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Volumn 397, Issue 2, 2015, Pages 191-202

Ptch2 shares overlapping functions with Ptch1 in Smo regulation and limb development

Author keywords

Apical ectodermal ridge; Mesenchyme; Patched; Patterning; Smoothened; Sonic hedgehog

Indexed keywords

PROTEIN PATCHED 1; PROTEIN PATCHED 2; SHH RECEPTOR; SMOOTHENED PROTEIN; UNCLASSIFIED DRUG; CELL SURFACE RECEPTOR; G PROTEIN COUPLED RECEPTOR; PATCHED RECEPTORS; SHH PROTEIN, MOUSE; SMO PROTEIN, MOUSE; SONIC HEDGEHOG PROTEIN;

EID: 84919625552     PISSN: 00121606     EISSN: 1095564X     Source Type: Journal    
DOI: 10.1016/j.ydbio.2014.10.023     Document Type: Article
Times cited : (38)

References (65)
  • 3
    • 34249007279 scopus 로고    scopus 로고
    • The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development
    • Allen B.L., Tenzen T., McMahon A.P. The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development. Genes Dev. 2007, 21:1244-1257.
    • (2007) Genes Dev. , vol.21 , pp. 1244-1257
    • Allen, B.L.1    Tenzen, T.2    McMahon, A.P.3
  • 4
    • 79958207835 scopus 로고    scopus 로고
    • Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function
    • Allen B.L., Song J.Y., Izzi L., Althaus I.W., Kang J.-S., Charron F., Krauss R.S., McMahon A.P. Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function. Dev. Cell 2011, 20:775-787.
    • (2011) Dev. Cell , vol.20 , pp. 775-787
    • Allen, B.L.1    Song, J.Y.2    Izzi, L.3    Althaus, I.W.4    Kang, J.-S.5    Charron, F.6    Krauss, R.S.7    McMahon, A.P.8
  • 5
    • 80051665525 scopus 로고    scopus 로고
    • Mutations in CDON, encoding a hedgehog receptor, result in holoprosencephaly and defective interactions with other hedgehog receptors
    • Bae G.-U., Domené S., Roessler E., Schachter K., Kang J.-S., Muenke M., Krauss R.S. Mutations in CDON, encoding a hedgehog receptor, result in holoprosencephaly and defective interactions with other hedgehog receptors. Am. J. Hum. Genet. 2011, 89:231-240.
    • (2011) Am. J. Hum. Genet. , vol.89 , pp. 231-240
    • Bae, G.-U.1    Domené, S.2    Roessler, E.3    Schachter, K.4    Kang, J.-S.5    Muenke, M.6    Krauss, R.S.7
  • 6
    • 77950428746 scopus 로고    scopus 로고
    • Shh pathway activation is present and required within the vertebrate limb bud apical ectodermal ridge for normal autopod patterning
    • Bouldin C.M., Gritli-Linde A., Ahn S., Harfe B.D. Shh pathway activation is present and required within the vertebrate limb bud apical ectodermal ridge for normal autopod patterning. Proc. Natl. Acad. Sci. USA 2010, 107:5489-5494.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 5489-5494
    • Bouldin, C.M.1    Gritli-Linde, A.2    Ahn, S.3    Harfe, B.D.4
  • 7
    • 0034964445 scopus 로고    scopus 로고
    • A hedgehog-insensitive form of patched provides evidence for direct long-range morphogen activity of sonic hedgehog in the neural tube
    • Briscoe J., Chen Y., Jessell T.M., Struhl G. A hedgehog-insensitive form of patched provides evidence for direct long-range morphogen activity of sonic hedgehog in the neural tube. Mol. Cell 2001, 7:1279-1291.
    • (2001) Mol. Cell , vol.7 , pp. 1279-1291
    • Briscoe, J.1    Chen, Y.2    Jessell, T.M.3    Struhl, G.4
  • 10
    • 0030297553 scopus 로고    scopus 로고
    • Dual roles for patched in sequestering and transducing Hedgehog
    • Chen Y., Struhl G. Dual roles for patched in sequestering and transducing Hedgehog. Cell 1996, 87:553-563.
    • (1996) Cell , vol.87 , pp. 553-563
    • Chen, Y.1    Struhl, G.2
  • 12
    • 0035881926 scopus 로고    scopus 로고
    • Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function
    • Chiang C., Litingtung Y., Harris M.P., Simandl B.K., Li Y., Beachy P.A., Fallon J.F. Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function. Dev. Biol. 2001, 236:421-435.
    • (2001) Dev. Biol. , vol.236 , pp. 421-435
    • Chiang, C.1    Litingtung, Y.2    Harris, M.P.3    Simandl, B.K.4    Li, Y.5    Beachy, P.A.6    Fallon, J.F.7
  • 13
    • 0033580269 scopus 로고    scopus 로고
    • Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein
    • Chuang P., Mcmahon A.P. Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. Nature 1999, 397:617-621.
    • (1999) Nature , vol.397 , pp. 617-621
    • Chuang, P.1    Mcmahon, A.P.2
  • 15
    • 84867678037 scopus 로고    scopus 로고
    • A smoothened-Evc2 complex transduces the Hedgehog signal at primary cilia
    • Dorn K.V., Hughes C.E., Rohatgi R. A smoothened-Evc2 complex transduces the Hedgehog signal at primary cilia. Dev. Cell 2012, 23:823-835.
    • (2012) Dev. Cell , vol.23 , pp. 823-835
    • Dorn, K.V.1    Hughes, C.E.2    Rohatgi, R.3
  • 17
    • 0030027059 scopus 로고    scopus 로고
    • Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog
    • Goodrich L.V., Johnson R.L., Milenkovic L., McMahon J.A., Scott M.P. Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog. Genes Dev. 1996, 10:301-312.
    • (1996) Genes Dev. , vol.10 , pp. 301-312
    • Goodrich, L.V.1    Johnson, R.L.2    Milenkovic, L.3    McMahon, J.A.4    Scott, M.P.5
  • 18
    • 0030866154 scopus 로고    scopus 로고
    • Altered neural cell fates and medulloblastoma in mouse patched mutants
    • Goodrich L.V., Milenkovic L., Higgins K.M., Scott M.P. Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 1997, 277:1109-1113.
    • (1997) Science , vol.277 , pp. 1109-1113
    • Goodrich, L.V.1    Milenkovic, L.2    Higgins, K.M.3    Scott, M.P.4
  • 19
    • 84880934981 scopus 로고    scopus 로고
    • Essential role for ligand-dependent feedback antagonism of vertebrate hedgehog signaling by PTCH1, PTCH2 and HHIP1 during neural patterning
    • Holtz A.M., Peterson K.a., Nishi Y., Morin S., Song J.Y., Charron F., McMahon A.P., Allen B.L. Essential role for ligand-dependent feedback antagonism of vertebrate hedgehog signaling by PTCH1, PTCH2 and HHIP1 during neural patterning. Development 2013, 140:3423-3434.
    • (2013) Development , vol.140 , pp. 3423-3434
    • Holtz, A.M.1    Peterson, K.2    Nishi, Y.3    Morin, S.4    Song, J.Y.5    Charron, F.6    McMahon, A.P.7    Allen, B.L.8
  • 20
    • 0024468746 scopus 로고
    • The Drosophila patched gene encodes a putative membrane protein required for segmental patterning
    • Hooper J.E., Scott M.P. The Drosophila patched gene encodes a putative membrane protein required for segmental patterning. Cell 1989, 59:751-765.
    • (1989) Cell , vol.59 , pp. 751-765
    • Hooper, J.E.1    Scott, M.P.2
  • 21
    • 80054022786 scopus 로고    scopus 로고
    • Gli proteins in development and disease
    • Hui C.-C., Angers S. Gli proteins in development and disease. Annu. Rev. Cell Dev. Biol. 2011, 27:513-537.
    • (2011) Annu. Rev. Cell Dev. Biol. , vol.27 , pp. 513-537
    • Hui, C.-C.1    Angers, S.2
  • 22
    • 0034687244 scopus 로고    scopus 로고
    • Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein
    • Ingham P.W., Nystedt S., Nakano Y., Brown W., Stark D., van den Heuvel M., Taylor A.M. Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein. Curr. Biol. 2000, 10:1315-1318.
    • (2000) Curr. Biol. , vol.10 , pp. 1315-1318
    • Ingham, P.W.1    Nystedt, S.2    Nakano, Y.3    Brown, W.4    Stark, D.5    van den Heuvel, M.6    Taylor, A.M.7
  • 24
    • 13344275921 scopus 로고    scopus 로고
    • Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1
    • Jeong J., McMahon A.P. Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1. Development 2005, 132:143-154.
    • (2005) Development , vol.132 , pp. 143-154
    • Jeong, J.1    McMahon, A.P.2
  • 25
    • 57049089995 scopus 로고    scopus 로고
    • Hedgehog signaling in development and cancer
    • Jiang J., Hui C.-C. Hedgehog signaling in development and cancer. Dev. Cell 2008, 15:801-812.
    • (2008) Dev. Cell , vol.15 , pp. 801-812
    • Jiang, J.1    Hui, C.-C.2
  • 27
    • 57649210196 scopus 로고    scopus 로고
    • Two patched protein subtypes and a conserved domain of group I proteins that regulates turnover
    • Kawamura S., Hervold K., Ramirez-Weber F.-A., Kornberg T.B. Two patched protein subtypes and a conserved domain of group I proteins that regulates turnover. J. Biol. Chem. 2008, 283:30964-30969.
    • (2008) J. Biol. Chem. , vol.283 , pp. 30964-30969
    • Kawamura, S.1    Hervold, K.2    Ramirez-Weber, F.-A.3    Kornberg, T.B.4
  • 28
    • 43149104980 scopus 로고    scopus 로고
    • Genetic analysis of the two zebrafish patched homologues identifies novel roles for the hedgehog signaling pathway
    • Koudijs M.J., den Broeder M.J., Groot E., van Eeden F.J. Genetic analysis of the two zebrafish patched homologues identifies novel roles for the hedgehog signaling pathway. BMC Dev. Biol. 2008, 8:15.
    • (2008) BMC Dev. Biol. , vol.8 , pp. 15
    • Koudijs, M.J.1    den Broeder, M.J.2    Groot, E.3    van Eeden, F.J.4
  • 29
    • 0035213877 scopus 로고    scopus 로고
    • Some distal limb structures develop in mice lacking Sonic hedgehog signaling
    • Kraus P., Fraidenraich D., Loomis C.A. Some distal limb structures develop in mice lacking Sonic hedgehog signaling. Mech. Dev. 2001, 100:45-58.
    • (2001) Mech. Dev. , vol.100 , pp. 45-58
    • Kraus, P.1    Fraidenraich, D.2    Loomis, C.A.3
  • 30
    • 67549137241 scopus 로고    scopus 로고
    • Msx genes are important apoptosis effectors downstream of the Shh/Gli3 pathway in the limb
    • Lallemand Y., Bensoussan V., Cloment C., Saint, Robert B. Msx genes are important apoptosis effectors downstream of the Shh/Gli3 pathway in the limb. Dev. Biol. 2009, 331:189-198.
    • (2009) Dev. Biol. , vol.331 , pp. 189-198
    • Lallemand, Y.1    Bensoussan, V.2    Cloment, C.3    Saint, R.B.4
  • 31
    • 0035113831 scopus 로고    scopus 로고
    • Embryonic expression patterns of the mouse and chick Gas1 genes
    • Lee C.S., Fan C.M. Embryonic expression patterns of the mouse and chick Gas1 genes. Mech. Dev. 2001, 101:293-297.
    • (2001) Mech. Dev. , vol.101 , pp. 293-297
    • Lee, C.S.1    Fan, C.M.2
  • 32
    • 0035949695 scopus 로고    scopus 로고
    • Evidence that the WNT-inducible growth arrest-specific gene 1 encodes an antagonist of sonic hedgehog signaling in the somite
    • Lee C.S., Buttitta L., Fan C.M. Evidence that the WNT-inducible growth arrest-specific gene 1 encodes an antagonist of sonic hedgehog signaling in the somite. Proc. Natl. Acad. Sci. USA 2001, 98:11347-11352.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 11347-11352
    • Lee, C.S.1    Buttitta, L.2    Fan, C.M.3
  • 35
    • 59449095489 scopus 로고    scopus 로고
    • Characterization of fluorescent sterol binding to purified human NPC1
    • Liu R., Lu P., Chu J.W.K., Sharom F.J. Characterization of fluorescent sterol binding to purified human NPC1. J. Biol. Chem. 2009, 284:1840-1852.
    • (2009) J. Biol. Chem. , vol.284 , pp. 1840-1852
    • Liu, R.1    Lu, P.2    Chu, J.W.K.3    Sharom, F.J.4
  • 36
    • 0036076389 scopus 로고    scopus 로고
    • Expression of Cre Recombinase in the developing mouse limb bud driven by a Prxl enhancer
    • Logan M., Martin J.F., Nagy A., Lobe C., Olson E.N., Tabin C.J. Expression of Cre Recombinase in the developing mouse limb bud driven by a Prxl enhancer. Genesis 2002, 33:77-80.
    • (2002) Genesis , vol.33 , pp. 77-80
    • Logan, M.1    Martin, J.F.2    Nagy, A.3    Lobe, C.4    Olson, E.N.5    Tabin, C.J.6
  • 37
    • 33748690784 scopus 로고    scopus 로고
    • The C-terminal tail of the Hedgehog receptor Patched regulates both localization and turnover
    • Lu X., Liu S., Kornberg T.B. The C-terminal tail of the Hedgehog receptor Patched regulates both localization and turnover. Genes Dev. 2006, 20:2539-2551.
    • (2006) Genes Dev. , vol.20 , pp. 2539-2551
    • Lu, X.1    Liu, S.2    Kornberg, T.B.3
  • 38
    • 0029975823 scopus 로고    scopus 로고
    • Conservation in hedgehog signaling: induction of a chicken patched homolog by Sonic hedgehog in the developing limb
    • Marigo V., Scott M.P., Johnson R.L., Goodrich L.V., Tabin C.J. Conservation in hedgehog signaling: induction of a chicken patched homolog by Sonic hedgehog in the developing limb. Development 1996, 122:1225-1233.
    • (1996) Development , vol.122 , pp. 1225-1233
    • Marigo, V.1    Scott, M.P.2    Johnson, R.L.3    Goodrich, L.V.4    Tabin, C.J.5
  • 39
    • 34249011892 scopus 로고    scopus 로고
    • Gas1 extends the range of Hedgehog action by facilitating its signaling
    • Martinelli D.C., Fan C.-M. Gas1 extends the range of Hedgehog action by facilitating its signaling. Genes Dev. 2007, 21:1231-1243.
    • (2007) Genes Dev. , vol.21 , pp. 1231-1243
    • Martinelli, D.C.1    Fan, C.-M.2
  • 40
    • 0032695265 scopus 로고    scopus 로고
    • Mouse patched1 controls body size determination and limb patterning
    • Milenkovic L., Goodrich L.V., Higgins K.M., Scott M.P. Mouse patched1 controls body size determination and limb patterning. Development 1999, 126:4431-4440.
    • (1999) Development , vol.126 , pp. 4431-4440
    • Milenkovic, L.1    Goodrich, L.V.2    Higgins, K.M.3    Scott, M.P.4
  • 41
    • 75549090700 scopus 로고    scopus 로고
    • Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium
    • Milenkovic L., Scott M.P., Rohatgi R. Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium. J. Cell Biol. 2009, 187:365-374.
    • (2009) J. Cell Biol. , vol.187 , pp. 365-374
    • Milenkovic, L.1    Scott, M.P.2    Rohatgi, R.3
  • 43
    • 0031989439 scopus 로고    scopus 로고
    • Ptch2, a second mouse Patched gene is co-expressed with Sonic hedgehog
    • Motoyama J., Takabatake T., Takeshima K., Hui C.-C. Ptch2, a second mouse Patched gene is co-expressed with Sonic hedgehog. Nat. Genet. 1998, 18:104-106.
    • (1998) Nat. Genet. , vol.18 , pp. 104-106
    • Motoyama, J.1    Takabatake, T.2    Takeshima, K.3    Hui, C.-C.4
  • 46
    • 0035504214 scopus 로고    scopus 로고
    • Ptc1 and Ptc2 transcripts provide distinct readouts of Hedgehog signaling activity during chick embryogenesis
    • Pearse R.V., Vogan K.J., Tabin C.J. Ptc1 and Ptc2 transcripts provide distinct readouts of Hedgehog signaling activity during chick embryogenesis. Dev. Biol. 2001, 239:15-29.
    • (2001) Dev. Biol. , vol.239 , pp. 15-29
    • Pearse, R.V.1    Vogan, K.J.2    Tabin, C.J.3
  • 47
    • 12144288863 scopus 로고    scopus 로고
    • Distinct roles of PTCH2 splice variants in Hedgehog signalling
    • Rahnama F., Toftgård R., Zaphiropoulos P.G. Distinct roles of PTCH2 splice variants in Hedgehog signalling. Biochem. J. 2004, 378:325-334.
    • (2004) Biochem. J. , vol.378 , pp. 325-334
    • Rahnama, F.1    Toftgård, R.2    Zaphiropoulos, P.G.3
  • 49
    • 34547110771 scopus 로고    scopus 로고
    • Patched1 regulates hedgehog signaling at the primary cilium
    • Rohatgi R., Milenkovic L., Scott M.P. Patched1 regulates hedgehog signaling at the primary cilium. Science 2007, 317:372-376.
    • (2007) Science , vol.317 , pp. 372-376
    • Rohatgi, R.1    Milenkovic, L.2    Scott, M.P.3
  • 50
    • 62549159642 scopus 로고    scopus 로고
    • Hedgehog signal transduction by Smoothened[U+202F]: Pharmacologic evidence for a 2-step activation process
    • Rohatgi R., Milenkovic L., Corcoran R.B., Scott M.P. Hedgehog signal transduction by Smoothened[U+202F]: Pharmacologic evidence for a 2-step activation process. Proc. Natl. Acad. Sci. USA 2009, 106:3196-3201.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 3196-3201
    • Rohatgi, R.1    Milenkovic, L.2    Corcoran, R.B.3    Scott, M.P.4
  • 51
    • 84878392551 scopus 로고    scopus 로고
    • Specialized filopodia direct long-range transport of SHH during vertebrate tissue patterning
    • Sanders T.A., Llagostera E., Barna M. Specialized filopodia direct long-range transport of SHH during vertebrate tissue patterning. Nature 2013, 497:628-632.
    • (2013) Nature , vol.497 , pp. 628-632
    • Sanders, T.A.1    Llagostera, E.2    Barna, M.3
  • 52
    • 3142696904 scopus 로고    scopus 로고
    • The limb bud Shh-Fgf feedback loop is terminated by expansion of former ZPA cells
    • Scherz P.J., Harfe B.D., McMahon A.P., Tabin C.J. The limb bud Shh-Fgf feedback loop is terminated by expansion of former ZPA cells. Science 2004, 305:396-399.
    • (2004) Science , vol.305 , pp. 396-399
    • Scherz, P.J.1    Harfe, B.D.2    McMahon, A.P.3    Tabin, C.J.4
  • 53
    • 34547699643 scopus 로고    scopus 로고
    • Extended exposure to Sonic hedgehog is required for patterning the posterior digits of the vertebrate limb
    • Scherz P.J., McGlinn E., Nissim S., Tabin C.J. Extended exposure to Sonic hedgehog is required for patterning the posterior digits of the vertebrate limb. Dev. Biol. 2007, 308:343-354.
    • (2007) Dev. Biol. , vol.308 , pp. 343-354
    • Scherz, P.J.1    McGlinn, E.2    Nissim, S.3    Tabin, C.J.4
  • 55
    • 0034103657 scopus 로고    scopus 로고
    • Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud development
    • Sun X., Lewandoski M., Meyers E.N., Liu Y.H., Maxson R.E., Martin G.R. Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud development. Nat. Genet. 2000, 25:83-86.
    • (2000) Nat. Genet. , vol.25 , pp. 83-86
    • Sun, X.1    Lewandoski, M.2    Meyers, E.N.3    Liu, Y.H.4    Maxson, R.E.5    Martin, G.R.6
  • 56
    • 0036682468 scopus 로고    scopus 로고
    • Functions of FGF signalling from the apical ectodermal ridge in limb development
    • Sun X., Mariani F.V., Martin G.R. Functions of FGF signalling from the apical ectodermal ridge in limb development. Nature 2002, 418:501-508.
    • (2002) Nature , vol.418 , pp. 501-508
    • Sun, X.1    Mariani, F.V.2    Martin, G.R.3
  • 58
    • 33646103902 scopus 로고    scopus 로고
    • The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice
    • Tenzen T., Allen B.L., Cole F., Kang J.-S., Krauss R.S., McMahon A.P. The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice. Dev. Cell 2006, 10:647-656.
    • (2006) Dev. Cell , vol.10 , pp. 647-656
    • Tenzen, T.1    Allen, B.L.2    Cole, F.3    Kang, J.-S.4    Krauss, R.S.5    McMahon, A.P.6
  • 59
    • 0033170990 scopus 로고    scopus 로고
    • The RND permease superfamily: an ancient, ubiquitous and diverse family that includes human disease and development proteins
    • Tseng T.T., Gratwick K.S., Kollman J., Park D., Nies D.H., Goffeau A., Saier M.H. The RND permease superfamily: an ancient, ubiquitous and diverse family that includes human disease and development proteins. J. Mol. Microbiol. Biotechnol. 1999, 1:107-125.
    • (1999) J. Mol. Microbiol. Biotechnol. , vol.1 , pp. 107-125
    • Tseng, T.T.1    Gratwick, K.S.2    Kollman, J.3    Park, D.4    Nies, D.H.5    Goffeau, A.6    Saier, M.H.7
  • 60
    • 48349106444 scopus 로고    scopus 로고
    • An Fgf/Gremlin inhibitory feedback loop triggers termination of limb bud outgrowth
    • Verheyden J.M., Sun X. An Fgf/Gremlin inhibitory feedback loop triggers termination of limb bud outgrowth. Nature 2008, 454:638-641.
    • (2008) Nature , vol.454 , pp. 638-641
    • Verheyden, J.M.1    Sun, X.2
  • 61
    • 62449174504 scopus 로고    scopus 로고
    • Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation
    • Wang Y., Zhou Z., Walsh C.T., McMahon A.P. Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation. Proc. Natl. Acad. Sci. USA 2009, 106:2623-2628.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 2623-2628
    • Wang, Y.1    Zhou, Z.2    Walsh, C.T.3    McMahon, A.P.4
  • 62
    • 65249123996 scopus 로고    scopus 로고
    • Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium
    • Wilson C.W., Chen M.-H., Chuang P.-T. Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium. PLoS ONE 2009, 4:e5182.
    • (2009) PLoS ONE , vol.4 , pp. e5182
    • Wilson, C.W.1    Chen, M.-H.2    Chuang, P.-T.3
  • 63
    • 33646120095 scopus 로고    scopus 로고
    • Cdo functions at multiple points in the Sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly
    • Zhang W., Kang J.-S., Cole F., Yi M.-J., Krauss R.S. Cdo functions at multiple points in the Sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly. Dev. Cell 2006, 10:657-665.
    • (2006) Dev. Cell , vol.10 , pp. 657-665
    • Zhang, W.1    Kang, J.-S.2    Cole, F.3    Yi, M.-J.4    Krauss, R.S.5
  • 64
    • 79956110764 scopus 로고    scopus 로고
    • Boc modifies the holoprosencephaly spectrum of Cdo mutant mice
    • Zhang W., Hong M., Bae G., Kang J.-S., Krauss R.S. Boc modifies the holoprosencephaly spectrum of Cdo mutant mice. Dis. Model. Mech. 2011, 4:368-380.
    • (2011) Dis. Model. Mech. , vol.4 , pp. 368-380
    • Zhang, W.1    Hong, M.2    Bae, G.3    Kang, J.-S.4    Krauss, R.S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.