Regulation of PD-1, PD-L1, and PD-L2 expression during normal and autoimmune responses

European Journal of Immunology

Volumn 33, Issue 10, 2003, Pages 2706-2716

  Liang, Spencer C ^a   Latchman, Yvette E ^a   Buhlmann, Janet E ^a   Tomczak, Michal F ^a   Horwitz, Bruce H ^a   Freeman, Gordon J ^a   Sharpe, Arlene H ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b Eugene Braunwald Research Center   (United States)

Author keywords

EAE; NOD; PD 1; PD L1; PD L2

Indexed keywords

B7 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROGRAMMED DEATH 1 PROTEIN; PROGRAMMED DEATH 1 PROTEIN LIGAND 1; PROGRAMMED DEATH 1 PROTEIN LIGAND 2; PROTEIN P50; RECEPTOR PROTEIN; STAT4 PROTEIN; STAT6 PROTEIN; SYNAPTOTAGMIN; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; MEMBRANE ANTIGEN; MEMBRANE PROTEIN; PDCD1 PROTEIN, MOUSE; PDCD1LG1 PROTEIN, MOUSE; PDCD1LG2 PROTEIN, MOUSE; PEPTIDE; PLASMA PROTEIN; STAT6 PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; BRAIN TISSUE; CELL INFILTRATION; CONTROLLED STUDY; DENDRITIC CELL; ENDOTHELIUM; EXPERIMENTAL MODEL; GENE EXPRESSION REGULATION; HEART; IMMUNE RESPONSE; INFLAMMATORY CELL; MOUSE; MOUSE MUTANT; NONHUMAN; PANCREAS; PANCREAS ISLET CELL; PLACENTA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; SPLEEN; THYMUS; TRANSCRIPTION REGULATION; TROPHOBLAST; UPREGULATION; ANIMAL; AUTOIMMUNE DISEASE; BAGG ALBINO MOUSE; C57BL MOUSE; CHEMISTRY; CHO CELL; GENETIC TRANSFECTION; GERMINAL CENTER; HAMSTER; METABOLISM; NONOBESE DIABETIC MOUSE; PHYSIOLOGY;

ANIMALS; ANTIGENS, CD80; ANTIGENS, SURFACE; APOPTOSIS REGULATORY PROTEINS; AUTOIMMUNE DISEASES; BLOOD PROTEINS; CHO CELLS; CRICETINAE; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; GERMINAL CENTER; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED NOD; NF-KAPPA B; PEPTIDES; SPLEEN; STAT6 TRANSCRIPTION FACTOR; THYMUS GLAND; TRANS-ACTIVATORS; TRANSFECTION; UP-REGULATION;

EID: 0242303572     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200324228     Document Type: Article

References (44)

1. Sharpe, A. H. and Freeman, G. J., The B7-CD28 superfamily. Nat. Rev. Immunol. 2002. 2: 116-126.
2. Okazaki, T., Iwai, Y. and Honjo, T., New regulatory co-receptors: inducible co-stimulator and PD-1. Curr. Opin. Immunol. 2002. 14: 779-782.
3. Dong, H. and Chen, L., B7-H1 pathway and its role in the evasion of tumor immunity. J. Mol. Med. 2003. 81: 281-287.
4. Ishida, Y., Agata, Y., Shibahara, K. and Honjo, T., Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J. 1992. 11: 3887-3895.
5. Okazaki, T., Maeda, A., Nishimura, H., Kurosaki, T. and Honjo, T., PD-1 immunoreceptor inhibits B cell receptor-mediated-signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine. Proc. Natl. Acad. Sci. USA 2001. 98: 13866-13871.
6. Nishimura, H., Nose, M., Hiai, H., Minato, N. and Honjo, T., Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 1999. 11: 141-151.
7. Dong, H., Zhu, G., Tamada, K. and Chen, L., B7-H1, a third member of the B7 family, co-stimulates T cell proliferation and interleukin-10 secretion. Nat. Med. 1999. 5: 1365-1369.
8. Freeman, G. J., Long, A. J., Iwai, Y., Bourque, K., Chernova, T., Nishimura, H., Fitz, L. J., Malenkovich, N., Okazaki, T., Byrne, M. C., Horton, H. F., Fouser, L., Carter, L., Ling, V., Bowman, M. R., Carreno, B. M., Collins, M., Wood, C. R. and Honjo, T., Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med. 2000. 192: 1027-1034.
9. Latchman, Y., Wood, C. R., Chernova, T., Chaudhary, D., Borde, M., Chernova, I., Iwai, Y., Long, A. J., Brown, J. A., Nunes, R., Greenfield, E. A., Bourque, K., Boussiotis, V. A., Carter, L. L., Carreno, B. M., Malenkovich, N., Nishimura, H., Okazaki, T, Honjo, T., Sharpe, A. H. and Freeman, G. J., PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat. Immunol. 2001. 2: 261-268.
10. Tseng, S. Y., Otsuji, M., Gorski, K., Huang, X., Slansky, J. E., Pai, S. I., Shalabi, A., Shin, T., Pardoll, D. M. and Tsuchiya, H., B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells. J. Exp. Med. 2001. 193: 839-846.
11. Bleul, C. C. and Boehm, T., Laser capture microdissection-based expression profiling identifies PD1-ligand as a target of the nude locus gene product. Eur. J. Immunol. 2001. 31: 2497-2503.
12. Agata, Y., Kawasaki, A., Nishimura, H., Ishida, Y., Tsubata, T., Yagita, H. and Honjo, T., Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes. Int. Immunol. 1996. 8: 765-772.
13. Dong, H., Strome, S. E., Salomao, D. R., Tamura, H., Hirano, F., Flies, D. B., Roche, P. C., Lu, J., Zhu, G., Tamada, K., Lennon, V. A., Celis, E. and Chen, L., Tumor-associated B7-H1 promotes T cell apoptosis: a potential mechanism of immune evasion. Nat. Med. 2002. 8: 793-800.
14. Atkinson, M. A. and Leiter, E. H., The NOD mouse model of type 1 diabetes: as good as it gets? Nat. Med. 1999. 5: 601-604.
15. Delovitch, T. L. and Singh, B., The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD. Immunity 1997. 7: 727-738.
16. Wang, B., Andre, I., Gonzalez, A., Katz, J. D., Aguet, M., Benoist, C. and Mathis, D., Interferon-gamma impacts at multiple points during the progression of autoimmune diabetes. Proc. Natl. Acad. Sci. USA 1997. 94: 13844-13849.
17. Gonzalez, A., Katz, J. D., Mattei, M. G., Kikutani, H., Benoist, C. and Mathis, D., Genetic control of diabetes progression. Immunity 1997. 7: 873-883.
18. Cua, D. J., Sherlock, J., Chen, Y., Murphy, C. A., Joyce, B., Seymour, B., Lucian, L., To, W., Kwan, S., Churakova, T., Zurawski, S., Wiekowski, M., Lira, S. A., Gorman, D., Kastelein, R. A. and Sedgwick, J. D., Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 2003. 421: 744-748.
19. Kuchroo, V. K., Anderson, A. C., Waldner, H., Munder, M., Bettelli, E. and Nicholson, L. B., T cell response in experimental autoimmune encephalomyelitis (EAE): role of self and cross-reactive antigens in shaping, tuning, and regulating the autopathogenic T cell repertoire. Annu. Rev. Immunol. 2002. 20: 101-123.
20. Yamazaki, T., Akiba, H., Iwai, H., Matsuda, H., Aoki, M., Tanno, Y., Shin, T., Tsuchiya, H., Pardoll, D. M., Okumura, K., Azuma, M. and Yagita, H., Expression of programmed death 1 ligands by murine T cells and APC. J. Immunol. 2002. 169: 5538-5545.
21. Coyle, A. J. and Gutierrez-Ramos, J. C., The expanding B7 superfamily: increasing complexity in costimulatory signals regulating T cell function. Nat. Immunol. 2001. 2: 203-209.
22. Kaplan, M. H., Sun, Y. L., Hoey, T. and Grusby, M. J., Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 1996. 382: 174-177.
23. Kaplan, M. H., Schindler, U., Smiley, S. T. and Grusby, M. J., Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity 1996. 4: 313-319.
24. DiDonato, J. A., Hayakawa, M., Rothwarf, D. M., Zandi, E. and Karin, M., A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB. Nature 1997. 388: 548-554.
25. Swallow, M. M., Wallin, J. J. and Sha, W. C., B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFalpha. Immunity 1999. 11: 423-432.
26. Yoshimura, S., Bondeson, J., Foxwell, B. M., Brennan, F. M. and Feldmann, M., Effective antigen presentation by dendritic cells is NF-kappaB dependent: coordinate regulation of MHC, co-stimulatory molecules and cytokines. Int. Immunol. 2001. 13: 675-683.
27. Erdman, S., Fox, J. G., Dangler, C. A., Feldman, D. and Horwitz, B. H., Typhlocolitis in NF-kappa B-deficient mice. J. Immunol. 2001. 166: 1443-1447.
28. Mazanet, M. M. and Hughes, C. C., B7-H1 is expressed by human endothelial cells and suppresses T cell cytokine synthesis. J. Immunol. 2002. 169: 3581-3588.
29. Brown, J. A., Dorfman, D. M., Ma, F. R., Sullivan, E. L., Munoz, O., Wood, C. R., Greenfield, E. A. and Freeman, G. J., Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production. J. Immunol. 2003. 170: 1257-1266.
30. Petroff, M. G., Chen, L., Phillips, T. A., Azzola, D., Sedlmayr, P. and Hunt, J. S., B7 family molecules are favorably positioned at the human maternal-fetal interface. Biol. Reprod. 2002.
31. -) thymocytes. Int. Immunol. 1996. 8: 773-780.
32. Anderson, G., Jenkinson, E. J., Moore, N. C. and Owen, J. J., MHC class II-positive epithelium and mesenchyme cells are both required for T cell development in the thymus. Nature 1993. 362: 70-73.
33. von Boehmer, H. and Hafen, K., Minor but not major histocompatibility antigens of thymus epithelium tolerize precursors of cytolytic T cells. Nature 1986. 320: 626-628.
34. Hoffmann, M. W., Allison, J. and Miller, J. F., Tolerance induction by thymic medullary epithelium. Proc. Natl. Acad. Sci. USA 1992. 89: 2526-2530.
35. Nishimura, H., Honjo, T. and Minato, N., Facilitation of beta selection and modification of positive selection in the thymus of PD-1-deficient mice. J. Exp. Med. 2000. 191: 891-898.
36. Iwai, Y., Okazaki, T., Nishimura, H., Kawasaki, A., Yagita, H. and Honjo, T., Microanatomical localization of PD-1 in human tonsils. Immunol. Lett. 2002. 83: 215-220.
37. Stephens, L. A. and Kay, T. W., Pancreatic expression of B7 costimulatory molecules in the non-obese diabetic mouse. Int. Immunol. 1995. 7: 1885-1895.
38. Sainio-Pollanen, S., Rulli, M., Pollanen, R and Simell, O., Appearance of cells expressing CD80 and CD86 costimulatory antigens in the pancreas of nonobese diabetic mice. Pancreas 1996. 13: 388-394.
39. Issazadeh, S., Navikas, V., Schaub, M., Sayegh, M. and Khoury, S., Kinetics of expression of costimulatory molecules and their ligands in murine relapsing experimental autoimmune encephalomyelitis in vivo. J. Immunol. 1998. 161: 1104-1112.
40. Karandikar, N. J., Vanderlugt, C. L., Eagar, T., Tan, L., Bluestone, J. A. and Miller, S. D., Tissue-specific up-regulation of B7-1 expression and function during the course of murine relapsing experimental autoimmune encephalomyelitis. J. Immunol. 1998. 161: 192-199.
41. Loke, P. and Allison, J. P., PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells. Proc. Natl. Acad. Sci. USA 2003. 100: 5336-5341.
42. Zhao, J., Freeman, G. J., Gray, G. S., Nadler, L. M. and Glimcher, L. H., A cell type-specific enhancer in the human B7.1 gene regulated by NF-kappaB. J. Exp. Med. 1996. 183: 777-789.
43. Eppihimer, M. J., Gunn, J., Freeman, G. J., Greenfield, E. A., Chernova, T., Erickson, J. and Leonard, J. P., Expression and regulation of the PD-L1 immunoinhibitory molecule on microvascular endothelial cells. Microcirculation 2002. 9: 133-145.
44. Dascher, C. C., Hiromatsu, K., Xiong, X., Sugita, M., Buhlmann, J. E., Dodge, I. L., Lee, S. Y., Roura-Mir, C., Watts, G. F., Roy, C. J., Behar, S. M., Clemens, D. L., Porcelli, S. A. and Brenner, M. B., Conservation of CD1 intracellular trafficking patterns between mammalian species. J. Immunol. 2002. 169: 6951-6958.