메뉴 건너뛰기




Volumn 20, Issue 24, 2014, Pages 6233-6241

New strategies in acute myelogenous leukemia: Leukemogenesis and personalized medicine

Author keywords

[No Author keywords available]

Indexed keywords

ANTILEUKEMIC AGENT;

EID: 84919662569     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-14-0900     Document Type: Article
Times cited : (19)

References (85)
  • 1
    • 84878372012 scopus 로고    scopus 로고
    • Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia
    • Cancer Genome Atlas Research Network. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med 2013;368:2059-74.
    • (2013) N Engl J Med , vol.368 , pp. 2059-2074
  • 2
    • 84862776906 scopus 로고    scopus 로고
    • Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing
    • Ding L, Ley TJ, Larson DE, Miller CA, Koboldt DC, Welch JS, et al. Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing. Nature 2012;481:506-10.
    • (2012) Nature , vol.481 , pp. 506-510
    • Ding, L.1    Ley, T.J.2    Larson, D.E.3    Miller, C.A.4    Koboldt, D.C.5    Welch, J.S.6
  • 4
    • 84919688350 scopus 로고    scopus 로고
    • Tandem duplication PCR (TD-PCR) is a novel method of detecting minimal residual disease in FLT3/ITD AML and is highly predictive of relapse risk following allogeneic transplant [abstract]
    • 2012 Dec 8-11; Atlanta, GA. Washington (DC): ASH Abstract nr 2479
    • th ASHAnnual Meeting and Exposition; 2012 Dec 8-11; Atlanta, GA. Washington (DC): ASH; 2012. Abstract nr 2479.
    • (2012) th ASHAnnual Meeting and Exposition
    • Grunwald, M.R.1    Lin, M.-T.2    Pratz, K.W.3    Gocke, C.D.4    Levis, M.J.5
  • 5
    • 84881478666 scopus 로고    scopus 로고
    • Minimal residual disease in acute myeloid leukaemia
    • Hourigan CS, Karp JE. Minimal residual disease in acute myeloid leukaemia. Nat Rev Clin Oncol 2013;10:460-71.
    • (2013) Nat Rev Clin Oncol , vol.10 , pp. 460-471
    • Hourigan, C.S.1    Karp, J.E.2
  • 6
    • 84877930402 scopus 로고    scopus 로고
    • Prospective evaluation of gene mutations and minimal residual disease in patients with core binding factor acute myeloid leukemia
    • Jourdan E, Boissel N, Chevret S, Delabesse E, Renneville A, Cornillet P, et al. Prospective evaluation of gene mutations and minimal residual disease in patients with core binding factor acute myeloid leukemia. Blood 2013;121:2213-23.
    • (2013) Blood , vol.121 , pp. 2213-2223
    • Jourdan, E.1    Boissel, N.2    Chevret, S.3    Delabesse, E.4    Renneville, A.5    Cornillet, P.6
  • 7
    • 79960127726 scopus 로고    scopus 로고
    • Monitoring of minimal residual disease in NPM1-mutated acute myeloid leukemia: A study from the German-Austrian acute myeloid leukemia study group
    • Kronke J, Schlenk RF, Jensen KO, Tschurtz F, Corbacioglu A, Gaidzik VI, et al. Monitoring of minimal residual disease in NPM1-mutated acute myeloid leukemia: a study from the German-Austrian acute myeloid leukemia study group. J Clin Oncol 2011;29:2709-16.
    • (2011) J Clin Oncol , vol.29 , pp. 2709-2716
    • Kronke, J.1    Schlenk, R.F.2    Jensen, K.O.3    Tschurtz, F.4    Corbacioglu, A.5    Gaidzik, V.I.6
  • 8
    • 84867297401 scopus 로고    scopus 로고
    • Minimal residual disease monitoring by quantitative RT-PCR in core binding factor AML allows risk stratification and predicts relapse: Results of the United Kingdom MRC AML-15 trial
    • Yin JA, O'Brien MA, Hills RK, Daly SB, Wheatley K, Burnett AK. Minimal residual disease monitoring by quantitative RT-PCR in core binding factor AML allows risk stratification and predicts relapse: results of the United Kingdom MRC AML-15 trial. Blood 2012;120:2826-35.
    • (2012) Blood , vol.120 , pp. 2826-2835
    • Yin, J.A.1    O'Brien, M.A.2    Hills, R.K.3    Daly, S.B.4    Wheatley, K.5    Burnett, A.K.6
  • 9
    • 70449726860 scopus 로고    scopus 로고
    • Real-time quantitative polymerase chain reaction detection of minimal residual disease by standardized WT1 assay to enhance risk stratification in acute myeloid leukemia: A European LeukemiaNet study
    • Cilloni D, Renneville A, Hermitte F, Hills RK, Daly S, Jovanovic JV, et al. Real-time quantitative polymerase chain reaction detection of minimal residual disease by standardized WT1 assay to enhance risk stratification in acute myeloid leukemia: a European LeukemiaNet study. J Clin Oncol 2009;27:5195-201.
    • (2009) J Clin Oncol , vol.27 , pp. 5195-5201
    • Cilloni, D.1    Renneville, A.2    Hermitte, F.3    Hills, R.K.4    Daly, S.5    Jovanovic, J.V.6
  • 10
    • 84882924200 scopus 로고    scopus 로고
    • Acute myelogenous leukemia stem cells: From bench to bedside
    • Felipe Rico J, Hassane DC, Guzman ML. Acute myelogenous leukemia stem cells: from Bench to Bedside. Cancer Lett 2013;338:4-9.
    • (2013) Cancer Lett , vol.338 , pp. 4-9
    • Felipe Rico, J.1    Hassane, D.C.2    Guzman, M.L.3
  • 11
    • 0028091194 scopus 로고
    • A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
    • Lapidot T, Sirard C, Vormoor J, Murdoch B, Hoang T, Caceres-Cortes J, et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 1994;367:645-8.
    • (1994) Nature , vol.367 , pp. 645-648
    • Lapidot, T.1    Sirard, C.2    Vormoor, J.3    Murdoch, B.4    Hoang, T.5    Caceres-Cortes, J.6
  • 12
    • 84859854912 scopus 로고    scopus 로고
    • A clinically relevant population of leukemic CD34(?)CD38(-) cells in acute myeloid leukemia
    • Gerber JM, Smith BD, Ngwang B, Zhang H, Vala MS, Morsberger L, et al. A clinically relevant population of leukemic CD34(?)CD38(-) cells in acute myeloid leukemia. Blood 2012;119:3571-7.
    • (2012) Blood , vol.119 , pp. 3571-3577
    • Gerber, J.M.1    Smith, B.D.2    Ngwang, B.3    Zhang, H.4    Vala, M.S.5    Morsberger, L.6
  • 13
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 1997;3:730-7.
    • (1997) Nat Med , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 14
    • 0035886024 scopus 로고    scopus 로고
    • Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells
    • Guzman ML, Neering SJ, Upchurch D, Grimes B, Howard DS, Rizzieri DA, et al. Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells. Blood 2001;98:2301-7.
    • (2001) Blood , vol.98 , pp. 2301-2307
    • Guzman, M.L.1    Neering, S.J.2    Upchurch, D.3    Grimes, B.4    Howard, D.S.5    Rizzieri, D.A.6
  • 15
    • 16844363378 scopus 로고    scopus 로고
    • The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells
    • Guzman ML, Rossi RM, Karnischky L, Li X, Peterson DR, Howard DS, et al. The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells. Blood 2005;105:4163-9.
    • (2005) Blood , vol.105 , pp. 4163-4169
    • Guzman, M.L.1    Rossi, R.M.2    Karnischky, L.3    Li, X.4    Peterson, D.R.5    Howard, D.S.6
  • 16
    • 84875693885 scopus 로고    scopus 로고
    • Bortezomib added to daunorubicin and cytarabine during induction therapy and to intermediate-dose cytarabine for consolidation in patients with previously untreated acute myeloid leukemia age 60 to 75 years: CALGB (Alliance) study 10502
    • Attar EC, Johnson JL, Amrein PC, Lozanski G, Wadleigh M, DeAngelo DJ, et al. Bortezomib added to daunorubicin and cytarabine during induction therapy and to intermediate-dose cytarabine for consolidation in patients with previously untreated acute myeloid leukemia age 60 to 75 years: CALGB (Alliance) study 10502. J Clin Oncol 2013;31:923-9.
    • (2013) J Clin Oncol , vol.31 , pp. 923-929
    • Attar, E.C.1    Johnson, J.L.2    Amrein, P.C.3    Lozanski, G.4    Wadleigh, M.5    DeAngelo, D.J.6
  • 17
    • 79960271775 scopus 로고    scopus 로고
    • Targeting the translational apparatus to improve leukemia therapy: Roles of the PI3K/PTEN/Akt/mTOR pathway
    • Martelli AM, Evangelisti C, Chappell W, Abrams SL, Basecke J, Stivala F, et al. Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway. Leukemia 2011;25:1064-79.
    • (2011) Leukemia , vol.25 , pp. 1064-1079
    • Martelli, A.M.1    Evangelisti, C.2    Chappell, W.3    Abrams, S.L.4    Basecke, J.5    Stivala, F.6
  • 18
    • 78650635068 scopus 로고    scopus 로고
    • Chemical genomic screening reveals synergism between parthenolide and inhibitors of the PI3 kinase and mTOR pathways
    • Hassane DC, Sen S, Minhajuddin M, Rossi RM, Corbett CA, Balys M, et al. Chemical genomic screening reveals synergism between parthenolide and inhibitors of the PI3 kinase and mTOR pathways. Blood 2010;116:5983-90.
    • (2010) Blood , vol.116 , pp. 5983-5990
    • Hassane, D.C.1    Sen, S.2    Minhajuddin, M.3    Rossi, R.M.4    Corbett, C.A.5    Balys, M.6
  • 19
    • 84884818193 scopus 로고    scopus 로고
    • Phase I study of UCN-01 and perifosine in patients with relapsed and refractory acute leukemias and high-risk myelodysplastic syndrome
    • Gojo I, Perl A, Luger S, Baer MR, Norsworthy KJ, Bauer KS, et al. Phase I study of UCN-01 and perifosine in patients with relapsed and refractory acute leukemias and high-risk myelodysplastic syndrome. Invest New Drugs 2013;31:1217-27.
    • (2013) Invest New Drugs , vol.31 , pp. 1217-1227
    • Gojo, I.1    Perl, A.2    Luger, S.3    Baer, M.R.4    Norsworthy, K.J.5    Bauer, K.S.6
  • 20
    • 70350726344 scopus 로고    scopus 로고
    • A phase I study of the mammalian target of rapamycin inhibitor sirolimus andMECchemotherapy in relapsed and refractory acute myelogenous leukemia
    • Perl AE, Kasner MT, Tsai DE, Vogl DT, Loren AW, Schuster SJ, et al. A phase I study of the mammalian target of rapamycin inhibitor sirolimus andMECchemotherapy in relapsed and refractory acute myelogenous leukemia. Clin Cancer Res 2009;15:6732-9.
    • (2009) Clin Cancer Res , vol.15 , pp. 6732-6739
    • Perl, A.E.1    Kasner, M.T.2    Tsai, D.E.3    Vogl, D.T.4    Loren, A.W.5    Schuster, S.J.6
  • 21
    • 51449096670 scopus 로고    scopus 로고
    • A phase 2 clinical trial of deforolimus (AP23573, MK-8669), a novel mammalian target of rapamycin inhibitor, in patients with relapsed or refractory hematologic malignancies
    • Rizzieri DA, Feldman E, Dipersio JF, Gabrail N, Stock W, Strair R, et al.A phase 2 clinical trial of deforolimus (AP23573, MK-8669), a novel mammalian target of rapamycin inhibitor, in patients with relapsed or refractory hematologic malignancies. Clin Cancer Res 2008;14: 2756-62.
    • (2008) Clin Cancer Res , vol.14 , pp. 2756-2762
    • Rizzieri, D.A.1    Feldman, E.2    Dipersio, J.F.3    Gabrail, N.4    Stock, W.5    Strair, R.6
  • 22
    • 84867490138 scopus 로고    scopus 로고
    • Relative mitochondrial priming of myeloblasts and normal HSCs determines chemotherapeutic success in AML
    • Vo TT, Ryan J, Carrasco R, Neuberg D, Rossi DJ, Stone RM, et al. Relative mitochondrial priming of myeloblasts and normal HSCs determines chemotherapeutic success in AML. Cell 2012;151: 344-55.
    • (2012) Cell , vol.151 , pp. 344-355
    • Vo, T.T.1    Ryan, J.2    Carrasco, R.3    Neuberg, D.4    Rossi, D.J.5    Stone, R.M.6
  • 23
    • 84875143073 scopus 로고    scopus 로고
    • BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells
    • Lagadinou ED, Sach A, Callahan K, Rossi RM, Neering SJ, Minhajuddin M, et al. BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells. Cell Stem Cell 2013;12:329-41.
    • (2013) Cell Stem Cell , vol.12 , pp. 329-341
    • Lagadinou, E.D.1    Sach, A.2    Callahan, K.3    Rossi, R.M.4    Neering, S.J.5    Minhajuddin, M.6
  • 24
    • 33750628289 scopus 로고    scopus 로고
    • Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia
    • Konopleva M, Contractor R, Tsao T, Samudio I, Ruvolo PP, Kitada S, et al. Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia. Cancer Cell 2006;10: 375-88.
    • (2006) Cancer Cell , vol.10 , pp. 375-388
    • Konopleva, M.1    Contractor, R.2    Tsao, T.3    Samudio, I.4    Ruvolo, P.P.5    Kitada, S.6
  • 25
    • 84859627981 scopus 로고    scopus 로고
    • MEK inhibition enhances ABT-737-induced leukemia cell apoptosis via prevention of ERK-activated MCL-1 induction and modulation of MCL-1/BIM complex
    • Konopleva M, Milella M, Ruvolo P, Watts JC, Ricciardi MR, Korchin B, et al. MEK inhibition enhances ABT-737-induced leukemia cell apoptosis via prevention of ERK-activated MCL-1 induction and modulation of MCL-1/BIM complex. Leukemia 2012;26:778-87.
    • (2012) Leukemia , vol.26 , pp. 778-787
    • Konopleva, M.1    Milella, M.2    Ruvolo, P.3    Watts, J.C.4    Ricciardi, M.R.5    Korchin, B.6
  • 26
    • 84862737555 scopus 로고    scopus 로고
    • Inhibition of Bcl-2 antiapoptotic members by obatoclax potently enhances sorafenib-induced apoptosis in human myeloid leukemia cells through a Bim-dependent process
    • Rahmani M, Aust MM, Attkisson E, Williams DC Jr,Ferreira-Gonzalez A, Grant S. Inhibition of Bcl-2 antiapoptotic members by obatoclax potently enhances sorafenib-induced apoptosis in human myeloid leukemia cells through a Bim-dependent process. Blood 2012;119: 6089-98.
    • (2012) Blood , vol.119 , pp. 6089-6098
    • Rahmani, M.1    Aust, M.M.2    Attkisson, E.3    Williams, D.C.4    Ferreira-Gonzalez, A.5    Grant, S.6
  • 27
    • 0033815950 scopus 로고    scopus 로고
    • The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells
    • Jordan CT, Upchurch D, Szilvassy SJ, Guzman ML, Howard DS, Pettigrew AL, et al. The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells. Leukemia 2000;14:1777-84.
    • (2000) Leukemia , vol.14 , pp. 1777-1784
    • Jordan, C.T.1    Upchurch, D.2    Szilvassy, S.J.3    Guzman, M.L.4    Howard, D.S.5    Pettigrew, A.L.6
  • 28
    • 67649200331 scopus 로고    scopus 로고
    • Monoclonal antibody-mediated targeting of CD123, IL-3 receptor alpha chain, eliminates human acute myeloid leukemic stem cells
    • Jin L, Lee EM, Ramshaw HS, Busfield SJ, Peoppl AG, Wilkinson L, et al. Monoclonal antibody-mediated targeting of CD123, IL-3 receptor alpha chain, eliminates human acute myeloid leukemic stem cells. Cell Stem Cell 2009;5:31-42.
    • (2009) Cell Stem Cell , vol.5 , pp. 31-42
    • Jin, L.1    Lee, E.M.2    Ramshaw, H.S.3    Busfield, S.J.4    Peoppl, A.G.5    Wilkinson, L.6
  • 30
    • 67650632683 scopus 로고    scopus 로고
    • CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells
    • Majeti R, Chao MP, Alizadeh AA, Pang WW, Jaiswal S, Gibbs KD Jr, et al. CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. Cell 2009; 138:286-99.
    • (2009) Cell , vol.138 , pp. 286-299
    • Majeti, R.1    Chao, M.P.2    Alizadeh, A.A.3    Pang, W.W.4    Jaiswal, S.5    Gibbs, K.D.6
  • 31
    • 84869200371 scopus 로고    scopus 로고
    • Disruption of SIRPalpha signaling in macrophages eliminates human acute myeloid leukemia stem cells in xenografts
    • Theocharides AP, Jin L, Cheng PY, Prasolava TK, Malko AV, Ho JM, et al. Disruption of SIRPalpha signaling in macrophages eliminates human acute myeloid leukemia stem cells in xenografts. J Exp Med 2012;209:1883-99.
    • (2012) J Exp Med , vol.209 , pp. 1883-1899
    • Theocharides, A.P.1    Jin, L.2    Cheng, P.Y.3    Prasolava, T.K.4    Malko, A.V.5    Ho, J.M.6
  • 32
    • 84896735528 scopus 로고    scopus 로고
    • Advances in understanding the leukaemia microenvironment
    • Tabe Y, Konopleva M. Advances in understanding the leukaemia microenvironment. Br J Haematol 2014;164:767-78.
    • (2014) Br J Haematol , vol.164 , pp. 767-778
    • Tabe, Y.1    Konopleva, M.2
  • 33
    • 3142620882 scopus 로고    scopus 로고
    • Relation between CXCR-4 expression, Flt3 mutations, and unfavorable prognosis of adult acute myeloid leukemia
    • Rombouts EJ, Pavic B, Lowenberg B, Ploemacher RE. Relation between CXCR-4 expression, Flt3 mutations, and unfavorable prognosis of adult acute myeloid leukemia. Blood 2004;104:550-7.
    • (2004) Blood , vol.104 , pp. 550-557
    • Rombouts, E.J.1    Pavic, B.2    Lowenberg, B.3    Ploemacher, R.E.4
  • 34
    • 13744255245 scopus 로고    scopus 로고
    • CXCR4 regulates migration and development of human acute myelogenous leukemia stem cells in transplanted NOD/SCID mice
    • Tavor S, Petit I, Porozov S, Avigdor A, Dar A, Leider-Trejo L, et al. CXCR4 regulates migration and development of human acute myelogenous leukemia stem cells in transplanted NOD/SCID mice. Cancer Res 2004;64:2817-24.
    • (2004) Cancer Res , vol.64 , pp. 2817-2824
    • Tavor, S.1    Petit, I.2    Porozov, S.3    Avigdor, A.4    Dar, A.5    Leider-Trejo, L.6
  • 35
    • 84860349448 scopus 로고    scopus 로고
    • A phase 1/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia
    • Uy GL, Rettig MP, Motabi IH, McFarland K, Trinkaus KM, Hladnik LM, et al. A phase 1/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia. Blood 2012;119:3917-24.
    • (2012) Blood , vol.119 , pp. 3917-3924
    • Uy, G.L.1    Rettig, M.P.2    Motabi, I.H.3    McFarland, K.4    Trinkaus, K.M.5    Hladnik, L.M.6
  • 36
    • 0141461414 scopus 로고    scopus 로고
    • Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia
    • Matsunaga T, Takemoto N, Sato T, Takimoto R, Tanaka I, Fujimi A, et al. Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia. Nat Med 2003;9:1158-65.
    • (2003) Nat Med , vol.9 , pp. 1158-1165
    • Matsunaga, T.1    Takemoto, N.2    Sato, T.3    Takimoto, R.4    Tanaka, I.5    Fujimi, A.6
  • 37
    • 84877666481 scopus 로고    scopus 로고
    • CD44 integrates signaling in normal stem cell, cancer stem cell and (pre)metastatic niches
    • Williams K, Motiani K, Giridhar PV, Kasper S. CD44 integrates signaling in normal stem cell, cancer stem cell and (pre)metastatic niches. Exp Biol Med 2013;238:324-38.
    • (2013) Exp Biol Med , vol.238 , pp. 324-338
    • Williams, K.1    Motiani, K.2    Giridhar, P.V.3    Kasper, S.4
  • 38
    • 61849173436 scopus 로고    scopus 로고
    • CXCR4 expression and biologic activity in acute myeloid leukemia are dependent on oxygen partial pressure
    • Fiegl M, Samudio I, Clise-Dwyer K, Burks JK, Mnjoyan Z, Andreeff M. CXCR4 expression and biologic activity in acute myeloid leukemia are dependent on oxygen partial pressure. Blood 2009; 113:1504-12.
    • (2009) Blood , vol.113 , pp. 1504-1512
    • Fiegl, M.1    Samudio, I.2    Clise-Dwyer, K.3    Burks, J.K.4    Mnjoyan, Z.5    Andreeff, M.6
  • 40
    • 84877589557 scopus 로고    scopus 로고
    • Azacitidine fails to eradicate leukemic stem/progenitor cell populations in patients with acute myeloid leukemia and myelodysplasia
    • Craddock C, Quek L, Goardon N, Freeman S, Siddique S, Raghavan M, et al. Azacitidine fails to eradicate leukemic stem/progenitor cell populations in patients with acute myeloid leukemia and myelodysplasia. Leukemia 2013;27:1028-36.
    • (2013) Leukemia , vol.27 , pp. 1028-1036
    • Craddock, C.1    Quek, L.2    Goardon, N.3    Freeman, S.4    Siddique, S.5    Raghavan, M.6
  • 41
    • 84894245627 scopus 로고    scopus 로고
    • Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
    • Shlush LI, Zandi S, Mitchell A, Chen WC, Brandwein JM, Gupta V, et al. Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia. Nature 2014;506:328-33.
    • (2014) Nature , vol.506 , pp. 328-333
    • Shlush, L.I.1    Zandi, S.2    Mitchell, A.3    Chen, W.C.4    Brandwein, J.M.5    Gupta, V.6
  • 43
    • 84858796262 scopus 로고    scopus 로고
    • IDH mutation impairs histone demethylation and results in a block to cell differentiation
    • Lu C, Ward PS, Kapoor GS, Rohle D, Turcan S, Abdel-Wahab O, et al. IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature 2012;483:474-8.
    • (2012) Nature , vol.483 , pp. 474-478
    • Lu, C.1    Ward, P.S.2    Kapoor, G.S.3    Rohle, D.4    Turcan, S.5    Abdel-Wahab, O.6
  • 45
    • 84877620952 scopus 로고    scopus 로고
    • Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation
    • Wang F, Travins J, DeLaBarre B, Penard-Lacronique V, Schalm S, Hansen E, et al. Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation. Science 2013;340:622-6.
    • (2013) Science , vol.340 , pp. 622-626
    • Wang, F.1    Travins, J.2    DeLaBarre, B.3    Penard-Lacronique, V.4    Schalm, S.5    Hansen, E.6
  • 46
    • 84860772157 scopus 로고    scopus 로고
    • DNMT3A mutations and response to the hypomethylating agent decitabine in acute myeloid leukemia
    • Metzeler KH, Walker A, Geyer S, Garzon R, Klisovic RB, Bloomfield CD, et al. DNMT3A mutations and response to the hypomethylating agent decitabine in acute myeloid leukemia. Leukemia 2012;26:1106-7.
    • (2012) Leukemia , vol.26 , pp. 1106-1107
    • Metzeler, K.H.1    Walker, A.2    Geyer, S.3    Garzon, R.4    Klisovic, R.B.5    Bloomfield, C.D.6
  • 47
    • 84901412022 scopus 로고    scopus 로고
    • Phase 2 trial of CPX-351, a fixed 5:1 molar ratio of cytarabine/ daunorubicin, vs cytarabine/daunorubicin in older adults with untreated AML
    • Lancet JE, Cortes JE, Hogge DE, Tallman MS, Kovacsovics TJ, Damon LE, et al. Phase 2 trial of CPX-351, a fixed 5:1 molar ratio of cytarabine/ daunorubicin, vs cytarabine/daunorubicin in older adults with untreated AML. Blood 2014;123:3239-46.
    • (2014) Blood , vol.123 , pp. 3239-3246
    • Lancet, J.E.1    Cortes, J.E.2    Hogge, D.E.3    Tallman, M.S.4    Kovacsovics, T.J.5    Damon, L.E.6
  • 49
    • 84866924927 scopus 로고    scopus 로고
    • Effects of selective checkpoint kinase 1 inhibition on cytarabine cytotoxicity in acute myelogenous leukemia cells in vitro
    • Schenk EL, Koh BD, Flatten KS, Peterson KL, Parry D, Hess AD, et al. Effects of selective checkpoint kinase 1 inhibition on cytarabine cytotoxicity in acute myelogenous leukemia cells in vitro. Clin Cancer Res 2012;18:5364-73.
    • (2012) Clin Cancer Res , vol.18 , pp. 5364-5373
    • Schenk, E.L.1    Koh, B.D.2    Flatten, K.S.3    Peterson, K.L.4    Parry, D.5    Hess, A.D.6
  • 50
    • 84871234067 scopus 로고    scopus 로고
    • Phase I and pharmacologic trial of cytosine arabinoside with the selective checkpoint 1 inhibitor Sch 900776 in refractory acute leukemias
    • Karp JE, Thomas BM, Greer JM, Sorge C, Gore SD, Pratz KW, et al. Phase I and pharmacologic trial of cytosine arabinoside with the selective checkpoint 1 inhibitor Sch 900776 in refractory acute leukemias. Clin Cancer Res 2012;18:6723-31.
    • (2012) Clin Cancer Res , vol.18 , pp. 6723-6731
    • Karp, J.E.1    Thomas, B.M.2    Greer, J.M.3    Sorge, C.4    Gore, S.D.5    Pratz, K.W.6
  • 51
    • 82955217793 scopus 로고    scopus 로고
    • Phase 1/2 study to assess the safety, efficacy, and pharmacokinetics of barasertib (AZD1152) in patients with advanced acute myeloid leukemia
    • Lowenberg B, Muus P, Ossenkoppele G, Rousselot P, Cahn JY, Ifrah N, et al. Phase 1/2 study to assess the safety, efficacy, and pharmacokinetics of barasertib (AZD1152) in patients with advanced acute myeloid leukemia. Blood 2011;118:6030-6.
    • (2011) Blood , vol.118 , pp. 6030-6036
    • Lowenberg, B.1    Muus, P.2    Ossenkoppele, G.3    Rousselot, P.4    Cahn, J.Y.5    Ifrah, N.6
  • 52
    • 84884155615 scopus 로고    scopus 로고
    • Phase I study assessing the safety and tolerability of barasertib (AZD1152) with low-dose cytosine arabinoside in elderly patients with AML
    • Kantarjian HM, Sekeres MA, Ribrag V, Rousselot P, Garcia-Manero G, Jabbour EJ, et al. Phase I study assessing the safety and tolerability of barasertib (AZD1152) with low-dose cytosine arabinoside in elderly patients with AML. Clin Lymphoma Myeloma 2013;13:559-67.
    • (2013) Clin Lymphoma Myeloma , vol.13 , pp. 559-567
    • Kantarjian, H.M.1    Sekeres, M.A.2    Ribrag, V.3    Rousselot, P.4    Garcia-Manero, G.5    Jabbour, E.J.6
  • 53
    • 84874106884 scopus 로고    scopus 로고
    • Phase I/II study of volasertib (BI 6727), an intravenous pololike kinase (Plk) inhibitor, in patients with acute myeloid leukemia (AML): Results from the randomized phase II part for volasertib in combination with low-dose cytarabine (LDAC) versus LDAC monotherapy in patients with previously untreated AML ineligible for intensive treatment [abstract]
    • Dec 8-11; Atlanta, GA. Washington (DC): ASH; 2012. Abstract nr 411
    • th ASH Annual Meeting and Exposition; 2012 Dec 8-11; Atlanta, GA. Washington (DC): ASH; 2012. Abstract nr 411.
    • (2012) th ASH Annual Meeting and Exposition
    • Maertens, J.1    Lubbert, M.2    Fiedler, W.3    Fouillard, L.4    Haaland, A.5    Brandwein, J.M.6
  • 54
    • 78649964060 scopus 로고    scopus 로고
    • Targeting DNA repair pathways in AML
    • D'Andrea AD. Targeting DNA repair pathways in AML. Best Pract Res Clin Haematol 2010;23:469-73.
    • (2010) Best Pract Res Clin Haematol , vol.23 , pp. 469-473
    • D'Andrea, A.D.1
  • 55
    • 0037093250 scopus 로고    scopus 로고
    • Myeloid leukemias have increased activity of the nonhomologous end-joining pathway and concomitant DNA misrepair that is dependent on the Ku70/86 heterodimer
    • Gaymes TJ, Mufti GJ, Rassool FV. Myeloid leukemias have increased activity of the nonhomologous end-joining pathway and concomitant DNA misrepair that is dependent on the Ku70/86 heterodimer. Cancer Res 2002;62:2791-7.
    • (2002) Cancer Res , vol.62 , pp. 2791-2797
    • Gaymes, T.J.1    Mufti, G.J.2    Rassool, F.V.3
  • 56
    • 66049084743 scopus 로고    scopus 로고
    • Inhibitors of poly ADP-ribose polymerase (PARP) induce apoptosis of myeloid leukemic cells: Potential for therapy of myeloid leukemia and myelodysplastic syndromes
    • Gaymes TJ, Shall S, MacPherson LJ, Twine NA, Lea NC, Farzaneh F, et al. Inhibitors of poly ADP-ribose polymerase (PARP) induce apoptosis of myeloid leukemic cells: potential for therapy of myeloid leukemia and myelodysplastic syndromes. Haematologica 2009; 94:638-46.
    • (2009) Haematologica , vol.94 , pp. 638-646
    • Gaymes, T.J.1    Shall, S.2    MacPherson, L.J.3    Twine, N.A.4    Lea, N.C.5    Farzaneh, F.6
  • 58
    • 68849128273 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase inhibitor ABT-888 potentiates the cytotoxic activity of temozolomide in leukemia cells: Influence of mismatch repair status and O6-methylguanine-DNA methyltransferase activity
    • Horton TM, Jenkins G, Pati D, Zhang L, Dolan ME, Ribes-Zamora A, et al. Poly(ADP-ribose) polymerase inhibitor ABT-888 potentiates the cytotoxic activity of temozolomide in leukemia cells: influence of mismatch repair status and O6-methylguanine-DNA methyltransferase activity. Mol Cancer Ther 2009;8:2232-42.
    • (2009) Mol Cancer Ther , vol.8 , pp. 2232-2242
    • Horton, T.M.1    Jenkins, G.2    Pati, D.3    Zhang, L.4    Dolan, M.E.5    Ribes-Zamora, A.6
  • 59
    • 84856738573 scopus 로고    scopus 로고
    • Enhanced killing of cancer cells by poly(ADP-ribose) polymerase inhibitors and topoisomerase I inhibitors refl ects poisoning of both enzymes
    • Patel AG, Flatten KS, Schneider PA, Dai NT, McDonald JS, Poirier GG, et al. Enhanced killing of cancer cells by poly(ADP-ribose) polymerase inhibitors and topoisomerase I inhibitors refl ects poisoning of both enzymes. J Biol Chem 2012;287:4198-210.
    • (2012) J Biol Chem , vol.287 , pp. 4198-4210
    • Patel, A.G.1    Flatten, K.S.2    Schneider, P.A.3    Dai, N.T.4    McDonald, J.S.5    Poirier, G.G.6
  • 60
    • 84873534154 scopus 로고    scopus 로고
    • The role of B7 family molecules in hematologic malignancy
    • Greaves P, Gribben JG. The role of B7 family molecules in hematologic malignancy. Blood 2013;121:734-44.
    • (2013) Blood , vol.121 , pp. 734-744
    • Greaves, P.1    Gribben, J.G.2
  • 61
    • 84991030654 scopus 로고    scopus 로고
    • Immune evasion in acute myeloid leukemia: Current concepts and future directions
    • 1:pii: 1/1/13
    • Teague RM, Kline J. Immune evasion in acute myeloid leukemia: current concepts and future directions. J Immunother Cancer 2013;1:pii: 1/1/13.
    • (2013) J Immunother Cancer
    • Teague, R.M.1    Kline, J.2
  • 62
    • 81055148087 scopus 로고    scopus 로고
    • Regulatory T cells in acute myelogenous leukemia: Is it time for immunomodulation?
    • Ustun C, Miller JS, Munn DH, Weisdorf DJ, Blazar BR. Regulatory T cells in acute myelogenous leukemia: is it time for immunomodulation? Blood 2011;118:5084-95.
    • (2011) Blood , vol.118 , pp. 5084-5095
    • Ustun, C.1    Miller, J.S.2    Munn, D.H.3    Weisdorf, D.J.4    Blazar, B.R.5
  • 63
    • 79955529454 scopus 로고    scopus 로고
    • Trans-endocytosis of CD80 and CD86: A molecular basis for the cell-extrinsic function of CTLA-4
    • Qureshi OS, Zheng Y, Nakamura K, Attridge K, Manzotti C, Schmidt EM, et al. Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Science 2011;332:600-3.
    • (2011) Science , vol.332 , pp. 600-603
    • Qureshi, O.S.1    Zheng, Y.2    Nakamura, K.3    Attridge, K.4    Manzotti, C.5    Schmidt, E.M.6
  • 65
    • 33344466283 scopus 로고    scopus 로고
    • CTLA-4 blockade by a human mAb enhances the capacity of AML-derived DC to induce T-cell responses against AML cells in an autologous culture system
    • Zhong RK, Loken M, Lane TA, Ball ED. CTLA-4 blockade by a human mAb enhances the capacity of AML-derived DC to induce T-cell responses against AML cells in an autologous culture system. Cytotherapy 2006;8:3-12.
    • (2006) Cytotherapy , vol.8 , pp. 3-12
    • Zhong, R.K.1    Loken, M.2    Lane, T.A.3    Ball, E.D.4
  • 66
    • 62549090160 scopus 로고    scopus 로고
    • CTLA-4 genotype and relapse incidence in patients with acute myeloid leukemia in fi rst complete remission after induction chemotherapy
    • Perez-Garcia A, Brunet S, Berlanga JJ, Tormo M, Nomdedeu J, Guardia R, et al. CTLA-4 genotype and relapse incidence in patients with acute myeloid leukemia in fi rst complete remission after induction chemotherapy. Leukemia 2009;23:486-91.
    • (2009) Leukemia , vol.23 , pp. 486-491
    • Perez-Garcia, A.1    Brunet, S.2    Berlanga, J.J.3    Tormo, M.4    Nomdedeu, J.5    Guardia, R.6
  • 68
    • 0037111483 scopus 로고    scopus 로고
    • Expression of programmed death 1 ligands by murine T cells and APC
    • Yamazaki T, Akiba H, Iwai H, Matsuda H, Aoki M, Tanno Y, et al. Expression of programmed death 1 ligands by murine T cells and APC. J Immunol 2002;169:5538-45.
    • (2002) J Immunol , vol.169 , pp. 5538-5545
    • Yamazaki, T.1    Akiba, H.2    Iwai, H.3    Matsuda, H.4    Aoki, M.5    Tanno, Y.6
  • 69
    • 70349561448 scopus 로고    scopus 로고
    • PD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model
    • Zhang L, Gajewski TF, Kline J. PD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model. Blood 2009;114:1545-52.
    • (2009) Blood , vol.114 , pp. 1545-1552
    • Zhang, L.1    Gajewski, T.F.2    Kline, J.3
  • 70
    • 84873192230 scopus 로고    scopus 로고
    • Increased level of myeloid-derived suppressor cells, programmed death receptor ligand 1/programmed death receptor 1, and soluble CD25 in Sokal high risk chronic myeloid leukemia
    • Christiansson L, Soderlund S, Svensson E, Mustjoki S, Bengtsson M, Simonsson B, et al. Increased level of myeloid-derived suppressor cells, programmed death receptor ligand 1/programmed death receptor 1, and soluble CD25 in Sokal high risk chronic myeloid leukemia. PloS ONE 2013;8:e55818.
    • (2013) Plos ONE , vol.8 , pp. e55818
    • Christiansson, L.1    Soderlund, S.2    Svensson, E.3    Mustjoki, S.4    Bengtsson, M.5    Simonsson, B.6
  • 73
    • 78751526006 scopus 로고    scopus 로고
    • Early lymphocyte recovery after intensive timed sequential chemotherapy for acute myelogenous leukemia: Peripheral oligoclonal expansion of regulatory T cells
    • Kanakry CG, Hess AD, Gocke CD, Thoburn C, Kos F, Meyer C, et al. Early lymphocyte recovery after intensive timed sequential chemotherapy for acute myelogenous leukemia: peripheral oligoclonal expansion of regulatory T cells. Blood 2011;117:608-17.
    • (2011) Blood , vol.117 , pp. 608-617
    • Kanakry, C.G.1    Hess, A.D.2    Gocke, C.D.3    Thoburn, C.4    Kos, F.5    Meyer, C.6
  • 74
    • 66149179122 scopus 로고    scopus 로고
    • Increased frequency and suppression by regulatory T cells in patients with acute myelogenous leukemia
    • Szczepanski MJ, Szajnik M, Czystowska M, Mandapathil M, Strauss L, Welsh A, et al. Increased frequency and suppression by regulatory T cells in patients with acute myelogenous leukemia. Clin Cancer Res 2009;15:3325-32.
    • (2009) Clin Cancer Res , vol.15 , pp. 3325-3332
    • Szczepanski, M.J.1    Szajnik, M.2    Czystowska, M.3    Mandapathil, M.4    Strauss, L.5    Welsh, A.6
  • 75
    • 70449723156 scopus 로고    scopus 로고
    • Depletion of endogenous tumor-associated regulatory T cells improves the efficacy of adoptive cytotoxic T-cell immunotherapy in murine acute myeloid leukemia
    • Zhou Q, Bucher C, Munger ME, Highfill SL, Tolar J, Munn DH, et al. Depletion of endogenous tumor-associated regulatory T cells improves the efficacy of adoptive cytotoxic T-cell immunotherapy in murine acute myeloid leukemia. Blood 2009;114:3793-802.
    • (2009) Blood , vol.114 , pp. 3793-3802
    • Zhou, Q.1    Bucher, C.2    Munger, M.E.3    Highfill, S.L.4    Tolar, J.5    Munn, D.H.6
  • 76
    • 77957747417 scopus 로고    scopus 로고
    • Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia
    • Zhou Q, Munger ME, Highfill SL, Tolar J, Weigel BJ, Riddle M, et al. Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia. Blood 2010;116:2484-93.
    • (2010) Blood , vol.116 , pp. 2484-2493
    • Zhou, Q.1    Munger, M.E.2    Highfill, S.L.3    Tolar, J.4    Weigel, B.J.5    Riddle, M.6
  • 78
    • 57349164479 scopus 로고    scopus 로고
    • High INDO (indoleamine 2,3-dioxygenase) mRNA level in blasts of acute myeloid leukemic patients predicts poor clinical outcome
    • Chamuleau ME, van de Loosdrecht AA, Hess CJ, Janssen JJ, Zevenbergen A, Delwel R, et al. High INDO (indoleamine 2,3-dioxygenase) mRNA level in blasts of acute myeloid leukemic patients predicts poor clinical outcome. Haematologica 2008;93:1894-8.
    • (2008) Haematologica , vol.93 , pp. 1894-1898
    • Chamuleau, M.E.1    Van De Loosdrecht, A.A.2    Hess, C.J.3    Janssen, J.J.4    Zevenbergen, A.5    Delwel, R.6
  • 79
    • 33846465963 scopus 로고    scopus 로고
    • Acute myeloid leukemia cells constitutively express the immunoregulatory enzyme indoleamine 2,3-dioxygenase
    • Curti A, Aluigi M, Pandolfi S, Ferri E, Isidori A, Salvestrini V, et al. Acute myeloid leukemia cells constitutively express the immunoregulatory enzyme indoleamine 2,3-dioxygenase. Leukemia 2007;21:353-5.
    • (2007) Leukemia , vol.21 , pp. 353-355
    • Curti, A.1    Aluigi, M.2    Pandolfi, S.3    Ferri, E.4    Isidori, A.5    Salvestrini, V.6
  • 80
    • 63849112500 scopus 로고    scopus 로고
    • The role of indoleamine 2,3-dioxygenase in the induction of immune tolerance: Focus on hematology
    • Curti A, Trabanelli S, Salvestrini V, Baccarani M, Lemoli RM. The role of indoleamine 2,3-dioxygenase in the induction of immune tolerance: focus on hematology. Blood 2009;113:2394-401.
    • (2009) Blood , vol.113 , pp. 2394-2401
    • Curti, A.1    Trabanelli, S.2    Salvestrini, V.3    Baccarani, M.4    Lemoli, R.M.5
  • 81
    • 84869856060 scopus 로고    scopus 로고
    • A phase 1 trial of the anti-inhibitory KIR mAb IPH2101 for AML in complete remission
    • Vey N, Bourhis JH, Boissel N, Bordessoule D, Prebet T, Charbonnier A, et al. A phase 1 trial of the anti-inhibitory KIR mAb IPH2101 for AML in complete remission. Blood 2012;120:4317-23.
    • (2012) Blood , vol.120 , pp. 4317-4323
    • Vey, N.1    Bourhis, J.H.2    Boissel, N.3    Bordessoule, D.4    Prebet, T.5    Charbonnier, A.6
  • 83
    • 79955847224 scopus 로고    scopus 로고
    • CD200 expression suppresses natural killer cell function and directly inhibits patient anti-tumor response in acute myeloid leukemia
    • Coles SJ, Wang EC, Man S, Hills RK, Burnett AK, Tonks A, et al. CD200 expression suppresses natural killer cell function and directly inhibits patient anti-tumor response in acute myeloid leukemia. Leukemia 2011;25:792-9.
    • (2011) Leukemia , vol.25 , pp. 792-799
    • Coles, S.J.1    Wang, E.C.2    Man, S.3    Hills, R.K.4    Burnett, A.K.5    Tonks, A.6
  • 84
    • 84887506002 scopus 로고    scopus 로고
    • NK cells from an AML patient have recovered in remission and reached comparable cytolytic activity to that of a healthy monozygotic twin mediated by the single-chain triplebody SPM-2
    • Braciak TA, Wildenhain S, Roskopf CC, Schubert IA, Fey GH, Jacob U, et al. NK cells from an AML patient have recovered in remission and reached comparable cytolytic activity to that of a healthy monozygotic twin mediated by the single-chain triplebody SPM-2. J Transl Med 2013;11:289.
    • (2013) J Transl Med , vol.11 , pp. 289
    • Braciak, T.A.1    Wildenhain, S.2    Roskopf, C.C.3    Schubert, I.A.4    Fey, G.H.5    Jacob, U.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.