Extracellular Signal-regulated Kinases 1/2 Are Serum-stimulated "BimEL Kinases" That Bind to the BH3-only Protein Bim EL Causing Its Phosphorylation and Turnover

Journal of Biological Chemistry

Volumn 279, Issue 10, 2004, Pages 8837-8847

  Ley, Rebecca ^a   Ewings, Katherine E ^a   Hadfield, Kathryn ^a   Howes, Elizabeth ^a   Balmanno, Kathryn ^a   Cook, Simon J ^a  

^a BABRAHAM INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOCHEMISTRY; BLOOD; CELL CULTURE; CHEMICAL ACTIVATION; PHOSPHORUS; PROTEINS;

BIOCHEMICAL PATHWAYS; PHOSPHORYLATION; SERUM;

ENZYME KINETICS;

BH3 PROTEIN; BIM PROTEIN; CYCLOPHILIN; GLUTATHIONE TRANSFERASE; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN BIM EL; PROTEIN KINASE; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; AMINO ACID METABOLISM; ARTICLE; CELL SURVIVAL; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DECISION MAKING; ENZYME ANALYSIS; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CARRIER PROTEINS; CELL LINE; ENZYME ACTIVATION; HUMANS; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS; SIGNAL TRANSDUCTION;

EID: 1542275411     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M311578200     Document Type: Article

References (43)

1. Cory, S., and Adams, J. M. (2002) Nat. Rev. Cancer 2, 647-656
2. Puthalakath, H., and Strasser, A. (2002) Cell Death Differ. 9, 505-512
3. Oda, E., Ohki, R., Murasawa, H., Nemoto, J., Shibue, T., Yamashita, T., Tokino, T., Taniguchi, T., and Tanaka, N. (2000) Science 288, 1053-1058
4. Nakano, K., and Vousden, K. H. (2001) Mol. Cell 7, 683-694
5. Li, H., Zhu, H., Xu, C. J., and Yuan, J. (1998) Cell 94, 491-501
6. Ballif, B. A., and Blenis, J. (2001) Cell Growth Differ. 12, 397-408
7. Datta, S. R., Katsov, A., Hu, L., Petros, A., Fesik, S. W., Yaffe, M. B., and Greenberg, M. E. (2000) Mol. Cell 6, 41-51
8. Shimamura, A., Ballif, B. A., Richards, S. A., and Blenis, J. (2000) Curr. Biol. 10, 127-135
9. Harada, H., Becknell, B., Wilm, M., Mann, M., Huang, L. J., Taylor, S. S., Scott, J. D., and Korsmeyer, S. J. (1999) Mol. Cell 3, 413-422
10. Dijkers, P. F., Medema, R. H., Lammers, J. W., Koenderman, L., and Coffer, P. J. (2000) Curr. Biol. 10, 1201-1204
11. Shinjyo, T., Kuribara, R., Inukai, T., Hosoi, H., Kinoshita, T., Miyajima, A., Houghton, P. J., Look, A. T., Ozawa, K., and Inaba, T. (2001) Mol. Cell. Biol. 21, 854-864
12. Putcha, G. V., Moulder, K. L., Golden, J. P., Bouillet, P., Adams, J. A., Strasser, A., and Johnson, E. M., Jr. (2001) Neuron 29, 615-628
13. Whitfield, J., Neame, S. J., Paquet, L., Bernard, O., and Ham, J. (2001) Neuron 29, 629-643
14. Weston, C., Balmanno, K., Chalmers, C., Hadfield, K., Molton, S., Ley, R., Wagner, E. F., and Cook, S. J. (2003) Oncogene 22, 1281-1293
15. Gilley, J., Coffer, P. J., and Ham, J. (2003) J. Cell Biol. 162, 613-622
16. Bouillet, P., Zhang, L. C., Huang, D. C., Webb, G. C., Bottema, C. D., Shore, P., Eyre, H. J., Sutherland, G. R., and Adams, J. M. (2001) Mamm. Genome 12, 163-168
17. Hsu, S. Y., Lin, P., and Hsueh, A. J. (1998) Mol. Endocrinol. 9, 1432-1440
18. O'Connor, L., Strasser, A., O'Reilly, L. A., Hausmann, G., Adams, J. M., Cory S., and Huang, D. C. (1998) EMBO J. 17, 384-395
19. Puthalakath, H., Huang, D. C., O'Reilly, L. A., King, S. M., and Strasser, A. (1999) Mol. Cell 3, 287-296
20. Biswas, S. C., and Greene, L. A. (2002) J. Biol. Chem. 277, 49511-49516
21. Lei, K., and Davis, R. J. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 2432-2437
22. Seward, R. J., von Haller, P. D., Aebersold, R., and Huber, B. T. (2003) Mol. Immunol. 39, 983-993
23. Putcha, G. V., Le, S., Frank, S., Besirli, C. G., Clark, K., Chu, B., Alix, S., Youle, R. J., LaMarche, A., Maroney, A. C., Johnson, E. M., Jr. (2003) Neuron 38, 899-914
24. Ley, R., Balmanno, K., Hadfield, K., Weston, C., and Cook, S. J. (2003) J. Biol. Chem. 278, 18811-18816
25. Garner, A. P., Weston, C. R., Todd, D. E., Balmanno, K., and Cook, S. J. (2002) Oncogene 21, 8089-8104
26. Squires, M. S., Nixon, P. M., and Cook, S. J. (2002) Biochem. J. 366, 673-680
27. Sambrook, J., Fritsch, E. F., and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, 2nd Ed., pp. 16.32-16.37, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
28. Smith, D. B., and Johnson, K. S. (1988) Gene (Amst.) 67, 31-40
29. Marani, M., Tenev, T., Hancock, D., Downward, J., and Lemoine, N. R. (2002) Mol. Cell. Biol. 22, 3577-3589
30. Verdecia, M. A., Bowman, M. E., Lu, K. P., Hunter, T., and Noel, J. P. (2000) Nat. Struct. Biol. 7, 639-643
31. Yaffe, M. B., Schutkowski, M., Shen, M., Zhou, X. Z., Stukenberg, P. T., Rahfeld, J. U., Xu, J., Kuang, J., Kirschner, M. W., Fischer, G., Cantley, L. C., and Lu, K. P. (1997) Science 278, 1957-1960
32. He, J., Xu, J., Xu, X. X., and Hall, R. A. (2003) Oncogene 22, 4524-4530
33. Ryo, A., Nakamura, M., Wulf, G., Liou, Y. C., and Lu, K. P. (2001) Nat. Cell Biol. 3, 793-801
34. Hsu, T., McRackan, D., Vincent, T. S., and Gert de Couet, H. (2001) Nat. Cell Biol. 3, 538-543
35. Wulf, G. M., Ryo, A., Wulf, G. G., Lee, S. W., Niu, T., Petkova, V., and Lu, K. P. (2001) EMBO J. 20, 3459-3472
36. Lu, P.-J., Zhou, X. Z., Shen, M., and Lu, K. P. (1999) Science 283, 1325-1328
37. Hibi, M., Lin, A., Smeal, T., Minden, A., and Karin, M. (1993) Genes Dev. 7, 2135-2148
38. Yang, S.-H., Whitmarsh, A. J., Davis, R. J., and Sharrocks, A. D. (1998) EMBO J. 17, 1740-1749
39. Davis, R. J. (1993) J. Biol. Chem. 268, 14553-14556
40. Holland, P. M., and Cooper, J. A. (1999) Curr. Biol. 9, R329-R331
41. Sharrocks, A. D., Yang, S. H., and Galanis, A. (2000) Trends Biochem. Sci. 25, 448-453
42. Tanoue, T., and Nishida, E. (2002) Pharmacol. Ther. 93, 193-202
43. May, G. H., Allen, K. E., Clark, W., Funk, M., and Gillespie, D. A. F. (1998) J. Biol. Chem. 273, 33429-33435