The transient receptor potential channel antagonist SKF96365 is a potent blocker of low-voltage-activated T-type calcium channels

British Journal of Pharmacology

Volumn 160, Issue 6, 2010, Pages 1464-1475

  Singh, A ^a   Hildebrand, M E ^b   Garcia, E ^a   Snutch, T P ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b Neuromed Pharmaceuticals   (Canada)

Author keywords

SKF 96365; T type calcium channel inhibition; T type calcium channels; TRPC antagonist

Indexed keywords

1 [2 (4 METHOXYPHENYL) 2 [3 (4 METHOXYPHENYL)PROPOXY]ETHYL] 1H IMIDAZOLE; CALCIUM CHANNEL T TYPE; RECOMBINANT PROTEIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL; 1-(2-(3-(4-METHOXYPHENYL)PROPOXY)-4-METHOXYPHENYLETHYL)-1H-IMIDAZOLE; CALCIUM CHANNEL BLOCKING AGENT; IMIDAZOLE DERIVATIVE;

ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; CONTROLLED STUDY; HUMAN; HUMAN CELL; MALE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN FUNCTION; PURKINJE CELL; RAT; RECEPTOR BLOCKING; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CYTOLOGY; DRUG EFFECTS; IC50; KIDNEY; METABOLISM; PATCH CLAMP TECHNIQUE; WISTAR RAT;

ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, T-TYPE; CELL LINE; HUMANS; IMIDAZOLES; INHIBITORY CONCENTRATION 50; KIDNEY; MALE; PATCH-CLAMP TECHNIQUES; PURKINJE CELLS; RATS; RATS, WISTAR; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

EID: 77954065755     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.00786.x     Document Type: Article

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