Neuronal Receptors for Nicotine: Functional Diversity and Developmental Changes

Brain Development: Normal Processes and the Effects of Alcohol and Nicotine

Volumn , Issue , 2006, Pages

  Mansvelder, Huibert D ^a   Role, Lorna W ^b  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Acetylcholine receptors; Neural development; Neuronal receptors; Nicotine

Indexed keywords

EID: 84919708917     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1093/acprof:oso/9780195183139.003.0021     Document Type: Chapter

References (201)

1. Abreu-Villaca Y, Seidler FJ, Slotkin TA (2004a) Does prenatal nicotine exposure sensitize the brain to nicotine-induced neurotoxicity in adolescence? Neuropsychopharmacology 29:1440-1450.
2. Abreu-Villaca Y, Seidler FJ, Tate CA, Cousins MM, Slotkin TA (2004b) Prenatal nicotine exposure alters the response to nicotine administration in adolescence: effects on cholinergic systems during exposure and withdrawal. Neuropsychopharmacology 29:879-890.
3. Alkondon M, Albuquerque EX (2004) The nicotinic acetylcholine receptor subtypes and their function in the hippocampus and cerebral cortex. Prog Brain Res 145:109-120.
4. Alkondon M, (2005) Nicotinic receptor subtypes in rat hippocampal slices are differentially sensitive to desensitization and early in vivo functional upregulation by nicotine and to block by bupropion. J Pharmacol Exp Ther 313:740-750.
5. Alkondon M, Pereira EF, Barbosa CT, Albuquerque EX (1997) Neuronal nicotinic acetylcholine receptor activation modulates γ-aminobutyric acid release from CA1 neurons of rat hippocampal slices. J Pharmacol Exp Ther 283:1396-1411.
6. Alkondon M, Pereira EF, Eisenberg HM, Albuquerque EX (1999) Choline and selective antagonists identify two subtypes of nicotinic acetylcholine receptors that modulate GAB A release from CA1 interneurons in rat hippocampal slices. J Neurosci 19:2693-2705.
7. Alkondon M, (2000) Nicotinic receptor activation in human cerebral cortical interneurons: a mechanism for inhibition and disinhibition of neuronal networks. J Neurosci 20:66-75.
8. Atluri P, Fleck MW, Shen Q, Mah SJ, Stadfelt D, Barnes W, Goderie SK, Temple S, Schneider AS (2001) Functional nicotinic acetylcholine receptor expression in stem and progenitor cells of the early embryonic mouse cerebral cortex. Dev Biol 240:143-156.
9. Audet MA, Descarries L, Doucet G (1989) Quantified regional and laminar distribution of the serotonin innervation in the anterior half of adult rat cerebral cortex. J Chem Neuroanat 2:29-44.
10. Audet MA, Doucet G, Oleskevich S, Descarries L (1988) Quantified regional and laminar distribution of the noradrenaline innervation in the anterior half of the adult rat cerebral cortex. J Comp Neurol 274:307-318.
11. Avendano C, Umbriaco D, Dykes RW, Descarries L (1996) Acetylcholine innervation of sensory and motor neocortical areas in adult cat: a choline acetyltransferase immunohistochemical study. J Chem Neuroanat 11:113-130.
12. Benes FM, Taylor JB, Cunningham MC (2000) Convergence and plasticity of monoaminergic systems in the medial prefrontal cortex during the postnatal period: implications for the development of psychopathology. Cereb Cortex 10:1014-1027.
13. Berg DK, Conroy WG (2002) Nicotinic α7 receptors: synaptic options and downstream signaling in neurons. J Neurobiol 53:512-523.
14. Blank M, Triana-Baltzer GB, Richards CS, Berg DK (2004) A-protocadherins are pre-synaptic and axonal in nicotinic pathways. Mol Cell Neurosci 26:530-543.
15. Brejc K, van Dijk WJ, Klaassen RV, Schuurmans M, van Der OJ, Smit AB, Sixma TK (2001) Crystal structure of an ACh-binding protein reveals the ligandbinding domain of nicotinic receptors. Nature 411:269-276.
16. Broide RS, Leslie FM (1999) The α7 nicotinic acetylcholine receptor in neuronal plasticity. Mol Neurobiol 20:1-16.
17. Broide RS, Robertson RT, Leslie FM (1996) Regulation of α7 nicotinic acetylcholine receptors in the developing rat somatosensory cortex by thalamocortical afferents. J Neurosci 16:2956-2971.
18. Broide RS, O'Connor LT, Smith MA, Smith JA, Leslie FM (1995) Developmental expression of α7 neuronal nicotinic receptor messenger RNA in rat sensory cortex and thalamus. Neuroscience 67:83-94.
19. Brumwell CL, Johnson JL, Jacob MH (2002) Extrasynaptic α7-nicotinic acetylcholine receptor expression in developing neurons is regulated by inputs, targets, and activity. J Neurosci 22:8101-8109.
20. Buznikov GA, Rakich L (2000) Cholinoreceptors of early (preneural) sea urchin embryos. Neurosci Behav Physiol 30:53-62.
21. Cauli B, Audinat E, Lambolez B, Angulo MC, Ropert N, Tsuzuki K, Hestrin S, Rossier J (1997) Molecular and physiological diversity of cortical nonpyramidal cells. J Neurosci 17:3894-3906.
22. Champtiaux N, Gotti C, Cordero-Erausquin M, David DJ, Przybylski C, Lena C, Clementi F, Moretti M, Rossi FM, Le Novere N, Mclntosh JM, Gardier AM, Changeux JP (2003) Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice. J Neurosci 23:7820-7829.
23. Champtiaux N, Han ZY, Bessis A, Rossi FM, Zoli M, Marubio L, McIntosh JM, Changeux JP (2002) Distribution and pharmacology of α6-containing nicotinic acetylcholine receptors analyzed with mutant mice. J Neurosci 22:1208-1217.
24. Changeux J, Edelstein SJ (2001) Allosteric mechanisms in normal and pathological nicotinic acetylcholine receptors. Curr Opin Neurobiol 11:369-377.
25. Charpantier E, Barneoud P, Moser P, Besnard F, Sgard F (1998) Nicotinic acetylcholine subunit mRNA expression in dopaminergic neurons of the rat substantia nigra and ventral tegmental area. Neuroreport 9:3097-3101.
26. Chassin L, Presson CC, Rose JS, Sherman SJ (1996) The natural history of cigarette smoking from adolescence to adulthood: demographic predictors of continuity and change. Health Psychol 15:478-484.
27. Clarke PB, Schwartz RD, Paul SM, Pert CB, Pert A (1985) Nicotinic binding in rat brain: autoradiographic comparison of [3H]acetylcholine, [3H]nicotine, and [125I]-α-bungarotoxin. J Neurosci 5:1307-1315.
28. Cohen G, Roux JC, Grailhe R, Malcolm G, Changeux JP, Lagercrantz H (2005) Perinatal exposure to nicotine causes deficits associated with a loss of nicotinic receptor function. Proc Natl Acad Sci USA 102:3817-3821.
29. Colquhoun LM, Patrick JW (1997) Pharmacology of neuronal nicotinic acetylcholine receptor subtypes. Adv Pharmacol 39:191-220.
30. Connors BW, Telfeian AE (2000) Dynamic properties of cells, synapses, circuits, and seizures in neocortex. Adv Neurol 84:141-152.
31. Contant C, Umbriaco D, Garcia S, Watkins KC, Descarries L (1996) Ultrastructural characterization of the acetylcholine innervation in adult rat neostriatum. Neuroscience 71:937-947.
32. Cordero-Erausquin M, Marubio LM, Klink R, Changeux JP (2000) Nicotinic receptor function: new perspectives from knockout mice. Trends Pharmacol Sci 21:211-217.
33. Court JA, Lloyd S, Johnson M, Griffiths M, Birdsall NJ, Piggott MA, Oakley AE, Ince PG, Perry EK, Perry RH (1997) Nicotinic and muscarinic cholinergic receptor binding in the human hippocampal formation during development and aging. Brain Res Dev Brain Res 101:93-105.
34. Cuevas J, Roth AL, Berg DK (2000) Two distinct classes of functional 7-containing nicotinic receptor on rat superior cervical ganglion neurons. J Physiol 525(Pt 3):735-746.
35. Dajas-Bailador F, Wonnacott S (2004) Nicotinic acetylcholine receptors and the regulation of neuronal signalling. Trends Pharmacol Sci 25:317-324.
36. Dani JA (2001) Overview of nicotinic receptors and their roles in the central nervous system. Biol Psychiatry 49:166-174.
37. Dani JA, Ji D, Zhou FM (2001) Synaptic plasticity and nicotine addiction. Neuron 31:349-352.
38. de Rover M, Lodder JC, Kits KS, Schoffelmeer AN, Brussaard AB (2002) Cholinergic modulation of nucleus accumbens medium spiny neurons. Eur J Neurosci 16:2279-2290.
39. de Rover M, Mansvelder HD, Lodder JC, Wardeh G, Schoffelmeer AN, Brussaard AB (2004) Long-lasting nicotinic modulation of GABAergic synaptic transmission in the rat nucleus accumbens associated with behavioural sensitization to amphetamine. Eur J Neurosci 19:2859-2870.
40. Descarries L, Gisiger V, Steriade M (1997) Diffuse transmission by acetylcholine in the CNS. Prog Neurobiol 53:603-625.
41. Descarries L, Mechawar N (2000) Ultrastructural evidence for diffuse transmission by monoamine and acetylcholine neurons of the central nervous system. Prog Brain Res 125:27-47.
42. Devay P, McGehee DS, Yu CR, Role LW (1999) Target-specific control of nicotinic receptor expression at developing interneuronal synapses in chick. Nat Neurosci 2:528-534.
43. Di Angelantonio S, Giniatullin R, Costa V, Sokolova E, Nistri A (2003) Modulation of neuronal nicotinic receptor function by the neuropeptides CGRP and substance P on autonomie nerve cells. Br J Pharmacol 139:1061-1073.
44. Drisdel RC, Manzana E, Green WN (2004) The role of palmitoylation in functional expression of nicotinic α7 receptors. J Neurosci 24:10502-10510.
45. Ebrahim SH, Floyd RL, Merritt RK 2nd, Decoufle P, Holtzman D (2000) Trends in pregnancy-related smoking rates in the United States, 1987-1996. JAMA 283:361-366.
46. Elgoyhen AB, Vetter DE, Katz E, Rothlin CV, Heinemann SF, Boulter J (2001) α10: a determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells. Proc Nati Acad Sci USA 98:3501-3506.
47. Ernst M, Moolchan ET, Robinson ML (2001) Behavioral and neural consequences of prenatal exposure to nicotine. J Am Acad Child Adolesc Psychiatry 40:630-641.
48. Everitt BJ, Dickinson A, Robbins TW (2001) The neuropsychological basis of addictive behaviour. Brain Res Brain Res Rev 36:129-138.
49. Falk L, Nordberg A, Seiger A, Kjaeldgaard A, Hellstrom-Lindahl E (2002) The α7 nicotinic receptors in human fetal brain and spinal cord. J Neurochem 80:457-465.
50. Falk L, (2003) Higher expression of α7 nicotinic acetylcholine receptors in human fetal compared to adult brain. Brain Res Dev Brain Res 142:151-160.
51. Falugi C (1993) Localization and possible role of molecules associated with the cholinergic system during "non-nervous" developmental events. Eur J Histochem 37:287-294.
52. Fischer H, Orr-Urtreger A, Role LW, Huck S (2005) Selective deletion of the α5 subunit differentially affects somatic-dendritic versus axonally targeted nicotinic ACh receptors in mouse. J Physiol 563:119-137.
53. Fisher JL, Pidoplichko VI, Dani JA (1998) Nicotine modifies the activity of ventral tegmental area dopaminergic neurons and hippocampal GABAergic neurons. J Physiol Paris 92:209-213.
54. Frank MG, Srere H, Ledezma C, O'Hara B, Heller HC (2001) Prenatal nicotine alters vigilance states and AchR gene expression in the neonatal rat: implications for SIDS. Am J Physiol (Regul Integr Comp Physiol) 280:R1134-1140.
55. Frazier CJ, Rollins YD, Breese CR, Leonard S, Freedman R, Dunwiddie TV (1998) Acetylcholine activates an α-bungarotoxin-sensitive nicotinic current in rat hippocampal interneurons, but not pyramidal cells. JNeurosci 18:1187-1195.
56. Freedman R, Olincy A, Ross RG, Waldo MC, Stevens KE, Adler LE, Leonard S (2003) The genetics of sensory gating deficits in schizophrenia. Curr Psychiatry Rep 5:155-161.
57. Fuchs JL (1989) [125I]α-bungarotoxin binding marks primary sensory area developing rat neocortex. Brain Res 501:223-234.
58. Fucile S (2004) Ca2+ permeability of nicotinic acetylcholine receptors. Cell Calcium 35:1-8.
59. Fujii S, Ji Z, Morita N, Sumikawa K (1999) Acute and chronic nicotine exposure differentially facilitate the induction of LTP. Brain Res 846:137-143.
60. Gabbott PL, Dickie BG, Vaid RR, Headlam AJ, Bacon SJ (1997) Local-circuit neurones in the medial pre-frontal cortex (areas 25, 32 and 24b) in the rat: morphology and quantitative distribution. J Comp Neurol 377:465-499.
61. Gabbott PL, Warner TA, Jays PR, Bacon SJ (2003) Areal and synaptic interconnectivity of prelimbic (area 32), infralimbic (area 25) and insular cortices in the rat. Brain Res 993:59-71.
62. Gentry CL, Lukas RJ (2002) Regulation of nicotinic acetylcholine receptor numbers and function by chronic nicotine exposure. Curr Drug Targets CNS Neurol Disord 1:359-385.
63. Genzen JR, McGehee DS (2003) Short- and long-term enhancement of excitatory transmission in the spinal cord dorsal horn by nicotinic acetylcholine receptors. Proc Nati Acad Sci USA 100:6807-6812.
64. Gerzanich V, Wang F, Kuryatov A, Lindstrom J (1998) α5 subunit alters desensitization, pharmacology, Ca++ permeability and Ca++ modulation of human neuronal α3 nicotinic receptors. J Pharmacol Exp Ther 286:311-320.
65. Gil Z, Connors BW, Amitai Y (1997) Differential regulation of neocortical synapses by neuromodulators and activity. Neuron 19:679-686.
66. Gioanni Y, Rougeot C, Clarke PB, Lepouse C, Thierry AM, Vidal C (1999) Nicotinic receptors in the rat prefrontal cortex: increase in glutamate release and facilitation of mediodorsal thalamocortical transmission. Eur J Neurosci 11:18-30.
67. Girod R, Role LW (2001) Long-lasting enhancement of glutamatergic synaptic transmission by acetylcholine contrasts with response adaptation after exposure to low-level nicotine. J Neurosci 21:5182-5190.
68. Gotti C, Clementi F (2004) Neuronal nicotinic receptors: from structure to pathology. Prog Neurobiol 74:363-396.
69. Grady S, Marks MJ, Wonnacott S, Collins AC (1992) Characterization of nicotinic receptor-mediated [3H]dopamine release from synaptosomes prepared from mouse striatum. J Neurochem 59:848-856.
70. Grant BF, Dawson DA (1997) Age at onset of alcohol use and its association with DSM-IV alcohol abuse and dependence: results from the National Longitudinal Alcohol Epidemiologic Survey. J Subst Abuse 9:103-110.
71. Gray R, Rajan AS, Radcliffe KA, Yakehiro M, Dani JA (1996) Hippocampal synaptic transmission enhanced by low concentrations of nicotine. Nature 383:713-716.
72. Groot-Kormelink PJ, Luyten WH, Colquhoun D, Sivilotti LG (1998) A reporter mutation approach shows incorporation of the "orphan" subunit β3 into a functional nicotinic receptor. J Biol Chem 273:15317-15320.
73. Hellstrom-Lindahl E, Court JA (2000) Nicotinic acetylcholine receptors during prenatal development and brain pathology in human aging. Behav Brain Res 113:159-168.
74. Hellstrom-Lindahl E, Gorbounova O, Seiger A, Mousavi M, Nordberg A (1998) Regional distribution of nicotinic receptors during prenatal development of (p.358) human brain and spinal cord. Dev Brain Res 108:147-160.
75. Hellstrom-Lindahl E, Seiger A, Kjaeldgaard A, Nordberg A (2001) Nicotineinduced alterations in the expression of nicotinic receptors in primary cultures from human prenatal brain. Neuroscience 105:527-534.
76. Hogg RC, Raggenbass M, Bertrand D (2003) Nicotinic acetylcholine receptors: from structure to brain function. Rev Physiol Biochem Pharmacol 147:1-46.
77. Hohmann CF, Berger-Sweeney J (1998) Cholinergic regulation of cortical development and plasticity. New twists to an old story. Perspect Dev Neurobiol 5:401-425.
78. Houser CR, Crawford GD, Salvaterra PM, Vaughn JE (1985) Immunocytochemical localization of choline acetyltransferase in rat cerebral cortex: a study of cholinergic neurons and synapses. J Comp Neurol 234:17-34.
79. Howard MJ, Gershon MD, Margiotta JF (1995) Expression of nicotinic acetylcholine receptors and sub-unit mRNA transcripts in cultures of neural crest cells. Dev Biol 170:479-495.
80. Hume RI, Role LW, Fischbach GD (1983) Acetylcholine release from growth cones detected with patches of acetylcholine receptorrich membranes. Nature 305:632-634.
81. Ivonnet PI, Chambers EL (1997) Nicotinic acetylcholine receptors of the neuronal type occur in the plasma membrane of sea urchin eggs. Zygote 5:277-287.
82. Jensen ML, Schousboe A, Ahring PK (2005) Charge selectivity of the Cys-loop family of ligand-gated ion channels. J Neurochem 92:217-225.
83. Ji D, Dani JA (2000) Inhibition and disinhibition of pyramidal neurons by activation of nicotinic receptors on hippocampal interneurons. J Neurophysiol 83:2682-2690.
84. Ji D, Lape R, Dani JA (2001) Timing and location of nicotinic activity enhances or depresses hippocampal synaptic plasticity. Neuron 31:131-141.
85. Jones IW, Bolam JP, Wonnacott S (2001) Pre-synaptic localisation of the nicotinic acetylcholine receptor β2 subunit immunoreactivity in rat nigrostriatal dopaminergic neurones. J Comp Neurol 439:235-247.
86. Jones IW, Wonnacott S (2004) Precise localization of α7 nicotinic acetylcholine receptors on glutamatergic axon terminals in the rat ventral tegmental area. J Neurosci 24:11244-11252.
87. Jones S, Sudweeks S, Yakel JL (1999) Nicotinic receptors in the brain: correlating physiology with function. Trends Neurosci 22:555-561.
88. Jones S, Yakel JL (1997) Functional nicotinic ACh receptors on interneurones in the rat hippocampus. J Physiol 504:603-610.
89. Kandel DB, Yamaguchi K, Chen K (1992) Stages of progression in drug involvement from adolescence to adulthood-further evidence for the gateway theory. J Stud Alcohol 53:447-457.
90. Kaneko WM, Britto LR, Lindstrom JM, Karten HJ (1998) Distribution of the α7 nicotinic acetylcholine receptor subunit in the developing chick cerebellum. Dev Brain Res 105:141-145.
91. Karlin A (2002) Emerging structure of the nicotinic acetylcholine receptors. Nat Rev Neurosci 3:102-114.
92. Kawaguchi Y (1993) Groupings of nonpyramidal and pyramidal cells with specific physiological and morphological characteristics in rat frontal cortex. J Neurophysiol 69:416-431.
93. Kawaguchi Y (1995) Physiological subgroups of nonpyramidal cells with specific morphological characteristics in layer II/III of rat frontal cortex. J Neurosci 15:2638-2655.
94. Kawaguchi Y, Kondo S (2002) Parvalbumin, somatostatin and cholecystokinin as chemical markers for specific GABAergic interneuron types in the rat frontal cortex. J Neurocytol 31:277-287.
95. Keiger CJ, Prevette D, Conroy WG, Oppenheim RW (2003) Developmental expression of nicotinic receptors in the chick and human spinal cord. J Comp Neurol 455:86-99.
96. Khiroug SS, Harkness PC, Lamb PW, Sudweeks SN, Khiroug L, Millar NS, Yakel JL (2002) Rat nicotinic ACh receptor α7 and β2 subunits co-assemble to form functional heteromerie nicotinic receptor channels. J Physiol 540:425-434.
97. Khiroug SS, Khiroug L, Yakel JL (2004) Rat nicotinic acetylcholine receptor α2 β2 channels: comparison of functional properties with α4 β2 channels in Xenopus oocytes. Neuroscience 124:817-822.
98. King SL, Marks MJ, Grady SR, Caldarone BJ, Koren AO, Mukhin AG, Collins AC, Picciotto MR (2003) Conditional expression in corticothalamic efferents reveals a developmental role for nicotinic acetylcholine receptors in modulation of passive avoidance behavior. J Neurosci 23:3837-3843.
99. Kinney HC, O'Donnell TJ, Kriger P, White WF (1993) Early developmental changes in [3H]nicotine binding in the human brainstem. Neuroscience 55:1127-1138.
100. Klink R, de Kerchove dEA, Zoli M, Changeux JP (2001) Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei. J Neurosci 21:1452-1463.
101. Kuryatov A, Olale F, Cooper J, Choi C, Lindstrom J (2000) Human α6 AChR subtypes: subunit composition, assembly, and pharmacological responses. Neuropharmacology 39:2570-2590.
102. Lambe EK, Picciotto MR, Aghajanian GK (2003) Nicotine induces glutamate release from thalamocortical terminals in prefrontal cortex. Neuropsychopharmacology 28:216-225.
103. Lauder JM, Schambra UB (1999) Morphogenetic roles of acetylcholine. Environ Health Persp 107(Suppl l):65-69.
104. Laurie DJ, Wisden W, Seeburg PH (1992) The distribution of thirteen GABAA receptor subunit mRNAs in the rat brain. III. Embryonic and postnatal development. J Neurosci 12:4151-4172.
105. Laviolette SR, van der Kooy D (2004) The neurobiology of nicotine addiction: bridging the gap from molecules to behaviour. Nat Rev Neurosci 5:55-65.
106. Leech SL, Richardson GA, Goldschmidt L, Day NL (1999) Prenatal substance exposure: effects on attention and impulsivity of 6-year-olds. Neurotoxicol Teratol 21:109-118.
107. Le Foil B, Goldberg SR (2004) Rimonabant, a CB1 antagonist, blocks nicotineconditioned place preferences. Neuroreport 15:2139-2143.
108. Lena C, Changeux JP (1997) Role of Ca2+ ions in nicotinic facilitation of GAB A release in mouse thalamus. J Neurosci 17:576-585.
109. Lena C, Changeux JP, Mulle C (1993) Evidence for "preterminal" nicotinic receptors on GABAergic axons in the rat interpeduncular nucleus. J Neurosci 13:2680-2688.
110. Lena C, de Kerchove D'Exaerde A, Cordero-Erausquin M, Le Novere N, del Mar Arroyo-Jimenez M, Changeux JP (1999) Diversity and distribution of nicotinic acetylcholine receptors in the locus ceruleus neurons. Proc Natl Acad Sci USA 96:12126-12131.
111. Le Novere N, Changeux JP (1995) Molecular evolution of the nicotinic acetylcholine receptor: an example of multigene family in excitable cells. J Mol Evol 40:155-172.
112. Le Novere N, Corringer PJ, Changeux JP (2002a) The diversity of subunit composition in nAChRs: evolutionary origins, physiologic and pharmacologie consequences. J Neurobiol 53:447-456.
113. Le Novere N, Grutter T, Changeux JP (2002b) Models of the extracellular domain of the nicotinic receptors and of agonist- and Ca2+-binding sites. Proc Natl Acad Sci USA 99:3210-3215.
114. Le Novere N, Zoli M, Changeux JP (1996) Neuronal nicotinic receptor α6 subunit mRNA is selectively concentrated in catecholaminergic nuclei of the rat brain. Eur J Neurosci 8:2428-2439.
115. Lester HA, Dibas MI, Dahan DS, Leite JF, Dougherty DA (2004) Cys-loop receptors: new twists and turns. Trends Neurosci 27:329-336.
116. Lester HA, Fonck C, Tapper AR, McKinney S, Damaj MI, Balogh S, Owens J, Wehner JM, Collins AC, Labarca C (2003), Hypersensitive knockin mouse strains identify receptors and pathways for nicotine action. Curr Opin Drug Disc Dev 6:633-639.
117. Liu Z, Tearle AW, Nai Q, Berg DK (2005) Rapid activity-driven SNAREdependent trafficking of nicotinic receptors on somatic spines. J Neurosci 25:1159-1168.
118. Lu Y, Marks MJ, Collins AC (1999) Desensitization of nicotinic agonist-induced [3H]γ-aminobutyric acid release from mouse brain synaptosomes is produced by subactivatirig concentrations of agonists. J Pharmacol Exp Ther 291:1127-1134.
119. Lukas RJ, Changeux JP, Le Novere N, Albuquerque EX, Balfour DJ, Berg DK, Bertrand D, Chiappinelli VA, Clarke PB, Collins AC, Dani JA, Grady SR, Kellar KJ, Lindstrom JM, Marks MJ, Quik M, Taylor PW, Worinacott S (1999) International Union of Pharmacology. XX. Current status of the nomenclature for nicotinic acetylcholine receptors and their subunits. Pharmacol Rev 51:397-401.
120. MacDermott AB, Role LW, Siegelbaum SA (1999) Pre-synaptic ionotropic receptors and the control of transmitter release. Annu Rev Neurosci 22:443-485.
121. Maggi L, Le Magueresse C, Changeux JP, Cherubini E (2003) Nicotine activates immature "silent" connections in the developing hippocampus. Proc Natl Acad Sci USA 100:2059-2064.
122. Maggi L, Sola E, Minneci F, Le Magueresse C, Changeux JP, Cherubini E (2004) Persistent decrease in synaptic efficacy induced by nicotine at Schaffer collateral-CAl synapses in the immature rat hippocampus. J Physiol 559:863-874.
123. Mann EO, Greenfield SA (2003) Novel modulatory mechanisms revealed by the sustained application of nicotine in the guinea-pig hippocampus in vitro. J Physiol 551:539-550.
124. Mansvelder HD, Keath JR, McGehee DS (2002) Synaptic mechanisms underlie nicotine-induced excitability of brain reward areas. Neuron 33:905-919.
125. Mansvelder HD, McGehee DS (2000) Long-term potentiation of excitatory inputs to brain reward areas by nicotine. Neuron 27:349-357.
126. Mansvelder HD, (2002) Cellular and synaptic mechanisms of nicotine addiction. J Neurobiol 53:606-617.
127. Marubio LM, Changeux J (2000) Nicotinic acetylcholine receptor knockout mice as animal models for studying receptor function. Eur J Pharmacol 393:113-121.
128. Mathews TJ (2001) Smoking during pregnancy in the 1990s. Nati Vital Stat Rep 49:1-14.
129. Matsubayashi H, Amano T, Seki T, Sasa M, Sakai N (2004) Post-synaptic α4 β2 and α7 type nicotinic acetylcholine receptors contribute to the local and endogenous acetylcholine-mediated synaptic transmissions in nigral dopaminergic neurons. Brain Res 1005:1-8.
130. McGehee DS, Heath MJ, Gelber S, Devay P, Role LW (1995) Nicotine enhancement of fast excitatory synaptic transmission in CNS by pre-synaptic receptors. Science 269:1692-1696.
131. McGehee DS, Role LW (1996) Pre-synaptic ionotropic receptors. Curr Opin Neurobiol 6:342-349.
132. McQuiston AR, Madison DV (1999) Nicotinic receptor activation excites distinct subtypes of interneurons in the rat hippocampus. J Neurosei 19:2887-2896.
133. Mechawar N, Descarries L (2001) The cholinergic innervation develops early and rapidly in the rat cerebral cortex: a quantitative immunocytochemical study. Neuroscience 108:555-567.
134. Mechawar N, Watkins KC, Descarries L (2002) Ultra-structural features of the acetylcholine innervation in the developing parietal cortex of rat. J Comp Neurol 443:250-258.
135. Metherate R (2004) Nicotinic acetylcholine receptors in sensory cortex. Learn Mem 11:50-59.
136. Metherate R, Hsieh CY (2003) Regulation of glutamate synapses by nicotinic acetylcholine receptors in auditory cortex. Neurobiol Learn Mem 80:285-290.
137. Miwa JM, Ibanez-Tallon I, Crabtree GW, Sanchez R, Sali A, Role LW, Heintz N (1999) lynxl, an endogenous toxin-like modulator of nicotinic acetylcholine receptors in the mammalian CNS. Neuron 23:105-114.
138. Monyer H, Burnashev N, Laurie DJ, Sakmann B, Seeburg PH (1994) Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 12:529-540.
139. Mulle C, Vidal C, Benoit P, Changeux JP (1991) Existence of different subtypes of nicotinic acetylcholine receptors in the rat habenulo-interpeduncular system. J Neurosei 11:2588-2597.
140. Nai Q, Mclntosh JM, Margiotta JF (2003) Relating neuronal nicotinic acetylcholine receptor subtypes defined by subunit composition and channel function. Mol Pharmacol 63:311-324.
141. Newhouse PA, Potter A, Singh A (2004a) Effects of nicotinic stimulation on cognitive performance. Curr Opin Pharmacol 4:36-46.
142. Newhouse P, Sirigh A, Potter A (2004b) Nicotine and nicotinic receptor involvement in neuropsychiatrie disorders. Curr Top Med Chem 4:267-282.
143. Nicke A (2004) Learning about structure and function of neuronal nicotinic acetylcholine receptors. Lessons from snails. Eur J Biochem 271:2293.
144. Nicke A, Wonnacott S, Lewis RJ (2004) A-conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes. Eur J Biochem 271:2305-2319.
145. Oz M, Zhang L, Ravindran A, Morales M, Lupica CR (2004) Differential effects of endogenous and synthetic cannabinoids on α7-nicotinic acetylcholine receptor-mediated responses in Xenopus oocytes. J Pharmacol Exp Ther 310:1152-1160.
146. Peters A, Jones EG (1984) Cerebral Cortex. Vol. 1. Cellular Components of the Cerebral Cortex. Wiley-Liss, New York.
147. Picciotto MR (2003) Nicotine as a modulator of behavior: beyond the inverted U. Trends Pharmacol Sci 24:493-499.
148. Picciotto MR, Caldarone BJ, Brunzell DH, Zachariou V, Stevens TR, King SL (2001) Neuronal nicotinic acetylcholine receptor subunit knockout mice: physiological and behavioral phenotypes and possible clinical implications. Pharmacol Ther 92:89-108.
149. Picciotto MR, Corrigall WA (2002) Neuronal systems underlying behaviors related to nicotine addiction: neural circuits and molecular genetics. J Neurosei 22:3338-3341.
150. Picciotto MR, Zoli M, Lena C, Bessis A, Lallemand Y, Le Novere N, Vincent P, Pich EM, Brulet P, Changeux JP (1995) Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain. Nature 374:65-67.
151. Picciotto MR, Zoli M, Rimondini R, Lena C, Marubio LM, Pich EM, Fuxe K, Changeux JP (1998) Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine. Nature 391:173-177.
152. Pidoplichko VI, DeBiasi M, Williams JT, Dani JA (1997) Nicotine activates and desensitizes midbrain dopamine neurons. Nature 390:401-404.
153. Pidoplichko VI, Noguchi J, Areola OO, Liang Y, Peterson J, Zhang T, Dani JA (2004) Nicotinic cholinergic synaptic mechanisms in the ventral tegmental area contribute to nicotine addiction. Learn Mem 11:60-69.
154. Porter JT, Cauli B, Tsuzuki K, Lambolez B, Rossier J, Audinat E (1999) Selective excitation of subtypes of neocortical interneurons by nicotinic receptors. J Neurosei 19:5228-5235.
155. Quick MW, Lester RA (2002) Desensitization of neuronal nicotinic receptors. J Neurobiol 53:457-478.
156. Radcliffe KA, Fisher JL, Gray R, Dani JA (1999) Nicotinic modulation of glutamate and GABA synaptic (p.361) transmission of hippocampal neurons. Ann NY AcadSci 868:591-610.
157. Ramirez-Latorre J, Yu CR, Qu X, Perin F, Karlin A, Role L (1996) Functional contributions of α5 subunit to neuronal acetylcholine receptor channels. Nature 380:347-351.
158. Rapier C, Lunt GG, Wonnacott S (1988) Stereoselective nicotine-induced release of dopamine from striatal synaptosomes: concentration dependence and repetitive stimulation. J Neurochem 50:1123-1130.
159. Robertson RT, Mostamand F, Kageyama GH, Gallardo KA, Yu J (1991) Primary auditory cortex in the rat: transient expression of acetylcholinesterase activity in developing geniculocortical projections. Dev Brain Res 58:81-95.
160. Roy TS, Andrews JE, Seidler FJ, Slotkin TA (1998) Nicotine evokes cell death in embryonic rat brain during neurulation. J Pharmacol Exp Ther 287:1136-1144.
161. Saal D, Dong Y, Bonci A, Malenka RC (2003) Drugs of abuse and stress trigger a common synaptic adaptation in dopamine neurons. Neuron 37:577-582.
162. Sabbagh MN, Lukas RJ, Sparks DL, Reid RT (2002) The nicotinic acetylcholine receptor, smoking, and Alzheimer's disease. J Alzheimers Dis 4:317-325.
163. Sacco KA, Bannon KL, George TP (2004) Nicotinic receptor mechanisms and cognition in normal states and neuropsychiatrie disorders. J Psychopharmacol 18:457-474.
164. Seguela P, Watkins KC, Descarries L (1989) Ultrastructural relationships of serotonin axon terminals in the cerebral cortex of the adult rat. J Comp Neurol 289:129-142.
165. Seguela P, Watkins KC, Geffard M, Descarries L (1990) Noradrenaline axon terminals in adult rat neocortex: an immunocytochemical analysis in serial thin sections. Neuroscience 35:249-264.
166. Shacka JJ, Robinson SE (1998a) Exposure to prenatal nicotine transiently increases neuronal nicotinic receptor subunit α7, α4 and β2 messenger RNAs in the postnatal rat brain. Neuroscience 84:1151-1161.
167. Shacka JJ, (1998b) Postnatal developmental regulation of neuronal nicotinic receptor subunit α7 and multiple α4 and β2 mRNA species in the rat. Dev Brain Res 109:67-75.
168. Sher E, Chen Y, Sharpies TJ, Broad LM, Benedetti G, Zwart R, McPhie GI, Pearson KH, Baldwinson T, De Filippi G (2004) Physiological roles of neuronal nicotinic receptor subtypes: new insights on the nicotinic modulation of neurotransmitter release, synaptic transmission and plasticity. Curr Top Med Chem 4:283-297.
169. Sivilotti LG, McNeil DK, Lewis TM, Nassar MA, Schoepfer R, Colquhoun D (1997) Recombinant nicotinic receptors, expressed in Xenopus oocytes, do not resemble native rat sympathetic ganglion receptors in single-channel behaviour. J Physiol 500:123-138.
170. Slotkin TA (1998) Fetal nicotine or cocaine exposure: which one is worse? J Pharmacol Exp Ther 285:931-945.
171. Slotkin TA (2002) Nicotine and the adolescent brain: insights from an animal model. Neurotoxicol Teratol 24:369-384.
172. Slotkin TA (2004) Cholinergic systems in brain development and disruption by neurotoxicants: nicotine, environmental tobacco smoke, organophosphates. Toxicol Appl Pharmacol 198:132-151.
173. Slotkin TA, Seidler FJ, Qiao D, Aldridge JE, Tate CA, Cousins MM, Proskocil BJ, Sekhon HS, Clark JA, Lupo SL, Spindel ER (2005) Effects of prenatal nicotine exposure on primate brain development and attempted amelioration with supplemental choline or vitamin C: neurotransmitter receptors, cell signaling and cell development biomarkers in fetal brain regions of rhesus monkeys. Neuropsychopharmacology 30:129-144.
174. Smith J, Fauquet M, Ziller C, Le Douarin NM (1979) Acetylcholine synthesis by mesencephalic neural crest cells in the process of migration in vivo. Nature 282:853-855.
175. Tapper AR, McKinney SL, Nashmi R, Schwarz J, Deshpande P, Labarca C, Whiteaker P, Marks MJ, Collins AC, Lester HA (2004) Nicotine activation of α4* receptors: sufficient for reward, tolerance, and sensitization. Science 306:1029-1032.
176. Temburni MK, Blitzblau RC, Jacob MH (2000) Receptor targeting and heterogeneity at interneuronal nicotinic cholinergic synapses in vivo. J Physiol 525(Pt 1):21-29.
177. Temburni MK, Rosenberg MM, Pathak N, McConnell R, Jacob MH (2004) Neuronal nicotinic synapse assembly requires the adenomatous polyposis coli tumor suppressor protein. J Neurosci 24:6776-6784.
178. Torrao AS, Carmona FM, Lindstrom J, Britto LR (2000) Expression of cholinergic system molecules during development of the chick nervous system. Dev Brain Res 124:81-92.
179. Turrini P, Casu MA, Wong TP, De Koninck Y, Ribeiro-da-Silva A, Cuello AC (2001) Cholinergic nerve terminals establish classical synapses in the rat cerebral cortex: synaptic pattern and age-related atrophy. Neuroscience 105:277-285.
180. Umbriaco D, Garcia S, Beaulieu C, Descarries L (1995) Relational features of acetylcholine, noradrenaline, serotonin and GABA axon terminals in the stratum (p.362) radiatum of adult rat hippocampus (CA1). Hippocampus 5:605-620.
181. Umbriaco D, Watkins KC, Descarries L, Cozzari C, Hartman BK (1994) Ultrastructural and morphometric features of the acetylcholine innervation in adult rat parietal cortex: an electron microscopic study in serial sections. J Comp Neurol 348:351-373.
182. Vidal C, Changeux JP (1993) Nicotinic and muscarinic modulations of excitatory synaptic transmission in the rat prefrontal cortex in vitro. Neuroscience 56:23-32.
183. Vizi ES, Kiss JP (1998) Neurochemistry and pharmacology of the major hippocampal transmitter systems: synaptic and nonsynaptic interactions. Hippocampus 8:566-607.
184. Wakschlag LS, Pickett KE, Cook E Jr, Benowitz NL, Leventhal BL (2002) Maternal smoking during pregnancy and severe antisocial behavior in offspring: a review. Am J Public Health 92:966-974.
185. Walsh RA, Lowe JB, Hopkins PJ (2001) Quitting smoking in pregnancy. Med J Aust 175:320-323.
186. Wang F, Gerzanich V, Wells GB, Anand R, Peng X, Keyser K, Lindstrom J (1996) Assembly of human neuronal nicotinic receptor α5 subunits with α3, β2, and β4 subunits. J Biol Chem 271:17656-17665.
187. Williams BM, Temburni MK, Levey MS, Bertrand S, Bertrand D, Jacob MH (1998) The long internal loop of the α3 subunit targets nAChRs to subdomains within individual synapses on neurons in vivo. Nat Neurosci 1:557-562.
188. Winzer-Serhan UH, Leslie FM (1997) Codistribution of nicotinic acetylcholine receptor subunit α3 and β4 mRNAs during rat brain development. J Comp Neurol 386:540-554.
189. Wonnacott S, Harrison R, Lunt G (1982) Immunological cross-reactivity between the α-bungarotoxin-binding component from rat brain and nicotinic acetylcholine receptor. J Neuroimmunol 3:1-13.
190. Wonnacott S, Irons J, Rapier C, Thorne B, Lunt GG (1989) Presynaptic modulation of transmitter release by nicotinic receptors. Prog Brain Res 79:157-163.
191. Wonnacott S, Sidhpura N, Balfour DJ (2005) Nicotine: from molecular mechanisms to behaviour. Curr Opin Pharmacol 5:53-59.
192. Woolf NJ (1991) Cholinergic systems in mammalian brain and spinal cord. Prog Neurobiol 37:475-524.
193. Wooltorton JR, Pidoplichko VI, Broide RS, Dani JA (2003) Differential desensitization and distribution of nicotinic acetylcholine receptor subtypes in midbrain dopamine areas. J Neurosci 23:3176-3185.
194. Xu W, Gelber S, Orr-Urtreger A, Armstrong D, Lewis RA, Ou CN, Patrick J, Role L, De Biasi M, Beaudet AL (1999) Megacystis, mydriasis, and ion channel defect in mice lacking the α3 neuronal nicotinic acetylcholine receptor. Proc Natl Acad Sci USA 96:5746-5751.
195. Yu CR, Role LW (1998a) Functional contribution of the α7 subunit to multiple subtypes of nicotinic receptors in embryonic chick sympathetic neurones. JPhysiol 509:651-665.
196. Yu CR, (1998b) Functional contribution of the a 5 subunit to neuronal nicotinic channels expressed by chick sympathetic ganglion neurones. J Physiol 509:667-681.
197. Zhang X, Liu C, Miao H, Gong ZH, Nordberg A (1998) Postnatal changes of nicotinic acetylcholine receptor α2, α3, α4, α7 and β2 subunits genes expression in rat brain. Int J Dev Neurosci 16:507-518.
198. Zheng JQ, Felder M, Connor JA, Poo MM (1994) Turning of nerve growth cones induced by neurotrans-mitters. Nature 368:140-144.
199. Zoli M, Jansson A, Sykova E, Agnati LF, Fuxe K (1999) Volume transmission in the CNS and its relevance for neuropsychopharmacology. Trends Pharmacol Sci 20:142-150.
200. Zoli M, Le Novere N, Hill JA Jr, Changeux JP (1995) Developmental regulation of nicotinic ACh receptor subunit mRNAs in the rat central and peripheral nervous systems. J Neurosci 15:1912-1939.
201. Zoli M, Moretti M, Zanardi A, Mclntosh JM, Clementi F, Gotti C (2002) Identification of the nicotinic receptor subtypes expressed on dopaminergic terminals in the rat striatum. J Neurosci 22:8785-8789.