-
1
-
-
31844449374
-
Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor
-
Adams, G.B., Chabner, K.T., Alley, I.R., Olson, D.P., Szczepiorkowski, Z.M., Poznansky, M.C., Kos, C.H., Pollak, M.R., Brown, E.M. & Scadden, D.T. (2006) Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor. Nature, 439, 599-603.
-
(2006)
Nature
, vol.439
, pp. 599-603
-
-
Adams, G.B.1
Chabner, K.T.2
Alley, I.R.3
Olson, D.P.4
Szczepiorkowski, Z.M.5
Poznansky, M.C.6
Kos, C.H.7
Pollak, M.R.8
Brown, E.M.9
Scadden, D.T.10
-
2
-
-
3242669145
-
Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche
-
Arai, F., Hirao, A., Ohmura, M., Sato, H., Matsuoka, S., Takubo, K., Ito, K., Koh, G.Y. & Suda, T. (2004) Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell, 118, 149-161.
-
(2004)
Cell
, vol.118
, pp. 149-161
-
-
Arai, F.1
Hirao, A.2
Ohmura, M.3
Sato, H.4
Matsuoka, S.5
Takubo, K.6
Ito, K.7
Koh, G.Y.8
Suda, T.9
-
3
-
-
11144358161
-
CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34+ stem/progenitor cells to bone marrow
-
Avigdor, A., Goichberg, P., Shivtiel, S., Dar, A., Peled, A., Samira, S., Kollet, O., Hershkoviz, R., Alon, R., Hardan, I., Ben-Hur, H., Naor, D., Nagler, A. & Lapidot, T. (2004) CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34+ stem/progenitor cells to bone marrow. Blood, 103, 2981-2989.
-
(2004)
Blood
, vol.103
, pp. 2981-2989
-
-
Avigdor, A.1
Goichberg, P.2
Shivtiel, S.3
Dar, A.4
Peled, A.5
Samira, S.6
Kollet, O.7
Hershkoviz, R.8
Alon, R.9
Hardan, I.10
Ben-Hur, H.11
Naor, D.12
Nagler, A.13
Lapidot, T.14
-
4
-
-
80051628334
-
Pronounced hypoxia in models of murine and human leukemia: high efficacy of hypoxia-activated prodrug PR-104
-
Benito, J., Shi, Y., Szymanska, B., Carol, H., Boehm, I., Lu, H., Konoplev, S., Fang, W., Zweidler-McKay, P.A., Campana, D., Borthakur, G., Bueso-Ramos, C., Shpall, E., Thomas, D.A., Jordan, C.T., Kantarjian, H., Wilson, W.R., Lock, R., Andreeff, M. & Konopleva, M. (2011) Pronounced hypoxia in models of murine and human leukemia: high efficacy of hypoxia-activated prodrug PR-104. PLoS ONE, 6, e23108.
-
(2011)
PLoS ONE
, vol.6
-
-
Benito, J.1
Shi, Y.2
Szymanska, B.3
Carol, H.4
Boehm, I.5
Lu, H.6
Konoplev, S.7
Fang, W.8
Zweidler-McKay, P.A.9
Campana, D.10
Borthakur, G.11
Bueso-Ramos, C.12
Shpall, E.13
Thomas, D.A.14
Jordan, C.T.15
Kantarjian, H.16
Wilson, W.R.17
Lock, R.18
Andreeff, M.19
Konopleva, M.20
more..
-
5
-
-
84873567259
-
Hematopoietic stem cell mobilization: updated conceptual renditions
-
Bonig, H. & Papayannopoulou, T. (2013) Hematopoietic stem cell mobilization: updated conceptual renditions. Leukemia, 27, 24-31.
-
(2013)
Leukemia
, vol.27
, pp. 24-31
-
-
Bonig, H.1
Papayannopoulou, T.2
-
6
-
-
0030789242
-
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
-
Bonnet, D. & Dick, J.E. (1997) Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nature Medicine, 3, 730-737.
-
(1997)
Nature Medicine
, vol.3
, pp. 730-737
-
-
Bonnet, D.1
Dick, J.E.2
-
7
-
-
0242268524
-
Osteoblastic cells regulate the haematopoietic stem cell niche
-
Calvi, L.M., Adams, G.B., Weibrecht, K.W., Weber, J.M., Olson, D.P., Knight, M.C., Martin, R.P., Schipani, E., Divieti, P., Bringhurst, F.R., Milner, L.A., Kronenberg, H.M. & Scadden, D.T. (2003) Osteoblastic cells regulate the haematopoietic stem cell niche. Nature, 425, 841-846.
-
(2003)
Nature
, vol.425
, pp. 841-846
-
-
Calvi, L.M.1
Adams, G.B.2
Weibrecht, K.W.3
Weber, J.M.4
Olson, D.P.5
Knight, M.C.6
Martin, R.P.7
Schipani, E.8
Divieti, P.9
Bringhurst, F.R.10
Milner, L.A.11
Kronenberg, H.M.12
Scadden, D.T.13
-
8
-
-
4043184065
-
Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
-
Ceradini, D.J., Kulkarni, A.R., Callaghan, M.J., Tepper, O.M., Bastidas, N., Kleinman, M.E., Capla, J.M., Galiano, R.D., Levine, J.P. & Gurtner, G.C. (2004) Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nature Medicine, 10, 858-864.
-
(2004)
Nature Medicine
, vol.10
, pp. 858-864
-
-
Ceradini, D.J.1
Kulkarni, A.R.2
Callaghan, M.J.3
Tepper, O.M.4
Bastidas, N.5
Kleinman, M.E.6
Capla, J.M.7
Galiano, R.D.8
Levine, J.P.9
Gurtner, G.C.10
-
9
-
-
79951694373
-
Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche
-
Chow, A., Lucas, D., Hidalgo, A., Méndez-Ferrer, S., Hashimoto, D., Scheiermann, C., Battista, M., Leboeuf, M., Prophete, C., van Rooijen, N., Tanaka, M., Merad, M. & Frenette, P.S. (2011) Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche. Journal of Experimental Medicine, 208, 261-271.
-
(2011)
Journal of Experimental Medicine
, vol.208
, pp. 261-271
-
-
Chow, A.1
Lucas, D.2
Hidalgo, A.3
Méndez-Ferrer, S.4
Hashimoto, D.5
Scheiermann, C.6
Battista, M.7
Leboeuf, M.8
Prophete, C.9
van Rooijen, N.10
Tanaka, M.11
Merad, M.12
Frenette, P.S.13
-
10
-
-
65549165761
-
Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization
-
Christopher, M.J., Liu, F., Hilton, M.J., Long, F. & Link, D.C. (2009) Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization. Blood, 114, 1331-1339.
-
(2009)
Blood
, vol.114
, pp. 1331-1339
-
-
Christopher, M.J.1
Liu, F.2
Hilton, M.J.3
Long, F.4
Link, D.C.5
-
11
-
-
57849108116
-
Leukemic cells create bone marrow niches that disrupt the behaviour of normal hematopoietic progenitor cells
-
Colmone, A., Amorim, M., Pontier, A.L., Wang, S., Jablonski, E. & Sipkins, D.A. (2008) Leukemic cells create bone marrow niches that disrupt the behaviour of normal hematopoietic progenitor cells. Science, 322, 1861-1865.
-
(2008)
Science
, vol.322
, pp. 1861-1865
-
-
Colmone, A.1
Amorim, M.2
Pontier, A.L.3
Wang, S.4
Jablonski, E.5
Sipkins, D.A.6
-
12
-
-
0035676386
-
High expression of the chemokine receptor CXCR4 predicts extramedullary organ infiltration in childhood acute lymphoblastic leukaemia
-
Crazzolara, R., Kreczy, A., Mann, G., Heitger, A., Eibl, G., Fink, F.M., Mohle, R. & Meister, B. (2001) High expression of the chemokine receptor CXCR4 predicts extramedullary organ infiltration in childhood acute lymphoblastic leukaemia. British Journal of Haematology, 115, 545-553.
-
(2001)
British Journal of Haematology
, vol.115
, pp. 545-553
-
-
Crazzolara, R.1
Kreczy, A.2
Mann, G.3
Heitger, A.4
Eibl, G.5
Fink, F.M.6
Mohle, R.7
Meister, B.8
-
13
-
-
0036530301
-
VEGF(165) promotes survival of leukemic cells by Hsp90-mediated induction of Bcl-2 expression and apoptosis inhibition
-
Dias, S., Shmelkov, S.V., Lam, G. & Rafii, S. (2002) VEGF(165) promotes survival of leukemic cells by Hsp90-mediated induction of Bcl-2 expression and apoptosis inhibition. Blood, 99, 2532-2540.
-
(2002)
Blood
, vol.99
, pp. 2532-2540
-
-
Dias, S.1
Shmelkov, S.V.2
Lam, G.3
Rafii, S.4
-
14
-
-
84856147560
-
Endothelial and perivascular cells maintain haematopoietic stem cells
-
Ding, L., Saunders, T.L., Enikolopov, G. & Morrison, S.J. (2012) Endothelial and perivascular cells maintain haematopoietic stem cells. Nature, 481, 457-462.
-
(2012)
Nature
, vol.481
, pp. 457-462
-
-
Ding, L.1
Saunders, T.L.2
Enikolopov, G.3
Morrison, S.J.4
-
15
-
-
0029760129
-
Stromal abnormalities in neoplastic bone marrow diseases
-
Dührsen, U. & Hossfeld, D.K. (1996) Stromal abnormalities in neoplastic bone marrow diseases. Annals of Hematology, 73, 53-70.
-
(1996)
Annals of Hematology
, vol.73
, pp. 53-70
-
-
Dührsen, U.1
Hossfeld, D.K.2
-
16
-
-
0037699954
-
The biology of VEGF and its receptors
-
Ferrara, N., Gerber, H.P. & LeCouter, J. (2003) The biology of VEGF and its receptors. Nature Medicine, 9, 669-676.
-
(2003)
Nature Medicine
, vol.9
, pp. 669-676
-
-
Ferrara, N.1
Gerber, H.P.2
LeCouter, J.3
-
17
-
-
61849173436
-
CXCR4 expression and biologic activity in acute myeloid leukemia are dependent on oxygen partial pressure
-
Fiegl, M., Samudio, I., Clise-Dwyer, K., Burks, J.K., Mnjoyan, Z. & Andreeff, M. (2009) CXCR4 expression and biologic activity in acute myeloid leukemia are dependent on oxygen partial pressure. Blood, 113, 1504-1512.
-
(2009)
Blood
, vol.113
, pp. 1504-1512
-
-
Fiegl, M.1
Samudio, I.2
Clise-Dwyer, K.3
Burks, J.K.4
Mnjoyan, Z.5
Andreeff, M.6
-
18
-
-
79958279325
-
In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche
-
Fujisaki, J., Wu, J., Carlson, A.L., Silberstein, L., Putheti, P., Larocca, R., Gao, W., Saito, T.I., Lo Celso, C., Tsuyuzaki, H., Sato, T., Côté, D., Sykes, M., Strom, T.B., Scadden, D.T. & Lin, C.P. (2011) In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche. Nature, 474, 216-219.
-
(2011)
Nature
, vol.474
, pp. 216-219
-
-
Fujisaki, J.1
Wu, J.2
Carlson, A.L.3
Silberstein, L.4
Putheti, P.5
Larocca, R.6
Gao, W.7
Saito, T.I.8
Lo Celso, C.9
Tsuyuzaki, H.10
Sato, T.11
Côté, D.12
Sykes, M.13
Strom, T.B.14
Scadden, D.T.15
Lin, C.P.16
-
19
-
-
0036232873
-
Adhesion to fibronectin via alpha4 integrin (CD49d) protects B cells from apoptosis induced by serum deprivation but not via IgM or Fas/Apo-1 receptors
-
Garcia-Gila, M., Lopez-Martin, E.M. & Garcia-Pardo, A. (2002) Adhesion to fibronectin via alpha4 integrin (CD49d) protects B cells from apoptosis induced by serum deprivation but not via IgM or Fas/Apo-1 receptors. Clinical & Experimental Immunology, 127, 455-462.
-
(2002)
Clinical & Experimental Immunology
, vol.127
, pp. 455-462
-
-
Garcia-Gila, M.1
Lopez-Martin, E.M.2
Garcia-Pardo, A.3
-
20
-
-
84858590826
-
Accessories to the crime: functions of cells recruited to the tumor microenvironment
-
Hanahan, D. & Coussens, L.M. (2012) Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell, 21, 309-322.
-
(2012)
Cancer Cell
, vol.21
, pp. 309-322
-
-
Hanahan, D.1
Coussens, L.M.2
-
21
-
-
34447616779
-
Oxygen saturation in the bone marrow of healthy volunteers
-
Harrison, J.S., Rameshwar, P., Chang, V. & Bandari, P. (2002) Oxygen saturation in the bone marrow of healthy volunteers. Blood, 99, 394.
-
(2002)
Blood
, vol.99
, pp. 394
-
-
Harrison, J.S.1
Rameshwar, P.2
Chang, V.3
Bandari, P.4
-
22
-
-
0033941950
-
CD44 acts both as a growth- and invasiveness-promoting molecule and as a tumor-suppressing cofactor
-
Herrlich, P., Morrison, H., Sleeman, J., Orian-Rousseau, V., Konig, H., Weg-Remers, S. & Ponta, H. (2000) CD44 acts both as a growth- and invasiveness-promoting molecule and as a tumor-suppressing cofactor. Annals of the New York Academy of Sciences, 910, 106-118.
-
(2000)
Annals of the New York Academy of Sciences
, vol.910
, pp. 106-118
-
-
Herrlich, P.1
Morrison, H.2
Sleeman, J.3
Orian-Rousseau, V.4
Konig, H.5
Weg-Remers, S.6
Ponta, H.7
-
23
-
-
84875677396
-
Integrin alpha4 blockade sensitizes drug resistant pre-B acute lymphoblastic leukemia to chemotherapy
-
Hsieh, Y.T., Gang, E.J., Geng, H., Park, E., Huantes, S., Chudziak, D., Dauber, K., Schaefer, P., Scharman, C., Shimada, H., Shojaee, S., Klemm, L., Parameswaran, R., Loh, M., Kang, E.S., Koo, H.H., Hofmann, W.K., Andrade, J., Crooks, G.M., Willman, C.L., Müschen, M., Papayannopoulou, T., Heisterkamp, N., Bönig, H. & Kim, Y.M. (2013) Integrin alpha4 blockade sensitizes drug resistant pre-B acute lymphoblastic leukemia to chemotherapy. Blood, 121, 1814-1818.
-
(2013)
Blood
, vol.121
, pp. 1814-1818
-
-
Hsieh, Y.T.1
Gang, E.J.2
Geng, H.3
Park, E.4
Huantes, S.5
Chudziak, D.6
Dauber, K.7
Schaefer, P.8
Scharman, C.9
Shimada, H.10
Shojaee, S.11
Klemm, L.12
Parameswaran, R.13
Loh, M.14
Kang, E.S.15
Koo, H.H.16
Hofmann, W.K.17
Andrade, J.18
Crooks, G.M.19
Willman, C.L.20
Müschen, M.21
Papayannopoulou, T.22
Heisterkamp, N.23
Bönig, H.24
Kim, Y.M.25
more..
-
24
-
-
0033957420
-
Evidence of increased angiogenesis in patients with acute myeloid leukemia
-
Hussong, J.W., Rodgers, G.M. & Shami, P.J. (2000) Evidence of increased angiogenesis in patients with acute myeloid leukemia. Blood, 95, 309-313.
-
(2000)
Blood
, vol.95
, pp. 309-313
-
-
Hussong, J.W.1
Rodgers, G.M.2
Shami, P.J.3
-
25
-
-
0036682474
-
CXCR4 expression is associated with survival in familial chronic lymphocytic leukemia, but CD38 expression is not
-
Ishibe, N., Albitar, M., Jilani, I.B., Goldin, L.R., Marti, G.E. & Caporaso, N.E. (2002) CXCR4 expression is associated with survival in familial chronic lymphocytic leukemia, but CD38 expression is not. Blood, 100, 1100-1101.
-
(2002)
Blood
, vol.100
, pp. 1100-1101
-
-
Ishibe, N.1
Albitar, M.2
Jilani, I.B.3
Goldin, L.R.4
Marti, G.E.5
Caporaso, N.E.6
-
26
-
-
34147153377
-
Mesenchymal cells regulate the response of acute lymphoblastic leukemia cells to asparaginase
-
Iwamoto, S., Mihara, K., Downing, J.R., Pui, C.H. & Campana, D. (2007) Mesenchymal cells regulate the response of acute lymphoblastic leukemia cells to asparaginase. The Journal of Clinical Investigation, 117, 1049-1057.
-
(2007)
The Journal of Clinical Investigation
, vol.117
, pp. 1049-1057
-
-
Iwamoto, S.1
Mihara, K.2
Downing, J.R.3
Pui, C.H.4
Campana, D.5
-
27
-
-
67449092765
-
Cancer stem cells and their niche
-
Iwasaki, H. & Suda, T. (2009) Cancer stem cells and their niche. Cancer Science, 100, 1166-1172.
-
(2009)
Cancer Science
, vol.100
, pp. 1166-1172
-
-
Iwasaki, H.1
Suda, T.2
-
28
-
-
0033678457
-
Increased cellular hypoxia and reduced proliferation of both normal and leukaemic cells during progression of acute myeloid leukaemia in rats
-
Jensen, P.O., Mortensen, B.T., Hodgkiss, R.J., Iversen, P.O., Christensen, I.J., Helledie, N. & Larsen, J.K. (2000) Increased cellular hypoxia and reduced proliferation of both normal and leukaemic cells during progression of acute myeloid leukaemia in rats. Cell Proliferation, 33, 381-395.
-
(2000)
Cell Proliferation
, vol.33
, pp. 381-395
-
-
Jensen, P.O.1
Mortensen, B.T.2
Hodgkiss, R.J.3
Iversen, P.O.4
Christensen, I.J.5
Helledie, N.6
Larsen, J.K.7
-
29
-
-
33749515476
-
Targeting of CD44 eradicates human acute myeloid leukemic stem cells
-
Jin, L., Hope, K.J., Zhai, Q., Smadja-Joffe, F. & Dick, J.E. (2006) Targeting of CD44 eradicates human acute myeloid leukemic stem cells. Nature Medicine, 12, 1167-1174.
-
(2006)
Nature Medicine
, vol.12
, pp. 1167-1174
-
-
Jin, L.1
Hope, K.J.2
Zhai, Q.3
Smadja-Joffe, F.4
Dick, J.E.5
-
30
-
-
38349086394
-
CXCR4 up-regulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cells
-
Jin, L., Tabe, Y., Konoplev, S., Xu, Y., Leysath, C.E., Lu, H., Kimura, S., Ohsaka, A., Rios, M.B., Calvert, L., Kantarjian, H., Andreeff, M. & Konopleva, M. (2008) CXCR4 up-regulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cells. Molecular Cancer Therapeutics, 7, 48-58.
-
(2008)
Molecular Cancer Therapeutics
, vol.7
, pp. 48-58
-
-
Jin, L.1
Tabe, Y.2
Konoplev, S.3
Xu, Y.4
Leysath, C.E.5
Lu, H.6
Kimura, S.7
Ohsaka, A.8
Rios, M.B.9
Calvert, L.10
Kantarjian, H.11
Andreeff, M.12
Konopleva, M.13
-
31
-
-
79961074770
-
Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells
-
Jinushi, M., Chiba, S., Yoshiyama, H., Masutomi, K., Kinoshita, I., Dosaka-Akita, H., Yagita, H., Takaoka, A. & Tahara, H. (2011) Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells. Proceedings of the National Academy of Sciences of the United States of America, 108, 12425-12430.
-
(2011)
Proceedings of the National Academy of Sciences of the United States of America
, vol.108
, pp. 12425-12430
-
-
Jinushi, M.1
Chiba, S.2
Yoshiyama, H.3
Masutomi, K.4
Kinoshita, I.5
Dosaka-Akita, H.6
Yagita, H.7
Takaoka, A.8
Tahara, H.9
-
32
-
-
37549069749
-
No place like home: anatomy and function of the stem cell niche
-
Jones, D.L. & Wagers, A.J. (2008) No place like home: anatomy and function of the stem cell niche. Nature Reviews Molecular Cell Biology, 9, 11-21.
-
(2008)
Nature Reviews Molecular Cell Biology
, vol.9
, pp. 11-21
-
-
Jones, D.L.1
Wagers, A.J.2
-
33
-
-
0038103869
-
Effects of inhibitors of the chemokine receptor CXCR4 on acute lymphoblastic leukemia cells in vitro
-
Juarez, J., Bradstock, K.F., Gottlieb, D.J. & Bendall, L.J. (2003) Effects of inhibitors of the chemokine receptor CXCR4 on acute lymphoblastic leukemia cells in vitro. Leukemia, 17, 1294-1300.
-
(2003)
Leukemia
, vol.17
, pp. 1294-1300
-
-
Juarez, J.1
Bradstock, K.F.2
Gottlieb, D.J.3
Bendall, L.J.4
-
34
-
-
31044450303
-
Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow
-
Katayama, Y., Battista, M., Kao, W.M., Hidalgo, A., Peired, A.J., Thomas, S.A. & Frenette, P.S. (2006) Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow. Cell, 124, 407-421.
-
(2006)
Cell
, vol.124
, pp. 407-421
-
-
Katayama, Y.1
Battista, M.2
Kao, W.M.3
Hidalgo, A.4
Peired, A.J.5
Thomas, S.A.6
Frenette, P.S.7
-
35
-
-
41149109622
-
Uncertainty in the niches that maintain haematopoietic stem cells
-
Kiel, M.J. & Morrison, S.J. (2008) Uncertainty in the niches that maintain haematopoietic stem cells. Nature Reviews Immunology, 8, 290-301.
-
(2008)
Nature Reviews Immunology
, vol.8
, pp. 290-301
-
-
Kiel, M.J.1
Morrison, S.J.2
-
36
-
-
21244463426
-
SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells
-
Kiel, M.J., Yilmaz, O.H., Iwashita, T., Terhorst, C. & Morrison, S.J. (2005) SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell, 121, 1109-1121.
-
(2005)
Cell
, vol.121
, pp. 1109-1121
-
-
Kiel, M.J.1
Yilmaz, O.H.2
Iwashita, T.3
Terhorst, C.4
Morrison, S.J.5
-
37
-
-
38349092288
-
Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1alpha
-
Koh, M.Y., Spivak-Kroizman, T., Venturini, S., Welsh, S., Williams, R.R., Kirkpatrick, D.L. & Powis, G. (2008) Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1alpha. Molecular Cancer Therapeutics, 7, 90-100.
-
(2008)
Molecular Cancer Therapeutics
, vol.7
, pp. 90-100
-
-
Koh, M.Y.1
Spivak-Kroizman, T.2
Venturini, S.3
Welsh, S.4
Williams, R.R.5
Kirkpatrick, D.L.6
Powis, G.7
-
38
-
-
33744983304
-
Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells
-
Kollet, O., Dar, A., Shivtiel, S., Kalinkovich, A., Lapid, K., Sztainberg, Y., Tesio, M., Samstein, R.M., Goichberg, P., Spiegel, A., Elson, A. & Lapidot, T. (2006) Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells. Nature Medicine, 12, 657-664.
-
(2006)
Nature Medicine
, vol.12
, pp. 657-664
-
-
Kollet, O.1
Dar, A.2
Shivtiel, S.3
Kalinkovich, A.4
Lapid, K.5
Sztainberg, Y.6
Tesio, M.7
Samstein, R.M.8
Goichberg, P.9
Spiegel, A.10
Elson, A.11
Lapidot, T.12
-
39
-
-
0033611467
-
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
-
Kong, Y.Y., Yoshida, H., Sarosi, I., Tan, H.L., Timms, E., Capparelli, C., Morony, S., Oliveira-dos-Santos, A.J., Van, G., Itie, A., Khoo, W., Wakeham, A., Dunstan, C.R., Lacey, D.L., Mak, T.W., Boyle, W.J. & Penninger, J.M. (1999) OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature, 397, 315-323.
-
(1999)
Nature
, vol.397
, pp. 315-323
-
-
Kong, Y.Y.1
Yoshida, H.2
Sarosi, I.3
Tan, H.L.4
Timms, E.5
Capparelli, C.6
Morony, S.7
Oliveira-dos-Santos, A.J.8
Van, G.9
Itie, A.10
Khoo, W.11
Wakeham, A.12
Dunstan, C.R.13
Lacey, D.L.14
Mak, T.W.15
Boyle, W.J.16
Penninger, J.M.17
-
40
-
-
33947200199
-
Overexpression of CXCR4 predicts adverse overall and event-free survival in patients with unmutated FLT3 acute myeloid leukemia with normal karyotype
-
Konoplev, S., Rassidakis, G.Z., Estey, E., Kantarjian, H., Liakou, C.I., Huang, X., Xiao, L., Andreeff, M., Konopleva, M. & Medeiros, L.J. (2007) Overexpression of CXCR4 predicts adverse overall and event-free survival in patients with unmutated FLT3 acute myeloid leukemia with normal karyotype. Cancer, 109, 1152-1156.
-
(2007)
Cancer
, vol.109
, pp. 1152-1156
-
-
Konoplev, S.1
Rassidakis, G.Z.2
Estey, E.3
Kantarjian, H.4
Liakou, C.I.5
Huang, X.6
Xiao, L.7
Andreeff, M.8
Konopleva, M.9
Medeiros, L.J.10
-
41
-
-
79952092993
-
Leukemia stem cells and microenvironment: biology and therapeutic targeting
-
Konopleva, M.Y. & Jordan, C.T. (2011) Leukemia stem cells and microenvironment: biology and therapeutic targeting. Journal of Clinical Oncology, 29, 591-599.
-
(2011)
Journal of Clinical Oncology
, vol.29
, pp. 591-599
-
-
Konopleva, M.Y.1
Jordan, C.T.2
-
42
-
-
0035186128
-
Vascular endothelial growth factor in newly diagnosed and recurrent childhood acute lymphoblastic leukemia as measured by real-time quantitative polymerase chain reaction
-
Koomagi, R., Zintl, F., Sauerbrey, A. & Volm, M. (2001) Vascular endothelial growth factor in newly diagnosed and recurrent childhood acute lymphoblastic leukemia as measured by real-time quantitative polymerase chain reaction. Clinical Cancer Research, 7, 3381-3384.
-
(2001)
Clinical Cancer Research
, vol.7
, pp. 3381-3384
-
-
Koomagi, R.1
Zintl, F.2
Sauerbrey, A.3
Volm, M.4
-
43
-
-
17944378995
-
Prognostic evaluation of the microvascular network in myelodysplastic syndromes
-
Korkolopoulou, P., Apostolidou, E., Pavlopoulos, P.M., Kavantzas, N., Vyniou, N., Thymara, I., Terpos, E., Patsouris, E., Yataganas, X. & Davaris, P. (2001) Prognostic evaluation of the microvascular network in myelodysplastic syndromes. Leukemia, 15, 1369-1376.
-
(2001)
Leukemia
, vol.15
, pp. 1369-1376
-
-
Korkolopoulou, P.1
Apostolidou, E.2
Pavlopoulos, P.M.3
Kavantzas, N.4
Vyniou, N.5
Thymara, I.6
Terpos, E.7
Patsouris, E.8
Yataganas, X.9
Davaris, P.10
-
44
-
-
33749521890
-
Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cells
-
Krause, D.S., Lazarides, K., von Andrian, U.H. & Van Etten, R.A. (2006) Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cells. Nature Medicine, 12, 1175-1180.
-
(2006)
Nature Medicine
, vol.12
, pp. 1175-1180
-
-
Krause, D.S.1
Lazarides, K.2
von Andrian, U.H.3
Van Etten, R.A.4
-
45
-
-
84872510051
-
BMS-936564/MDX-1338: a fully human anti-CXCR4 antibody induces apoptosis in vitro and shows antitumor activity in vivo in hematologic malignancies
-
Kuhne, M.R., Mulvey, T., Belanger, B., Chen, S., Pan, C., Chong, C., Cao, F., Niekro, W., Kempe, T., Henning, K.A., Cohen, L.J., Korman, A.J. & Cardarelli, P.M. (2013) BMS-936564/MDX-1338: a fully human anti-CXCR4 antibody induces apoptosis in vitro and shows antitumor activity in vivo in hematologic malignancies. Clinical Cancer Research, 19, 357-366.
-
(2013)
Clinical Cancer Research
, vol.19
, pp. 357-366
-
-
Kuhne, M.R.1
Mulvey, T.2
Belanger, B.3
Chen, S.4
Pan, C.5
Chong, C.6
Cao, F.7
Niekro, W.8
Kempe, T.9
Henning, K.A.10
Cohen, L.J.11
Korman, A.J.12
Cardarelli, P.M.13
-
46
-
-
84886947010
-
Arteriolar niches maintain haematopoietic stem cell quiescence
-
Kunisaki, Y., Bruns, I., Scheiermann, C., Ahmed, J., Pinho, S., Zhang, D., Mizoguchi, T., Wei, Q., Lucas, D., Ito, K., Mar, J.C., Bergman, A. & Frenette, P.S. (2013) Arteriolar niches maintain haematopoietic stem cell quiescence. Nature, 502, 637-643.
-
(2013)
Nature
, vol.502
, pp. 637-643
-
-
Kunisaki, Y.1
Bruns, I.2
Scheiermann, C.3
Ahmed, J.4
Pinho, S.5
Zhang, D.6
Mizoguchi, T.7
Wei, Q.8
Lucas, D.9
Ito, K.10
Mar, J.C.11
Bergman, A.12
Frenette, P.S.13
-
47
-
-
84855862268
-
Bad to the bone
-
Lane, S.W. (2012) Bad to the bone. Blood, 119, 323-325.
-
(2012)
Blood
, vol.119
, pp. 323-325
-
-
Lane, S.W.1
-
48
-
-
33646428091
-
Normal stem cells and cancer stem cells: the niche matters
-
Li, L. & Neaves, W.B. (2006) Normal stem cells and cancer stem cells: the niche matters. Cancer Research, 66, 4553-4557.
-
(2006)
Cancer Research
, vol.66
, pp. 4553-4557
-
-
Li, L.1
Neaves, W.B.2
-
49
-
-
33746072622
-
Imatinib inhibits c-Kit-induced hypoxia-inducible factor-1alpha activity and vascular endothelial growth factor expression in small cell lung cancer cells
-
Litz, J. & Krystal, G.W. (2006) Imatinib inhibits c-Kit-induced hypoxia-inducible factor-1alpha activity and vascular endothelial growth factor expression in small cell lung cancer cells. Molecular Cancer Therapeutics, 5, 1415-1422.
-
(2006)
Molecular Cancer Therapeutics
, vol.5
, pp. 1415-1422
-
-
Litz, J.1
Krystal, G.W.2
-
50
-
-
84880301799
-
Chemotherapy-induced bone marrow nerve injury impairs hematopoietic regeneration
-
Lucas, D., Scheiermann, C., Chow, A., Kunisaki, Y., Bruns, I., Barrick, C., Tessarollo, L. & Frenette, P.S. (2013) Chemotherapy-induced bone marrow nerve injury impairs hematopoietic regeneration. Nature Medicine, 19, 695-703.
-
(2013)
Nature Medicine
, vol.19
, pp. 695-703
-
-
Lucas, D.1
Scheiermann, C.2
Chow, A.3
Kunisaki, Y.4
Bruns, I.5
Barrick, C.6
Tessarollo, L.7
Frenette, P.S.8
-
51
-
-
79551620014
-
Inhibition of osteoclast function reduces hematopoietic stem cell numbers in vivo
-
Lymperi, S., Ersek, A., Ferraro, F., Dazzi, F. & Horwood, N.J. (2010) Inhibition of osteoclast function reduces hematopoietic stem cell numbers in vivo. Blood, 117, 1540-1549.
-
(2010)
Blood
, vol.117
, pp. 1540-1549
-
-
Lymperi, S.1
Ersek, A.2
Ferraro, F.3
Dazzi, F.4
Horwood, N.J.5
-
52
-
-
84860378826
-
Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow
-
Mansour, A., Abou-Ezzi, G., Sitnicka, E., Jacobsen, S.E., Wakkach, A. & Blin-Wakkach, C. (2012) Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow. Journal of Experimental Medicine, 209, 537-549.
-
(2012)
Journal of Experimental Medicine
, vol.209
, pp. 537-549
-
-
Mansour, A.1
Abou-Ezzi, G.2
Sitnicka, E.3
Jacobsen, S.E.4
Wakkach, A.5
Blin-Wakkach, C.6
-
53
-
-
42149132696
-
Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL
-
Matsuoka, S., Oike, Y., Onoyama, I., Iwama, A., Arai, F., Takubo, K., Mashimo, Y., Oguro, H., Nitta, E., Ito, K., Miyamoto, K., Yoshiwara, H., Hosokawa, K., Nakamura, Y., Gomei, Y., Iwasaki, H., Hayashi, Y., Matsuzaki, Y., Nakayama, K., Ikeda, Y., Hata, A., Chiba, S., Nakayama, K.I. & Suda, T. (2008) Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL. Genes and Development, 22, 986-991.
-
(2008)
Genes and Development
, vol.22
, pp. 986-991
-
-
Matsuoka, S.1
Oike, Y.2
Onoyama, I.3
Iwama, A.4
Arai, F.5
Takubo, K.6
Mashimo, Y.7
Oguro, H.8
Nitta, E.9
Ito, K.10
Miyamoto, K.11
Yoshiwara, H.12
Hosokawa, K.13
Nakamura, Y.14
Gomei, Y.15
Iwasaki, H.16
Hayashi, Y.17
Matsuzaki, Y.18
Nakayama, K.19
Ikeda, Y.20
Hata, A.21
Chiba, S.22
Nakayama, K.I.23
Suda, T.24
more..
-
54
-
-
0037111665
-
BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1alpha, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin
-
Mayerhofer, M., Valent, P., Sperr, W.R., Griffin, J.D. & Sillaber, C. (2002) BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1alpha, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin. Blood, 100, 3767-3775.
-
(2002)
Blood
, vol.100
, pp. 3767-3775
-
-
Mayerhofer, M.1
Valent, P.2
Sperr, W.R.3
Griffin, J.D.4
Sillaber, C.5
-
55
-
-
77955646193
-
Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
-
Mendez-Ferrer, S., Michurina, T.V., Ferraro, F., Mazloom, A.R., Macarthur, B.D., Lira, S.A., Scadden, D.T., Ma'ayan, A., Enikolopov, G.N. & Frenette, P.S. (2010) Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature, 466, 829.
-
(2010)
Nature
, vol.466
, pp. 829
-
-
Mendez-Ferrer, S.1
Michurina, T.V.2
Ferraro, F.3
Mazloom, A.R.4
Macarthur, B.D.5
Lira, S.A.6
Scadden, D.T.7
Ma'ayan, A.8
Enikolopov, G.N.9
Frenette, P.S.10
-
56
-
-
0029850558
-
Selective homing of human leukemic B-cell precursors to specific lymphohematopoietic microenvironments in SCID mice: a role for the beta 1 integrin family surface adhesion molecules VLA-4 and VLA-5
-
Messinger, Y., Chelstrom, L., Gunther, R. & Ukmi, F.M. (1996) Selective homing of human leukemic B-cell precursors to specific lymphohematopoietic microenvironments in SCID mice: a role for the beta 1 integrin family surface adhesion molecules VLA-4 and VLA-5. Leukemia and Lymphoma, 23, 61-69.
-
(1996)
Leukemia and Lymphoma
, vol.23
, pp. 61-69
-
-
Messinger, Y.1
Chelstrom, L.2
Gunther, R.3
Ukmi, F.M.4
-
57
-
-
84880011146
-
In vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling
-
Miller, P.G., Al-Shahrour, F., Hartwell, K.A., Chu, L.P., Järås, M., Puram, R.V., Puissant, A., Callahan, K.P., Ashton, J., McConkey, M.E., Poveromo, L.P., Cowley, G.S., Kharas, M.G., Labelle, M., Shterental, S., Fujisaki, J., Silberstein, L., Alexe, G., Al-Hajj, M.A., Shelton, C.A., Armstrong, S.A., Root, D.E., Scadden, D.T., Hynes, R.O., Mukherjee, S., Stegmaier, K., Jordan, C.T. & Ebert, B.L. (2013) In vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling. Cancer Cell, 24, 45-58.
-
(2013)
Cancer Cell
, vol.24
, pp. 45-58
-
-
Miller, P.G.1
Al-Shahrour, F.2
Hartwell, K.A.3
Chu, L.P.4
Järås, M.5
Puram, R.V.6
Puissant, A.7
Callahan, K.P.8
Ashton, J.9
McConkey, M.E.10
Poveromo, L.P.11
Cowley, G.S.12
Kharas, M.G.13
Labelle, M.14
Shterental, S.15
Fujisaki, J.16
Silberstein, L.17
Alexe, G.18
Al-Hajj, M.A.19
Shelton, C.A.20
Armstrong, S.A.21
Root, D.E.22
Scadden, D.T.23
Hynes, R.O.24
Mukherjee, S.25
Stegmaier, K.26
Jordan, C.T.27
Ebert, B.L.28
more..
-
58
-
-
0025861825
-
A VCAM-like adhesion molecule on murine bone marrow stromal cells mediates binding of lymphocyte precursors in culture
-
Miyake, K., Medina, K., Ishihara, K., Kimoto, M., Auerbach, R. & Kincade, P.W. (1991) A VCAM-like adhesion molecule on murine bone marrow stromal cells mediates binding of lymphocyte precursors in culture. Journal of Cell Biology, 114, 557-565.
-
(1991)
Journal of Cell Biology
, vol.114
, pp. 557-565
-
-
Miyake, K.1
Medina, K.2
Ishihara, K.3
Kimoto, M.4
Auerbach, R.5
Kincade, P.W.6
-
59
-
-
0033781363
-
Functional response of leukaemic blasts to stromal cell-derived factor-1 correlates with preferential expression of the chemokine receptor CXCR4 in acute myelomonocytic and lymphoblastic leukaemia
-
Mohle, R., Shittenhelm, M., Faienschmid, C., Bautz, F., Kratz-Albers, K., Serve, H., Brugger, W. & Kanz, L. (2000) Functional response of leukaemic blasts to stromal cell-derived factor-1 correlates with preferential expression of the chemokine receptor CXCR4 in acute myelomonocytic and lymphoblastic leukaemia. British Journal of Haematology, 110, 563-572.
-
(2000)
British Journal of Haematology
, vol.110
, pp. 563-572
-
-
Mohle, R.1
Shittenhelm, M.2
Faienschmid, C.3
Bautz, F.4
Kratz-Albers, K.5
Serve, H.6
Brugger, W.7
Kanz, L.8
-
60
-
-
0031822253
-
Changing bone marrow micro-environment during development of acute myeloid leukaemia in rats
-
Mortensen, B.T., Jensen, P.O., Helledie, N., Iversen, P.O., Ralfkiaer, E., Larsen, J.K. & Madsen, M.T. (1998) Changing bone marrow micro-environment during development of acute myeloid leukaemia in rats. British Journal of Haematology, 102, 458-464.
-
(1998)
British Journal of Haematology
, vol.102
, pp. 458-464
-
-
Mortensen, B.T.1
Jensen, P.O.2
Helledie, N.3
Iversen, P.O.4
Ralfkiaer, E.5
Larsen, J.K.6
Madsen, M.T.7
-
61
-
-
0034284302
-
Stromal cells regulate survival of B-lineage leukemic cells during chemotherapy
-
Mudry, R.E., Fortney, J.E., York, T., Hall, B.M. & Gibson, L.F. (2000) Stromal cells regulate survival of B-lineage leukemic cells during chemotherapy. Blood, 96, 1926-1932.
-
(2000)
Blood
, vol.96
, pp. 1926-1932
-
-
Mudry, R.E.1
Fortney, J.E.2
York, T.3
Hall, B.M.4
Gibson, L.F.5
-
62
-
-
84886416794
-
Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment
-
Mussai, F., De Santo, C., Abu-Dayyeh, I., Booth, S., Quek, L., McEwen-Smith, R.M., Qureshi, A., Dazzi, F., Vyas, P. & Cerundolo, V. (2013) Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment. Blood, 122, 749-758.
-
(2013)
Blood
, vol.122
, pp. 749-758
-
-
Mussai, F.1
De Santo, C.2
Abu-Dayyeh, I.3
Booth, S.4
Quek, L.5
McEwen-Smith, R.M.6
Qureshi, A.7
Dazzi, F.8
Vyas, P.9
Cerundolo, V.10
-
63
-
-
0029758113
-
Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
-
Nagasawa, T., Hirota, S., Tachibana, K., Takakura, N., Nishikawa, S., Kitamura, Y., Yoshida, N., Kikutani, H. & Kishimoto, T. (1996) Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature, 382, 635-638.
-
(1996)
Nature
, vol.382
, pp. 635-638
-
-
Nagasawa, T.1
Hirota, S.2
Tachibana, K.3
Takakura, N.4
Nishikawa, S.5
Kitamura, Y.6
Yoshida, N.7
Kikutani, H.8
Kishimoto, T.9
-
64
-
-
79959810834
-
Control of hematopoietic stem cells by the bone marrow stromal niche: the role of reticular cells
-
Nagasawa, T., Omatsu, Y. & Sugiyama, T. (2011) Control of hematopoietic stem cells by the bone marrow stromal niche: the role of reticular cells. Trends in Immunology, 32, 315-320.
-
(2011)
Trends in Immunology
, vol.32
, pp. 315-320
-
-
Nagasawa, T.1
Omatsu, Y.2
Sugiyama, T.3
-
65
-
-
67650410440
-
Chemosensitization of AML following mobilization by the CXCR4 antagonist AMD3100
-
Nervi, B., Ramirez, P., Rettig, M.P., Uy, G.L., Holt, M.S., Ritchey, J.K., Prior, J.L., Piwnica-Worms, D., Bridger, G., Ley, T.J. & DiPersio, J.F. (2009) Chemosensitization of AML following mobilization by the CXCR4 antagonist AMD3100. Blood, 113, 6206-6214.
-
(2009)
Blood
, vol.113
, pp. 6206-6214
-
-
Nervi, B.1
Ramirez, P.2
Rettig, M.P.3
Uy, G.L.4
Holt, M.S.5
Ritchey, J.K.6
Prior, J.L.7
Piwnica-Worms, D.8
Bridger, G.9
Ley, T.J.10
DiPersio, J.F.11
-
66
-
-
21344474104
-
Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells
-
Nilsson, S.K., Johnston, H.M., Whitty, G.A., Williams, B., Webb, R.J., Denhardt, D.T., Bertoncello, I., Bendall, L.J., Simmons, P.J. & Haylock, D.N. (2005) Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells. Blood, 106, 1232-1239.
-
(2005)
Blood
, vol.106
, pp. 1232-1239
-
-
Nilsson, S.K.1
Johnston, H.M.2
Whitty, G.A.3
Williams, B.4
Webb, R.J.5
Denhardt, D.T.6
Bertoncello, I.7
Bendall, L.J.8
Simmons, P.J.9
Haylock, D.N.10
-
67
-
-
84877575509
-
Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment
-
Nombela-Arrieta, C., Pivarnik, G., Winkel, B., Canty, K.J., Harley, B., Mahoney, J.E., Park, S.Y., Lu, J., Protopopov, A. & Silberstein, L.E. (2013) Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment. Nature Cell Biology, 15, 533-543.
-
(2013)
Nature Cell Biology
, vol.15
, pp. 533-543
-
-
Nombela-Arrieta, C.1
Pivarnik, G.2
Winkel, B.3
Canty, K.J.4
Harley, B.5
Mahoney, J.E.6
Park, S.Y.7
Lu, J.8
Protopopov, A.9
Silberstein, L.E.10
-
68
-
-
84873343485
-
The bone marrow microenvironment ironment as niche retreats for hematopoietic and leukemic stem cells
-
Nwajei, F. & Konopleva, M. (2013) The bone marrow microenvironment ironment as niche retreats for hematopoietic and leukemic stem cells. Advances in Hematology, 2013, 953982.
-
(2013)
Advances in Hematology
, vol.2013
, pp. 953982
-
-
Nwajei, F.1
Konopleva, M.2
-
69
-
-
77957020167
-
The essential functions of adipo-osteogenic progenitors as the hematopoietic stem and progenitor cell niche
-
Omatsu, Y., Sugiyama, T., Kohara, H., Kondoh, G., Fujii, N., Kohno, K. & Nagasawa, T. (2010) The essential functions of adipo-osteogenic progenitors as the hematopoietic stem and progenitor cell niche. Immunity, 33, 387-399.
-
(2010)
Immunity
, vol.33
, pp. 387-399
-
-
Omatsu, Y.1
Sugiyama, T.2
Kohara, H.3
Kondoh, G.4
Fujii, N.5
Kohno, K.6
Nagasawa, T.7
-
70
-
-
28544436371
-
Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates
-
Passegue, E., Wagers, A.J., Giuriato, S., Anderson, W.C. & Weissman, I.L. (2005) Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates. Journal of Experimental Medicine, 202, 1599-1611.
-
(2005)
Journal of Experimental Medicine
, vol.202
, pp. 1599-1611
-
-
Passegue, E.1
Wagers, A.J.2
Giuriato, S.3
Anderson, W.C.4
Weissman, I.L.5
-
71
-
-
18344389548
-
Immature leukemic CD34+CXCR4+ cells from CML patients have lower integrin-dependent migration and adhesion in response to the chemokine SDF-1
-
Peled, A., Hardan, I., Trakhtenbrot, L., Gur, E., Magid, M., Darash-Yahana, M., Cohen, N., Grabovsky, V., Franitza, S., Kollet, O., Lider, O., Alon, R., Rechavi, G. & Lapidot, T. (2002) Immature leukemic CD34+CXCR4+ cells from CML patients have lower integrin-dependent migration and adhesion in response to the chemokine SDF-1. Stem Cells, 20, 259-266.
-
(2002)
Stem Cells
, vol.20
, pp. 259-266
-
-
Peled, A.1
Hardan, I.2
Trakhtenbrot, L.3
Gur, E.4
Magid, M.5
Darash-Yahana, M.6
Cohen, N.7
Grabovsky, V.8
Franitza, S.9
Kollet, O.10
Lider, O.11
Alon, R.12
Rechavi, G.13
Lapidot, T.14
-
72
-
-
34250009604
-
Disrupting the stem cell niche: good seeds in bad soil
-
Perry, J.M. & Li, L. (2007) Disrupting the stem cell niche: good seeds in bad soil. Cell, 129, 1045-1047.
-
(2007)
Cell
, vol.129
, pp. 1045-1047
-
-
Perry, J.M.1
Li, L.2
-
73
-
-
78649520015
-
Stem cell integrins: implications for ex-vivo culture and cellular therapies
-
Prowse, A.B., Chong, F., Gray, P.P. & Munro, T.P. (2011) Stem cell integrins: implications for ex-vivo culture and cellular therapies. Stem Cell Research, 6, 1-12.
-
(2011)
Stem Cell Research
, vol.6
, pp. 1-12
-
-
Prowse, A.B.1
Chong, F.2
Gray, P.P.3
Munro, T.P.4
-
74
-
-
47249140444
-
Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: a potential mechanism underlying osteolytic bone lesions in multiple myeloma
-
Qiang, Y.W., Chen, Y., Stephens, O., Brown, N., Chen, B., Epstein, J., Barlogie, B. & Shaughnessy, J.D. Jr (2008) Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: a potential mechanism underlying osteolytic bone lesions in multiple myeloma. Blood, 112, 196-207.
-
(2008)
Blood
, vol.112
, pp. 196-207
-
-
Qiang, Y.W.1
Chen, Y.2
Stephens, O.3
Brown, N.4
Chen, B.5
Epstein, J.6
Barlogie, B.7
Shaughnessy Jr., J.D.8
-
75
-
-
77950862042
-
Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia
-
Raaijmakers, M.H., Mukherjee, S., Guo, S., Zhang, S., Kobayashi, T., Schoonmaker, J.A., Ebert, B.L., Al-Shahrour, F., Hasserjian, R.P., Scadden, E.O., Aung, Z., Matza, M., Merkenschlager, M., Lin, C., Rommens, J.M. & Scadden, D.T. (2010) Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia. Nature, 464, 852-857.
-
(2010)
Nature
, vol.464
, pp. 852-857
-
-
Raaijmakers, M.H.1
Mukherjee, S.2
Guo, S.3
Zhang, S.4
Kobayashi, T.5
Schoonmaker, J.A.6
Ebert, B.L.7
Al-Shahrour, F.8
Hasserjian, R.P.9
Scadden, E.O.10
Aung, Z.11
Matza, M.12
Merkenschlager, M.13
Lin, C.14
Rommens, J.M.15
Scadden, D.T.16
-
76
-
-
0033902037
-
Prognostic value of bone marrow angiogenesis in multiple myeloma
-
Rajkumar, S.V., Leong, T., Roche, P.C., Fonseca, R., Dispenzieri, A., Lacy, M.Q., Lust, J.A., Witzig, T.E., Kyle, R.A., Gertz, M.A. & Greipp, P.R. (2000) Prognostic value of bone marrow angiogenesis in multiple myeloma. Clinical Cancer Research, 6, 3111-3116.
-
(2000)
Clinical Cancer Research
, vol.6
, pp. 3111-3116
-
-
Rajkumar, S.V.1
Leong, T.2
Roche, P.C.3
Fonseca, R.4
Dispenzieri, A.5
Lacy, M.Q.6
Lust, J.A.7
Witzig, T.E.8
Kyle, R.A.9
Gertz, M.A.10
Greipp, P.R.11
-
77
-
-
47249093296
-
Alpha4beta1 integrin and 190-kDa CD44v constitute a cell surface docking complex for gelatinase B/MMP-9 in chronic leukemic but not in normal B cells
-
Redondo-Munoz, J., Ugarte-Berzal, E., Garcia-Marco, J.A., del Cerro, M.H., Van den Steen, P.E., Opdenakker, G., Terol, M.J. & Garcia-Pardo, A. (2008) Alpha4beta1 integrin and 190-kDa CD44v constitute a cell surface docking complex for gelatinase B/MMP-9 in chronic leukemic but not in normal B cells. Blood, 112, 169-178.
-
(2008)
Blood
, vol.112
, pp. 169-178
-
-
Redondo-Munoz, J.1
Ugarte-Berzal, E.2
Garcia-Marco, J.A.3
del Cerro, M.H.4
Van den Steen, P.E.5
Opdenakker, G.6
Terol, M.J.7
Garcia-Pardo, A.8
-
78
-
-
3142620882
-
Relation between CXCR-4 expression, Flt3 mutations, and unfavorable prognosis of adult acute myeloid leukemia
-
Rombouts, E.J., Pavic, B., Löwenberg, B. & Ploemacher, R.E. (2004) Relation between CXCR-4 expression, Flt3 mutations, and unfavorable prognosis of adult acute myeloid leukemia. Blood, 104, 550-557.
-
(2004)
Blood
, vol.104
, pp. 550-557
-
-
Rombouts, E.J.1
Pavic, B.2
Löwenberg, B.3
Ploemacher, R.E.4
-
79
-
-
20244364979
-
Stroma-mediated dysregulation of myelopoiesis in mice lacking I kappa B alpha
-
Rupec, R.A., Jundt, F., Rebholz, B., Eckelt, B., Weindl, G., Herzinger, T., Flaig, M.J., Moosmann, S., Plewig, G., Dörken, B., Förster, I., Huss, R. & Pfeffer, K. (2005) Stroma-mediated dysregulation of myelopoiesis in mice lacking I kappa B alpha. Immunity, 22, 479-491.
-
(2005)
Immunity
, vol.22
, pp. 479-491
-
-
Rupec, R.A.1
Jundt, F.2
Rebholz, B.3
Eckelt, B.4
Weindl, G.5
Herzinger, T.6
Flaig, M.J.7
Moosmann, S.8
Plewig, G.9
Dörken, B.10
Förster, I.11
Huss, R.12
Pfeffer, K.13
-
80
-
-
79958816890
-
The biology of CD44 and HCELL in hematopoiesis: the 'step 2-bypass pathway' and other emerging perspectives
-
Sackstein, R. (2011) The biology of CD44 and HCELL in hematopoiesis: the 'step 2-bypass pathway' and other emerging perspectives. Current Opinion in Hematology, 18, 239-248.
-
(2011)
Current Opinion in Hematology
, vol.18
, pp. 239-248
-
-
Sackstein, R.1
-
81
-
-
84878298113
-
Targeting self-renewal pathways in myeloid malignancies
-
Sands, W.A., Copland, M. & Wheadon, H. (2013) Targeting self-renewal pathways in myeloid malignancies. Cell Communication and Signaling, 11, 33.
-
(2013)
Cell Communication and Signaling
, vol.11
, pp. 33
-
-
Sands, W.A.1
Copland, M.2
Wheadon, H.3
-
82
-
-
84884164883
-
Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche
-
Schepers, K., Pietras, E.M., Reynaud, D., Flach, J., Binnewies, M., Garg, T., Wagers, A.J., Hsiao, E.C. & Passegué, E. (2013) Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche. Cell Stem Cell, 13, 285-299.
-
(2013)
Cell Stem Cell
, vol.13
, pp. 285-299
-
-
Schepers, K.1
Pietras, E.M.2
Reynaud, D.3
Flach, J.4
Binnewies, M.5
Garg, T.6
Wagers, A.J.7
Hsiao, E.C.8
Passegué, E.9
-
83
-
-
0018102359
-
The relationship between the spleen colony-forming cell and the haemopoietic stem cell
-
Schofield, R. (1978) The relationship between the spleen colony-forming cell and the haemopoietic stem cell. Blood Cells, 4, 7-25.
-
(1978)
Blood Cells
, vol.4
, pp. 7-25
-
-
Schofield, R.1
-
84
-
-
84864975561
-
Silicate modulates the cross-talk between osteoblasts (SaOS-2) and osteoclasts (RAW 264.7 cells): inhibition of osteoclast growth and differentiation
-
Schroder, H.C., Wang, X.H., Wiens, M., Diehl-Seifert, B., Kropf, K., Schloßmacher, U. & Müller, W.E. (2012) Silicate modulates the cross-talk between osteoblasts (SaOS-2) and osteoclasts (RAW 264.7 cells): inhibition of osteoclast growth and differentiation. Journal of Cellular Biochemistry, 113, 3197-3206.
-
(2012)
Journal of Cellular Biochemistry
, vol.113
, pp. 3197-3206
-
-
Schroder, H.C.1
Wang, X.H.2
Wiens, M.3
Diehl-Seifert, B.4
Kropf, K.5
Schloßmacher, U.6
Müller, W.E.7
-
85
-
-
0035652927
-
The chemokine receptor CXCR4 enhances integrin-mediated in vitro adhesion and facilitates engraftment of leukemic precursor-B cells in the bone marrow
-
Shen, W., Bendall, L.J., Gottlieb, D.J. & Bradstock, K.F. (2001) The chemokine receptor CXCR4 enhances integrin-mediated in vitro adhesion and facilitates engraftment of leukemic precursor-B cells in the bone marrow. Experimental Hematology, 29, 1439-1447.
-
(2001)
Experimental Hematology
, vol.29
, pp. 1439-1447
-
-
Shen, W.1
Bendall, L.J.2
Gottlieb, D.J.3
Bradstock, K.F.4
-
86
-
-
0141828145
-
Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL
-
Staller, P., Sulitkova, J., Lisztwan, J., Moch, H., Oakeley, E.J. & Krek, W. (2003) Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL. Nature, 425, 307-311.
-
(2003)
Nature
, vol.425
, pp. 307-311
-
-
Staller, P.1
Sulitkova, J.2
Lisztwan, J.3
Moch, H.4
Oakeley, E.J.5
Krek, W.6
-
87
-
-
80053916176
-
Metabolic regulation of hematopoietic stem cells in the hypoxic niche
-
Suda, T., Takubo, K. & Semenza, G.L. (2011) Metabolic regulation of hematopoietic stem cells in the hypoxic niche. Cell Stem Cell, 9, 298-310.
-
(2011)
Cell Stem Cell
, vol.9
, pp. 298-310
-
-
Suda, T.1
Takubo, K.2
Semenza, G.L.3
-
88
-
-
33845445939
-
Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches
-
Sugiyama, T., Kohara, H., Noda, M. & Nagasawa, T. (2006) Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches. Immunity, 25, 977-988.
-
(2006)
Immunity
, vol.25
, pp. 977-988
-
-
Sugiyama, T.1
Kohara, H.2
Noda, M.3
Nagasawa, T.4
-
89
-
-
84860702901
-
Role of stromal microenvironment in nonpharmacological resistance of CML to imatinib through Lyn/CXCR4 interactions in lipid rafts
-
Tabe, Y., Jin, L., Iwabuchi, K., Wang, R.Y., Ichikawa, N., Miida, T., Cortes, J., Andreeff, M. & Konopleva, M. (2012) Role of stromal microenvironment in nonpharmacological resistance of CML to imatinib through Lyn/CXCR4 interactions in lipid rafts. Leukemia, 26, 883-892.
-
(2012)
Leukemia
, vol.26
, pp. 883-892
-
-
Tabe, Y.1
Jin, L.2
Iwabuchi, K.3
Wang, R.Y.4
Ichikawa, N.5
Miida, T.6
Cortes, J.7
Andreeff, M.8
Konopleva, M.9
-
90
-
-
84879542661
-
TGF-β-neutralizing antibody 1D11 enhances cytarabine-induced apoptosis in AML cells in the bone marrow microenvironment
-
Tabe, Y., Shi, Y.X., Zeng, Z., Jin, L., Shikami, M., Hatanaka, Y., Miida, T., Hsu, F.J., Andreeff, M. & Konopleva, M. (2013) TGF-β-neutralizing antibody 1D11 enhances cytarabine-induced apoptosis in AML cells in the bone marrow microenvironment. PLoS ONE, 8, e62785.
-
(2013)
PLoS ONE
, vol.8
-
-
Tabe, Y.1
Shi, Y.X.2
Zeng, Z.3
Jin, L.4
Shikami, M.5
Hatanaka, Y.6
Miida, T.7
Hsu, F.J.8
Andreeff, M.9
Konopleva, M.10
-
91
-
-
77956620024
-
Can inhibition of the SDF-1/CXCR4 axis eradicate acute leukemia?
-
Tavor, S. & Petit, I. (2010) Can inhibition of the SDF-1/CXCR4 axis eradicate acute leukemia? Seminars in Cancer Biology, 20, 178-185.
-
(2010)
Seminars in Cancer Biology
, vol.20
, pp. 178-185
-
-
Tavor, S.1
Petit, I.2
-
92
-
-
34250363611
-
Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment
-
Walkley, C.R., Shea, J.M., Sims, N.A., Purton, L.E. & Orkin, S.H. (2007a) Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment. Cell, 129, 1081-1095.
-
(2007)
Cell
, vol.129
, pp. 1081-1095
-
-
Walkley, C.R.1
Shea, J.M.2
Sims, N.A.3
Purton, L.E.4
Orkin, S.H.5
-
93
-
-
34250331610
-
A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency
-
Walkley, C.R., Olsen, G.H., Dworkin, S., Fabb, S.A., Swann, J., McArthur, G.A., Westmoreland, S.V., Chambon, P., Scadden, D.T. & Purton, L.E. (2007b) A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency. Cell, 129, 1097-1110.
-
(2007)
Cell
, vol.129
, pp. 1097-1110
-
-
Walkley, C.R.1
Olsen, G.H.2
Dworkin, S.3
Fabb, S.A.4
Swann, J.5
McArthur, G.A.6
Westmoreland, S.V.7
Chambon, P.8
Scadden, D.T.9
Purton, L.E.10
-
94
-
-
77950287628
-
The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML
-
Wang, Y., Krivtsov, A.V., Sinha, A.U., North, T.E., Goessling, W., Feng, Z., Zon, L.I. & Armstrong, S.A. (2010) The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML. Science, 327, 1650-1653.
-
(2010)
Science
, vol.327
, pp. 1650-1653
-
-
Wang, Y.1
Krivtsov, A.V.2
Sinha, A.U.3
North, T.E.4
Goessling, W.5
Feng, Z.6
Zon, L.I.7
Armstrong, S.A.8
-
95
-
-
6044229354
-
Concepts of human leukemic development
-
Warner, J.K., Wang, J.C., Hope, K.J., Jin, L. & Dick, J.E. (2004) Concepts of human leukemic development. Oncogene, 23, 7164-7177.
-
(2004)
Oncogene
, vol.23
, pp. 7164-7177
-
-
Warner, J.K.1
Wang, J.C.2
Hope, K.J.3
Jin, L.4
Dick, J.E.5
-
96
-
-
2342578097
-
Activation of the HIF pathway in childhood ALL, prognostic implications of VEGF
-
Wellmann, S., Guschmann, M., Griethe, W., Eckert, C., von Stackelberg, A., Lottaz, C., Moderegger, E. & Seeger, K. (2004) Activation of the HIF pathway in childhood ALL, prognostic implications of VEGF. Leukemia, 18, 926-933.
-
(2004)
Leukemia
, vol.18
, pp. 926-933
-
-
Wellmann, S.1
Guschmann, M.2
Griethe, W.3
Eckert, C.4
von Stackelberg, A.5
Lottaz, C.6
Moderegger, E.7
Seeger, K.8
-
97
-
-
84877666481
-
CD44 integrates signaling in normal stem cell, cancer stem cell and (pre)metastatic niches
-
Williams, K., Motiani, K., Giridhar, P.V. & Kasper, S. (2013) CD44 integrates signaling in normal stem cell, cancer stem cell and (pre)metastatic niches. Experimental Biology and Medicine (Maywood), 238, 324-338.
-
(2013)
Experimental Biology and Medicine (Maywood)
, vol.238
, pp. 324-338
-
-
Williams, K.1
Motiani, K.2
Giridhar, P.V.3
Kasper, S.4
-
98
-
-
81855183667
-
Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche
-
Yamazaki, S., Ema, H., Karlsson, G., Yamaguchi, T., Miyoshi, H., Shioda, S., Taketo, M.M., Karlsson, S., Iwama, A. & Nakauchi, H. (2011) Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche. Cell, 147, 1146-1158.
-
(2011)
Cell
, vol.147
, pp. 1146-1158
-
-
Yamazaki, S.1
Ema, H.2
Karlsson, G.3
Yamaguchi, T.4
Miyoshi, H.5
Shioda, S.6
Taketo, M.M.7
Karlsson, S.8
Iwama, A.9
Nakauchi, H.10
-
99
-
-
33646376411
-
Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
-
Yilmaz, O.H., Valdez, R., Theisen, B.K., Guo, W., Ferguson, D.O., Wu, H. & Morrison, S.J. (2006) Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature, 441, 475-482.
-
(2006)
Nature
, vol.441
, pp. 475-482
-
-
Yilmaz, O.H.1
Valdez, R.2
Theisen, B.K.3
Guo, W.4
Ferguson, D.O.5
Wu, H.6
Morrison, S.J.7
-
100
-
-
33846254013
-
Inhibition of CXCR4 with the novel RCP168 peptide overcomes stroma-mediated chemoresistance in chronic and acute leukemias
-
Zeng, Z., Samudio, I.J., Munsell, M., An, J., Huang, Z., Estey, E., Andreeff, M. & Konopleva, M. (2006) Inhibition of CXCR4 with the novel RCP168 peptide overcomes stroma-mediated chemoresistance in chronic and acute leukemias. Molecular Cancer Therapeutics, 5, 3113-3121.
-
(2006)
Molecular Cancer Therapeutics
, vol.5
, pp. 3113-3121
-
-
Zeng, Z.1
Samudio, I.J.2
Munsell, M.3
An, J.4
Huang, Z.5
Estey, E.6
Andreeff, M.7
Konopleva, M.8
-
101
-
-
67650367598
-
Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML
-
Zeng, Z., Shi, Y.X., Samudio, I.J., Wang, R.Y., Ling, X., Frolova, O., Levis, M., Rubin, J.B., Negrin, R.R., Estey, E.H., Konoplev, S., Andreeff, M. & Konopleva, M. (2009) Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML. Blood, 113, 6215-6224.
-
(2009)
Blood
, vol.113
, pp. 6215-6224
-
-
Zeng, Z.1
Shi, Y.X.2
Samudio, I.J.3
Wang, R.Y.4
Ling, X.5
Frolova, O.6
Levis, M.7
Rubin, J.B.8
Negrin, R.R.9
Estey, E.H.10
Konoplev, S.11
Andreeff, M.12
Konopleva, M.13
-
102
-
-
84862777168
-
Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia
-
Zhang, W., Trachootham, D., Liu, J., Chen, G., Pelicano, H., Garcia-Prieto, C., Lu, W., Burger, J.A., Croce, C.M., Plunkett, W., Keating, M.J. & Huang, P. (2012) Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia. Nature Cell Biology, 14, 276-286.
-
(2012)
Nature Cell Biology
, vol.14
, pp. 276-286
-
-
Zhang, W.1
Trachootham, D.2
Liu, J.3
Chen, G.4
Pelicano, H.5
Garcia-Prieto, C.6
Lu, W.7
Burger, J.A.8
Croce, C.M.9
Plunkett, W.10
Keating, M.J.11
Huang, P.12
-
103
-
-
84876543495
-
Microenvironmental protection of CML stem and progenitor cells from tyrosine kinase inhibitors through N-cadherin and Wnt-β-catenin signaling
-
Zhang, B., Li, M., McDonald, T., Holyoake, T.L., Moon, R.T., Campana, D., Shultz, L. & Bhatia, R. (2013) Microenvironmental protection of CML stem and progenitor cells from tyrosine kinase inhibitors through N-cadherin and Wnt-β-catenin signaling. Blood, 121, 1824-1938.
-
(2013)
Blood
, vol.121
, pp. 1824-1938
-
-
Zhang, B.1
Li, M.2
McDonald, T.3
Holyoake, T.L.4
Moon, R.T.5
Campana, D.6
Shultz, L.7
Bhatia, R.8
-
104
-
-
36649002031
-
Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo
-
Zhao, C., Blum, J., Chen, A., Kwon, H.Y., Jung, S.H., Cook, J.M., Lagoo, A. & Reya, T. (2007) Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo. Cancer Cell, 12, 528-541.
-
(2007)
Cancer Cell
, vol.12
, pp. 528-541
-
-
Zhao, C.1
Blum, J.2
Chen, A.3
Kwon, H.Y.4
Jung, S.H.5
Cook, J.M.6
Lagoo, A.7
Reya, T.8
|