메뉴 건너뛰기




Volumn 134, Issue 7, 2014, Pages 1981-1990

Patched 1 and patched 2 redundancy has a key role in regulating epidermal differentiation

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; PROTEIN PATCHED 1; PROTEIN PATCHED 2; TRANSCRIPTION FACTOR GLI1;

EID: 84902549198     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2014.63     Document Type: Article
Times cited : (28)

References (48)
  • 1
    • 33644509505 scopus 로고    scopus 로고
    • Patched1 functions as a gatekeeper by promoting cell cycle progression
    • Adolphe C, Hetherington R, Ellis T et al. (2006) Patched1 functions as a gatekeeper by promoting cell cycle progression. Cancer Res 66: 2081-8
    • (2006) Cancer Res , vol.66 , pp. 2081-2088
    • Adolphe, C.1    Hetherington, R.2    Ellis, T.3
  • 2
    • 8444228878 scopus 로고    scopus 로고
    • An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates epidermal stem cell homeostasis
    • Adolphe C, Narang M, Ellis T et al. (2004) An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates epidermal stem cell homeostasis. Development 131: 5009-19
    • (2004) Development , vol.131 , pp. 5009-5019
    • Adolphe, C.1    Narang, M.2    Ellis, T.3
  • 3
    • 0037072736 scopus 로고    scopus 로고
    • Several PATCHED1 missense mutations display activity in patched1-deficient fibroblasts
    • Bailey EC, Milenkovic L, Scott MP et al. (2002) Several PATCHED1 missense mutations display activity in patched1-deficient fibroblasts. J Biol Chem 277: 33632-40
    • (2002) J Biol Chem , vol.277 , pp. 33632-33640
    • Bailey, E.C.1    Milenkovic, L.2    Scott, M.P.3
  • 4
    • 32044455785 scopus 로고    scopus 로고
    • Desert hedgehog-patched 2 expression in peripheral nerves during Wallerian degeneration and regeneration
    • Bajestan SN, Umehara F, Shirahama Y et al. (2006) Desert hedgehog-patched 2 expression in peripheral nerves during Wallerian degeneration and regeneration. J Neurobiol 66: 243-55
    • (2006) J Neurobiol , vol.66 , pp. 243-255
    • Bajestan, S.N.1    Umehara, F.2    Shirahama, Y.3
  • 5
    • 0032506115 scopus 로고    scopus 로고
    • Characterization of two patched receptors for the vertebrate hedgehog protein family
    • Carpenter D, Stone DM, Brush J et al. (1998) Characterization of two patched receptors for the vertebrate hedgehog protein family. Proc Natl Acad Sci USA 95: 13630-4
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 13630-13634
    • Carpenter, D.1    Stone, D.M.2    Brush, J.3
  • 6
    • 0030297553 scopus 로고    scopus 로고
    • Dual roles for patched in sequestering and transducing Hedgehog
    • Chen Y, Struhl G (1996) Dual roles for patched in sequestering and transducing Hedgehog. Cell 87: 553-63
    • (1996) Cell , vol.87 , pp. 553-563
    • Chen, Y.1    Struhl, G.2
  • 7
    • 0032953901 scopus 로고    scopus 로고
    • Essential role for Sonic hedgehog during hair follicle morphogenesis
    • Chiang C, Swan RZ, Grachtchouk M et al. (1999) Essential role for Sonic hedgehog during hair follicle morphogenesis. Dev Biol 205: 1-9
    • (1999) Dev Biol , vol.205 , pp. 1-9
    • Chiang, C.1    Swan, R.Z.2    Grachtchouk, M.3
  • 8
    • 0030844141 scopus 로고    scopus 로고
    • Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours
    • Dahmane N, Lee J, Robins P et al. (1997) Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours. Nature 389: 876-81
    • (1997) Nature , vol.389 , pp. 876-881
    • Dahmane, N.1    Lee, J.2    Robins, P.3
  • 9
    • 0041569927 scopus 로고    scopus 로고
    • Patched 1 conditional null allele in mice
    • Ellis T, Smyth I, Riley E et al. (2003) Patched 1 conditional null allele in mice. Genesis 36: 158-61
    • (2003) Genesis , vol.36 , pp. 158-161
    • Ellis, T.1    Smyth, I.2    Riley, E.3
  • 10
    • 0030802458 scopus 로고    scopus 로고
    • Induction of basal cell carcinoma features in transgenic human skin expressing Sonic Hedgehog
    • Fan H, Oro AE, Scott MP et al. (1997) Induction of basal cell carcinoma features in transgenic human skin expressing Sonic Hedgehog. Nat Med 3: 788-92
    • (1997) Nat Med , vol.3 , pp. 788-792
    • Fan, H.1    Oro, A.E.2    Scott, M.P.3
  • 11
    • 0030866154 scopus 로고    scopus 로고
    • Altered neural cell fates and medulloblastoma in mouse patched mutants
    • Goodrich LV, Milenkovic L, Higgins KM et al. (1997) Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 277: 1109-13
    • (1997) Science , vol.277 , pp. 1109-1113
    • Goodrich, L.V.1    Milenkovic, L.2    Higgins, K.M.3
  • 12
    • 0034091805 scopus 로고    scopus 로고
    • Basal cell carcinomas in mice overexpressing Gli2 in skin
    • Grachtchouk M, Mo R, Yu S et al. (2000) Basal cell carcinomas in mice overexpressing Gli2 in skin. Nat Genet 24: 216-7
    • (2000) Nat Genet , vol.24 , pp. 216-217
    • Grachtchouk, M.1    Mo, R.2    Yu, S.3
  • 13
    • 79955508675 scopus 로고    scopus 로고
    • Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations
    • Grachtchouk M, Pero J, Yang SH et al. (2011) Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations. J Clin Invest 121: 1768-81
    • (2011) J Clin Invest , vol.121 , pp. 1768-1781
    • Grachtchouk, M.1    Pero, J.2    Yang, S.H.3
  • 14
    • 0037844870 scopus 로고    scopus 로고
    • The magnitude of hedgehog signaling activity defines skin tumor phenotype
    • Grachtchouk V, Grachtchouk M, Lowe L et al. (2003) The magnitude of hedgehog signaling activity defines skin tumor phenotype. EMBO J 22: 2741-51
    • (2003) EMBO J , vol.22 , pp. 2741-2751
    • Grachtchouk, V.1    Grachtchouk, M.2    Lowe, L.3
  • 15
    • 33845735216 scopus 로고    scopus 로고
    • Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling
    • Gritli-Linde A, Hallberg K, Harfe BD et al. (2007) Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling. Dev Cell 12: 99-112
    • (2007) Dev Cell , vol.12 , pp. 99-112
    • Gritli-Linde, A.1    Hallberg, K.2    Harfe, B.D.3
  • 16
    • 77951224807 scopus 로고    scopus 로고
    • Repression of Hedgehog signalling is required for the acquisition of dorsolateral cell fates in the zebrafish otic vesicle
    • Hammond KL, van Eeden FJ, Whitfield TT (2010) Repression of Hedgehog signalling is required for the acquisition of dorsolateral cell fates in the zebrafish otic vesicle. Development 137: 1361-71
    • (2010) Development , vol.137 , pp. 1361-1371
    • Hammond, K.L.1    Van Eeden, F.J.2    Whitfield, T.T.3
  • 17
    • 79956308325 scopus 로고    scopus 로고
    • Mechanisms and functions of Hedgehog signalling across the metazoa
    • Ingham PW, Nakano Y, Seger C (2011) Mechanisms and functions of Hedgehog signalling across the metazoa. Nat Rev Genet 12: 393-406
    • (2011) Nat Rev Genet , vol.12 , pp. 393-406
    • Ingham, P.W.1    Nakano, Y.2    Seger, C.3
  • 18
    • 5344236034 scopus 로고    scopus 로고
    • Pax9 is required for filiform papilla development and suppresses skin-specific differentiation of the mammalian tongue epithelium
    • Jonker L, Kist R, Aw A et al. (2004) Pax9 is required for filiform papilla development and suppresses skin-specific differentiation of the mammalian tongue epithelium. Mech Dev 121: 1313-22
    • (2004) Mech Dev , vol.121 , pp. 1313-1322
    • Jonker, L.1    Kist, R.2    Aw, A.3
  • 19
    • 79952745374 scopus 로고    scopus 로고
    • Wounding enhances epidermal tumorigenesis by recruiting hair follicle keratinocytes
    • Kasper M, Jaks V, Are A et al. (2011) Wounding enhances epidermal tumorigenesis by recruiting hair follicle keratinocytes. Proc Natl Acad Sci USA 108: 4099-104
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 4099-4104
    • Kasper, M.1    Jaks, V.2    Are, A.3
  • 20
    • 57649210196 scopus 로고    scopus 로고
    • Two patched protein subtypes and a conserved domain of group i proteins that regulates turnover
    • Kawamura S, Hervold K, Ramirez-Weber FA et al. (2008) Two patched protein subtypes and a conserved domain of group I proteins that regulates turnover. J Biol Chem 283: 30964-9
    • (2008) J Biol Chem , vol.283 , pp. 30964-30969
    • Kawamura, S.1    Hervold, K.2    Ramirez-Weber, F.A.3
  • 21
    • 43149104980 scopus 로고    scopus 로고
    • Genetic analysis of the two zebrafish patched homologues identifies novel roles for the hedgehog signaling pathway
    • Koudijs MJ, den Broeder MJ, Groot E et al. (2008) Genetic analysis of the two zebrafish patched homologues identifies novel roles for the hedgehog signaling pathway. BMC Dev Biol 8:15
    • (2008) BMC Dev Biol , vol.8 , pp. 15
    • Koudijs, M.J.1    Den Broeder, M.J.2    Groot, E.3
  • 22
    • 33746879125 scopus 로고    scopus 로고
    • Patched2 modulates tumorigenesis in patched1 heterozygous mice
    • Lee Y, Miller HL, Russell HR et al. (2006) Patched2 modulates tumorigenesis in patched1 heterozygous mice. Cancer Res 66: 6964-71
    • (2006) Cancer Res , vol.66 , pp. 6964-6971
    • Lee, Y.1    Miller, H.L.2    Russell, H.R.3
  • 23
    • 0034609819 scopus 로고    scopus 로고
    • Skin abnormalities generated by temporally controlled RXRalpha mutations in mouse epidermis
    • Li M, Indra AK, Warot X et al. (2000) Skin abnormalities generated by temporally controlled RXRalpha mutations in mouse epidermis. Nature 407: 633-6
    • (2000) Nature , vol.407 , pp. 633-636
    • Li, M.1    Indra, A.K.2    Warot, X.3
  • 24
    • 84867868803 scopus 로고    scopus 로고
    • Kif7 regulates Gli2 through Sufudependent and -independent functions during skin development and tumorigenesis
    • Li ZJ, Nieuwenhuis E, Nien W et al. (2012) Kif7 regulates Gli2 through Sufudependent and -independent functions during skin development and tumorigenesis. Development 139: 4152-61
    • (2012) Development , vol.139 , pp. 4152-4161
    • Li, Z.J.1    Nieuwenhuis, E.2    Nien, W.3
  • 25
    • 33748690784 scopus 로고    scopus 로고
    • The C-terminal tail of the Hedgehog receptor Patched regulates both localization and turnover
    • Lu X, Liu S, Kornberg TB (2006) The C-terminal tail of the Hedgehog receptor Patched regulates both localization and turnover. Genes Dev 20: 2539-51
    • (2006) Genes Dev , vol.20 , pp. 2539-2551
    • Lu, X.1    Liu, S.2    Kornberg, T.B.3
  • 26
    • 0011827668 scopus 로고    scopus 로고
    • Co-localization of patched and activated sonic hedgehog to lysosomes in neurons
    • Mastronardi FG, Dimitroulakos J, Kamel-Reid S et al. (2000) Co-localization of patched and activated sonic hedgehog to lysosomes in neurons. Neuroreport 11: 581-5
    • (2000) Neuroreport , vol.11 , pp. 581-585
    • Mastronardi, F.G.1    Dimitroulakos, J.2    Kamel-Reid, S.3
  • 27
    • 0031989439 scopus 로고    scopus 로고
    • Ptch2, a second mouse Patched gene is co-expressed with Sonic hedgehog
    • Motoyama J, Takabatake T, Takeshima K et al. (1998) Ptch2, a second mouse Patched gene is co-expressed with Sonic hedgehog. Nat Genet 18: 104-6
    • (1998) Nat Genet , vol.18 , pp. 104-106
    • Motoyama, J.1    Takabatake, T.2    Takeshima, K.3
  • 28
    • 33747776126 scopus 로고    scopus 로고
    • Mice with a targeted mutation of patched2 are viable but develop alopecia and epidermal hyperplasia
    • Nieuwenhuis E, Motoyama J, Barnfield PC et al. (2006) Mice with a targeted mutation of patched2 are viable but develop alopecia and epidermal hyperplasia. Mol Cell Biol 26: 6609-22
    • (2006) Mol Cell Biol , vol.26 , pp. 6609-6622
    • Nieuwenhuis, E.1    Motoyama, J.2    Barnfield, P.C.3
  • 29
    • 0034724219 scopus 로고    scopus 로고
    • Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1
    • Nilsson M, Unden AB, Krause D et al. (2000) Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1. Proc Natl Acad Sci USA 97: 3438-43
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 3438-3443
    • Nilsson, M.1    Unden, A.B.2    Krause, D.3
  • 30
    • 0030955557 scopus 로고    scopus 로고
    • Basal cell carcinomas in mice overexpressing sonic hedgehog
    • Oro AE, Higgins KM, Hu Z et al. (1997) Basal cell carcinomas in mice overexpressing sonic hedgehog. Science 276: 817-21
    • (1997) Science , vol.276 , pp. 817-821
    • Oro, A.E.1    Higgins, K.M.2    Hu, Z.3
  • 31
    • 12144288863 scopus 로고    scopus 로고
    • Distinct roles of PTCH2 splice variants in Hedgehog signalling
    • Rahnama F, Toftgard R, Zaphiropoulos PG (2004) Distinct roles of PTCH2 splice variants in Hedgehog signalling. Biochem J 378: 325-34
    • (2004) Biochem J , vol.378 , pp. 325-334
    • Rahnama, F.1    Toftgard, R.2    Zaphiropoulos, P.G.3
  • 32
    • 34547110771 scopus 로고    scopus 로고
    • Patched1 regulates hedgehog signaling at the primary cilium
    • Rohatgi R, Milenkovic L, Scott MP (2007) Patched1 regulates hedgehog signaling at the primary cilium. Science 317: 372-6
    • (2007) Science , vol.317 , pp. 372-376
    • Rohatgi, R.1    Milenkovic, L.2    Scott, M.P.3
  • 33
    • 0032741860 scopus 로고    scopus 로고
    • Induction of the hair growth phase in postnatal mice by localized transient expression of Sonic hedgehog
    • Sato N, Leopold PL, Crystal RG (1999) Induction of the hair growth phase in postnatal mice by localized transient expression of Sonic hedgehog. J Clin Invest 104: 855-64
    • (1999) J Clin Invest , vol.104 , pp. 855-864
    • Sato, N.1    Leopold, P.L.2    Crystal, R.G.3
  • 34
    • 0037105656 scopus 로고    scopus 로고
    • Dissecting the oncogenic potential of Gli2: Deletion of an NH(2)-terminal fragment alters skin tumor phenotype
    • Sheng H, Goich S, Wang A et al. (2002) Dissecting the oncogenic potential of Gli2: deletion of an NH(2)-terminal fragment alters skin tumor phenotype. Cancer Res 62: 5308-16
    • (2002) Cancer Res , vol.62 , pp. 5308-5316
    • Sheng, H.1    Goich, S.2    Wang, A.3
  • 35
    • 13144259688 scopus 로고    scopus 로고
    • Sonic hedgehog signaling is essential for hair development
    • St-Jacques B, Dassule HR, Karavanova I et al. (1998) Sonic hedgehog signaling is essential for hair development. Curr Biol 8: 1058-68
    • (1998) Curr Biol , vol.8 , pp. 1058-1068
    • St-Jacques, B.1    Dassule, H.R.2    Karavanova, I.3
  • 36
    • 0030788667 scopus 로고    scopus 로고
    • Hedgehog and patched gene expression in adult ocular tissues
    • Takabatake T, Ogawa M, Takahashi TC et al. (1997) Hedgehog and patched gene expression in adult ocular tissues. FEBS Lett 410: 485-9
    • (1997) FEBS Lett , vol.410 , pp. 485-489
    • Takabatake, T.1    Ogawa, M.2    Takahashi, T.C.3
  • 37
    • 0030825272 scopus 로고    scopus 로고
    • Tissue-specific knockout of the mouse Pig - A gene reveals important roles for GPI-anchored proteins in skin development
    • Tarutani M, Itami S, Okabe M et al. (1997) Tissue-specific knockout of the mouse Pig-a gene reveals important roles for GPI-anchored proteins in skin development. Proc Natl Acad Sci USA 94: 7400-5
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 7400-7405
    • Tarutani, M.1    Itami, S.2    Okabe, M.3
  • 38
    • 77958517140 scopus 로고    scopus 로고
    • Patched1 inhibits epidermal progenitor cell expansion and basal cell carcinoma formation by limiting Igfbp2 activity
    • Villani RM, Adolphe C, Palmer J et al. (2010) Patched1 inhibits epidermal progenitor cell expansion and basal cell carcinoma formation by limiting Igfbp2 activity. Cancer Prev Res (Phila) 3: 1222-34
    • (2010) Cancer Prev Res (Phila) , vol.3 , pp. 1222-1234
    • Villani, R.M.1    Adolphe, C.2    Palmer, J.3
  • 39
    • 41649110614 scopus 로고    scopus 로고
    • Gene duplications, robustness and evolutionary innovations
    • Wagner A (2008) Gene duplications, robustness and evolutionary innovations. Bioessays 30: 367-73
    • (2008) Bioessays , vol.30 , pp. 367-373
    • Wagner, A.1
  • 40
    • 78651467232 scopus 로고    scopus 로고
    • Basal cell carcinomas arise from hair follicle stem cells in Ptch1(+/-) mice
    • Wang GY, Wang J, Mancianti ML et al. (2011) Basal cell carcinomas arise from hair follicle stem cells in Ptch1(+/-) mice. Cancer Cell 19: 114-24
    • (2011) Cancer Cell , vol.19 , pp. 114-124
    • Wang, G.Y.1    Wang, J.2    Mancianti, M.L.3
  • 41
    • 0034183346 scopus 로고    scopus 로고
    • Regular articles: Conditional disruption of hedgehog signaling pathway defines its critical role in hair development and regeneration
    • Wang LC, Liu ZY, Gambardella L et al. (2000) Regular articles: conditional disruption of hedgehog signaling pathway defines its critical role in hair development and regeneration. J Invest Dermatol 114: 901-8
    • (2000) J Invest Dermatol , vol.114 , pp. 901-908
    • Wang, L.C.1    Liu, Z.Y.2    Gambardella, L.3
  • 42
    • 79952741709 scopus 로고    scopus 로고
    • Wounding mobilizes hair follicle stem cells to form tumors
    • Wong SY, Reiter JF (2011) Wounding mobilizes hair follicle stem cells to form tumors. Proc Natl Acad Sci USA 108: 4093-8
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 4093-4098
    • Wong, S.Y.1    Reiter, J.F.2
  • 43
    • 0031913524 scopus 로고    scopus 로고
    • Activating Smoothened mutations in sporadic basal-cell carcinoma
    • Xie J, Murone M, Luoh SM et al. (1998) Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature 391: 90-2
    • (1998) Nature , vol.391 , pp. 90-92
    • Xie, J.1    Murone, M.2    Luoh, S.M.3
  • 44
    • 50449084075 scopus 로고    scopus 로고
    • Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/ beta3-catenin signaling
    • Yang SH, Andl T, Grachtchouk V et al. (2008a) Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/ beta3-catenin signaling. Nat Genet 40: 1130-5
    • (2008) Nat Genet , vol.40 , pp. 1130-1135
    • Yang, S.H.1    Andl, T.2    Grachtchouk, V.3
  • 45
    • 48449101742 scopus 로고    scopus 로고
    • Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells
    • Yang ZJ, Ellis T, Markant SL et al. (2008b) Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. Cancer Cell 14: 135-45
    • (2008) Cancer Cell , vol.14 , pp. 135-145
    • Yang, Z.J.1    Ellis, T.2    Markant, S.L.3
  • 46
    • 84870583964 scopus 로고    scopus 로고
    • Adult interfollicular tumourinitiating cells are reprogrammed into an embryonic hair follicle progenitor-like fate during basal cell carcinoma initiation
    • Youssef KK, Lapouge G, Bouvree K et al. (2012) Adult interfollicular tumourinitiating cells are reprogrammed into an embryonic hair follicle progenitor-like fate during basal cell carcinoma initiation. Nat Cell Biol 14: 1282-94
    • (2012) Nat Cell Biol , vol.14 , pp. 1282-1294
    • Youssef, K.K.1    Lapouge, G.2    Bouvree, K.3
  • 47
    • 77649258546 scopus 로고    scopus 로고
    • Identification of the cell lineage at the origin of basal cell carcinoma
    • Youssef KK, Van Keymeulen A, Lapouge G et al. (2010) Identification of the cell lineage at the origin of basal cell carcinoma. Nat Cell Biol 12: 299-305
    • (2010) Nat Cell Biol , vol.12 , pp. 299-305
    • Youssef, K.K.1    Van Keymeulen, A.2    Lapouge, G.3
  • 48
    • 0033557853 scopus 로고    scopus 로고
    • PTCH2, a novel human patched gene, undergoing alternative splicing and up-regulated in basal cell carcinomas
    • Zaphiropoulos PG, Unden AB, Rahnama F et al. (1999) PTCH2, a novel human patched gene, undergoing alternative splicing and up-regulated in basal cell carcinomas. Cancer Res 59: 787-92
    • (1999) Cancer Res , vol.59 , pp. 787-792
    • Zaphiropoulos, P.G.1    Unden, A.B.2    Rahnama, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.