메뉴 건너뛰기




Volumn 5, Issue SEP, 2014, Pages

Elucidation of pathways driving asthma pathogenesis: Development of a systems-level analytic strategy

Author keywords

Allergy; Asthma; Birth cohort; Childhood; Epidemiology; Immune function; Systems biology; Virus infection

Indexed keywords

ALLERGEN; CONNECTIVE TISSUE GROWTH FACTOR; GAMMA INTERFERON; IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 17; TOLL LIKE RECEPTOR; TRANSCRIPTION FACTOR RUNX2; TRANSFORMING GROWTH FACTOR BETA;

EID: 84919644827     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2014.00447     Document Type: Article
Times cited : (19)

References (195)
  • 1
    • 33644774556 scopus 로고    scopus 로고
    • Asthma genetics 2006: the long and winding road to gene discovery
    • Ober C, Hoffjan S. Asthma genetics 2006: the long and winding road to gene discovery. Genes Immun (2006) 7:95-100. doi: 10.1038/sj.gene.6364284
    • (2006) Genes Immun , vol.7 , pp. 95-100
    • Ober, C.1    Hoffjan, S.2
  • 2
    • 78650923970 scopus 로고    scopus 로고
    • Gene-environment interaction for childhood asthma and exposure to farming in Central Europe
    • Ege MJ, Strachan DP, Cookson WO, Moffatt MF, Gut I, Lathrop M, et al. Gene-environment interaction for childhood asthma and exposure to farming in Central Europe. J Allergy Clin Immunol (2011) 127:e1-4. doi:10.1016/j.jaci.2010.09.041
    • (2011) J Allergy Clin Immunol , vol.127 , pp. e1-e4
    • Ege, M.J.1    Strachan, D.P.2    Cookson, W.O.3    Moffatt, M.F.4    Gut, I.5    Lathrop, M.6
  • 3
    • 77957113600 scopus 로고    scopus 로고
    • A large-scale, consortium-based genomewide association study of asthma
    • Moffatt MF, Gut IG, Demenais F, Strachan DP, Bouzigon E, Heath S, et al. A large-scale, consortium-based genomewide association study of asthma. N Engl J Med (2010) 363:1211-21. doi:10.1056/NEJMoa0906312
    • (2010) N Engl J Med , vol.363 , pp. 1211-1221
    • Moffatt, M.F.1    Gut, I.G.2    Demenais, F.3    Strachan, D.P.4    Bouzigon, E.5    Heath, S.6
  • 4
    • 34547216747 scopus 로고    scopus 로고
    • Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma
    • Moffatt MF, Kabesch M, Liang L, Dixon AL, Strachan D, Heath S, et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature (2007) 448:470-3. doi:10.1038/nature06014
    • (2007) Nature , vol.448 , pp. 470-473
    • Moffatt, M.F.1    Kabesch, M.2    Liang, L.3    Dixon, A.L.4    Strachan, D.5    Heath, S.6
  • 6
    • 84864442093 scopus 로고    scopus 로고
    • Genome-wide prediction of childhood asthma and related phenotypes in a longitudinal birth cohort
    • Spycher BD, Henderson J, Granell R, Evans DM, Smith GD, Timpson NJ, et al. Genome-wide prediction of childhood asthma and related phenotypes in a longitudinal birth cohort. J Allergy Clin Immunol (2012) 130(503-9):e7. doi:10.1016/j.jaci.2012.06.002
    • (2012) J Allergy Clin Immunol , vol.130 , Issue.503-509
    • Spycher, B.D.1    Henderson, J.2    Granell, R.3    Evans, D.M.4    Smith, G.D.5    Timpson, N.J.6
  • 7
    • 0028870592 scopus 로고
    • Asthma and wheezing in the first six years of life. The group health medical associates.
    • Martinez FD, Wright AL, Taussig LM, Holberg CJ, Halonen M, Morgan WJ. Asthma and wheezing in the first six years of life. The group health medical associates. N Engl J Med (1995) 332:133-8. doi:10.1056/NEJM199501193320301
    • (1995) N Engl J Med , vol.332 , pp. 133-138
    • Martinez, F.D.1    Wright, A.L.2    Taussig, L.M.3    Holberg, C.J.4    Halonen, M.5    Morgan, W.J.6
  • 8
    • 0026764023 scopus 로고
    • Asthma from birth to age 23: incidence and relation to prior and concurrent atopic disease
    • Anderson HR, Pottier AC, Strachan DP. Asthma from birth to age 23: incidence and relation to prior and concurrent atopic disease. Thorax (1992) 47:537-42. doi:10.1136/thx.47.7.537
    • (1992) Thorax , vol.47 , pp. 537-542
    • Anderson, H.R.1    Pottier, A.C.2    Strachan, D.P.3
  • 9
    • 0022492864 scopus 로고
    • Physiologic growth and development of the lung during the first year of life [erratum appears in Am Rev Respir Dis 1987;136(3):800]
    • Tepper RS, Morgan WJ, Cota K, Wright A, Taussig LM. Physiologic growth and development of the lung during the first year of life [erratum appears in Am Rev Respir Dis 1987;136(3):800]. Am Rev Respir Dis (1986) 134:513-9.
    • (1986) Am Rev Respir Dis , vol.134 , pp. 513-519
    • Tepper, R.S.1    Morgan, W.J.2    Cota, K.3    Wright, A.4    Taussig, L.M.5
  • 10
    • 79960994853 scopus 로고    scopus 로고
    • Risk factors for bronchial hyperresponsiveness in teenagers differ with sex and atopic status
    • Collins RA, Parsons F, Deverell M, Hollams EM, Holt PG, Sly PD. Risk factors for bronchial hyperresponsiveness in teenagers differ with sex and atopic status. J Allergy Clin Immunol (2011) 128(301-7):e1. doi:10.1016/j.jaci.2011.03.016
    • (2011) J Allergy Clin Immunol , vol.128 , Issue.301-307
    • Collins, R.A.1    Parsons, F.2    Deverell, M.3    Hollams, E.M.4    Holt, P.G.5    Sly, P.D.6
  • 11
    • 52049092296 scopus 로고    scopus 로고
    • Early identification of atopy in the prediction of persistent asthma in children
    • Sly P, Boner A, Bjorksten B, Bush A, Custovic A, Eigenmann PA, et al. Early identification of atopy in the prediction of persistent asthma in children. Lancet (2008) 372:1100-6. doi:10.1016/S0140-6736(08)61451-8
    • (2008) Lancet , vol.372 , pp. 1100-1106
    • Sly, P.1    Boner, A.2    Bjorksten, B.3    Bush, A.4    Custovic, A.5    Eigenmann, P.A.6
  • 12
    • 84874004801 scopus 로고    scopus 로고
    • Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene
    • Himes BE, Sheppard K, Berndt A, Leme AS, Myers RA, Gignoux CR, et al. Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene. PLoS One (2013) 8:e56179. doi:10.1371/journal.pone.0056179
    • (2013) PLoS One , vol.8
    • Himes, B.E.1    Sheppard, K.2    Berndt, A.3    Leme, A.S.4    Myers, R.A.5    Gignoux, C.R.6
  • 13
    • 68249141746 scopus 로고    scopus 로고
    • Therapeutic manipulation of immune tolerance in allergic disease
    • Akdis M, Akdis CA. Therapeutic manipulation of immune tolerance in allergic disease. Nat Rev Drug Discov (2009) 8:645-60. doi:10.1038/nrd2653
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 645-660
    • Akdis, M.1    Akdis, C.A.2
  • 14
    • 38549139719 scopus 로고    scopus 로고
    • Regulation of immunological homeostasis in the respiratory tract
    • Holt PG, Strickland DH, Wikstrom ME, Jahnsen FL. Regulation of immunological homeostasis in the respiratory tract. Nat Rev Immunol (2008) 8:142-52. doi:10.1038/nri2236
    • (2008) Nat Rev Immunol , vol.8 , pp. 142-152
    • Holt, P.G.1    Strickland, D.H.2    Wikstrom, M.E.3    Jahnsen, F.L.4
  • 15
    • 80051946336 scopus 로고    scopus 로고
    • T-regulatory cells in childhood asthma
    • Strickland D, Holt P. T-regulatory cells in childhood asthma. Trends Immunol (2011) 32:420-7. doi:10.1016/j.it.2011.06.010
    • (2011) Trends Immunol , vol.32 , pp. 420-427
    • Strickland, D.1    Holt, P.2
  • 16
    • 84919681886 scopus 로고    scopus 로고
    • Childhood asthma: a varying disease
    • Sly P. Childhood asthma: a varying disease. Curr Opin Paediatr Asthma (2003) 111:1340-7.
    • (2003) Curr Opin Paediatr Asthma , vol.111 , pp. 1340-1347
    • Sly, P.1
  • 17
    • 77951665666 scopus 로고    scopus 로고
    • Weekly monitoring of children with asthma for infections and illness during common cold seasons
    • Olenec JP, Kim WK, Lee WM, Vang F, Pappas TE, Salazar LE, et al. Weekly monitoring of children with asthma for infections and illness during common cold seasons. J Allergy Clin Immunol (2010) 125(1001-6):e1. doi:10.1016/j.jaci.2010.01.059
    • (2010) J Allergy Clin Immunol , vol.125 , Issue.1001-1006
    • Olenec, J.P.1    Kim, W.K.2    Lee, W.M.3    Vang, F.4    Pappas, T.E.5    Salazar, L.E.6
  • 19
    • 0037120589 scopus 로고    scopus 로고
    • Long-term outcome of childhood asthma
    • Robertson C. Long-term outcome of childhood asthma. Med J Aust (2002) 177:S42-4.
    • (2002) Med J Aust , vol.177 , pp. S42-S44
    • Robertson, C.1
  • 20
    • 80055008094 scopus 로고    scopus 로고
    • Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function
    • Soler Artigas M, Loth DW, Wain LV, Gharib SA, Obeidat M, Tang W, et al. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet (2011) 43:1082-90. doi:10.1038/ng.941
    • (2011) Nat Genet , vol.43 , pp. 1082-1090
    • Soler Artigas, M.1    Loth, D.W.2    Wain, L.V.3    Gharib, S.A.4    Obeidat, M.5    Tang, W.6
  • 22
    • 80052235990 scopus 로고    scopus 로고
    • Decreased lung function after preschool wheezing rhinovirus illnesses in children at risk to develop asthma
    • Guilbert TW, Singh AM, Danov Z, Evans MD, Jackson DJ, Burton R, et al. Decreased lung function after preschool wheezing rhinovirus illnesses in children at risk to develop asthma. J Allergy Clin Immunol (2011) 128:532.e-8.e. doi:10.1016/j.jaci.2011.06.037
    • (2011) J Allergy Clin Immunol , vol.128 , pp. 532.e-538.e
    • Guilbert, T.W.1    Singh, A.M.2    Danov, Z.3    Evans, M.D.4    Jackson, D.J.5    Burton, R.6
  • 23
    • 77952744331 scopus 로고    scopus 로고
    • Do early-life viral infections cause asthma?
    • Sly PD, Kusel M, Holt PG. Do early-life viral infections cause asthma? J Allergy Clin Immunol (2010) 125:1202-5. doi:10.1016/j.jaci.2010.01.024
    • (2010) J Allergy Clin Immunol , vol.125 , pp. 1202-1205
    • Sly, P.D.1    Kusel, M.2    Holt, P.G.3
  • 24
    • 36049007283 scopus 로고    scopus 로고
    • Early detection of airway wall remodelling and eosinophilic inflammation in preschool wheezers
    • Saglani S, Payne DN, Zhu J, Wang Z, Nicholson AG, Bush A, et al. Early detection of airway wall remodelling and eosinophilic inflammation in preschool wheezers. Am J Respir Crit Care Med (2007) 176:858-64. doi:10.1164/rccm.200702-212OC
    • (2007) Am J Respir Crit Care Med , vol.176 , pp. 858-864
    • Saglani, S.1    Payne, D.N.2    Zhu, J.3    Wang, Z.4    Nicholson, A.G.5    Bush, A.6
  • 25
    • 79251608789 scopus 로고    scopus 로고
    • Lung function, airway remodelling and inflammation in symptomatic infants: outcome at 3 years
    • Malmström K, Pelkonen AS, Malmberg LP, Sarna S, Lindahl H, Kajosaari M, et al. Lung function, airway remodelling and inflammation in symptomatic infants: outcome at 3 years. Thorax (2011) 66:157-62. doi:10.1136/thx.2010.139246
    • (2011) Thorax , vol.66 , pp. 157-162
    • Malmström, K.1    Pelkonen, A.S.2    Malmberg, L.P.3    Sarna, S.4    Lindahl, H.5    Kajosaari, M.6
  • 26
    • 82555185032 scopus 로고    scopus 로고
    • Relationship between past airway pathology and current lung function in preschool wheezers
    • Sonnappa S, Bastardo C, Saglani S, Bush A, Aurora P. Relationship between past airway pathology and current lung function in preschool wheezers. Eur Respir J (2011) 38:1431-6. doi:10.1183/09031936.00164910
    • (2011) Eur Respir J , vol.38 , pp. 1431-1436
    • Sonnappa, S.1    Bastardo, C.2    Saglani, S.3    Bush, A.4    Aurora, P.5
  • 27
    • 42649096323 scopus 로고    scopus 로고
    • Increased airway smooth muscle mass in children with astham, cystic fibrosis and non-cytsic fibrosis bronchiectasis
    • Regamey N, Ochs M, Hilliard TN, Mühlfeld C, Cornish N, Fleming L, et al. Increased airway smooth muscle mass in children with astham, cystic fibrosis and non-cytsic fibrosis bronchiectasis. Am J Respir Crit Care Med (2008) 177:837-43. doi:10.1164/rccm.200707-977OC
    • (2008) Am J Respir Crit Care Med , vol.177 , pp. 837-843
    • Regamey, N.1    Ochs, M.2    Hilliard, T.N.3    Mühlfeld, C.4    Cornish, N.5    Fleming, L.6
  • 28
    • 79957512933 scopus 로고    scopus 로고
    • Effect of bronchoconstriction on airway remodelling in asthma
    • Grainge C, Lau L, Ward J, Dulay V, Lahiff G, Wilson S, et al. Effect of bronchoconstriction on airway remodelling in asthma. N Engl J Med (2011) 364:2006-15. doi:10.1056/NEJMoa1014350
    • (2011) N Engl J Med , vol.364 , pp. 2006-2015
    • Grainge, C.1    Lau, L.2    Ward, J.3    Dulay, V.4    Lahiff, G.5    Wilson, S.6
  • 31
    • 33745394558 scopus 로고    scopus 로고
    • Periostin: a novel component of subepithelial fibrosis of bronchial asthma downstream of IL-4 and IL-13 signals
    • Takayama G, Arima K, Kanaji T, Toda S, Tanaka H, Shoji S, et al. Periostin: a novel component of subepithelial fibrosis of bronchial asthma downstream of IL-4 and IL-13 signals. J Allergy ClinImmunol (2006) 118:98-104. doi:10.1016/j.jaci.2006.02.046
    • (2006) J Allergy ClinImmunol , vol.118 , pp. 98-104
    • Takayama, G.1    Arima, K.2    Kanaji, T.3    Toda, S.4    Tanaka, H.5    Shoji, S.6
  • 33
    • 0035509050 scopus 로고    scopus 로고
    • Reduced airway distensibility, fixed airflow limitation, and airway wall remodelling in asthma
    • Ward C, Johns DP, Bish R, Pais M, Reid DW, Ingram C, et al. Reduced airway distensibility, fixed airflow limitation, and airway wall remodelling in asthma. Am J Respir Crit Care Med (2001) 164:1718-21. doi:10.1164/ajrccm.164.9.2102039
    • (2001) Am J Respir Crit Care Med , vol.164 , pp. 1718-1721
    • Ward, C.1    Johns, D.P.2    Bish, R.3    Pais, M.4    Reid, D.W.5    Ingram, C.6
  • 34
    • 79251582522 scopus 로고    scopus 로고
    • Gene expression patterns of Th2 inflammation and intercellular communication in asthmatic airways
    • Choy DF, Modrek B, Abbas AR, Kummerfeld S, Clark HF, Wu LC, et al. Gene expression patterns of Th2 inflammation and intercellular communication in asthmatic airways. J Immunol (2011) 186:1861-9. doi:10.4049/jimmunol.1002568
    • (2011) J Immunol , vol.186 , pp. 1861-1869
    • Choy, D.F.1    Modrek, B.2    Abbas, A.R.3    Kummerfeld, S.4    Clark, H.F.5    Wu, L.C.6
  • 35
    • 76149146032 scopus 로고    scopus 로고
    • Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program
    • Moore WC, Meyers DA, Wenzel SE, Teague WG, Li H, Li X, et al. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med (2010) 181:315-23. doi:10.1164/rccm.200906-0896OC
    • (2010) Am J Respir Crit Care Med , vol.181 , pp. 315-323
    • Moore, W.C.1    Meyers, D.A.2    Wenzel, S.E.3    Teague, W.G.4    Li, H.5    Li, X.6
  • 36
    • 84889092877 scopus 로고    scopus 로고
    • Th17-mediated inflammation in asthma
    • Newcomb DC, Peebles RS Jr. Th17-mediated inflammation in asthma. Curr Opin Immunol (2013) 25:755-60. doi:10.1016/j.coi.2013.08.002
    • (2013) Curr Opin Immunol , vol.25 , pp. 755-760
    • Newcomb, D.C.1    Peebles R.S, Jr.2
  • 37
    • 0001712741 scopus 로고    scopus 로고
    • Eosinophilic inflammation in the bronchial mucosa of children with bronchial asthma
    • Pohunek P, Roche WR, Turzikova J, Kudrmann J, Warner JO. Eosinophilic inflammation in the bronchial mucosa of children with bronchial asthma. Eur Respir J (1997) 10:160.
    • (1997) Eur Respir J , vol.10 , pp. 160
    • Pohunek, P.1    Roche, W.R.2    Turzikova, J.3    Kudrmann, J.4    Warner, J.O.5
  • 38
    • 29544445309 scopus 로고    scopus 로고
    • Bidirectional interactions between viral respiratory illnesses and cytokine responses in the first year of life
    • Gern JE, Brooks GD, Meyer P, Chang A, Shen K, Evans MD, et al. Bidirectional interactions between viral respiratory illnesses and cytokine responses in the first year of life. J Allergy Clin Immunol (2006) 117:72-8. doi:10.1016/j.jaci.2005.10.002
    • (2006) J Allergy Clin Immunol , vol.117 , pp. 72-78
    • Gern, J.E.1    Brooks, G.D.2    Meyer, P.3    Chang, A.4    Shen, K.5    Evans, M.D.6
  • 39
    • 33747779733 scopus 로고    scopus 로고
    • Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study
    • Illi S, von Mutius E, Lau S, Niggemann B, Gruber C, Wahn U. Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study. Lancet (2006) 368:763-70. doi:10.1016/S0140-6736(06)69286-6
    • (2006) Lancet , vol.368 , pp. 763-770
    • Illi, S.1    von Mutius, E.2    Lau, S.3    Niggemann, B.4    Gruber, C.5    Wahn, U.6
  • 40
    • 34247500952 scopus 로고    scopus 로고
    • Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma
    • Kusel MM, de Klerk NH, Kebadze T, Vohma V, Holt PG, Johnston SL, et al. Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma. J Allergy Clin Immunol (2007) 119:1105-10. doi:10.1016/j.jaci.2006.12.669
    • (2007) J Allergy Clin Immunol , vol.119 , pp. 1105-1110
    • Kusel, M.M.1    de Klerk, N.H.2    Kebadze, T.3    Vohma, V.4    Holt, P.G.5    Johnston, S.L.6
  • 41
    • 0036014535 scopus 로고    scopus 로고
    • The effects of respiratory infections, atopy, and breastfeeding on childhood asthma
    • Oddy WH, de Klerk NH, Sly PD, Holt PG. The effects of respiratory infections, atopy, and breastfeeding on childhood asthma. Eur Respir J (2002) 19:899-905. doi:10.1183/09031936.02.00103602
    • (2002) Eur Respir J , vol.19 , pp. 899-905
    • Oddy, W.H.1    de Klerk, N.H.2    Sly, P.D.3    Holt, P.G.4
  • 42
    • 0025165185 scopus 로고
    • Longitudinal changes in atopy during a 4-year period: relation to broncial hyperresponsiveness and respiratory symptoms in a population sample of Australian schoolchildren
    • Peat JK, Salome CM, Woolcock AJ. Longitudinal changes in atopy during a 4-year period: relation to broncial hyperresponsiveness and respiratory symptoms in a population sample of Australian schoolchildren. J Allergy Clin Immunol (1990) 85:65-74. doi:10.1016/0091-6749(90)90223-Q
    • (1990) J Allergy Clin Immunol , vol.85 , pp. 65-74
    • Peat, J.K.1    Salome, C.M.2    Woolcock, A.J.3
  • 43
    • 0037080928 scopus 로고    scopus 로고
    • A birth cohort study of subjects at risk of atopy: twenty-two-year follow-up of wheeze and atopic status
    • Rhodes HL, Thomas P, Sporik R, Holgate ST, Cogswell JJ. A birth cohort study of subjects at risk of atopy: twenty-two-year follow-up of wheeze and atopic status. Am J Respir Crit Care Med (2002) 165:176-80. doi:10.1164/ajrccm.165.2.2104032
    • (2002) Am J Respir Crit Care Med , vol.165 , pp. 176-180
    • Rhodes, H.L.1    Thomas, P.2    Sporik, R.3    Holgate, S.T.4    Cogswell, J.J.5
  • 44
    • 0033057519 scopus 로고    scopus 로고
    • Early senstization to allergens and development of respiratory symptoms
    • Sherrill D, Stein R, Kurzius-Spencer M, Martinez F. Early senstization to allergens and development of respiratory symptoms. Clin Exp Allergy (1999) 29:905-11. doi:10.1046/j.1365-2222.1999.00631.x
    • (1999) Clin Exp Allergy , vol.29 , pp. 905-911
    • Sherrill, D.1    Stein, R.2    Kurzius-Spencer, M.3    Martinez, F.4
  • 45
    • 84979358123 scopus 로고
    • Development of atopic disease in relation to family history and cord blood IgE levels. Eleven year follow-up in 1654 children.
    • Croner S, Kjellman NIM. Development of atopic disease in relation to family history and cord blood IgE levels. Eleven year follow-up in 1654 children. Pediatr Allergy Immunol (1990) 1:14-20. doi:10.1111/j.1399-3038.1990.tb00003.x
    • (1990) Pediatr Allergy Immunol , vol.1 , pp. 14-20
    • Croner, S.1    Kjellman, N.I.M.2
  • 46
    • 52049088955 scopus 로고    scopus 로고
    • Wheezing and bronchial hyper-responsiveness in early childhood as predictors of newly diagnosed asthma in early adulthood: a longitudinal birth-cohort study
    • Stern DA, Morgan WJ, Halonen M, Wright AL, Martinez FD. Wheezing and bronchial hyper-responsiveness in early childhood as predictors of newly diagnosed asthma in early adulthood: a longitudinal birth-cohort study. Lancet (2008) 372:1058-64. doi:10.1016/S0140-6736(08)61447-6
    • (2008) Lancet , vol.372 , pp. 1058-1064
    • Stern, D.A.1    Morgan, W.J.2    Halonen, M.3    Wright, A.L.4    Martinez, F.D.5
  • 47
    • 77952762424 scopus 로고    scopus 로고
    • Beyond atopy: multiple patterns of sensitization in relation to asthma in a birth cohort study
    • Simpson A, Tan VY, Winn J, Svensén M, Bishop CM, Heckerman DE, et al. Beyond atopy: multiple patterns of sensitization in relation to asthma in a birth cohort study. Am J Respir Crit Care Med (2010) 181:1200-6. doi:10.1164/rccm.200907-1101OC
    • (2010) Am J Respir Crit Care Med , vol.181 , pp. 1200-1206
    • Simpson, A.1    Tan, V.Y.2    Winn, J.3    Svensén, M.4    Bishop, C.M.5    Heckerman, D.E.6
  • 48
    • 46149101983 scopus 로고    scopus 로고
    • Living on a farm: impact on asthma induction and clinical course
    • von Mutius E, Radon K. Living on a farm: impact on asthma induction and clinical course. Immunol Allergy Clin North Am (2008) 28:631-47. doi:10.1016/j.iac.2008.03.010
    • (2008) Immunol Allergy Clin North Am , vol.28 , pp. 631-647
    • von Mutius, E.1    Radon, K.2
  • 49
    • 84860666096 scopus 로고    scopus 로고
    • Viral infections and atopy in asthma pathogenesis: new rationales for asthma prevention and treatment
    • Holt PG, Sly PD. Viral infections and atopy in asthma pathogenesis: new rationales for asthma prevention and treatment. Nat Med (2012) 18:726-35. doi:10.1038/nm.2768
    • (2012) Nat Med , vol.18 , pp. 726-735
    • Holt, P.G.1    Sly, P.D.2
  • 50
    • 0032985772 scopus 로고    scopus 로고
    • Rhinovirus and respiratory syncytial virus in wheezing children requiring emergency care. IgE and eosinophil analyses.
    • Rakes GP, Arruda E, Ingram JM, Hoover GE, Zambrano JC, Hayden FG, et al. Rhinovirus and respiratory syncytial virus in wheezing children requiring emergency care. IgE and eosinophil analyses. Am J Respir Crit Care Med (1999) 159:785-90. doi:10.1164/ajrccm.159.3.9801052
    • (1999) Am J Respir Crit Care Med , vol.159 , pp. 785-790
    • Rakes, G.P.1    Arruda, E.2    Ingram, J.M.3    Hoover, G.E.4    Zambrano, J.C.5    Hayden, F.G.6
  • 51
    • 79955674573 scopus 로고    scopus 로고
    • Association between human rhinovirus C and severity of acute asthma in children
    • Bizzintino J, Lee WM, Laing IA, Vang F, Pappas T, Zhang G, et al. Association between human rhinovirus C and severity of acute asthma in children. Eur Respir J (2011) 37:1037-42. doi:10.1183/09031936.00092410
    • (2011) Eur Respir J , vol.37 , pp. 1037-1042
    • Bizzintino, J.1    Lee, W.M.2    Laing, I.A.3    Vang, F.4    Pappas, T.5    Zhang, G.6
  • 52
    • 79955704258 scopus 로고    scopus 로고
    • Molecular modeling, organ culture and reverse genetics for a newly identified human rhinovirus C
    • Bochkov YA, Palmenberg AC, Lee WM, Rathe JA, Amineva SP, Sun X, et al. Molecular modeling, organ culture and reverse genetics for a newly identified human rhinovirus C. Nat Med (2011) 17:627-32. doi:10.1038/nm.2358
    • (2011) Nat Med , vol.17 , pp. 627-632
    • Bochkov, Y.A.1    Palmenberg, A.C.2    Lee, W.M.3    Rathe, J.A.4    Amineva, S.P.5    Sun, X.6
  • 53
    • 84882921553 scopus 로고    scopus 로고
    • Risk of childhood asthma following infant bronchiolitis during the respiratory syncytial virus season
    • James KM, Gebretsadik T, Escobar GJ, Wu P, Carroll KN, Li SX, et al. Risk of childhood asthma following infant bronchiolitis during the respiratory syncytial virus season. J Allergy Clin Immunol (2013) 132:227-9. doi:10.1016/j.jaci.2013.01.009
    • (2013) J Allergy Clin Immunol , vol.132 , pp. 227-229
    • James, K.M.1    Gebretsadik, T.2    Escobar, G.J.3    Wu, P.4    Carroll, K.N.5    Li, S.X.6
  • 54
    • 77958471150 scopus 로고    scopus 로고
    • Asthma and allergy patterns over 18 years after severe RSV bronchiolitis in the first year of life
    • Sigurs N, Aljassim F, Kjellman B, Robinson PD, Sigurbergsson F, Bjarnason R, et al. Asthma and allergy patterns over 18 years after severe RSV bronchiolitis in the first year of life. Thorax (2010) 65:1045-52. doi:10.1136/thx.2009.121582
    • (2010) Thorax , vol.65 , pp. 1045-1052
    • Sigurs, N.1    Aljassim, F.2    Kjellman, B.3    Robinson, P.D.4    Sigurbergsson, F.5    Bjarnason, R.6
  • 55
  • 56
    • 0033554244 scopus 로고    scopus 로고
    • Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years [see comment]
    • Stein RT, Sherrill D, Morgan WJ, Holberg CJ, Halonen M, Taussig LM, et al. Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years [see comment]. Lancet (1999) 354:541-5. doi:10.1016/S0140-6736(98)10321-5
    • (1999) Lancet , vol.354 , pp. 541-545
    • Stein, R.T.1    Sherrill, D.2    Morgan, W.J.3    Holberg, C.J.4    Halonen, M.5    Taussig, L.M.6
  • 59
    • 0036225349 scopus 로고    scopus 로고
    • Rhinovirus-induced alterations on peripheral blood mononuclear cell phenotype and costimulatory molecule expression in normal and atopic asthmatic subjects
    • Papadopoulos NG, Stanciu LA, Papi A, Holgate ST, Johnston SL. Rhinovirus-induced alterations on peripheral blood mononuclear cell phenotype and costimulatory molecule expression in normal and atopic asthmatic subjects. Clin Exp Allergy (2002) 32:537-42. doi:10.1046/j.0954-7894.2002.01313.x
    • (2002) Clin Exp Allergy , vol.32 , pp. 537-542
    • Papadopoulos, N.G.1    Stanciu, L.A.2    Papi, A.3    Holgate, S.T.4    Johnston, S.L.5
  • 60
    • 17144403499 scopus 로고    scopus 로고
    • Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus
    • Wark PA, Johnston SL, Bucchieri F, Powell R, Puddicombe S, Laza-Stanca V, et al. Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus. J Exp Med (2005) 201:937-47. doi:10.1084/jem.20041901
    • (2005) J Exp Med , vol.201 , pp. 937-947
    • Wark, P.A.1    Johnston, S.L.2    Bucchieri, F.3    Powell, R.4    Puddicombe, S.5    Laza-Stanca, V.6
  • 61
    • 77649248142 scopus 로고    scopus 로고
    • Toward improved prediction of risk for atopy and asthma amongst preschoolers: a prospective cohort study
    • Holt PG, Rowe J, Kusel M, Parsons F, Hollams EM, Bosco A, et al. Toward improved prediction of risk for atopy and asthma amongst preschoolers: a prospective cohort study. J Allergy Clin Immunol (2010) 125:643-51. doi:10.1016/j.jaci.2009.12.018
    • (2010) J Allergy Clin Immunol , vol.125 , pp. 643-651
    • Holt, P.G.1    Rowe, J.2    Kusel, M.3    Parsons, F.4    Hollams, E.M.5    Bosco, A.6
  • 62
    • 84863037691 scopus 로고    scopus 로고
    • Evidence for a causal relationship between allergic sensitization and rhinovirus wheezing in early life
    • Jackson DJ, Evans MD, Gangnon RE, Tisler CJ, Pappas TE, Lee WM, et al. Evidence for a causal relationship between allergic sensitization and rhinovirus wheezing in early life. Am J Respir Crit Care Med (2012) 185:281-5. doi:10.1164/rccm.201104-0660OC
    • (2012) Am J Respir Crit Care Med , vol.185 , pp. 281-285
    • Jackson, D.J.1    Evans, M.D.2    Gangnon, R.E.3    Tisler, C.J.4    Pappas, T.E.5    Lee, W.M.6
  • 63
    • 84858148726 scopus 로고    scopus 로고
    • Febrile respiratory illnesses in infancy and atopy are risk factors for persistent asthma and wheeze
    • Kusel MMH, Kebadze T, Johnston SL, Holt PG, Sly PD. Febrile respiratory illnesses in infancy and atopy are risk factors for persistent asthma and wheeze. Eur Respir J (2012) 39:876-82. doi:10.1183/09031936.00193310
    • (2012) Eur Respir J , vol.39 , pp. 876-882
    • Kusel, M.M.H.1    Kebadze, T.2    Johnston, S.L.3    Holt, P.G.4    Sly, P.D.5
  • 66
    • 34247588114 scopus 로고    scopus 로고
    • Innate immunity of the newborn: basic mechanisms and clinical correlates
    • Levy O. Innate immunity of the newborn: basic mechanisms and clinical correlates. Nat Rev Immunol (2007) 7:379-90. doi:10.1038/nri2075
    • (2007) Nat Rev Immunol , vol.7 , pp. 379-390
    • Levy, O.1
  • 67
    • 0034110206 scopus 로고    scopus 로고
    • Vaccination in the neonatal period and early infancy
    • Siegrist CA. Vaccination in the neonatal period and early infancy. Int Rev Immunol (2000) 19:195-219. doi:10.3109/08830180009088505
    • (2000) Int Rev Immunol , vol.19 , pp. 195-219
    • Siegrist, C.A.1
  • 68
    • 0027207375 scopus 로고
    • Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a Th2 phenomenon?
    • Wegmann TG, Lin H, Guilbert L, Mosmann TR. Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a Th2 phenomenon? Immunol Today (1993) 14:353-6. doi:10.1016/0167-5699(93)90235-D
    • (1993) Immunol Today , vol.14 , pp. 353-356
    • Wegmann, T.G.1    Lin, H.2    Guilbert, L.3    Mosmann, T.R.4
  • 69
    • 0033866604 scopus 로고    scopus 로고
    • The immunology of fetuses and infants: the development of the immune system during pregnancy and early life [review]
    • Holt PG, Jones CA. The immunology of fetuses and infants: the development of the immune system during pregnancy and early life [review]. Allergy (2000) 55:688-97. doi:10.1034/j.1398-9995.2000.00118.x
    • (2000) Allergy , vol.55 , pp. 688-697
    • Holt, P.G.1    Jones, C.A.2
  • 70
    • 0037087421 scopus 로고    scopus 로고
    • Differential patterns of methylation of the IFNg promoter at CpG and non-CpG sites underlie differences in IFNg gene expression between human neonatal and adult CD45RO- T-cells
    • White GP, Watt PM, Holt BJ, Holt PG. Differential patterns of methylation of the IFNg promoter at CpG and non-CpG sites underlie differences in IFNg gene expression between human neonatal and adult CD45RO- T-cells. J Immunol (2002) 168:2820-7. doi:10.4049/jimmunol.168.6.2820
    • (2002) J Immunol , vol.168 , pp. 2820-2827
    • White, G.P.1    Watt, P.M.2    Holt, B.J.3    Holt, P.G.4
  • 71
    • 84856038216 scopus 로고    scopus 로고
    • Developmental regulation of Th17-cell capacity in human neonates
    • Black A, Bhaumik S, Kirkman RL, Weaver CT, Randolph DA. Developmental regulation of Th17-cell capacity in human neonates. Eur J Immunol (2012) 42:311-9. doi:10.1002/eji.201141847
    • (2012) Eur J Immunol , vol.42 , pp. 311-319
    • Black, A.1    Bhaumik, S.2    Kirkman, R.L.3    Weaver, C.T.4    Randolph, D.A.5
  • 72
    • 58149268052 scopus 로고    scopus 로고
    • Induction, function and regulation of IL-17-producing T cells
    • Mills KH. Induction, function and regulation of IL-17-producing T cells. Eur J Immunol (2008) 38:2636-49. doi:10.1002/eji.200838535
    • (2008) Eur J Immunol , vol.38 , pp. 2636-2649
    • Mills, K.H.1
  • 73
    • 33847206969 scopus 로고    scopus 로고
    • IL-17 family cytokines and the expanding diversity of effector T cell lineages
    • Weaver CT, Hatton RD, Mangan PR, Harrington LE. IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol (2007) 25:821-52. doi:10.1146/annurev.immunol.25.022106.141557
    • (2007) Annu Rev Immunol , vol.25 , pp. 821-852
    • Weaver, C.T.1    Hatton, R.D.2    Mangan, P.R.3    Harrington, L.E.4
  • 74
    • 73349130456 scopus 로고    scopus 로고
    • Neonatal innate TLR-mediated responses are distinct from those of adults
    • Kollmann TR, Crabtree J, Rein-Weston A, Blimkie D, Thommai F, Wang XY, et al. Neonatal innate TLR-mediated responses are distinct from those of adults. J Immunol (2009) 183:7150-60. doi:10.4049/jimmunol.0901481
    • (2009) J Immunol , vol.183 , pp. 7150-7160
    • Kollmann, T.R.1    Crabtree, J.2    Rein-Weston, A.3    Blimkie, D.4    Thommai, F.5    Wang, X.Y.6
  • 75
    • 0027103823 scopus 로고
    • Genetic 'risk' for atopy is associated with delayed postnatal maturation of T-cell competence
    • Holt PG, Clough JB, Holt BJ, Baron-Hay MJ, Rose AH, Robinson BW, et al. Genetic 'risk' for atopy is associated with delayed postnatal maturation of T-cell competence. Clin Exp Allergy (1992) 22:1093-9. doi:10.1111/j.1365-2222.1992.tb00135.x
    • (1992) Clin Exp Allergy , vol.22 , pp. 1093-1099
    • Holt, P.G.1    Clough, J.B.2    Holt, B.J.3    Baron-Hay, M.J.4    Rose, A.H.5    Robinson, B.W.6
  • 76
    • 0028169324 scopus 로고
    • Reduced interferon-gamma secretion in neonates and subsequent atopy
    • Tang MLK, Kemp AS, Thorburn J, Hill DJ. Reduced interferon-gamma secretion in neonates and subsequent atopy. Lancet (1994) 344:983-6. doi:10.1016/S0140-6736(94)91641-1
    • (1994) Lancet , vol.344 , pp. 983-986
    • Tang, M.L.K.1    Kemp, A.S.2    Thorburn, J.3    Hill, D.J.4
  • 77
    • 0027279251 scopus 로고
    • Interferon-gamma production by cord-blood mononuclear cells is reduced in newborns with a family history of atopic disease and is independent from cord blood IgE-levels
    • Rinas U, Horneff G, Wahn V. Interferon-gamma production by cord-blood mononuclear cells is reduced in newborns with a family history of atopic disease and is independent from cord blood IgE-levels. Pediatr Allergy Immunol (1993) 4:60-4. doi:10.1111/j.1399-3038.1993.tb00068.x
    • (1993) Pediatr Allergy Immunol , vol.4 , pp. 60-64
    • Rinas, U.1    Horneff, G.2    Wahn, V.3
  • 78
    • 1642369060 scopus 로고    scopus 로고
    • Low numbers of interleukin-12-producing cord blood mononuclear cells and immunoglobulin E sensitization in early childhood
    • Nilsson C, Larsson AK, Hoglind A, Gabrielsson S, Troye Blomberg M, Lilja G. Low numbers of interleukin-12-producing cord blood mononuclear cells and immunoglobulin E sensitization in early childhood. Clin Exp Allergy (2004) 34:373-80. doi:10.1111/j.1365-2222.2004.01896.x
    • (2004) Clin Exp Allergy , vol.34 , pp. 373-380
    • Nilsson, C.1    Larsson, A.K.2    Hoglind, A.3    Gabrielsson, S.4    Troye Blomberg, M.5    Lilja, G.6
  • 79
    • 0037903556 scopus 로고    scopus 로고
    • Neonatal interleukin-12 capacity is associated with variations in allergen-specific immune responses in the neonatal and postnatal periods
    • Prescott SL, Taylor A, King B, Dunstan J, Upham JW, Thornton CA, et al. Neonatal interleukin-12 capacity is associated with variations in allergen-specific immune responses in the neonatal and postnatal periods. Clin Exp Allergy (2003) 33:566-72. doi:10.1046/j.1365-2222.2003.01659.x
    • (2003) Clin Exp Allergy , vol.33 , pp. 566-572
    • Prescott, S.L.1    Taylor, A.2    King, B.3    Dunstan, J.4    Upham, J.W.5    Thornton, C.A.6
  • 80
    • 7944228606 scopus 로고    scopus 로고
    • HLA-DR expression on neonatal monocytes is associated with allergen-specific immune responses
    • Upham JW, Holt PG, Taylor A, Thornton CA, Prescott SL. HLA-DR expression on neonatal monocytes is associated with allergen-specific immune responses. J Allergy ClinImmunol (2004) 114:1202-8. doi:10.1016/j.jaci.2004.06.051
    • (2004) J Allergy ClinImmunol , vol.114 , pp. 1202-1208
    • Upham, J.W.1    Holt, P.G.2    Taylor, A.3    Thornton, C.A.4    Prescott, S.L.5
  • 81
    • 44649151107 scopus 로고    scopus 로고
    • Impairment of T-regulatory cells in cord blood of atopic mothers
    • Schaub B, Liu J, Höppler S, Haug S, Sattler C, Lluis A, et al. Impairment of T-regulatory cells in cord blood of atopic mothers. J Allergy ClinImmunol (2008) 121:e1-13. doi:10.1016/j.jaci.2008.04.010
    • (2008) J Allergy ClinImmunol , vol.121 , pp. e1-13
    • Schaub, B.1    Liu, J.2    Höppler, S.3    Haug, S.4    Sattler, C.5    Lluis, A.6
  • 82
    • 0037565371 scopus 로고    scopus 로고
    • Differences in circulating dendritic cell subtypes in cord blood and peripheral blood of healthy and allergic children
    • Hagendorens MM, Ebo DG, Schuerwegh AJ, Huybrechs A, Van Bever HP, Bridts CH, et al. Differences in circulating dendritic cell subtypes in cord blood and peripheral blood of healthy and allergic children. Clin Exp Allergy (2003) 33:633-9. doi:10.1046/j.1365-2222.2003.01649.x
    • (2003) Clin Exp Allergy , vol.33 , pp. 633-639
    • Hagendorens, M.M.1    Ebo, D.G.2    Schuerwegh, A.J.3    Huybrechs, A.4    Van Bever, H.P.5    Bridts, C.H.6
  • 83
    • 68349097522 scopus 로고    scopus 로고
    • Lower levels of plasmacytoid dendritic cells in peripheral blood are associated with a diagnosis of asthma 6 yr after severe respiratory syncytial virus bronchiolitis
    • Silver E, Yin-Declue H, Schechtman KB, Grayson MH, Bacharier LB, Castro M. Lower levels of plasmacytoid dendritic cells in peripheral blood are associated with a diagnosis of asthma 6 yr after severe respiratory syncytial virus bronchiolitis. Pediatr Allergy Immunol (2009) 20(5):471-6. doi:10.1111/j.1399-3038.2008.00818.x
    • (2009) Pediatr Allergy Immunol , vol.20 , Issue.5 , pp. 471-476
    • Silver, E.1    Yin-Declue, H.2    Schechtman, K.B.3    Grayson, M.H.4    Bacharier, L.B.5    Castro, M.6
  • 84
    • 70449707289 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells during infancy are inversely associated with childhood respiratory tract infections and wheezing
    • Upham JW, Zhang G, Rate A, Yerkovich ST, Kusel M, Sly PD, et al. Plasmacytoid dendritic cells during infancy are inversely associated with childhood respiratory tract infections and wheezing. J Allergy Clin Immunol (2009) 124(707-13):e2. doi:10.1016/j.jaci.2009.07.009
    • (2009) J Allergy Clin Immunol , vol.124 , Issue.707-713
    • Upham, J.W.1    Zhang, G.2    Rate, A.3    Yerkovich, S.T.4    Kusel, M.5    Sly, P.D.6
  • 85
    • 3142707105 scopus 로고    scopus 로고
    • Cytokine response patterns, exposure to viruses, and respiratory infections in the first year of life
    • Copenhaver CC, Gern JE, Li Z, Shult PA, Rosenthal LA, Mikus LD, et al. Cytokine response patterns, exposure to viruses, and respiratory infections in the first year of life. Am J Respir Crit Care Med (2004) 170:175-80. doi:10.1164/rccm.200312-1647OC
    • (2004) Am J Respir Crit Care Med , vol.170 , pp. 175-180
    • Copenhaver, C.C.1    Gern, J.E.2    Li, Z.3    Shult, P.A.4    Rosenthal, L.A.5    Mikus, L.D.6
  • 86
    • 0032874088 scopus 로고    scopus 로고
    • Decreased interleukin-12 levels in umbilical cord blood in children who developed acute bronchiolitis
    • Blanco-Quiros A, Gonzalez H, Arranz E, Lapena S. Decreased interleukin-12 levels in umbilical cord blood in children who developed acute bronchiolitis. Pediatr Pulmonol (1999) 28:175-80. doi:10.1002/(SICI)1099-0496(199909)28:3<175::AID-PPUL3>3.0.CO;2-U
    • (1999) Pediatr Pulmonol , vol.28 , pp. 175-180
    • Blanco-Quiros, A.1    Gonzalez, H.2    Arranz, E.3    Lapena, S.4
  • 87
    • 0034096978 scopus 로고    scopus 로고
    • Monocyte interleukin-12 production is inversely related to duration of respiratory failure in respiratory syncytial virus bronchiolitis
    • Bont L, Kavelaars A, Heijnen CJ, van Vught AJ, Kimpen JL. Monocyte interleukin-12 production is inversely related to duration of respiratory failure in respiratory syncytial virus bronchiolitis. J Infect Dis (2000) 181:1772-5. doi:10.1086/315433
    • (2000) J Infect Dis , vol.181 , pp. 1772-1775
    • Bont, L.1    Kavelaars, A.2    Heijnen, C.J.3    van Vught, A.J.4    Kimpen, J.L.5
  • 88
    • 61449208946 scopus 로고    scopus 로고
    • Interleukin-10/Interleukin-5 responses at birth predict risk for respiratory infections in children with atopic family history
    • Zhang G, Rowe J, Kusel M, Bosco A, McKenna K, de Klerk N, et al. Interleukin-10/Interleukin-5 responses at birth predict risk for respiratory infections in children with atopic family history. Am J Respir Crit Care Med (2009) 179:205-11. doi:10.1164/rccm.200803-438OC
    • (2009) Am J Respir Crit Care Med , vol.179 , pp. 205-211
    • Zhang, G.1    Rowe, J.2    Kusel, M.3    Bosco, A.4    McKenna, K.5    de Klerk, N.6
  • 89
    • 0035400061 scopus 로고    scopus 로고
    • Heterogeneity in diphtheria-tetanus-acellular pertussis vaccine-specific cellular immunity during infancy: relationship to variations in the kinetics of postnatal maturation of systemic Th1 function
    • Rowe J, Macaubas C, Monger T, Holt BJ, Harvey J, Poolman JT, et al. Heterogeneity in diphtheria-tetanus-acellular pertussis vaccine-specific cellular immunity during infancy: relationship to variations in the kinetics of postnatal maturation of systemic Th1 function. J Infect Dis (2001) 184:80-8. doi:10.1086/320996
    • (2001) J Infect Dis , vol.184 , pp. 80-88
    • Rowe, J.1    Macaubas, C.2    Monger, T.3    Holt, B.J.4    Harvey, J.5    Poolman, J.T.6
  • 90
    • 0033780097 scopus 로고    scopus 로고
    • Atopic eczema is associated with delayed maturation of the antibody response to pneumococcal vaccine
    • Arkwright PD, Patel L, Moran A, Haeney MR, Ewing CI, David TJ. Atopic eczema is associated with delayed maturation of the antibody response to pneumococcal vaccine. Clin Exp Immunol (2000) 122:16-9. doi:10.1046/j.1365-2249.2000.01338.x
    • (2000) Clin Exp Immunol , vol.122 , pp. 16-19
    • Arkwright, P.D.1    Patel, L.2    Moran, A.3    Haeney, M.R.4    Ewing, C.I.5    David, T.J.6
  • 91
    • 0035999873 scopus 로고    scopus 로고
    • Increased Th1 and Th2 allergen-induced cytokine responses in children with atopic disease
    • Smart JM, Kemp AS. Increased Th1 and Th2 allergen-induced cytokine responses in children with atopic disease. Clin Exp Allergy (2002) 32:796-802. doi:10.1046/j.1365-2222.2002.01391.x
    • (2002) Clin Exp Allergy , vol.32 , pp. 796-802
    • Smart, J.M.1    Kemp, A.S.2
  • 92
    • 19944427405 scopus 로고    scopus 로고
    • An immunoepidemiological approach to asthma: identification of in-vitro T-cell response patterns associated with different wheezing phenotypes in children
    • Heaton T, Rowe J, Turner S, Aalberse RC, de Klerk N, Suriyaarachchi D, et al. An immunoepidemiological approach to asthma: identification of in-vitro T-cell response patterns associated with different wheezing phenotypes in children. Lancet (2005) 365:142-9. doi:10.1016/S0140-6736(05)17704-6
    • (2005) Lancet , vol.365 , pp. 142-149
    • Heaton, T.1    Rowe, J.2    Turner, S.3    Aalberse, R.C.4    de Klerk, N.5    Suriyaarachchi, D.6
  • 93
    • 69349094115 scopus 로고    scopus 로고
    • Elucidation of asthma phenotypes in atopic teenagers through parallel immunophenotypic and clinical profiling
    • Hollams EM, Deverell M, Serralha M, Suriyaarachchi D, Parsons F, Zhang G, et al. Elucidation of asthma phenotypes in atopic teenagers through parallel immunophenotypic and clinical profiling. J Allergy Clin Immunol (2009) 124:e1-16. doi:10.1016/j.jaci.2009.06.019
    • (2009) J Allergy Clin Immunol , vol.124 , pp. e1-16
    • Hollams, E.M.1    Deverell, M.2    Serralha, M.3    Suriyaarachchi, D.4    Parsons, F.5    Zhang, G.6
  • 94
    • 0024417450 scopus 로고
    • Hay fever, hygiene, and household size
    • Strachan DP. Hay fever, hygiene, and household size. Br Med J (1989) 299:1259-60. doi:10.1136/bmj.299.6710.1259
    • (1989) Br Med J , vol.299 , pp. 1259-1260
    • Strachan, D.P.1
  • 95
    • 0028969925 scopus 로고
    • Environmental factors and primary T-cell sensitization to inhalant allergens in infancy: reappraisal of the role of infections and air pollution [review]
    • Holt PG. Environmental factors and primary T-cell sensitization to inhalant allergens in infancy: reappraisal of the role of infections and air pollution [review]. Pediatr Allergy Immunol (1995) 6:1-10. doi:10.1111/j.1399-3038.1995.tb00250.x
    • (1995) Pediatr Allergy Immunol , vol.6 , pp. 1-10
    • Holt, P.G.1
  • 96
    • 58449119188 scopus 로고    scopus 로고
    • Establishment of the gut microbiota in western infants
    • Adlerberth I, Wold AE. Establishment of the gut microbiota in western infants. Acta Paediatr (2009) 98:229-38. doi:10.1111/j.1651-2227.2008.01060.x
    • (2009) Acta Paediatr , vol.98 , pp. 229-238
    • Adlerberth, I.1    Wold, A.E.2
  • 97
    • 0031571230 scopus 로고    scopus 로고
    • The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction
    • Sudo N, Sawamura S-A, Tanaka K, Aiba Y, Kubo C, Koga Y. The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction. J Immunol (1997) 159:1739-45.
    • (1997) J Immunol , vol.159 , pp. 1739-1745
    • Sudo, N.1    Sawamura, S-A.2    Tanaka, K.3    Aiba, Y.4    Kubo, C.5    Koga, Y.6
  • 98
    • 56649089777 scopus 로고    scopus 로고
    • Is caesarean delivery associated with sensitization to food allergens and IgE-mediated food allergy: a systematic review
    • Koplin J, Allen K, Gurrin L, Osborne N, Tang ML, Dharmage S. Is caesarean delivery associated with sensitization to food allergens and IgE-mediated food allergy: a systematic review. Pediatr Allergy Immunol (2008) 19:682-7. doi:10.1111/j.1399-3038.2008.00731.x
    • (2008) Pediatr Allergy Immunol , vol.19 , pp. 682-687
    • Koplin, J.1    Allen, K.2    Gurrin, L.3    Osborne, N.4    Tang, M.L.5    Dharmage, S.6
  • 99
    • 40949096946 scopus 로고    scopus 로고
    • A meta-analysis of the association between Caesarean section and childhood asthma
    • Thavagnanam S, Fleming J, Bromley A, Shields MD, Cardwell CR. A meta-analysis of the association between Caesarean section and childhood asthma. Clin Exp Allergy (2008) 38:629-33. doi:10.1111/j.1365-2222.2007.02780.x
    • (2008) Clin Exp Allergy , vol.38 , pp. 629-633
    • Thavagnanam, S.1    Fleming, J.2    Bromley, A.3    Shields, M.D.4    Cardwell, C.R.5
  • 100
    • 0035040495 scopus 로고    scopus 로고
    • Caesarean section and risk of asthma and allergy in adulthood
    • Xu B, Pekkanen J, Hartikainen AL, Jarvelin MR. Caesarean section and risk of asthma and allergy in adulthood. J Allergy Clin Immunol (2001) 107:732-3. doi:10.1067/mai.2001.113048
    • (2001) J Allergy Clin Immunol , vol.107 , pp. 732-733
    • Xu, B.1    Pekkanen, J.2    Hartikainen, A.L.3    Jarvelin, M.R.4
  • 101
    • 84860337429 scopus 로고    scopus 로고
    • Hospitalisation for bronchiolitis in infants is more common after elective caesarean delivery
    • Moore HC, de Klerk NH, Holt PG, Richmond PC, Lehmann D. Hospitalisation for bronchiolitis in infants is more common after elective caesarean delivery. Arch Dis Child (2012) 97:410-4. doi:10.1136/archdischild-2011-300607
    • (2012) Arch Dis Child , vol.97 , pp. 410-414
    • Moore, H.C.1    de Klerk, N.H.2    Holt, P.G.3    Richmond, P.C.4    Lehmann, D.5
  • 102
    • 0034643729 scopus 로고    scopus 로고
    • Relation between house-dust endotoxin exposure, type 1 T-cell development, and allergen sensitisation in infants at high risk of asthma
    • Gereda JE, Leung DY, Thatayatikom A, Streib JE, Price MR, Klinnert MD, et al. Relation between house-dust endotoxin exposure, type 1 T-cell development, and allergen sensitisation in infants at high risk of asthma. Lancet (2000) 355:1680-3. doi:10.1016/S0140-6736(00)02239-X
    • (2000) Lancet , vol.355 , pp. 1680-1683
    • Gereda, J.E.1    Leung, D.Y.2    Thatayatikom, A.3    Streib, J.E.4    Price, M.R.5    Klinnert, M.D.6
  • 103
    • 63649143905 scopus 로고    scopus 로고
    • Maternal farm exposure modulates neonatal immune mechanisms through regulatory T cells
    • Schaub B, Liu J, Höppler S, Schleich I, Huehn J, Olek S, et al. Maternal farm exposure modulates neonatal immune mechanisms through regulatory T cells. J Allergy ClinImmunol (2009) 123(774-82):e5. doi:10.1016/j.jaci.2009.01.056
    • (2009) J Allergy ClinImmunol , vol.123 , Issue.774-782
    • Schaub, B.1    Liu, J.2    Höppler, S.3    Schleich, I.4    Huehn, J.5    Olek, S.6
  • 104
    • 73949103214 scopus 로고    scopus 로고
    • Maternal TLR signaling is required for prenatal asthma protection by the nonpathogenic microbe Acinetobacter lwoffii F78
    • Conrad ML, Ferstl R, Teich R, Brand S, Blümer N, Yildirim AO, et al. Maternal TLR signaling is required for prenatal asthma protection by the nonpathogenic microbe Acinetobacter lwoffii F78. J Exp Med (2009) 206:2869-77. doi:10.1084/jem.20090845
    • (2009) J Exp Med , vol.206 , pp. 2869-2877
    • Conrad, M.L.1    Ferstl, R.2    Teich, R.3    Brand, S.4    Blümer, N.5    Yildirim, A.O.6
  • 105
    • 73949130825 scopus 로고    scopus 로고
    • Soothing signals: transplacental transmission of resistance to asthma and allergy
    • Holt PG, Strickland DH. Soothing signals: transplacental transmission of resistance to asthma and allergy. J Exp Med (2009) 206:2861-4. doi:10.1084/jem.20092469
    • (2009) J Exp Med , vol.206 , pp. 2861-2864
    • Holt, P.G.1    Strickland, D.H.2
  • 106
    • 0033497811 scopus 로고    scopus 로고
    • Neural control mechanisms within airways: disruption by respiratory syncytial virus
    • Larsen GL, Colasurdo GN. Neural control mechanisms within airways: disruption by respiratory syncytial virus. J Pediatr (1999) 136:s21-7.
    • (1999) J Pediatr , vol.136 , pp. s21-s27
    • Larsen, G.L.1    Colasurdo, G.N.2
  • 107
    • 0025946924 scopus 로고
    • Neurogenic inflammation in airways
    • Barnes P. Neurogenic inflammation in airways. Int Arch Allergy Immunol (1991) 94:303-9. doi:10.1159/000235392
    • (1991) Int Arch Allergy Immunol , vol.94 , pp. 303-309
    • Barnes, P.1
  • 108
    • 0035888714 scopus 로고    scopus 로고
    • Altered respiratory tissue mechanics in asymptomatic wheezy infants
    • Hall GL, Hantos Z, Sly PD. Altered respiratory tissue mechanics in asymptomatic wheezy infants. Am J Respir Crit Care Med (2001) 164:1387-91. doi:10.1164/ajrccm.164.8.2012148
    • (2001) Am J Respir Crit Care Med , vol.164 , pp. 1387-1391
    • Hall, G.L.1    Hantos, Z.2    Sly, P.D.3
  • 109
    • 0036844560 scopus 로고    scopus 로고
    • The development of airway function in infancy following preterm delivery
    • Hoo AF, Dezateux C, Henschen M, Costeloe K, Stocks J. The development of airway function in infancy following preterm delivery. J Pediatr (2002) 141:652-8. doi:10.1111/1440-1681.12068
    • (2002) J Pediatr , vol.141 , pp. 652-658
    • Hoo, A.F.1    Dezateux, C.2    Henschen, M.3    Costeloe, K.4    Stocks, J.5
  • 110
    • 0024372516 scopus 로고
    • Lung function values from a longitudinal study of healthy children and adolescents [erratum appears in Pediatr Pulmonol 1990;8(1):68]
    • Hibbert ME, Lannigan A, Landau LI, Phelan PD. Lung function values from a longitudinal study of healthy children and adolescents [erratum appears in Pediatr Pulmonol 1990;8(1):68]. Pediatr Pulmonol (1989) 7:101-9. doi:10.1002/ppul.1950070209
    • (1989) Pediatr Pulmonol , vol.7 , pp. 101-109
    • Hibbert, M.E.1    Lannigan, A.2    Landau, L.I.3    Phelan, P.D.4
  • 112
    • 80053575852 scopus 로고    scopus 로고
    • The protective effect of farm milk consumption on childhood asthma and atopy: the GABRIELA study
    • Loss G, Apprich S, Waser M, Kneifel W, Genuneit J, Büchele G, et al. The protective effect of farm milk consumption on childhood asthma and atopy: the GABRIELA study. J Allergy Clin Immunol (2011) 128(766-73):e4. doi:10.1016/j.jaci.2011.07.048
    • (2011) J Allergy Clin Immunol , vol.128 , Issue.766-773
    • Loss, G.1    Apprich, S.2    Waser, M.3    Kneifel, W.4    Genuneit, J.5    Büchele, G.6
  • 114
    • 0028225863 scopus 로고
    • A longitudinal study of the effects of parental smoking on pulmonary function in children 6-18 years
    • Wang X, Wypij D, Gold DR, Speizer FE, Ware JH, Ferris BG Jr, et al. A longitudinal study of the effects of parental smoking on pulmonary function in children 6-18 years. Am J Respir Crit Care Med (1994) 149:1420-5. doi:10.1164/ajrccm.149.6.8004293
    • (1994) Am J Respir Crit Care Med , vol.149 , pp. 1420-1425
    • Wang, X.1    Wypij, D.2    Gold, D.R.3    Speizer, F.E.4    Ware, J.H.5    Ferris B.G, Jr.6
  • 115
    • 84894242124 scopus 로고    scopus 로고
    • Persistent effects of maternal smoking during pregnancy on lung function and asthma in adolescents
    • Hollams E, de Klerk N, Holt P, Sly P. Persistent effects of maternal smoking during pregnancy on lung function and asthma in adolescents. Am J Respir Crit Care Med (2014) 189:401-7. doi:10.1164/rccm.201302-0323OC
    • (2014) Am J Respir Crit Care Med , vol.189 , pp. 401-407
    • Hollams, E.1    de Klerk, N.2    Holt, P.3    Sly, P.4
  • 116
    • 84922334792 scopus 로고    scopus 로고
    • A longitudinal study of lung function from 1 month to 18 years of age
    • Turner S, Fielding S, Mullane D, Cox DW, Goldblatt J, Landau L, et al. A longitudinal study of lung function from 1 month to 18 years of age. Thorax (2014). doi:10.1136/thoraxjnl-2013-204931
    • (2014) Thorax
    • Turner, S.1    Fielding, S.2    Mullane, D.3    Cox, D.W.4    Goldblatt, J.5    Landau, L.6
  • 117
    • 0035135109 scopus 로고    scopus 로고
    • Effects of maternal smoking during pregnancy and environmental tobacco smoke on asthma and wheezing in children
    • Gilliland FD, Li YF, Peters JM. Effects of maternal smoking during pregnancy and environmental tobacco smoke on asthma and wheezing in children. Am J Respir Crit Care Med (2001) 163:429-36. doi:10.1164/ajrccm.163.2.2006009
    • (2001) Am J Respir Crit Care Med , vol.163 , pp. 429-436
    • Gilliland, F.D.1    Li, Y.F.2    Peters, J.M.3
  • 118
    • 0141953261 scopus 로고    scopus 로고
    • Association between antenatal cytokine production and the development of atopy and asthma at age 6 years
    • Macaubas C, de Klerk NH, Holt BJ, Wee C, Kendall G, Firth M, et al. Association between antenatal cytokine production and the development of atopy and asthma at age 6 years. Lancet (2003) 362:1192-7. doi:10.1016/S0140-6736(03)14542-4
    • (2003) Lancet , vol.362 , pp. 1192-1197
    • Macaubas, C.1    de Klerk, N.H.2    Holt, B.J.3    Wee, C.4    Kendall, G.5    Firth, M.6
  • 119
    • 84857194031 scopus 로고    scopus 로고
    • Cord blood Tregs with stable FOXP3 expression are influenced by prenatal environment and associated with atopic dermatitis at the age of one year
    • Hinz D, Bauer M, Röder S, Olek S, Huehn J, Sack U, et al. Cord blood Tregs with stable FOXP3 expression are influenced by prenatal environment and associated with atopic dermatitis at the age of one year. Allergy (2012) 67:380-9. doi:10.1111/j.1398-9995.2011.02767.x
    • (2012) Allergy , vol.67 , pp. 380-389
    • Hinz, D.1    Bauer, M.2    Röder, S.3    Olek, S.4    Huehn, J.5    Sack, U.6
  • 120
    • 0033822964 scopus 로고    scopus 로고
    • Indoor air pollution in developing countries: a major environmental and public health challenge
    • Bruce N, Perez-Padilla R, Albalak R. Indoor air pollution in developing countries: a major environmental and public health challenge. Bull WHO (2000) 78:1078-92.
    • (2000) Bull WHO , vol.78 , pp. 1078-1092
    • Bruce, N.1    Perez-Padilla, R.2    Albalak, R.3
  • 121
    • 0034067117 scopus 로고    scopus 로고
    • Indoor air pollution and acute lower respiratory infections in children
    • Smith K, Samet J, Romieu I, Bruce N. Indoor air pollution and acute lower respiratory infections in children. Thorax (2000) 55:518-32. doi:10.1136/thorax.55.6.518
    • (2000) Thorax , vol.55 , pp. 518-532
    • Smith, K.1    Samet, J.2    Romieu, I.3    Bruce, N.4
  • 122
    • 0037106386 scopus 로고    scopus 로고
    • The importance of prenatal exposures on the development of allergic disease: a birth cohort study using the west midlands general practice database
    • McKeever TM, Lewis SA, Smith C, Hubbard R. The importance of prenatal exposures on the development of allergic disease: a birth cohort study using the west midlands general practice database. Am J Respir Crit Care Med (2002) 166:827-32. doi:10.1164/rccm.200202-158OC
    • (2002) Am J Respir Crit Care Med , vol.166 , pp. 827-832
    • McKeever, T.M.1    Lewis, S.A.2    Smith, C.3    Hubbard, R.4
  • 123
    • 0032806005 scopus 로고    scopus 로고
    • Maternal infections in pregnancy and the development of asthma among offspring
    • Xu B, Pekkanen J, Jarvelin MR, Olsen P, Hartikainen AL. Maternal infections in pregnancy and the development of asthma among offspring. Int J Epidemiol (1999) 28:723-7. doi:10.1093/ije/28.4.723
    • (1999) Int J Epidemiol , vol.28 , pp. 723-727
    • Xu, B.1    Pekkanen, J.2    Jarvelin, M.R.3    Olsen, P.4    Hartikainen, A.L.5
  • 124
    • 0024491638 scopus 로고
    • Association of asthma with serum IgE levels and skin-test reactivity to allergens
    • Burrows B, Martinez F, Halonen M, Barbee R, Cline M. Association of asthma with serum IgE levels and skin-test reactivity to allergens. N Engl J Med (1989) 320:271-7. doi:10.1056/NEJM198902023200502
    • (1989) N Engl J Med , vol.320 , pp. 271-277
    • Burrows, B.1    Martinez, F.2    Halonen, M.3    Barbee, R.4    Cline, M.5
  • 126
    • 77953787260 scopus 로고    scopus 로고
    • Decreased activation of inflammatory networks during acute asthma exacerbations is associated with chronic airflow obstruction
    • Bosco A, Ehteshami S, Stern DA, Martinez FD. Decreased activation of inflammatory networks during acute asthma exacerbations is associated with chronic airflow obstruction. Mucosal Immunol (2010) 3:399-409. doi:10.1038/mi.2010.13
    • (2010) Mucosal Immunol , vol.3 , pp. 399-409
    • Bosco, A.1    Ehteshami, S.2    Stern, D.A.3    Martinez, F.D.4
  • 127
  • 128
    • 0037841802 scopus 로고    scopus 로고
    • Rhinitis and asthma: evidence for respiratory system integration
    • Togias A. Rhinitis and asthma: evidence for respiratory system integration. J Allergy Clin Immunol (2003) 111:1171-83. doi:10.1067/mai.2003.1592
    • (2003) J Allergy Clin Immunol , vol.111 , pp. 1171-1183
    • Togias, A.1
  • 129
    • 79551502309 scopus 로고    scopus 로고
    • Effect of day care attendance on sensitization and atopic wheezing differs by toll-like receptor 2 genotype in 2 population-based birth cohort studies
    • Custovic A, Rothers J, Stern D, Simpson A, Woodcock A, Wright AL, et al. Effect of day care attendance on sensitization and atopic wheezing differs by toll-like receptor 2 genotype in 2 population-based birth cohort studies. J Allergy Clin Immunol (2011) 127(390-7):e1-9. doi:10.1016/j.jaci.2010.10.050
    • (2011) J Allergy Clin Immunol , vol.127 , Issue.390-397 , pp. e1-e9
    • Custovic, A.1    Rothers, J.2    Stern, D.3    Simpson, A.4    Woodcock, A.5    Wright, A.L.6
  • 130
    • 0037055631 scopus 로고    scopus 로고
    • Expression of CD14 and toll-like receptor 2 in farmers' and non-farmers' children
    • Lauener RP, Birchler T, Adamski J, Braun-Fahrländer C, Bufe A, Herz U, et al. Expression of CD14 and toll-like receptor 2 in farmers' and non-farmers' children. Lancet (2002) 360:465-6. doi:10.1016/S0140-6736(02)09641-1
    • (2002) Lancet , vol.360 , pp. 465-466
    • Lauener, R.P.1    Birchler, T.2    Adamski, J.3    Braun-Fahrländer, C.4    Bufe, A.5    Herz, U.6
  • 131
    • 33747143424 scopus 로고    scopus 로고
    • Endotoxin exposure, CD14, and allergic disease: an interaction between genes and the environment [see comment]
    • Simpson A, John SL, Jury F, Niven R, Woodcock A, Ollier WE, et al. Endotoxin exposure, CD14, and allergic disease: an interaction between genes and the environment [see comment]. Am J Respir Crit Care Med (2006) 174:386-92. doi:10.1164/rccm.200509-1380OC
    • (2006) Am J Respir Crit Care Med , vol.174 , pp. 386-392
    • Simpson, A.1    John, S.L.2    Jury, F.3    Niven, R.4    Woodcock, A.5    Ollier, W.E.6
  • 132
    • 84871439801 scopus 로고    scopus 로고
    • Childhood overweight/obesity and asthma: is there a link? A systematic review of recent epidemiologic evidence
    • Papoutsakis C, Priftis KN, Drakouli M, Prifti S, Konstantaki E, Chondronikola M, et al. Childhood overweight/obesity and asthma: is there a link? A systematic review of recent epidemiologic evidence. J Acad Nutr Diet (2013) 113:77-105. doi:10.1016/j.jand.2012.08.025
    • (2013) J Acad Nutr Diet , vol.113 , pp. 77-105
    • Papoutsakis, C.1    Priftis, K.N.2    Drakouli, M.3    Prifti, S.4    Konstantaki, E.5    Chondronikola, M.6
  • 133
    • 77649119443 scopus 로고    scopus 로고
    • Disordered microbial communities in asthmatic airways
    • Hilty M, Burke C, Pedro H, Cardenas P, Bush A, Bossley C, et al. Disordered microbial communities in asthmatic airways. PLoS One (2010) 5:e8578. doi:10.1371/journal.pone.0008578
    • (2010) PLoS One , vol.5
    • Hilty, M.1    Burke, C.2    Pedro, H.3    Cardenas, P.4    Bush, A.5    Bossley, C.6
  • 134
    • 84893661752 scopus 로고    scopus 로고
    • Defective respiratory tract immume surveillance in asthma
    • Holt PG, Strickland DH, Hales BJ, Sly PD. Defective respiratory tract immume surveillance in asthma. Chest (2014) 145:370-8. doi:10.1378/chest.13-1341
    • (2014) Chest , vol.145 , pp. 370-378
    • Holt, P.G.1    Strickland, D.H.2    Hales, B.J.3    Sly, P.D.4
  • 136
    • 84858792388 scopus 로고    scopus 로고
    • Antibacterial antibody responses associated with the development of asthma in house dust mite-sensitised and non-sensitised children
    • Hales BJ, Chai LY, Elliot CE, Pearce LJ, Zhang G, Heinrich TK, et al. Antibacterial antibody responses associated with the development of asthma in house dust mite-sensitised and non-sensitised children. Thorax (2012) 67:321-7. doi:10.1136/thoraxjnl-2011-200650
    • (2012) Thorax , vol.67 , pp. 321-327
    • Hales, B.J.1    Chai, L.Y.2    Elliot, C.E.3    Pearce, L.J.4    Zhang, G.5    Heinrich, T.K.6
  • 137
    • 77956601960 scopus 로고    scopus 로고
    • Th2-associated immunity to bacteria in teenagers and susceptibility to asthma
    • Hollams EM, Hales BJ, Bachert C, Huvenne W, Parsons F, de Klerk NH, et al. Th2-associated immunity to bacteria in teenagers and susceptibility to asthma. Eur Respir J (2010) 36:509-16. doi:10.1183/09031936.00184109
    • (2010) Eur Respir J , vol.36 , pp. 509-516
    • Hollams, E.M.1    Hales, B.J.2    Bachert, C.3    Huvenne, W.4    Parsons, F.5    de Klerk, N.H.6
  • 138
    • 84892712729 scopus 로고    scopus 로고
    • Unifying immunology with informatics and multiscale biology
    • Kidd BA, Peters LA, Schadt EE, Dudley JT. Unifying immunology with informatics and multiscale biology. Nat Immunol (2014) 15:118-27. doi:10.1038/ni0914-894c
    • (2014) Nat Immunol , vol.15 , pp. 118-127
    • Kidd, B.A.1    Peters, L.A.2    Schadt, E.E.3    Dudley, J.T.4
  • 139
    • 33746752176 scopus 로고    scopus 로고
    • Role of respiratory viruses in acute upper and lower respiratory tract illness in the first year of life: a birth cohort study
    • Kusel MMH, de Klerk NH, Holt PG, Kebadze T, Johnston SL, Sly PD. Role of respiratory viruses in acute upper and lower respiratory tract illness in the first year of life: a birth cohort study. Pediatr Infect Dis J (2006) 25:680-6. doi:10.1097/01.inf.0000226912.88900.a3
    • (2006) Pediatr Infect Dis J , vol.25 , pp. 680-686
    • Kusel, M.M.H.1    de Klerk, N.H.2    Holt, P.G.3    Kebadze, T.4    Johnston, S.L.5    Sly, P.D.6
  • 140
    • 0035901102 scopus 로고    scopus 로고
    • Early childhood infectious diseases and the development of asthma up to school age: a birth cohort study
    • Illi S, von Mutius E, Lau S, Bergmann R, Niggemann B, Sommerfeld C, et al. Early childhood infectious diseases and the development of asthma up to school age: a birth cohort study. BMJ (2001) 322:390-5. doi:10.1136/bmj.322.7283.390
    • (2001) BMJ , vol.322 , pp. 390-395
    • Illi, S.1    von Mutius, E.2    Lau, S.3    Bergmann, R.4    Niggemann, B.5    Sommerfeld, C.6
  • 141
    • 66949159867 scopus 로고    scopus 로고
    • The urban environment and childhood asthma (URECA) birth cohort study: design, methods, and study population
    • Gern JE, Visness CM, Gergen PJ, Wood RA, Bloomberg GR, O'Connor GT, et al. The urban environment and childhood asthma (URECA) birth cohort study: design, methods, and study population. BMC Pulm Med (2009) 9:17. doi:10.1186/1471-2466-9-17
    • (2009) BMC Pulm Med , vol.9 , pp. 17
    • Gern, J.E.1    Visness, C.M.2    Gergen, P.J.3    Wood, R.A.4    Bloomberg, G.R.5    O'Connor, G.T.6
  • 142
    • 33745669107 scopus 로고    scopus 로고
    • Bayesian approach for clustered longitudinal ordinal outcome with nonignorable missing data: evaluation of an asthma education program
    • Kaciroti NA, Raghunathan TE, Schork MA, Clark NM, Gong MA. Bayesian approach for clustered longitudinal ordinal outcome with nonignorable missing data: evaluation of an asthma education program. J Am Stat Assoc (2006) 101:435-46. doi:10.1198/016214505000001221
    • (2006) J Am Stat Assoc , vol.101 , pp. 435-446
    • Kaciroti, N.A.1    Raghunathan, T.E.2    Schork, M.A.3    Clark, N.M.4    Gong, M.A.5
  • 143
    • 0042128693 scopus 로고    scopus 로고
    • Hierarchical regression with misaligned spatial data: relating ambient ozone and pediatric asthma ER visits in Atlanta
    • Zhu L, Carlin BP, Gelfand AE. Hierarchical regression with misaligned spatial data: relating ambient ozone and pediatric asthma ER visits in Atlanta. Environmetrics (2003) 14:537-57. doi:10.1002/env.614
    • (2003) Environmetrics , vol.14 , pp. 537-557
    • Zhu, L.1    Carlin, B.P.2    Gelfand, A.E.3
  • 144
    • 55849148482 scopus 로고    scopus 로고
    • The cytokine network in asthma and chronic obstructive pulmonary disease
    • Barnes PJ. The cytokine network in asthma and chronic obstructive pulmonary disease. J Clin Invest (2008) 118:3546. doi:10.1172/JCI36130
    • (2008) J Clin Invest , vol.118 , pp. 3546
    • Barnes, P.J.1
  • 147
    • 81055156705 scopus 로고    scopus 로고
    • Genome-wide association studies and systems biology: together at last
    • Ala-Korpela M, Kangas AJ, Inouye M. Genome-wide association studies and systems biology: together at last. Trends Genet (2011) 27:493-8. doi:10.1016/j.tig.2011.09.002
    • (2011) Trends Genet , vol.27 , pp. 493-498
    • Ala-Korpela, M.1    Kangas, A.J.2    Inouye, M.3
  • 148
    • 0034215972 scopus 로고    scopus 로고
    • Constructing Bayesian networks for medical diagnosis from incomplete and partially correct statistics
    • Nikovski D. Constructing Bayesian networks for medical diagnosis from incomplete and partially correct statistics. IEEE Trans (2000) 12:509-16. doi:10.1109/69.868904
    • (2000) IEEE Trans , vol.12 , pp. 509-516
    • Nikovski, D.1
  • 150
    • 0842288337 scopus 로고    scopus 로고
    • Inferring cellular networks using probabilistic graphical models
    • Friedman N. Inferring cellular networks using probabilistic graphical models. Science (2004) 303:799-805. doi:10.1126/science.1094068
    • (2004) Science , vol.303 , pp. 799-805
    • Friedman, N.1
  • 151
    • 34748862918 scopus 로고    scopus 로고
    • Prospective evaluation of a Bayesian network for detecting asthma exacerbations in a pediatric emergency department
    • Sanders DL, Aronsky D. Prospective evaluation of a Bayesian network for detecting asthma exacerbations in a pediatric emergency department. AMIA Annu Symp Proc (2006) 2006:1085.
    • (2006) AMIA Annu Symp Proc , vol.2006 , pp. 1085
    • Sanders, D.L.1    Aronsky, D.2
  • 153
    • 34547852213 scopus 로고    scopus 로고
    • Time-varying modeling of gene expression regulatory networks using the wavelet dynamic vector autoregressive method
    • Fujita A, Sato JR, Garay-Malpartida HM, Morettin PA, Sogayar MC, Ferreira CE. Time-varying modeling of gene expression regulatory networks using the wavelet dynamic vector autoregressive method. Bioinformatics (2007) 23:1623-30. doi:10.1093/bioinformatics/btm151
    • (2007) Bioinformatics , vol.23 , pp. 1623-1630
    • Fujita, A.1    Sato, J.R.2    Garay-Malpartida, H.M.3    Morettin, P.A.4    Sogayar, M.C.5    Ferreira, C.E.6
  • 154
    • 77957930628 scopus 로고    scopus 로고
    • Statistical inference of the time-varying structure of gene-regulation networks
    • Lebre S, Becq J, Devaux F, Stumpf M, Lelandais G. Statistical inference of the time-varying structure of gene-regulation networks. BMC Syst Biol (2010) 4:130. doi:10.1186/1752-0509-4-130
    • (2010) BMC Syst Biol , vol.4 , pp. 130
    • Lebre, S.1    Becq, J.2    Devaux, F.3    Stumpf, M.4    Lelandais, G.5
  • 155
    • 17644427718 scopus 로고    scopus 로고
    • Causal protein-signaling networks derived from multiparameter single-cell data
    • Sachs K, Perez O, Pe'er D, Lauffenburger DA, Nolan GP. Causal protein-signaling networks derived from multiparameter single-cell data. Science (2005) 308:523-9. doi:10.1126/science.1105809
    • (2005) Science , vol.308 , pp. 523-529
    • Sachs, K.1    Perez, O.2    Pe'er, D.3    Lauffenburger, D.A.4    Nolan, G.P.5
  • 156
    • 12344259602 scopus 로고    scopus 로고
    • Advances to Bayesian network inference for generating causal networks from observational biological data
    • Yu J, Smith VA, Wang PP, Hartemink AJ, Jarvis ED. Advances to Bayesian network inference for generating causal networks from observational biological data. Bioinformatics (2004) 20:3594-603. doi:10.1093/bioinformatics/bth448
    • (2004) Bioinformatics , vol.20 , pp. 3594-3603
    • Yu, J.1    Smith, V.A.2    Wang, P.P.3    Hartemink, A.J.4    Jarvis, E.D.5
  • 157
    • 38449101797 scopus 로고    scopus 로고
    • Using directed information to build biologically relevant influence networks
    • Rao A, Hero AO III, States DJ, Engel JD. Using directed information to build biologically relevant influence networks. Comput Syst Bioinformatics Conf (2007) 6:145-56. doi:10.1142/S0219720008003515
    • (2007) Comput Syst Bioinformatics Conf , vol.6 , pp. 145-156
    • Rao, A.1    Hero A.O, I.I.I.2    States, D.J.3    Engel, J.D.4
  • 158
  • 159
    • 0002629270 scopus 로고
    • Maximum likelihood from incomplete data via the EM algorithm
    • Dempster AP, Laird NM, Rubin DB. Maximum likelihood from incomplete data via the EM algorithm. J Roy Stat Soc (1977) 39:1-38.
    • (1977) J Roy Stat Soc , vol.39 , pp. 1-38
    • Dempster, A.P.1    Laird, N.M.2    Rubin, D.B.3
  • 161
    • 0000538525 scopus 로고    scopus 로고
    • Causal discovery via MML
    • Wallace C, Korb KB, Dai H. Causal discovery via MML. ICML (1996) 96:516-24.
    • (1996) ICML , vol.96 , pp. 516-524
    • Wallace, C.1    Korb, K.B.2    Dai, H.3
  • 163
    • 34249832377 scopus 로고
    • A Bayesian method for the induction of probabilistic networks from data
    • Cooper GF, Herskovits E. A Bayesian method for the induction of probabilistic networks from data. Mach Learn (1992) 9:309-47. doi:10.1023/A:1022649401552
    • (1992) Mach Learn , vol.9 , pp. 309-347
    • Cooper, G.F.1    Herskovits, E.2
  • 164
    • 33746035971 scopus 로고    scopus 로고
    • The max-min hill-climbing Bayesian network structure learning algorithm
    • Tsamardinos I, Brown LE, Aliferis CF. The max-min hill-climbing Bayesian network structure learning algorithm. Mach Learn (2006) 65:31-78. doi:10.1007/s10994-006-6889-7
    • (2006) Mach Learn , vol.65 , pp. 31-78
    • Tsamardinos, I.1    Brown, L.E.2    Aliferis, C.F.3
  • 166
    • 0003846041 scopus 로고
    • One Microsoft Way. Redmond, WA: Microsoft Research, Advanced Technology Division, Microsoft Corporation
    • Heckerman D. A Tutorial on Learning with Bayesian Networks. Technical Report. One Microsoft Way. Redmond, WA: Microsoft Research, Advanced Technology Division, Microsoft Corporation (1995).
    • (1995) A Tutorial on Learning with Bayesian Networks. Technical Report
    • Heckerman, D.1
  • 168
    • 0033349354 scopus 로고    scopus 로고
    • Joint Bayesian model selection and estimation of noisy sinusoids via reversible jump MCMC
    • Andrieu C, Doucet A. Joint Bayesian model selection and estimation of noisy sinusoids via reversible jump MCMC. IEEE Trans (1999) 47:2667-76.
    • (1999) IEEE Trans , vol.47 , pp. 2667-2676
    • Andrieu, C.1    Doucet, A.2
  • 169
    • 20744459144 scopus 로고    scopus 로고
    • Structural learning with time-varying components: tracking the cross-section of financial time series
    • Talih M, Hengartner N. Structural learning with time-varying components: tracking the cross-section of financial time series. J R Stat Soc Series B Stat Methodol (2005) 67:321-41. doi:10.1111/j.1467-9868.2005.00504.x
    • (2005) J R Stat Soc Series B Stat Methodol , vol.67 , pp. 321-341
    • Talih, M.1    Hengartner, N.2
  • 170
    • 84928251304 scopus 로고    scopus 로고
    • Bayesian inference of multiple Gaussian graphical models
    • Peterson C, Stingo F, Vannucci M. Bayesian inference of multiple Gaussian graphical models. J Am Stat Assoc (2014). doi:10.1080/01621459.2014.896806
    • (2014) J Am Stat Assoc
    • Peterson, C.1    Stingo, F.2    Vannucci, M.3
  • 171
    • 84892778654 scopus 로고    scopus 로고
    • Network inference method for large-scale unsupervised identification of novel drug-drug interactions
    • Guimerà R, Sales-Pardo MA. Network inference method for large-scale unsupervised identification of novel drug-drug interactions. PLoS Comput Biol (2013) 9:e1003374. doi:10.1371/journal.pcbi.1003374
    • (2013) PLoS Comput Biol , vol.9
    • Guimerà, R.1    Sales-Pardo, M.A.2
  • 172
    • 0032054827 scopus 로고    scopus 로고
    • Bayesian estimation of asthma prevalence, and comparison of exercise and questionnaire diagnostics in the absence of a gold standard
    • Demissie K, White N, Joseph L, Ernst P. Bayesian estimation of asthma prevalence, and comparison of exercise and questionnaire diagnostics in the absence of a gold standard. Ann Epidemiol (1998) 8:201-8. doi:10.1016/S1047-2797(97)00168-3
    • (1998) Ann Epidemiol , vol.8 , pp. 201-208
    • Demissie, K.1    White, N.2    Joseph, L.3    Ernst, P.4
  • 173
    • 0025253224 scopus 로고
    • Post-test probability of asthma following methacholine challenge
    • Gilbert R, Auchincloss JH Jr. Post-test probability of asthma following methacholine challenge. CHEST J (1990) 97:562-5. doi:10.1378/chest.97.3.562
    • (1990) CHEST J , vol.97 , pp. 562-565
    • Gilbert, R.1    Auchincloss J.H, Jr.2
  • 175
    • 34249966007 scopus 로고
    • The CN2 induction algorithm
    • Clark P, Niblett T. The CN2 induction algorithm. Mach Learn (1989) 3:261-83. doi:10.1023/A:1022641700528
    • (1989) Mach Learn , vol.3 , pp. 261-283
    • Clark, P.1    Niblett, T.2
  • 176
    • 0031276011 scopus 로고    scopus 로고
    • Bayesian network classifiers
    • Friedman N, Geiger D, Goldszmidt M. Bayesian network classifiers. Mach Learn (1997) 29:131-63. doi:10.1023/A:1007465528199
    • (1997) Mach Learn , vol.29 , pp. 131-163
    • Friedman, N.1    Geiger, D.2    Goldszmidt, M.3
  • 178
    • 0001069865 scopus 로고    scopus 로고
    • Case study of stochastic optimization in health policy: problem formulation and preliminary results
    • Draper D, Fouskakis DA. Case study of stochastic optimization in health policy: problem formulation and preliminary results. J Global Optim (2000) 18:399-416. doi:10.1023/A:1026504402220
    • (2000) J Global Optim , vol.18 , pp. 399-416
    • Draper, D.1    Fouskakis, D.A.2
  • 179
    • 26044441615 scopus 로고    scopus 로고
    • Feature selection in Bayesian classifiers for the prognosis of survival of cirrhotic patients treated with \TIPS\
    • Blanco R, Inza I, Merino M, Quiroga J, Larrañaga P. Feature selection in Bayesian classifiers for the prognosis of survival of cirrhotic patients treated with \TIPS\. J Biomed Inform (2005) 38:376-88. doi:10.1016/j.jbi.2005.05.004
    • (2005) J Biomed Inform , vol.38 , pp. 376-388
    • Blanco, R.1    Inza, I.2    Merino, M.3    Quiroga, J.4    Larrañaga, P.5
  • 180
    • 0026992322 scopus 로고
    • An analysis of Bayesian classifiers
    • Langley P, Iba W, Thompson K. An analysis of Bayesian classifiers. In AAAI (1992) 90:223-8.
    • (1992) In AAAI , vol.90 , pp. 223-228
    • Langley, P.1    Iba, W.2    Thompson, K.3
  • 181
    • 82455199451 scopus 로고    scopus 로고
    • Identifying rare variants using a Bayesian regression approach
    • Yan A, Laird NM, Li C. Identifying rare variants using a Bayesian regression approach. BMC Proc (2011) 5(Suppl 9):S99. doi:10.1186/1753-6561-5-S9-S99
    • (2011) BMC Proc , vol.5 , pp. S99
    • Yan, A.1    Laird, N.M.2    Li, C.3
  • 182
    • 0031269184 scopus 로고    scopus 로고
    • On the optimality of the simple Bayesian classifier under zero-one loss
    • Domingos P, Pazzani M. On the optimality of the simple Bayesian classifier under zero-one loss. Mach Learn (1997) 29:103-30. doi:10.1023/A:1007413511361
    • (1997) Mach Learn , vol.29 , pp. 103-130
    • Domingos, P.1    Pazzani, M.2
  • 183
    • 85139983802 scopus 로고
    • Supervised and unsupervised discretization of continuous features
    • Dougherty J, Kohavi R, Sahami M. Supervised and unsupervised discretization of continuous features. ICML (1995) 1995:194-202.
    • (1995) ICML , vol.1995 , pp. 194-202
    • Dougherty, J.1    Kohavi, R.2    Sahami, M.3
  • 184
    • 3843106208 scopus 로고    scopus 로고
    • An empirical study of the naive Bayes classifier
    • IJCAI 2001 Workshop on Empirical Methods in Artificial Intelligence
    • Rish I. An empirical study of the naive Bayes classifier. IJCAI 2001 Workshop on Empirical Methods in Artificial Intelligence. (2001). p. 41-6.
    • (2001) , pp. 41-46
    • Rish, I.1
  • 185
    • 0026992322 scopus 로고
    • An analysis of Bayesian classifiers. Proceedings of the Tenth National Conference on Artificial Intelligence
    • San Jose, CA: AAAI Press
    • Langley P, Iba W, Thompson K. An analysis of Bayesian classifiers. Proceedings of the Tenth National Conference on Artificial Intelligence. (Vol. 90), San Jose, CA: AAAI Press (1992). p. 223-8.
    • (1992) , vol.90 , pp. 223-228
    • Langley, P.1    Iba, W.2    Thompson, K.3
  • 186
    • 0037262814 scopus 로고    scopus 로고
    • An introduction to MCMC for machine learning
    • Andrieu C, de Freitas N, Doucet A, Jordan MI. An introduction to MCMC for machine learning. Mach Learn (2003) 50:5-43. doi:10.1023/A:1020281327116
    • (2003) Mach Learn , vol.50 , pp. 5-43
    • Andrieu, C.1    de Freitas, N.2    Doucet, A.3    Jordan, M.I.4
  • 187
    • 0021518209 scopus 로고
    • Stochastic relaxation, Gibbs distributions, and the Bayesian restoration of images.
    • PAMI-6
    • Geman S, Geman D. Stochastic relaxation, Gibbs distributions, and the Bayesian restoration of images. IEEE Trans (1984) PAMI-6:721-41.
    • (1984) IEEE Trans , pp. 721-741
    • Geman, S.1    Geman, D.2
  • 188
    • 77956890234 scopus 로고
    • Monte Carlo sampling methods using Markov chains and their applications
    • Hastings WK. Monte Carlo sampling methods using Markov chains and their applications. Biometrika (1970) 57:97-109. doi:10.1093/biomet/57.1.97
    • (1970) Biometrika , vol.57 , pp. 97-109
    • Hastings, W.K.1
  • 189
    • 21844520724 scopus 로고
    • Bayesian graphical models for discrete data
    • Madigan D, York J, Allard D. Bayesian graphical models for discrete data. Int Stat Rev (1995) 63:215-32.
    • (1995) Int Stat Rev , vol.63 , pp. 215-232
    • Madigan, D.1    York, J.2    Allard, D.3
  • 190
    • 33745955275 scopus 로고
    • The Monte Carlo method
    • Metropolis N, Ulam S. The Monte Carlo method. J Am Stat Assoc (1949) 44:335-41. doi:10.1080/01621459.1949.10483310
    • (1949) J Am Stat Assoc , vol.44 , pp. 335-341
    • Metropolis, N.1    Ulam, S.2
  • 191
    • 0000576595 scopus 로고
    • Markov chains for exploring posterior distributions
    • Tierney L. Markov chains for exploring posterior distributions. Ann Stat (1994) 22:1701-28. doi:10.1214/aos/1176325750
    • (1994) Ann Stat , vol.22 , pp. 1701-1728
    • Tierney, L.1
  • 192
    • 33746454738 scopus 로고    scopus 로고
    • klaR analyzing German business cycles
    • In: Baier D, Decker R, Schmidt-Thieme L, editors. Berlin: Springer-Verlag
    • Weihs C, Ligges U, Luebke K, Raabe N. klaR analyzing German business cycles. In: Baier D, Decker R, Schmidt-Thieme L, editors. Data Analysis and Decision Support. Berlin: Springer-Verlag (2005). p. 335-43.
    • (2005) Data Analysis and Decision Support , pp. 335-343
    • Weihs, C.1    Ligges, U.2    Luebke, K.3    Raabe, N.4
  • 193
    • 84916537550 scopus 로고
    • Bayesian analysis of binary and polychotomous response data
    • Albert JH, Chib S. Bayesian analysis of binary and polychotomous response data. J Am Stat Assoc (1993) 88:669-79. doi:10.1080/01621459.1993.10476321
    • (1993) J Am Stat Assoc , vol.88 , pp. 669-679
    • Albert, J.H.1    Chib, S.2
  • 194
    • 0003297017 scopus 로고
    • Causality, cointegration, and control
    • Granger CWJ. Causality, cointegration, and control. J Econ Dyn Control (1988) 12:551-9. doi:10.1016/0165-1889(88)90055-3
    • (1988) J Econ Dyn Control , vol.12 , pp. 551-559
    • Granger, C.W.J.1
  • 195
    • 84993869057 scopus 로고
    • Testing for linear and nonlinear granger causality in the stock price-volume relation
    • Hiemstra C, Jones JD. Testing for linear and nonlinear granger causality in the stock price-volume relation. J Finance (1994) 49:1639-64. doi:10.2307/2329266
    • (1994) J Finance , vol.49 , pp. 1639-1664
    • Hiemstra, C.1    Jones, J.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.