Simvastatin potently induces calcium-dependent apoptosis of human leiomyoma cells

Journal of Biological Chemistry

Volumn 289, Issue 51, 2014, Pages 35075-35086

  Borahay, Mostafa A ^a,b   Kilic, Gokhan S ^a   Yallampalli, Chrasekha ^c   Snyder, Russell R ^a   Hankins, Gary D V ^a   Al Hendy, Ayman ^d   Boehning, Darren ^b  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CELL DEATH; MACHINERY; TUMORS;

ANTITUMOR EFFECT; CALCIUM CHANNELS; CALCIUM RELEASE; CELL APOPTOSIS; CELL-CYCLE PROGRESSION; MITOGEN ACTIVATED PROTEIN KINASE; MULTIPLE CHANGES; PLASMA CHOLESTEROL;

CELL SIGNALING;

BIM PROTEIN; CALCIUM CHANNEL L TYPE; CELL NUCLEUS ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE 1; SIMVASTATIN; 1,2-BIS(2-AMINOPHENOXY)ETHANE N,N,N',N'-TETRAACETIC ACID ACETOXYMETHYL ESTER; CALCIUM; CHELATING AGENT; EGTAZIC ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CALCIUM TRANSPORT; CANCER CELL; CANCER INHIBITION; CELL CYCLE PROGRESSION; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LEIOMYOMA; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION; ANALOGS AND DERIVATIVES; CELL CYCLE; CELL SURVIVAL; CYTOSOL; DRUG EFFECTS; FLUORESCENCE MICROSCOPY; METABOLISM; PATHOLOGY; PHOSPHORYLATION; TUMOR CELL LINE; WESTERN BLOTTING;

APOPTOSIS; BLOTTING, WESTERN; CALCIUM; CALCIUM CHANNELS, L-TYPE; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CHELATING AGENTS; CYTOSOL; DOSE-RESPONSE RELATIONSHIP, DRUG; EGTAZIC ACID; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LEIOMYOMA; MAP KINASE SIGNALING SYSTEM; MICROSCOPY, FLUORESCENCE; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; SIMVASTATIN;

EID: 84919360782     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.583575     Document Type: Article

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