Caspase 3 cleavage of the inositol 1,4,5-trisphosphate receptor does not contribute to apoptotic calcium release

Cell Calcium

Volumn 53, Issue 2, 2013, Pages 152-158

  Akimzhanov, Askar M ^a   Barral, José M ^a   Boehning, Darren ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Apoptosis; Calcium; Caspase 3; Inositol 1,4,5 trisphosphate receptor; Staurosporine

Indexed keywords

CALCIUM; CASPASE 3; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; PROTEIN KINASE; STAUROSPORINE;

APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CALCIUM TRANSPORT; CELL DEATH; ENZYME ACTIVATION; ENZYME ACTIVITY; FIBROBLAST; HELA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN EXPRESSION;

EID: 84873523771     PISSN: 01434160     EISSN: 15321991     Source Type: Journal    
DOI: 10.1016/j.ceca.2012.10.002     Document Type: Article

References (34)

1. Orrenius S., Zhivotovsky B., Nicotera P. Regulation of cell death: the calcium-apoptosis link. Nature Reviews Molecular Cell Biology 2003, 4:552-565.
2. Sugawara H., Kurosaki M., Takata M., Kurosaki T. Genetic evidence for involvement of type 1, type 2 and type 3 inositol 1,4,5-trisphosphate receptors in signal transduction through the B-cell antigen receptor. EMBO Journal 1997, 16:3078-3088.
3. Khan A.A., Soloski M.J., Sharp A.H., Schilling G., Sabatini D.M., Li S.H., Ross C.A., Snyder S.H. Lymphocyte apoptosis: mediation by increased type 3 inositol 1,4,5-trisphosphate receptor. Science 1996, 273:503-507.
4. Jayaraman T., Marks A.R. T cells deficient in inositol 1,4,5-trisphosphate receptor are resistant to apoptosis. Molecular and Cellular Biology 1997, 17:3005-3012.
5. Hirota J., Furuichi T., Mikoshiba K. Inositol 1,4,5-trisphosphate receptor type 1 is a substrate for caspase-3 and is cleaved during apoptosis in a caspase-3-dependent manner. Journal of Biological Chemistry 1999, 274:34433-34437.
6. Assefa Z., Bultynck G., Szlufcik K., Nadif Kasri N., Vermassen E., Goris J., Missiaen L., Callewaert G., Parys J.B., De Smedt H. Caspase-3-induced truncation of type 1 inositol trisphosphate receptor accelerates apoptotic cell death and induces inositol trisphosphate-independent calcium release during apoptosis. Journal of Biological Chemistry 2004, 279:43227-43236.
7. Yoshikawa F., Morita M., Monkawa T., Michikawa T., Furuichi T., Mikoshiba K. Mutational analysis of the ligand binding site of the inositol 1,4,5-trisphosphate receptor. Journal of Biological Chemistry 1996, 271:18277-18284.
8. Szlufcik K., Bultynck G., Callewaert G., Missiaen L., Parys J.B., De Smedt H. The suppressor domain of inositol 1,4,5-trisphosphate receptor plays an essential role in the protection against apoptosis. Cell Calcium 2006, 39:325-336.
9. 2+-leak channel: cell biological and pathological consequences. Biologie Cellulaire 2006, 98:1-14.
10. Nakayama T., Hattori M., Uchida K., Nakamura T., Tateishi Y., Bannai H., Iwai M., Michikawa T., Inoue T., Mikoshiba K. The regulatory domain of the inositol 1,4,5-trisphosphate receptor is necessary to keep the channel domain closed: possible physiological significance of specific cleavage by caspase 3. Biochemical Journal 2004, 377:299-307.
11. Ramos-Franco J., Galvan D., Mignery G.A., Fill M. Location of the permeation pathway in the recombinant type 1 inositol 1,4,5-trisphosphate receptor. Journal of General Physiology 1999, 114:243-250.
12. Blackshaw S., Sawa A., Sharp A.H., Ross C.A., Snyder S.H., Khan A.A. Type 3 inositol 1,4,5-trisphosphate receptor modulates cell death. FASEB Journal 2000, 14:1375-1379.
13. 2+ signals into mitochondria. Journal of Biological Chemistry 2005, 280:40892-40900.
14. Boehning D., Patterson R.L., Sedaghat L., Glebova N.O., Kurosaki T., Snyder S.H. Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis. Nature Cell Biology 2003, 5:1051-1061.
15. Boehning D., van Rossum D.B., Patterson R.L., Snyder S.H. A peptide inhibitor of cytochrome c/inositol 1,4,5-trisphosphate receptor binding blocks intrinsic and extrinsic cell death pathways. Proceedings of the National Academy of Sciences of the United States of America 2005, 102:1466-1471.
16. Elkoreh G., Blais V., Beliveau E., Guillemette G., Denault J.B. Type 1 inositol-1,4,5-trisphosphate receptor is a late substrate of caspases during apoptosis. Journal of Cellular Biochemistry 2012, 113:2775-2784.
17. Uchiyama T., Yoshikawa F., Hishida A., Furuichi T., Mikoshiba K. A novel recombinant hyperaffinity inositol 1,4,5-trisphosphate (IP(3)) absorbent traps IP(3), resulting in specific inhibition of IP(3)-mediated calcium signaling. Journal of Biological Chemistry 2002, 277:8106-8113.
18. Joseph S.K., Samanta S. Detergent solubility of the inositol trisphosphate receptor in rat brain membranes. Evidence for association of the receptor with ankyrin. Journal of Biological Chemistry 1993, 268:6477-6486.
19. Denault J.B., Salvesen G.S. Expression, purification, and characterization of caspases. Current Protocols in Protein Science 2003, (Chapter 21, Unit 21.13).
20. Crameri A., Whitehorn E.A., Tate E., Stemmer W.P. Improved green fluorescent protein by molecular evolution using DNA shuffling. Nature Biotechnology 1996, 14:315-319.
21. Wozniak A.L., Wang X., Stieren E.S., Scarbrough S.G., Elferink C.J., Boehning D. Requirement of biphasic calcium release from the endoplasmic reticulum for Fas-mediated apoptosis. Journal of Cell Biology 2006, 175:709-714.
22. Jeschke M.G., Gauglitz G.G., Song J., Kulp G.A., Finnerty C.C., Cox R.A., Barral J.M., Herndon D.N., Boehning D. Calcium and ER stress mediate hepatic apoptosis after burn injury. Journal of Cellular and Molecular Medicine 2009, 13:1857-1865.
23. Janicke R.U., Ng P., Sprengart M.L., Porter A.G. Caspase-3 is required for alpha-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis. Journal of Biological Chemistry 1998, 273:15540-15545.
24. Janicke R.U., Sprengart M.L., Wati M.R., Porter A.G. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. Journal of Biological Chemistry 1998, 273:9357-9360.
25. Walsh J.G., Cullen S.P., Sheridan C., Luthi A.U., Gerner C., Martin S.J. Executioner caspase-3 and caspase-7 are functionally distinct proteases. Proceedings of the National Academy of Sciences of the United States of America 2008, 105:12815-12819.
26. Akimzhanov A.M., Wang X., Sun J., Boehning D. T-cell receptor complex is essential for Fas signal transduction. Proceedings of the National Academy of Sciences of the United States of America 2010, 107:15105-15110.
27. Varnai P., Balla T. Visualization of phosphoinositides that bind pleckstrin homology domains: calcium- and agonist-induced dynamic changes and relationship to myo-[3H]inositol-labeled phosphoinositide pools. Journal of Cell Biology 1998, 143:501-510.
28. Joseph S.K., Bokkala S., Boehning D., Zeigler S. Factors determining the composition of inositol trisphosphate receptor hetero-oligomers expressed in COS cells. Journal of Biological Chemistry 2000, 275:16084-16090.
29. Joseph S.K., Boehning D., Pierson S., Nicchitta C.V. Membrane insertion, glycosylation, and oligomerization of inositol trisphosphate receptors in a cell-free translation system. Journal of Biological Chemistry 1997, 272:1579-1588.
30. Monkawa T., Miyawaki A., Sugiyama T., Yoneshima H., Yamamoto-Hino M., Furuichi T., Saruta T., Hasegawa M., Mikoshiba K. Heterotetrameric complex formation of inositol 1,4,5-trisphosphate receptor subunits. Journal of Biological Chemistry 1995, 270:14700-14704.
31. Wojcikiewicz R.J. Type I, II, and III inositol 1,4,5-trisphosphate receptors are unequally susceptible to down-regulation and are expressed in markedly different proportions in different cell types. Journal of Biological Chemistry 1995, 270:11678-11683.
32. Khan M.T., Bhanumathy C.D., Schug Z.T., Joseph S.K. Role of inositol 1,4,5-trisphosphate receptors in apoptosis in DT40 lymphocytes. Journal of Biological Chemistry 2007, 282:32983-32990.
33. Kopil C.M., Siebert A.P., Kevin Foskett J., Neumar R.W. Calpain-cleaved type 1 inositol 1,4,5-trisphosphate receptor impairs ER Ca(2+) buffering and causes neurodegeneration in primary cortical neurons. Journal of Neurochemistry 2012, 123:147-158.
34. Kopil C.M., Vais H., Cheung K.H., Siebert A.P., Mak D.O., Foskett J.K., Neumar R.W. Calpain-cleaved type 1 inositol 1,4,5-trisphosphate receptor (InsP(3)R1) has InsP(3)-independent gating and disrupts intracellular Ca(2+) homeostasis. Journal of Biological Chemistry 2011, 286:35998-36010.