Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection

Nature Medicine

Volumn 6, Issue 9, 2000, Pages 1036-1042

  Hazenberg, Mette D ^a   Otto, Sigrid A ^a   Stuart, James W T Cohen ^b   Verschuren, Martie C M ^c   Borleffs, Jan C C ^b   Boucher, Charles A B ^b   Coutinho, Roel A ^d   Lange, Joep M A ^f   De Wit, Tobias F Rinke ^e   Tsegaye, Aster ^e   Van Dongen, Jacques J M ^c   Hamann, Dörte ^a   De Boer, Rob J ^f   Miedema, Frank ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^d MUNICIPAL HEALTH SERVICE   (Netherlands)

^e ETHIOPIAN PUBLIC HEALTH INSTITUTE   (Ethiopia)

^f NONE

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR;

ADULT; AGE DISTRIBUTION; ARTICLE; CELL DIVISION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; LEUKOCYTE COUNT; LYMPHOCYTE DEPLETION; MAJOR CLINICAL STUDY; MALE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; THYMUS FUNCTION;

ANTI-HIV AGENTS; CELL DIVISION; GENE REARRANGEMENT, T-LYMPHOCYTE; HIV INFECTIONS; HIV-1; HUMAN; RECEPTORS, ANTIGEN, T-CELL; SUPPORT, NON-U.S. GOV'T; T-LYMPHOCYTES; THYMUS GLAND;

EID: 0033831175     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/79549     Document Type: Article

References (40)

1. Gaulton, G.N., Scobie, J.V. & Rosenzweig, M. HIV-1 and the thymus. AIDS. 11, 403-414 (1997).
2. Hazenberg, M.D., Clark, D.R. & Miedema, F. Tilted balance of T cell renewal in HIV-1 infection. AIDS Rev. 1, 67-73 (1999).
3. Douek, D.C. et al. Changes in thymic function with age and during the treatment of HIV infection. Nature 396, 690-695 (1999).
4. Livak, F. & Schatz, D.G. T-cell receptor alpha locus V(D)J recombination by-products are abundant in thymocytes and mature T cells. Mol. Cell. Biol. 16, 609-618 (1998).
5. De Villartay, J.P., Hockett, R.D., Coran, D., Korsmeyer, S.J. & Cohen, D.I. Deletion of the human T-cell receptor δ-gene by a site specific recombination. Nature 335, 170-174 (1988).
6. Breit, T.M. et al. Rearrangements of the human TCRD-deleting elements. Immunogenetics 40, 70-75 (1994).
7. Verschuren, M.C.M. et al. Preferential rearrangements of the T cell receptor -deleting elements in human T cells. J. Immunol. 158, 1208-1216 (1997).
8. Breit, T.M., Verschuren, M.C.M., Wolvers-Tettero, I.L.M, Van Gastel-Mol, E.J. & Van Dongen, J.J.M. Human T cell leukemias with continuous V(D)J recombinase activity for TCR-δ gene deletion. J. Immunol. 159, 4341-4349 (1997).
9. Nakajima, P.B., Menetski, J.P., Roth, D.B., Gellert, M. & Bosma, M.J. V-D-J-Rearrangements at the T cell receptor δ locus in mouse thymocytes of the αβ lineage. Immunity 3, 609-621 (1995).
10. Zhang, L. et al. Measuring recent thymic emigrants in blood of normal and HIV-1-infected individuals before and after effective therapy. J. Exp. Med. 190, 725-732 (1999).
11. Jamieson, B.D. et al. Generation of functional thymocytes in the human adult. Immunity 10, 569-575 (1999).
12. Poulin, J.-F. et al. Direct evidence for thymic function in adult humans. J. Exp. Med. 190, 479-486 (1999).
13. Hatzakis, A. et al. Effect of recent thymic emigrants on progression of HIV-1 disease. Lancet 355, 599-604 (2000).
14. Hazenberg, M.D. et al. T cell division in human immunodeficiency virus (HIV-1)-infection is mainly due to immune activation: a longitudinal analysis in patients before and during highly active anti-retroviral therapy. Blood 95, 249-255 (2000).
15. Meyaard, L., Otto, S.A., Keet, I.P.M., Roos, M.Th.L. & Miedema, F. Programmed death of T cells in HIV-1 infection: no correlation with progression to disease. J. Clin. Invest. 93, 982-988 (1994).
16. Grossman, Z., Herberman, R.B. & Dimitrov, D.S. T cell turnover in SIV infection. Science 284, 555a-1999).
17. Gerdes, J. et al. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J. Immunol. 133, 1710-1715 (1984).
18. Kong, F.-K. Chen, C.-L.H., Six, A., Hockett, R.D. & Cooper, M.D. T cell receptor gene deletion circles identify recent thymic emigrants in the peripheral T cell pool. Proc. Natl. Acad. Sci. USA 96, 1536-1540 (1999).
19. Sprent, J. Lifespan of naive, memory and effector lymphocytes. Curr. Op. Immunol. 5, 433-438 (1993).
20. Mclean, A.R. & Michie, C.A. In vivo estimates of division and death rates of human T lymphocytes. Proc. Natl. Acad. Sci. USA 92, 3707-3711 (1995).
21. + T-cell regeneration in HIV-infected adults. Nature Med. 4, 852-856 (1998).
22. Messele, T. et al. Reduced naive and increased activated CD4 and CD8 cells in healthy adult Ethiopians compared with their Dutch counterparts. J. Clin. Exp. Immunol. 115, 443-450 (1999).
23. + T lymphocytes in HIV-1 infection as measured by Ki-67 antigen. J. Exp. Med. 187, 1295-1303 (1998).
24. Roos, M.Th.L. et al. Viro-immunological studies in acute HIV-1 infection. AIDS 8, 1533-1538 (1994).
25. Roos, M.Th.L. et al. Viral phenotype and immune response in primary human immunodeficiency virus type 1 (HIV-1) infection. J. Infect. Dis. 165, 427-432 (1992).
26. Hlntzen, R.Q. et al. Regulation of CD27 expression on subsets of mature T lymphocytes. J. Immunol. 151, 2426-2435 (1993).
27. Tough, D.F. & Sprent, J. Turnover of naive-and memory-phenotype T cells. J. Exp. Med. 179, 1127-1135 (1994).
28. Unutmaz, D., Baldoni, F. & Abrignani, S. Human naive T cells activated by cytokines differentiate into a split phenotype with functional features intermediate between naive and memory cells. Int. Immunol. 7, 1417-1424 (1995).
29. Unutmaz, D. Pileri, P. & Abrignani, S. Antigen-independent activation of naive and memory resting T cells by a cytokine combination. J. Exp. Med. 180, 1159-1164 (1994).
30. + T cell turnover. Science 274, 1543-1547 (1996).
31. + T cells in HIV-1 infection: a mathematical interpretation. AIDS Res. Hum. Retroviruses. 15, 1053-1062 (1999).
32. Clark, D.R., De Boer, R.J., Wolthers, K.C. & Miedema, F. T cell dynamics in HIV-1 infection. Adv. Immunol. 73, 301-327 (1999).
33. Pakker, N.G. et al. Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: a composite of redistribution and proliferation. Nature Med. 4, 208-214 (1998).
34. Hellerstein, M.K. & McCune, J.M. T cell turnover in HIV-1 disease. Immunity. 7, 583-589 (1997).
35. George, A.J.T. & Ritter, M.A. Thymic involution with aging: obsolescence or good housekeeping? Immunol. Today 17, 267-272 (1996).
36. Boom van Noorloos, A.A., Van Beek, A.A.M. & Melief, C.J.M. Cryopreservation of cells for immunological typing of non-Hodgkin's lymphomas. Cancer Res. 40, 2890-2894 (1980).
37. + T cells. J. Exp. Med. 186, 1407-1418 (1997).
38. . T-cell subset contains specialized primed cells. J. Immunol. 154, 17-25 (1995).
39. Hellerstein, M. et al. Directly measured kinetics of circulating T lymphocytes in normal and HIV-1 infected humans. Nature Med. 5, 83-89 (1999).
40. Pongers-Willemse, M.J. et al. Real-time quantitative PCR for the detection of minimal residual disease in acute lymphoblastic leukemia using junctional region specific TaqMan probes. Leukemia 12, 2006-2014 (1998).