Protein isotope effects in dihydrofolate reductase from geobacillus stearothermophilus show entropic-enthalpic compensatory effects on the rate constant

Journal of the American Chemical Society

Volumn 136, Issue 49, 2014, Pages 17317-17323

  Luk, Louis Y P ^a   Ruiz Pernía, J Javier ^c   Dawson, William M ^a   Loveridge, E Joel ^a   Tuñón, Iñaki ^b   Moliner, Vicent ^c   Allemann, Rudolf K ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF VALENCIA   (Spain)

^c UNIVERSITAT JAUME I   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER MOBILITY; ELECTRONIC STATES; ENZYMES; ESCHERICHIA COLI; RATE CONSTANTS;

DIHYDROFOLATE REDUCTASE; GEOBACILLUS STEAROTHERMOPHILUS; INCREASING TEMPERATURES; KINETIC ISOTOPE EFFECTS; MODERATELY THERMOPHILIC; PHYSIOLOGICAL TEMPERATURE; TRANSMISSION COEFFICIENTS; VARIATIONAL TRANSITION STATE THEORY;

ISOTOPES;

DIHYDROFOLATE REDUCTASE; ENZYME; ISOTOPE; PROTEIN; CARBON; NITROGEN;

ARTICLE; BACTERIAL STRAIN; CALCULATION; CONCEPTUAL FRAMEWORK; CONTROLLED STUDY; CROSS COUPLING REACTION; ENTHALPY; ENTROPY; ENZYME KINETICS; ESCHERICHIA COLI; GEOBACILLUS STEAROTHERMOPHILUS; HIGH TEMPERATURE; LOW TEMPERATURE; MOLECULAR DYNAMICS; NONHUMAN; PROTEIN STABILITY; SIMULATION; STATIC ELECTRICITY; THERMODYNAMICS; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; ENZYMOLOGY; METABOLISM;

CARBON ISOTOPES; GEOBACILLUS STEAROTHERMOPHILUS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NITROGEN ISOTOPES; STATIC ELECTRICITY; TETRAHYDROFOLATE DEHYDROGENASE; THERMODYNAMICS;

EID: 84918567332     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja5102536     Document Type: Article

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