Prethymic CD34+ Progenitors Capable of Developing into T Cells Are Not Committed to the T Cell Lineage

Journal of Immunology

Volumn 158, Issue 8, 1997, Pages 3571-3577

  Blom, Bianca ^a   Res, Pieter ^a   Noteboom, Eric ^a   Weijer, Kees ^a   Spits, Hergen ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN;

ANIMAL; ARTICLE; CELL DIFFERENTIATION; CELL LINEAGE; CYTOLOGY; FEMALE; HEMATOPOIETIC STEM CELL; HUMAN; MOUSE; ORGAN CULTURE TECHNIQUE; PREGNANCY; PRENATAL DEVELOPMENT; T LYMPHOCYTE; THYMUS;

ANIMALS; ANTIGENS, CD34; CELL DIFFERENTIATION; CELL LINEAGE; FEMALE; HEMATOPOIETIC STEM CELLS; HUMANS; MICE; ORGAN CULTURE TECHNIQUES; PREGNANCY; T-LYMPHOCYTES; THYMUS GLAND;

EID: 0031569460     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Haynes, B. F., and C. S. Heinly. 1995. Early human T cell development: analysis of the human thymus at the time of initial entry of hematopoietic stem cells into the fetal thymic microenvironment. J. Exp. Med. 181:1445.
2. Gale, R. P. 1987. Development of the immune system in human fetal liver. Thymus 10:45.
3. Scollay, R., J. Smith, and V. Stauffer. 1986. Dynamics of early T cells: prothymocyte migration and proliferation in the adult mouse thymus. Immunol. Rev. 91:129.
4. Donskoy, E., and I. Goldschneider. 1992. Thymocytopoiesis is maintained by blood-borne precursors throughout postnatal life: a study in parabiotic mice. J. Immunol. 148:1604.
5. Spits, H., L. L. Lanier, and J. H. Phillips. 1995. Development of human T and natural killer cells. Blood 85:2654.
6. Shortman, K., and L. Wu. 1996. Early T lymphocyte progenitors. Annu. Rev. Immunol. 14:29.
7. dim cells in the human thymus can differentiate into T, natural killer and dendritic cells but are distinct from stem cells. Blood 87:5196.
8. +-lineage cells in human thymic organ culture. J. Exp. Med. 180:123.
9. Ardavin, C., L. Wu, C. L. Li, and K. Shortman. 1993. Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population. Nature 362:761.
10. Rodewald, H. R., K. Kretzschmar, S. Takeda, C. Hohl, and M. Dessing. 1994. Identification of pro-thymocytes in murine fetal blood: T lineage commitment can precede thymus colonization. EMBO J. 13:4229.
11. Schmitt, C., S. Ktorza, S. Sarun, M. P. Verpilleux, C. Blanc, M. A. Deugnier, A. Dalloul, and P. Debre. 1995. CD34-positive early stages of human T-cell differentiation. Leuk. Lymphoma 17:43.
12. Ramiro, A. R., C. Trigueros, C. Marquez, J. L. San Millan, and M. Toribio. 1996. Regulation of pre-T cell receptor (pTα-TCRβ) gene expression during human thymic development. J. Exp. Med. 184:519.
13. - progenitor cells. Blood 77:1218.
14. Craig, W., S. Poppema, M. T. Little, W. Dragowska, and P. M. Lansdorp. 1994. CD45 isoform expression on human haemopoietic cells at different stages of development. Br. J. Haematol. 88:24.
15. + cells in the human thymus are defined by expression of CD34: delineation of early events in human thymic development. J. Exp. Med. 178:391.
16. Galy, A., M. Travis, D. Cen, and B. Chen. 1995. Human T, B, natural killer, and dendritic cells arise from a common bone marrow progenitor cell subset. Immunity 3:459.
17. Yssel, H., J. E. de Vries, M. Koken, W. Van Blitterswijk, and H. Spits. 1984. Serum-free medium for generation and propagation of functional human cytotoxic and helper T cell clones. J. Immunol. Methods 72:219.
18. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156.
19. D'Adamio, L., L. K. Clayton, K. M. Awad, and E. L. Reinherz. 1992. Negative selection of thymocytes: a novel polymerase chain reaction-based molecular analysis detects requirements for macromolecular synthesis. J. Immunol. 149:3550.
20. Breit, T. M., I. L. Wolvers-Tettero, A. Beishuizen, M. A. Verhoeven, E. R. van Wering, and J. J. van Dongen. 1993. Southern blot patterns, frequencies, and junctional diversity of T-cell receptor-delta gene rearrangements in acute lymphoblastic leukemia. Blood 82:3063.
21. Sleasman, J. W., T. O. Harville, G. B. White, J. F. George, D. J. Barrett, and M. M. Goodenow. 1994. Arrested rearrangement of TCR Vβ genes in thymocytes from children with X-linked severe combined immunodeficiency disease. J. Immunol. 153:442.
22. Res, P., B. Blom, T. Hori, K. Weijer, and H. Spits. 1997. Down-regulation of CD1 marks acquisition of functional competence by human thymocytes and defines a control point in a late stage of human T cell development. J. Exp. Med. 185:141.
23. - intermediate. J. Exp. Med. 178:265.
24. - subset. J. Immunol. 146:4078.
25. Krangel, M. S., H. Yssel, C. Brocklehurst, and H. Spits. 1990. A distinct wave of human T cell receptor gamma/delta lymphocytes in the early fetal thymus: evidence for controlled gene rearrangement and cytokine production. J. Exp. Med. 172:847.
26. Lauzurica, P., and M. S. Krangel. 1994. Enhancer-dependent and -independent steps in the rearrangement of a human T cell receptor delta transgene. J. Exp. Med. 179:43.
27. Biondi, A., P. Francia di Celle, V. Rossi, G. Casorati, G. Matullo, G. Giudici, R. Foa, and N. Migone. 1990. High prevalence of T-cell receptor Vδ2-(D)-Dδ3 or Dδ1/2-Dδ3 rearrangements in B-precursor acute lymphoblastic leukemias. Blood 75:1834.
28. Steenbergen, E. J., O. J. Verhagen, E. F. van Leeuwen, H. van den Berg, A. E. von dem Borne, and C. E. van der Schoot. 1995. Frequent ongoing T-cell receptor rearrangements in childhood B-precursor acute lymphoblastic leukemia: implications for monitoring minimal residual disease. Blood 86:692.
29. McVay, L. D., S. R. Carding, K. Bottomly, and A. C. Hayday. 1991. Regulated expression and structure of T cell receptor γδ transcripts in human thymic ontogeny. EMBO J. 10:83.
30. Gulwani-Akolkar, B., D. N. Posnett, C. H. Janson, J. Grunewald, H. Wigzell, P. Akolkar, P. K. Gregersen, and J. Silver. 1991. T cell receptor V-segment frequencies in peripheral blood T cells correlate with human leukocyte antigen type. J. Exp. Med. 174:1139.
31. Jores, R., and T. Meo. 1993. Few V gene segments dominate the T cell receptor β-chain repertoire of the human thymus. J. Immunol. 151:6110.
32. + human thymic precursors can be traced by the differential expression of CD44. J. Exp. Med. 181:475.
33. Shinkai, Y., G. Rathbun, K. P. Lam, E. M. Oltz, V. Stewart, M. Mendelsohn, J. Charron, M. Datta, F. Young, A. M. Stall, and F. W. Alt. 1992. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 68:855.
34. Mombaerts, P., J. Iacomini, R. S. Johnson, K. Herrup, S. Tonegawa, and V. E. Papaioannou. 1992. RAG-1-deficient mice have no mature B and T lymphocytes. Cell 68:869.
35. Saint-Ruf, C., K. Ungewiss, M. Groettrup, L. Bruno, H. J. Fehling, and H. Von Boehmer. 1994. Analysis and expression of a cloned pre-T cell receptor gene. Science 266:1208.
36. Fehling, H. J., A. Krotkova, C. Saint-Ruf, and H. Von Boehmer. 1995. Crucial role of the pre-T-cell receptor a gene in development of αβ but not γδ T cells. Nature 375:795.
37. Phillips, J. H., T. Hori, A. Nagler, N. Bhat, H. Spits, and L. L. Lanier. 1992. Ontogeny of human natural killer (NK) cells: fetal NK cells mediate cytolytic function and express cytoplasmic CD3 epsilon, delta proteins. J. Exp. Med. 175: 1055.
38. Terstappen, L. W., S. Huang, and L. J. Picker. 1992. Flow cyometric assessment of human T-cell differentiation in thymus and bone marrow. Blood 79:666.
39. Sánchez, M.-J., M. O. Muench, M. G. Roncarolo, L. Lanier, and J. H. Phillips. 1994. Identification of a common T/NK cell progenitor in human fetal thymus. J. Exp. Med. 180:569.
40. + precursors from human cord blood. J. Immunol. 156:4120.
41. Ktorza, S., S. Sarun, F. Rieux-Laucat, J. P. de Villartay, P. Debre, and C. Schmitt. 1995. CD34-positive early human thymocytes: T cell receptor and cytokine receptor gene expression. Eur. J. Immunol. 25:2471.
42. + human thymic precursors can be traced by the differential expression of CD44. J. Exp. Med. 181:475.
43. Kyoizumi, S., C. M. Baum, H. Kaneshima, J. M. McCune, E. J. Yee, and R. Namikawa. 1992. Implantation and maintenance of functional human bone. Blood 79:1704.
44. Wilson, A., W. Held, and H. R. MacDonald. 1994. Two waves of recombinase gene expression in developing thymocytes. J. Exp. Med. 179:1355.
45. Wilson, A., and H. R. MacDonald. 1995. Expression of genes encoding the preTCR and CD3 complex during thymus development. Int. Immunol. 7:1659.
46. Bruno, L., B. Rocha, A. Rolink, H. Von Boehmer, and H. R. Rodewald. 1995. Intra- and extra-thymic expression of the pre-T cell receptor a gene. Eur. J. Immunol. 25:1877.
47. Soloff, R. S., T. G. Wang, L. Lybarger, D. Dempsey, and R. Chervenak. 1995. Transcription of the TCR-β locus initiales in adult murine bone marrow. J. Immunol. 154:3888.
48. Dejbakhsh-Jones, S., L. Jerabek, I. L. Weissman, and S. Strober. 1995. Extra-thymic maturation of αβ T cells from hemopoietic stem cells. J. Immunol. 155:3338.