszner, M.2    Felsenfeld, G.3
  • 74
    • 0030992767 scopus 로고    scopus 로고
    • An enhancer blocking element between α and δ gene segments within the human T cell receptor α/δ locus
    • Zhong, X.-P. & Krangel, M.S. An enhancer blocking element between α and δ gene segments within the human T cell receptor α/δ locus. Proc. Natl. Acad. Sci. USA 94, 5219-5224 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 5219-5224
    • Zhong, X.-P.1    Krangel, M.S.2
  • 75
    • 0034796189 scopus 로고    scopus 로고
    • Assessing a role for enhancer-blocking activity in gene regulation within the murine T-cell receptor α/δ locus
    • Sleckman, B.P., Carabana, J., Zhong, X.-P. & Krangel, M.S. Assessing a role for enhancer-blocking activity in gene regulation within the murine T-cell receptor α/δ locus. Immunology 102 (2001).
    • (2001) Immunology , vol.102
    • Sleckman, B.P.1    Carabana, J.2    Zhong, X.-P.3    Krangel, M.S.4
  • 76
    • 0033215223 scopus 로고    scopus 로고
    • The roles of preB and B cell receptors in the stepwise allelic exclusion of mouse IgH and L chain gene loci
    • Melchers, F., ten Boekel, E., Yamagami, T., Andersson, J. & Rolink, A. The roles of preB and B cell receptors in the stepwise allelic exclusion of mouse IgH and L chain gene loci. Semin. Immunol. 11, 307-317 (1999).
    • (1999) Semin. Immunol. , vol.11 , pp. 307-317
    • Melchers, F.1    ten Boekel, E.2    Yamagami, T.3    Andersson, J.4    Rolink, A.5
  • 77
    • 0036525695 scopus 로고    scopus 로고
    • Allelic exclusion at the TCRβ locus
    • Khor, B. & Sleckman, B.P. Allelic exclusion at the TCRβ locus. Curr. Opin. Immunol. 14, 230-234 (2002).
    • (2002) Curr. Opin. Immunol. , vol.14 , pp. 230-234
    • Khor, B.1    Sleckman, B.P.2
  • 78
    • 0033583434 scopus 로고    scopus 로고
    • H rearrangement in immunoglobulin heavy chain transgenic mice: Implications for regulation of allelic exclusion
    • H rearrangement in immunoglobulin heavy chain transgenic mice: implications for regulation of allelic exclusion. J. Exp. Med. 189, 1295-1305 (1999).
    • (1999) J. Exp. Med. , vol.189 , pp. 1295-1305
    • Chang, Y.1    Bosma, M.J.2    Bosma, G.C.3
  • 79
  • 80
    • 0037332014 scopus 로고    scopus 로고
    • Transient I L-7/IL-7R signaling provides a mechanism for feedback inhibition of immunoglobulin heavy chain gene rearrangements
    • Chowdhury, D. & Sen, R. Transient I L-7/IL-7R signaling provides a mechanism for feedback inhibition of immunoglobulin heavy chain gene rearrangements. Immunity 18, 229-241 (2003).
    • (2003) Immunity , vol.18 , pp. 229-241
    • Chowdhury, D.1    Sen, R.2
  • 82
    • 0027485507 scopus 로고
    • Promoter, enhancer and silencer elements regulate rearrangement of an immunogloloulin transgene
    • Lauster, R. et al. Promoter, enhancer and silencer elements regulate rearrangement of an immunogloloulin transgene. EMBO J. 12, 4615-4623 (1993).
    • (1993) EMBO J. , vol.12 , pp. 4615-4623
    • Lauster, R.1
  • 84
    • 0035652459 scopus 로고    scopus 로고
    • The IL-7 receptor controls the accessibility of the TCRγ locus by Stat5 and histone acetylation
    • Ye, S.K. et al. The IL-7 receptor controls the accessibility of the TCRγ locus by Stat5 and histone acetylation. Immunity 15, 813-823 (2001).
    • (2001) Immunity , vol.15 , pp. 813-823
    • Ye, S.K.1
  • 85
    • 0037229028 scopus 로고    scopus 로고
    • Pax5 is required for recombination of transcribed, acetylated, 5′ IgH V gene segments
    • Hesslein, D.G. et al. Pax5 is required for recombination of transcribed, acetylated, 5′ IgH V gene segments. Genes Dev. 17, 37-42 (2003).
    • (2003) Genes Dev. , vol.17 , pp. 37-42
    • Hesslein, D.G.1
  • 86
    • 0035829551 scopus 로고    scopus 로고
    • Asynchronous replication and allelic exclusion in the immune system
    • Mostoslavsky, R. et al. Asynchronous replication and allelic exclusion in the immune system. Nature 414, 221-225 (2001).
    • (2001) Nature , vol.414 , pp. 221-225
    • Mostoslavsky, R.1
  • 87
    • 0037373265 scopus 로고    scopus 로고
    • Coordination of the random asynchronous replication of autosomal loci
    • Singh, N. et al. Coordination of the random asynchronous replication of autosomal loci. Nature Genet. 33, 339-341 (2003).
    • (2003) Nature Genet. , vol.33 , pp. 339-341
    • Singh, N.1
  • 88
    • 0036792721 scopus 로고    scopus 로고
    • Differential accessibility at the κ chain locus plays a role in allelic exclusion
    • Goldmit, M., Schlissel, M., Cedar, H. & Bergman, Y. Differential accessibility at the κ chain locus plays a role in allelic exclusion. EMBO J. 19, 5255-5261 (2002).
    • (2002) EMBO J. , vol.19 , pp. 5255-5261
    • Goldmit, M.1    Schlissel, M.2    Cedar, H.3    Bergman, Y.4
  • 89
    • 0345268756 scopus 로고    scopus 로고
    • Biallelic germline transcription at the κ immunoglobulin locus
    • Singh, N., Bergman, Y., Cedar, H. & Chess, A. Biallelic germline transcription at the κ immunoglobulin locus. J. Exp. Med. 197, 743-750 (2003).
    • (2003) J. Exp. Med. , vol.197 , pp. 743-750
    • Singh, N.1    Bergman, Y.2    Cedar, H.3    Chess, A.4
  • 90
    • 0036591890 scopus 로고    scopus 로고
    • Replication timing and transcriptional control: Beyond cause and effect
    • Gilbert, D.M. Replication timing and transcriptional control: beyond cause and effect. Curr. Opin. Cell Biol. 14, 377-383 (2002).
    • (2002) Curr. Opin. Cell Biol. , vol.14 , pp. 377-383
    • Gilbert, D.M.1
  • 92
    • 0037078986 scopus 로고    scopus 로고
    • Establishment of transcriptional competence in early and late S phase
    • Zhang, J., Xu, F., Hashimshony, T., Keshet, I. & Cedar, H. Establishment of transcriptional competence in early and late S phase. Nature 420, 198-202 (2002).
    • (2002) Nature , vol.420 , pp. 198-202
    • Zhang, J.1    Xu, F.2    Hashimshony, T.3    Keshet, I.4    Cedar, H.5
  • 93
    • 0036274021 scopus 로고    scopus 로고
    • Replication and subnuclear location dynamics of the immunoglobulin heavy-chain locus in B-lineage cells
    • Zhou, J., Ermakova, O.V., Riblet, R., Birshtein, B.K. & Schildkraut, C.L. Replication and subnuclear location dynamics of the immunoglobulin heavy-chain locus in B-lineage cells. Mol. Cell. Biol. 22, 4876-4889 (2002).
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 4876-4889
    • Zhou, J.1    Ermakova, O.V.2    Riblet, R.3    Birshtein, B.K.4    Schildkraut, C.L.5
  • 94
    • 0037023361 scopus 로고    scopus 로고
    • Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development
    • Kosak, S.T. et al. Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development. Science 296, 158-162 (2002).
    • (2002) Science , vol.296 , pp. 158-162
    • Kosak, S.T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.