Identification of a late stage of small noncycling pTα-pre-T cells as immediate precursors of T cell receptor α/β+ thymocytes

Journal of Experimental Medicine

Volumn 188, Issue 8, 1998, Pages 1401-1412

  Trigueros, César ^a   Ramiro, Almudena R ^a   Carrasco, Yolanda R ^a   De Yebenes, Virginia G ^a   Albar, Juan P ^a   Toribio, María L ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

Noncycling; Pre T cells; pT ; Recombination activating gene; T early

Indexed keywords

CD3 ANTIGEN; PROTEIN PRECURSOR; T LYMPHOCYTE RECEPTOR;

ANIMAL TISSUE; ARTICLE; CELL MATURATION; CONTROLLED STUDY; EMBRYO; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; INFANT; MOUSE; NONHUMAN; NORTHERN BLOTTING; PRESCHOOL CHILD; PRIORITY JOURNAL; PROLYMPHOCYTE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; THYMOCYTE; TRANSCRIPTION REGULATION;

ANIMALS; ANTIGENS, CD3; CELL CYCLE; CHILD, PRESCHOOL; GENE EXPRESSION; HEMATOPOIETIC STEM CELLS; HUMANS; INFANT; MICE; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTES;

EID: 0032547765     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.188.8.1401     Document Type: Article

References (38)

1. Dudley, E.C., H.T. Petrie, L.M. Shah, M.J. Owen, and A. Hayday. 1994. T cell receptor β chain gene rearrangement and selection during thymocyte development in adult mice. Immunity. 1:83-93.
2. Levelt, C.N., and K. Eichmann. 1995. Receptors and signals in early thymic selection. Immunity. 3:667-672.
3. von Boehmer, H., and H.J. Fehling. 1997. Structure and function of the pre-T cell receptor. Annu. Rev. Immunol. 15: 433-452.
4. Saint-Ruf, C., K. Ungewiss, M. Groettrup, L. Bruno, H.J. Fehling, and H. von Boehmer. 1994. Analysis and expression of a cloned pre-T cell receptor gene. Science. 266:1208-1212.
5. Groettrup, M., K. Ungewiss, O. Azogui, R. Palacios, M.J. Owen, A.C. Hayday, and H. von Boehmer. 1993. A novel disulfide-linked heterodimer on pre-T cells consists of the T cell receptor β chain and a novel 33 kd glycoprotein. Cell. 75:283-294.
6. Fehling, H.J., A. Krotkova, C. Saint-Ruf, and H. von Boehmer. 1995. Crucial role of the pre-T-cell receptor α gene in development of αβ but not γδ T cells. Nature. 375:795-798.
7. Jacobs, H., J. Iacomini, M. van den Ven, S. Tonegawa, and A. Berns. 1996. Domains of the TCRβ-chain required for early thymocyte development. J. Exp. Med. 184:1833-1843.
8. O'Shea, C.C., A.P. Thornell, I.R. Rosewell, B. Hayes, and M.J. Owen. 1997. Exit of the pre-TCR from the ER/cis-Golgi is necessary for signaling differentiation, proliferation, and allelic exclusion of immature thymocytes. Immunity. 7: 591-599.
9. Irving, B.A., F.W. Alt, and N. Killeen. 1998. Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains. Science. 280:905-908.
10. Borst, J., H. Jacobs, and G. Brouns. 1996. Composition and function of T-cell receptor and B-cell receptor complexes on precursor lymphocytes. Curr. Opin. Immunol. 8:181-190.
11. Hoffman, E.S., L. Passoni, T. Crompton, T.M.J. Leu, D.G. Schatz, A. Foff, M.J. Owen, and A.C. Hayday. 1996. Productive T-cell receptor β-chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo. Genes Dev. 10:948-962.
12. Wilson, A., and H.R. MacDonald. 1995. Expression of genes encoding the pre-TCR and CD3 complex during thymus development. Int. Immunol. 7:1659-1664.
13. Mombaerts, P., S.J. Anderson, R.G. Perlmutter, T.W. Mak, and S. Tonegawa. 1994. An activated lck transgene promotes thymocyte development in RAG-1 mutant mice. Immunity. 1:261-267.
14. Berger, M.A., V. Davé, M.R. Rhodes, G.C. Bosma, M.J. Bosma, D.J. Kappes, and D.L. Wiest. 1997. Subunit composition of pre-T cell receptor complexes expressed by primary thymocytes: CD3δ is physically associated but not functionally required. J. Exp. Med. 186:1461-1467.
15. Ramiro, A.R., C. Trigueros, C. Márquez, J.L. San Millán, and M.L. Toribio. 1996. Regulation of pre-T cell receptor (pTα-TCRβ) gene expression during human thymic development. J. Exp. Med. 184:519-530.
16. Wilson, A., W. Held, and H.R. MacDonald. 1994. Two waves of recombinase gene expression in developing thymocytes. J. Exp. Med. 179:1355-1360.
17. Wilson, A., J.P. de Villartay, and H.R. McDonald. 1996. T cell receptor γ gene rearrangement and T early α (TEA) expression in immature αβ lineage thymocytes: implications for αβ/γδ lineage commitment. Immunity. 4:37-45.
18. Levelt, C.N., B. Wang, A. Ehrfeld, C. Terhorst, and K. Eichmann. 1995. Regulation of T cell receptor (TCR)-β locus allelic exclusion and initiation of TCR-α locus rearrangement in immature thymocytes by signaling through the CD3 complex. Eur. J. Immunol. 25:1257-1261.
19. Petrie, H.T., M. Pearse, R. Scollay, and K. Shortman. 1990. Development of immature thymocytes: initiation of CD3, CD4, and CD8 acquisition parallels down-regulation of the interleukin-2 receptor α chain. Eur. J. Immunol. 20:2813-2816.
20. Petrie, H.T., F. Livak, D.G. Schatz, A. Strasser, I.N. Crispe, and K. Shortman. 1993. Multiple rearrangements in the T cell receptor α chain genes maximize the production of useful thymocytes. J. Exp. Med. 178:615-622.
21. Ernst, B., C.D. Surh, and J. Sprent. 1995. Thymic selection and cell division J. Exp. Med. 182:961-972.
22. Borst, J., J.J.M. van Dongen, E. de Vries, W.M. Comans-Bitter, M.J.D. van Tol, J.M. Vossen, and R. Kurrle. 1990. BMA031, a monoclonal antibody suited to identify the T-cell receptor αβ/CD3 complex on viable human T lymphocytes in normal and disease states. Hum. Immunol. 29:175-188.
23. Band, H., F. Hochstenbach, J. McLean, S. Hata, M.S. Krangel, and M.B. Brenner. 1987. Immunochemical proof that a novel rearranging gene encodes the T cell receptor δ subunit. Science. 238:682-684.
24. Posnett, D.N. 1996. First human TCR monoclonal antibody workshop. The Immunologist. 4:5-8.
25. + T cells: evidence that Vα participates in shaping the peripheral T cell repertoire. J. Exp. Med. 174:639-648.
26. Brenner, M.B., J. McLean, H. Scheft, R.A. Warnke, N. Jones, and J.L. Strominger. 1987. Characterization and expression of the human αβ T cell receptor by using a framework monoclonal antibody. J. Immunol. 138:1502-1509.
27. Mallabiabarrena, A., M.A. Jiménez, M. Rico, and B. Alarcón. 1995. A tyrosine-containing motif mediates ER retention of CD3-ε and adopts a helix-turn structure. EMBO (Eur. Mol. Biol. Organ.) J. 14:2257-2268.
28. Barber, D.F., D. López, and J.A. López de Castro. 1995. T cell receptor diversity in alloreactive responses against HLA-B27 (B*2705) is limited by multiple-level restriction in both α and β chains. Eur. J. Immunol. 25:2479-2485.
29. Yanagi, Y., A. Chan, B. Chin, M. Minden, and T.W. Mak. 1985. Analysis of cDNA clones specific for human T cells and the α and β chains of the T cell receptor heterodimer from a human T cell line. Proc. Natl. Acad. Sci. USA. 82:3430-3434.
30. Yoshikai, Y., D. Anatoniou, S.P. Clark, Y. Yanagi, R. Sangster, P. van den Elsen, C. Terhorst, and T.W. Mak. 1984. Sequence and expression of transcripts of the human T-cell receptor β-chain genes. Nature. 312: 521-524.
31. Turka, L.A., D.G. Schatz, M.A. Oettinger, J.J.M. Chun, C. Gorka, K. Lee, W.T. McCormack, and C.B. Thompson. 1991. Thymocyte expression of RAG-1 and RAG-2: termination by T-cell receptor cross-linking. Science. 253:778-781.
32. Broeren, C.P., G.M. Verjans, W. Van Eden, J.G. Kusters, J.A. Lenstra, and T. Logtenberg. 1991. Conserved nucleotide sequences at the 5′ end of T cell receptor variable genes facilitate polymerase chain reaction amplification. Eur. J. Immunol. 21:569-575.
33. Fisher, A.G., L. Larsson, L.K. Goff, D.E. Restall, L. Happerfield, and M. Merkenschlager. 1990. Human thymocyte development in organ cultures. Int. Immunol. 2:571-578.
34. Reynolds, T.C., S.D. Smith, and J. Sklar. 1987. Analysis of DNA surrounding the breakpoints of chromosomal translocations involving the beta T cell receptor gene in human lymphoblastic neoplasms. Cell 50:107-117.
35. Rajewsky, K. 1996. Clonal selection and learning in the antibody system. Nature. 381:751-758.
36. Falk, I., J. Biro, H. Kohler, and K. Eichmann. 1996. Proliferation kinetics associated with T cell receptor-β chain selection of fetal murine thymocytes. J. Exp. Med. 184:2327-2339.
37. Lundberg, K., and K. Shortman. 1994. Small cortical thymocytes are subject to positive selection. J. Exp. Med. 179: 1475-1483.
38. Ghia, P., E. ten Boekel, E. Sanz, A. de la Hera, A. Rolink, and F. Melchers. 1996. Ordering of human bone marrow B lymphocyte precursors by single-cell polymerase chain reaction analyses of the rearrangement status of the immunoglobulin H and L chain gene loci. J. Exp. Med. 184:2217-2229.