HtrA2 deficiency causes mitochondrial uncoupling through the F 1F0-ATP synthase and consequent ATP depletion

Cell Death and Disease

Volumn 3, Issue 6, 2012, Pages

  Plun Favreau, H ^a   Burchell, V S ^a   Holmstrom K M ^a   Yao, Z ^a,b   Deas, E ^a   Cain, K ^c   Fedele, V ^c   Moisoi, N ^c   Campanella, M ^d,e   Martins, L Miguel ^c   Wood, N W ^a   Gourine, A V ^b   Abramov, A Y ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c MRC TOXICOLOGY UNIT   (United Kingdom)

^d ROYAL VETERINARY COLLEGE   (United Kingdom)

^e EUROPEAN BRAIN RESEARCH INSTITUTE   (Italy)

Author keywords

ATP synthase; HtrA2; mitochondria; uncoupling

Indexed keywords

ADENOSINE TRIPHOSPHATE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; SERINE PROTEINASE OMI; MITOCHONDRIAL PROTEIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; REACTIVE OXYGEN METABOLITE; SERINE PROTEINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BREATHING; CONTROLLED STUDY; DEPOLARIZATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVITY; MITOCHONDRIAL RESPIRATION; MOUSE; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; AMINO ACID SEQUENCE; ANIMAL; CELL RESPIRATION; GENETICS; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOLECULAR GENETICS; MOUSE MUTANT; OXIDATIVE PHOSPHORYLATION; PHYSIOLOGY;

MUS;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; ANIMALS; CELL RESPIRATION; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, KNOCKOUT; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MOLECULAR SEQUENCE DATA; OXIDATIVE PHOSPHORYLATION; PROTON-TRANSLOCATING ATPASES; REACTIVE OXYGEN SPECIES; SERINE ENDOPEPTIDASES;

EID: 84863455932     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2012.77     Document Type: Article

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